Risk evaluation based on the clinical characteristics of Hematological malignancies in atomic bomb survivors
| Project/Area Number |
23590829
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Jikei University School of Medicine (2013-2014)
Teikyo University (2011-2012) |
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Principal Investigator |
IWANAGA Masako 東京慈恵会医科大学, 医学部, 講師 (00372772)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Yasushi 長崎大学, 原爆後障害医療研究所, 教授 (40304943)
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| Research Collaborator |
松尾 正稔 長崎大学, 血液内科, 医員
波多 智子 長崎大学, 血液内科, 准教授
対馬 秀樹 長崎大学, 血液内科, 助教
近藤 久義 長崎大学, 原爆後障害医療研究所, 助教
早田 みどり 長崎県腫瘍登録室, 室長
朝長 万左男 長崎原爆病院, 院長
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん疫学 / 臨床疫学 / リスク解析 / 原爆被爆者 / 造血器腫瘍 / 放射線被爆 / 発症リスク / 予後リスク / 放射線被曝 |
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| Outline of Final Research Achievements |
To clarify the detailed characteristics of hematological malignancies that occurred in Nagasaki atomic bomb survivors, we conducted clinico-epidemiological studies. We found that (1) myelodysplastic syndromes who were exposed proximally to atomic bomb had a high frequency of the poor chromosome score of the international prognostic scoring system of myelodysplastic syndromes, but exposure distance was not a significant risk-factor for the leukemic transformation and death; (2) monosomy 7 was the most frequent chromosomal abnormality in myelodysplastic syndromes who were exposed proximally, which was similar to chromosomal abnormality in therapy-related leukemia/myelodysplastic syndromes; and (3) exposure distance was not a significant risk-factor for the development of adult T-cell leukemia in atomic bomb survivors, even after adjusting for age and smoking.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] Correlation between dysplastic lineage and type of cytopenia in myelodysplastic syndromes patients with refractory anemia according to the FAB classification.2013
Author(s)
Matsuda A, Jinnai I, Iwanaga M, Okamura D, Ishikawa M, Maeda T, Hata T, Kawai N, Miyazaki Y, Bessho M, Tomonaga M.
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Journal Title
Am J Clin Pathol.
Volume: 140
Issue: 2
Pages: 253-257
DOI
Related Report
Peer Reviewed
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[Journal Article] Radiat2013
Author(s)
Hsu WL, Preston DL, Soda M, Sugiyama H, Funamoto S, Kodama K, Kimura A, Kamada N, Dohy H, Tomonaga M, Iwanaga M, Miyazaki Y, Cullings HM, Suyama A, Ozasa K, Shore RE, Mubuchi K
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Journal Title
Res
Volume: 179
Issue: 3
Pages: 361-382
DOI
Related Report
Peer Reviewed
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