Effects of compounds isolated from traditional drugs on UV-induced photochemotherapy and carcinogenesis and their mechanisms

• Project/Area Number: 23590883
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine (including Psychosomatic medicine)
• Research Institution: Ehime University
• Principal Investigator: KIMURA Yoshiyuki 愛媛大学, 医学(系)研究科(研究院), 講師 (20294796)
• Co-Investigator(Renkei-kenkyūsha): SUMIYOSHI Maho 愛媛大学, 大学院医学系研究科, 助教 (60444767)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 癌 / 植物成分 / 薬理学 / 生理活性 / 紫外線

Research Abstract

Tetrahydroxy-dimethoxyflavone and Pentahydroxyflavanone isolated from Scutellariae Radix inhibited the acute UVB-induced skin inflammation through the inhibition of MMP-9 expression and VEGF production. We found that wogonin isolated from Scutellariae Radix had anti-tumor and anti-metastatic actions through anti-lymphangiogenesis. We found that the anti-proliferative and anti-tumor actions of UVA plus furocoumarins isolated from Umbelliferae medicinal plants were due to G2/M arrest of the cell cycle by an increase in phospho-Chk1 and decrease in phospho-cdc2 of melanoma cells.

Research Products

• [Journal Article] Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation (2014)
  • Author(s): Sumiyoshi M, Sakanaka M, Tanigichi M, Baba K, Kimura Y
  • Journal Title: J. Nat. Med. Volume: 68 Pages: 83-94
  • NAID: 40019919803
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation (2014)
  • Author(s): M. Sumiyoshi, M. Sakanaka, M. Taniguchi, K. Baba, Yoshiyuki Kimura
  • Journal Title: Journal of Natural Medicine Volume: 68 Issue: 1 Pages: 83-94
  • DOI: 10.1007/s11418-013-0774-z
  • NAID: 40019919803
  • Peer Reviewed
• [Journal Article] In vitro and in vivo antiproliferative effect of a combination of ultraviolet-A and alkoxy furocoumarins isolated from Umblelliferae medicinal plants, in melanoma cells (2013)
  • Author(s): Kimura Y, Sumiyoshi M, Sakanaka M, Tanigichi M, Baba K
  • Journal Title: Photochem. Photobiol Volume: 89 Pages: 1216-1225
  • Peer Reviewed
• [Journal Article] Anti-tumor and anti-metastatic action of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis (2013)
  • Author(s): Kimura Y, Sumiyoshi M
  • Journal Title: Phytomedicine Volume: 20 Pages: 328-336
  • Peer Reviewed
• [Journal Article] In vitro and In vivo Antiproliferative Effects of a Combination of Ultraviolet-A and Alkoxy Furocoumarins Isolated from Umbelliferae Medicinal Plants, in Melanoma Cells (2013)
  • Author(s): Yoshiyuki Kimura, M. Sumiyoshi, M. Sakakanaka, M. Taniguchi, K. Baba
  • Journal Title: Photoｃhemistry and Photobiology Volume: 89 Issue: 5 Pages: 1216-1225
  • DOI: 10.1111/php.12122
  • Peer Reviewed
• [Journal Article] Anti-tumor and anti-metastatic actons of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis (2013)
  • Author(s): Yoshiyuki Kimura, M. Sumiyoshi
  • Journal Title: Phytomedicine Volume: 20 Pages: 328-336
  • Peer Reviewed
• [Journal Article] Effects of various flavonoids isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice (2011)
  • Author(s): Kimura Y, Sumiyoshi M
  • Journal Title: J. Pharm. Pharmacol Volume: 63 Pages: 1613-1623
  • Peer Reviewed
• [Journal Article] Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice (2011)
  • Author(s): Kimura Y, Sumiyoshi M
  • Journal Title: Eur. J. Pharmacol Volume: 661 Pages: 124-132
  • Peer Reviewed
• [Journal Article] Effects of baicalein and wogonin isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice (2011)
  • Author(s): Yoshiyuki Kimura, M. Sumiyoshi
  • Journal Title: Eurpean Journal of Pharmacology Volume: 661 Pages: 124-132
  • Peer Reviewed
• [Journal Article] Effects of various flavonoids isolated from Scutellaria baicalensis roots on skin damage in acute UVB-irradiated hairless mice (2011)
  • Author(s): Yoshiyuki Kimura, M. Sumiyoshi
  • Journal Title: Journal of Pharmacy and Pharmacology Volume: 63 Pages: 1613-1623
  • Peer Reviewed
• [Presentation] 紫外線A 波(UVA)照射下におけるセリ科植物由来のクマリン類の抗腫瘍効果とその作用機構 (2013)
  • Author(s): 木村善行、住吉真帆、阪中雅広、谷口雅彦、馬場きみ江
  • Organizer: 日本生薬学会第60回年会
  • Place of Presentation: 北海道医療大学 (北海道、当別)
  • Year and Date: 2013-09-08
• [Presentation] 紫外線A波(UVA)照射下におけるセリ科植物由来のクマリン類の抗腫瘍効果とその作用機構 (2013)
  • Author(s): 木村善行、住吉真帆、阪中雅広、谷口雅彦、馬場きみ江
  • Organizer: 日本生薬学会 第60回年会
  • Place of Presentation: 北海道医療大学当別キャンパス
• [Presentation] Photochemotherapy by ultraviolet A plus furocoumarins isolated from Angelica species in B16F10-bearing hairless mice (2012)
  • Author(s): Kimura Y, Sumiyoshi M, Taniguchi M, Baba K
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Assocoation
  • Place of Presentation: Sapporo
  • Year and Date: 2012-09-19
• [Presentation] Photochemotherapy by ultraviolet A plus furocoumarins isolated from Angelica species in B16F10-bearing hairless mice (2012)
  • Author(s): Yoshiyuki Kimura, M. Sumiyoshi, M. Taniguchi, K. Baba
  • Organizer: The 71st Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: Sapporo
• [Presentation] リンパ管新生を介した黄芩中のWogoniの抗腫瘍・抗転移効果 (2011)
  • Author(s): 木村善行、住吉真帆
  • Organizer: 日本生薬学会第58回年会
  • Place of Presentation: 昭和大学(東京)
  • Year and Date: 2011-09-25