Analysis of microRNA expression in the gastric mucosa after successful eradication of Helicobacter pylori

• Project/Area Number: 23590911
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: OHNO Hideki 東京大学, 医科学研究所, 助教 (30396866)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ヘリコバクター・ピロリ / 除菌 / 胃癌 / マイクロRNA

Research Abstract

The onset of gastric cancer after successful eradication of Helicobacter pylori was reported in recent several studies. We have investigated the dysregulation of micro-RNAs in gastric mucosa of the patients after successful eradication of H. pylori by miRNA microarray. The expression of some miRNAs such as miR-155 were higher in the gastric mucosa of patients after successful eradication than in those not infected with H. pylori. Some of these miRNAs are known to have effects on cell proliferation and carcinogenesis. This result suggests the possibility that the dysregulation of miRNAs in gastric mucosa is involved in the onset of gastric cancer after successful eradication of H. pylori.

Research Products

• [Journal Article] INSL5 may be a unique marker of colorectal endocrine cells and neuroendocrine tumors (2013)
  • Author(s): Mashima H, Ohno H, Yamada Y, Sakai T, Ohnishi H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 432 Issue: 4 Pages: 586-592
  • DOI: 10.1016/j.bbrc.2013.02.042
  • Peer Reviewed
• [Presentation] ピロリ菌外来での除菌療法におけるエソメプラゾールとラベプラゾールの比較検討 (2013)
  • Author(s): 大野秀樹,篠崎大,加藤直也
  • Organizer: 第19回日本ヘリコバクター学会総会
  • Place of Presentation: 長崎大学医学部
  • Year and Date: 2013-06-28
• [Presentation] ピロリ菌外来での除菌療法におけるエソメプラゾールとラベプラゾールの比較検討 (2013)
  • Author(s): 大野秀樹 篠崎大 加藤直也
  • Organizer: 第１９回日本ヘリコバクター学会学術集会
  • Place of Presentation: 長崎大学医学部
• [Presentation] 自由診療外来における除菌前後の自覚症状の変化に関するFスケールによる検討 (2012)
  • Author(s): 大野秀樹,畑啓介,水野靖大,篠崎大,山下直秀,加藤直也
  • Organizer: 第18回日本ヘリコバクター学会総会(シンポジウム3)
  • Place of Presentation: 岡山コンベンションセンター
  • Year and Date: 2012-06-29
• [Presentation] 当院における「ピロリ菌外来」の現況 (2011)
  • Author(s): 大野秀樹,水野靖大,畑啓介,篠崎大,加藤直也
  • Organizer: 第17回日本ヘリコバクター学会学術集会
  • Place of Presentation: 富山国際会議場
  • Year and Date: 2011-06-24
• [Presentation] 自由診療外来における除菌前後の自覚症状の変化に関するFスケールによる検討
  • Author(s): 大野秀樹
  • Organizer: 第１８回日本ヘリコバクター学会学術集会
  • Place of Presentation: 岡山コンベンションセンター