Research on the therapeutic and preventive effects of alternative medicine in senile osteoporosis

Research Project

Project/Area Number	23590899
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General internal medicine (including Psychosomatic medicine)
Research Institution	Suzuka University of Medical Science
Principal Investigator	NASU Fumio 鈴鹿医療科学大学, 医用工学部, 教授 (10180530)
Co-Investigator(Kenkyū-buntansha)	田野かおり , 講師 (40399035)
Project Period (FY)	2011 – 2013
Project Status	Completed (Fiscal Year 2013)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	老人性骨粗鬆症 / SAMP6 / 鍼 / 灸 / 補完代替医療 / Glutation Peroxidase / AGEs / ホモシステイン / osteoporosis / SAM
Research Abstract	The senescence accelerated mouse strain P6 (SAMP6) is a model of senile osteoporosis because it develops osteoporosis in an early stage of life. We investigated the effects of traditional Chinese medicine, acupuncture and moxibustion, on mechanical properties of femur in SAMP6 mice by using the 3-point bending. Male SAMP6 mice received acupuncture or moxibustion stimulation on the bilateral Zusanri (anterior tibial muscle at about 10 mm below the knee joint) for at least 8 weeks. The strength of the femur tended to increase in the acupuncture SAMP6 group compared with the control SAMP6 group. However such effect was not recognized in the moxibustion SAMP6 group. We further evaluated the quality of bone which influences bone strength. We employed a level of antioxidative effect and non-physiological binding in bone collagen. Neither acupuncture nor moxibusion has influence on the quality of bone.