Analysis of microRNA expression in the gastric mucosa after successful eradication of Helicobacter pylori
Project/Area Number |
23590911
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | The University of Tokyo |
Principal Investigator |
OHNO Hideki 東京大学, 医科学研究所, 助教 (30396866)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ヘリコバクター・ピロリ / 除菌 / 胃癌 / マイクロRNA |
Research Abstract |
The onset of gastric cancer after successful eradication of Helicobacter pylori was reported in recent several studies. We have investigated the dysregulation of micro-RNAs in gastric mucosa of the patients after successful eradication of H. pylori by miRNA microarray. The expression of some miRNAs such as miR-155 were higher in the gastric mucosa of patients after successful eradication than in those not infected with H. pylori. Some of these miRNAs are known to have effects on cell proliferation and carcinogenesis. This result suggests the possibility that the dysregulation of miRNAs in gastric mucosa is involved in the onset of gastric cancer after successful eradication of H. pylori.
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Report
(4 results)
Research Products
(6 results)