| Project/Area Number |
23590820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Fujita Health University |
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Principal Investigator |
KOJI Suzuki 藤田保健衛生大学, 医療科学部, 准教授 (60288470)
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| Co-Investigator(Kenkyū-buntansha) |
ICHINO Naohiro 藤田保健衛生大学, 医療科学部, 准教授 (50278280)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性腎臓病 / 酸化ストレス / アディポカイン / miRNA / カロテノイド / 疫学研究 |
|---|
| Research Abstract |
This study investigated the associations of kidney function with serum levels of carotenoids, adipokines, and miRNAs which are involved in vascular endothelial function, among Japanese adults who attended a health examination. Increased levels of serum provitamin A, especially serum beta-carotene, were independently associated with lower risk of albuminuria among women. Serum resistin levels were positively associated with serum cystatin C levels in both sexes. Longitudinal study showed that increases in body mass and serum resistin levels were associated with decrease in estimated glomerular filtration rate (eGFR). Moreover serum miR-21 and 122 were increased in albuminuria group compared with normal group, and serum miR-126 levels were independently and positively associated with eGFR. Kidney function decline was implicated with oxidative stress, abnormal resistin secretion, and changes in serum miRNAs which affect vascular endothelial dysfunction.
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