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Establishment of objective index markers for the mental health problem in workers

Research Project

Project/Area Number 23590825
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKansai University of Welfare Sciences

Principal Investigator

KURATSUNE HIROHIKO  関西福祉科学大学, 健康福祉学部, 教授 (50195533)

Co-Investigator(Kenkyū-buntansha) 平田 まり  関西福祉科学大学, 教授 (90173244)
大川 尚子  関西福祉科学大学, 教授 (70369685)
長見 まき子  関西福祉科学大学, 准教授 (10388663)
中富 康仁  大阪市立大学, 大学院医学, 研究科後期研究員 (90566184)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Keywords健康診断 / メンタルヘルス障害 / 自律神経機能 / 睡眠・覚醒リズム / 酸化ストレス / 抗酸化力 / 疲労 / 抑うつ / 睡眠異常
Research Abstract

To clarify the objective features of the fatigue state, we investigated subjective symptoms, autonomic nerve function, physical activities, and sleep parameters in 207 college students and 430 staff members of a school that had been affected by the Great East Japan Earthquake in A-city, and 304 staff members of a school in west Japan. College students study suggests that autonomic nerve function is related to the fatigue symptoms, physical activities, and sleep parameters. Furthermore, the study for the staff members of a school indicates that both members in A-city and west Japan have not only severe fatigue symptoms, but also sympathetic hyperactivity, low awake activity and increase counts of catnaps during waking hours.
These data suggests that autonomic nerve function is clearly related to the fatigue symptoms, physical activities, and sleep parameters, and that it is a possible to make a diagnostic algorithm for fatigue state by using these objective index markers.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (46 results)

All 2014 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 11 results) Presentation (21 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Neuro- inflammation in patients with chronic fatigue syndrome/myalgic encephalo- myelitis : a 11C-(R)-PK11195 positron emission tomography study2014

    • Author(s)
      Nakatomi Y, Mizuno K, Ishii A, Wada Y, Tanaka M, Tazawa S, Onoe K, Fukuda S, Kawabe J, Takahashi K, Kataoka Y, Shiomi S, Yamaguti K, Inaba M, Kuratsune H, Watanabe Y
    • Journal Title

      Journal of Nuclear Medicine

      Volume: (in press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 東日本大震災被災地域における教職員に対する健康評価2014

    • Author(s)
      大川尚子, 倉恒弘彦, 他
    • Journal Title

      日本疲労学会雑誌

      Volume: (印刷中)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autonomic Dysfunction in Chronic Fatigue Syndrome2013

    • Author(s)
      Yamaguti,K. Tajima S. and Kuratsune H
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 4(4) Pages: 281-289

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autonomic Function is Associated With Health-Related Quality of Life in Patients With End-Stage Renal Disease : A Case-Control Study2013

    • Author(s)
      Fujii H, Koyama H, Fukuda S, Tokai H, Tajima S, Koizumi JI, Yamaguti K, Kuratsune H, Watanabe Y, Hirayama Y, Shoji T, Inaba M, Nishizawa Y
    • Journal Title

      J Ren Nutr

      Volume: (pii : S1051-2276(13) 00004-6)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 大学生の疲労度と自律神経機能評価-保健室利用者と一般女子学生との比較-2013

    • Author(s)
      大川尚子, 平田まり, 長見まき子, 野口法子, 藤原和美, 松村歌子, 柳本静子, 田島世貴, 小泉淳一, 倉恒弘彦
    • Journal Title

      日本疲労学会雑

      Volume: 8(2) Pages: 60-65

    • Related Report
      2013 Final Research Report
  • [Journal Article] Autonomic Dysfunction in Chronic Fatigue Syndrome2013

    • Author(s)
      Kouzi Yamaguti,Seiki Tajima and Hirohiko Kuratsune.
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 4 Pages: 281-289

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 慢性疲労症候群におけるムスカリン性アセチルコリン受容体の自己抗体による脳内の神経伝達機能低下2013

    • Author(s)
      水野敬、倉恒弘彦、渡辺恭良
    • Journal Title

      リウマチ科

      Volume: 50 Pages: 238-245

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 慢性疲労症候群(CFS)と機能性身体症候群(FSS)2013

    • Author(s)
      倉恒弘彦
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 24 Pages: 222-227

    • NAID

      130005395496

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 外来診療のワンポイントアドバイス 慢性疲労症候群2013

    • Author(s)
      倉恒弘彦
    • Journal Title

      診断と治療

      Volume: 101 Pages: 1563-1568

    • NAID

      40019832134

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Chronic fatigue syndrome and Fibromyalgia pain. Patient-Reported Outcomes2013

    • Author(s)
      Fukuda S., Watanabe Y., Kuratsune H.
    • Journal Title

      Pain Res Treat

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fatigue-related Problem Scale for better understanding of pathophysiology of chronic fatigue syndrome: discriminating from fibromyalgia and related pain2013

    • Author(s)
      Fukuda S., Kuratsune H., Kajimoto O., Watanabe Y.
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: in press

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of monoamine-synthesizing genes with the temperament of chronic fatigue syndrome patients2013

    • Author(s)
      Fukuda S., Horiguchi M., Yamaguti K., Nakatomi Y., Kuratsune H., Ichinose H.,Watanabe Y.
    • Journal Title

      Life Sci

      Volume: 92 Pages: 183-186

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autonomic Function is Associated With Health-Related Quality of Life in Patients With End-Stage Renal Disease: A Case-Control Study2013

    • Author(s)
      Fujii H, Koyama H, Fukuda S, Tokai H, Tajima S, Koizumi JI, Yamaguti K, Kuratsune H, Watanabe Y, Hirayama Y, Shoji T, Inaba M, Nishizawa Y.
    • Journal Title

      J Ren Nutr

      Volume: S1051-2276 Pages: 4-6

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性疲労症候群と自律神経2013

    • Author(s)
      倉恒弘彦。
    • Journal Title

      自律神経

      Volume: 50 Pages: 36-38

    • NAID

      10031163537

    • Related Report
      2012 Research-status Report
  • [Journal Article] Fatigue-related Problem Scale for better understanding of pathophysiology of chronic fatigue syndrome : discriminating from fibromyalgia and related pain2012

    • Author(s)
      Fukuda S., Kur atsune H., Kajimoto O., Watanabe Y
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 3(3-4) Issue: 3,4 Pages: 361-366

    • DOI

      10.3233/nib-012906

    • Related Report
      2013 Final Research Report
  • [Journal Article] Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis2012

    • Author(s)
      Sakudo A., Kur atsune H., Hakariya KatoY., Ikuta K
    • Journal Title

      Clinica Chimica Acta

      Volume: 413(19-20) Pages: 1629-32

    • Related Report
      2013 Final Research Report
  • [Journal Article] Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers2012

    • Author(s)
      Kuratsune D, Tajima S, Koizumi J, Yamaguti K, Sasabe T, Mizuno K, Tanaka M, Okawa N, Mito H, Tsubone H, Watanabe Y, Inoue M, and Kur atsune H
    • Journal Title

      World Journal of Neuroscience

      Volume: 2 Pages: 113-118

    • Related Report
      2013 Final Research Report
  • [Journal Article] Reduction of [11C](+)3-MPB Binding in Brain of Chronic Fatigue Syndrome with Serum Autoantibody against Muscarinic Cholinergic Receptor2012

    • Author(s)
      Yamamoto S., Ouchi Y., Nakatsuka D., Tahara T., Mizuno K., Tajima S., Onoe H., Yoshikawa E., Tsukada H., Iwase M., Yamaguti K., Kuratsune H., Watanabe Y.
    • Journal Title

      PLoS One

      Volume: 7

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Visible and near-infrared spectra collected from the thumbs of patients with chronic fatigue syndrome for diagnosis2012

    • Author(s)
      Sakudo A., Kuratsune H., Hakariya KatoY., Ikuta K.
    • Journal Title

      Clinica Chimica Acta

      Volume: 413 Pages: 1629-1632

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in reaction time, coefficient of variance of reaction time, and autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload in healthy volunteers2012

    • Author(s)
      Kuratsune D, Tajima S, Koizumi J, Yamaguti K, Sasabe T, Mizuno K, Tanaka M, Okawa N, Mito H, Tsubone H, Watanabe Y, Inoue M, and Kuratsune H.
    • Journal Title

      World Journal of Neuroscience

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autonomic nervous alterations associated with daily level of fatigue2011

    • Author(s)
      Tanaka M., Mizuno K., Yamaguti K., Kuratsune H., Fujii A., Baba H., Matsuda K., Nishimae A., Takesaka T., Watanabe Y
    • Journal Title

      Behav Brain Funct

      Volume: 7 Pages: 46-46

    • URL

      http://www.behavioralandbrainfunctions.com/content/7/1/46

    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Journal Article] "Oxidation stress index" as a possible clinical marker for the clinical evaluation of non-Hodgkin lymphoma.2011

    • Author(s)
      Nojima J., Motoki Y., Tsuneoka H., Kuratsune H., Matsui T., Yamamoto M., Yanagihara M., Hinoda Y., Ichihara K.
    • Journal Title

      Br J Haematol

      Volume: 155 Pages: 528-530

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Mental fatigue caused by prolonged cognitive load associated with sympathetic hyperactivity2011

    • Author(s)
      Mizuno K., Tanaka M., Yamaguti K., Kajimoto O., Kuratsune H., Watanabe Y.
    • Journal Title

      Behav Brain Funct

      Volume: 7 Pages: 17-17

    • URL

      http://www.behavioralandbrainfunctions.com/content/7/1/17

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 疲労とメンタルヘルス2011

    • Author(s)
      倉恒弘彦。
    • Journal Title

      臨床と研究

      Volume: 88 Pages: 55-60

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 慢性疲労症候群患者の脳内炎症に関するPositron Emission Tomography(PET)研究 「疲労と疲労病態の生理学・脳科学」2013

    • Author(s)
      中富康仁、倉恒弘彦、渡辺恭良
    • Organizer
      第9回日本疲労学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 東日本大震災被災地域における教職員に対する健康評価 「疫学と調査」2013

    • Author(s)
      大川尚子、平田まり、長見まき子、野口法子、藤原和美、松村歌子、鹿野裕美、吉田俊子、倉恒弘彦
    • Organizer
      第9回日本疲労学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 慢性疲労症候群における還元型コエンザイムQ10の効果:二重盲検群間比較試験 「治療と介入」2013

    • Author(s)
      福田早苗、中富康仁、山口浩二、野島順三、近藤一博、梶本修身、倉恒弘彦、渡辺恭良。
    • Organizer
      第9回日本疲労学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新たな慢性疲労症候群(CFS)診断基準と客観的な疲労評価法 「CFSの実態調査結果と新たなCFS診断基準」2013

    • Author(s)
      倉恒弘彦
    • Organizer
      第9回日本疲労学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 疲労時における自律神経機能と単純計算課題による脳機能の関連 「機能と評価方法」2013

    • Author(s)
      山口浩二、笹部哲也、中富康仁、田島世貴、倉恒弘彦、稲葉雅章、渡辺恭良。
    • Organizer
      第9回日本疲労学会
    • Place of Presentation
      秋田
    • Related Report
      2013 Annual Research Report
  • [Presentation] 慢性疲労症候群(CFS) 精神科疾患とのcomorbidityが問題となる身体科疾患2013

    • Author(s)
      倉恒弘彦
    • Organizer
      第54回日本心身医学会総会ならびに学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] 特別講演慢性疲労に陥るメカニズム-前頭葉機能異常と疲労・疼痛との関連-2011

    • Author(s)
      倉恒弘彦。
    • Organizer
      第41回日本ペインクリニック学会関西支部学術集会(招待講演)
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Presentation] 大学生の疲労度と自律神経機能評価(1)保健室利用者と一般学生との比較2011

    • Author(s)
      大川尚子、平田まり、柳本静子、倉恒弘彦。
    • Organizer
      第7回日本疲労学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性疲労症候群患者における起立試験時の自律神経機能について(ローレンツプロットを用いた評価法)2011

    • Author(s)
      山口浩二、笹部哲也、中富康仁、田島世貴、倉恒弘彦、稲葉雅章、渡辺恭良。
    • Organizer
      第7回日本疲労学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Research-status Report
  • [Presentation] Objective biomakers for the fatigue state-the changes of oxidation stress-2011

    • Author(s)
      Kuratsune H., Nojima J.
    • Organizer
      International Association for Chronic Fatigue Syndrome
    • Place of Presentation
      Ottawa, Canada
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性疲労症候群と自律神経2011

    • Author(s)
      倉恒弘彦。
    • Organizer
      第64回日本自律神経学会総会(招待講演)
    • Place of Presentation
      秋田
    • Related Report
      2011 Research-status Report
  • [Presentation] 慢性疲労症候群と睡眠障害

    • Author(s)
      中富康仁、倉恒弘彦、吉田政樹、稲葉雅章、渡辺恭良。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性疲労症候群の実態調査

    • Author(s)
      福田早苗、中富康仁、山口浩二、渡辺恭良、倉恒弘彦。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 大学生における疲労と生活習慣に関する研究

    • Author(s)
      藤井比佐子、福田早苗、倉恒弘彦、渡辺恭良。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 東日本大震災支援者における疲労の適正評価について

    • Author(s)
      佐藤大介、霜山真、澤口利絵、山田志枝、倉恒大輔、倉恒弘彦、吉田俊子。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] みどりの香りと抗疲労効果の科学的検証

    • Author(s)
      大川尚子、柳本静子、平田まり、倉恒弘彦。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性疲労症候群患者の単純連続計算課題による疲労評価

    • Author(s)
      山口浩二、笹部哲也、中富康仁、田島世貴、倉恒弘彦、稲葉雅章、渡辺恭良。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 慢性疲労症候群における還元型コエンザイムQ10の効果:摂取栄養素との関連を含めて

    • Author(s)
      福田早苗、藤井比佐子、中富康仁、山口浩二、野島順三、梶本修身、倉恒弘彦、渡辺恭良。
    • Organizer
      第8回日本疲労学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 現代人の疲労と動物介在療法の役割

    • Author(s)
      倉恒弘彦。
    • Organizer
      第5回動物介在教育・療法学会
    • Place of Presentation
      青森
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 慢性疲労症候群(CFS)と機能性身体症候群(FSS)

    • Author(s)
      倉恒弘彦。
    • Organizer
      第34回日本生物学的精神医学会
    • Place of Presentation
      兵庫
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 東日本大震災の被災者と支援者における疲労状態の評価と疾病予防に向けた支援‐被災地域の小中学校における養護教諭の抱える問題解決を含めて‐

    • Author(s)
      倉恒弘彦、廣澤巖夫、三戸秀樹、大野太郎、平田まり、大川尚子、藤原和美。
    • Organizer
      第3回総合福祉科学学会
    • Place of Presentation
      大阪
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.fuksi-kagk-u.ac.jp/guide/efforts/research/kuratsune/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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