Effects of compounds isolated from traditional drugs on UV-induced photochemotherapy and carcinogenesis and their mechanisms
Project/Area Number |
23590883
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine (including Psychosomatic medicine)
|
Research Institution | Ehime University |
Principal Investigator |
KIMURA Yoshiyuki 愛媛大学, 医学(系)研究科(研究院), 講師 (20294796)
|
Co-Investigator(Renkei-kenkyūsha) |
SUMIYOSHI Maho 愛媛大学, 大学院医学系研究科, 助教 (60444767)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 癌 / 植物成分 / 薬理学 / 生理活性 / 紫外線 |
Research Abstract |
Tetrahydroxy-dimethoxyflavone and Pentahydroxyflavanone isolated from Scutellariae Radix inhibited the acute UVB-induced skin inflammation through the inhibition of MMP-9 expression and VEGF production. We found that wogonin isolated from Scutellariae Radix had anti-tumor and anti-metastatic actions through anti-lymphangiogenesis. We found that the anti-proliferative and anti-tumor actions of UVA plus furocoumarins isolated from Umbelliferae medicinal plants were due to G2/M arrest of the cell cycle by an increase in phospho-Chk1 and decrease in phospho-cdc2 of melanoma cells.
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Report
(4 results)
Research Products
(15 results)