Development of genomics-based prophylaxis strategy for gastric mucosal injury induced by anti-platelet agents

• Project/Area Number: 23590913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: FURUTA TAKAHISA 浜松医科大学, 医学部附属病院, 准教授 (10303546)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Mitsushige 浜松医科大学, 医学部附属病院, 助教 (80397398) ; OGAWA Noriyoshi 浜松医科大学, 医学部附属病院, 講師 (80308618) ; TAKEUCHI Kazuhiko 浜松医科大学, 医学部, 準教授 (00419425) ; MATSUYAMA Yukihiro 浜松医科大学, 医学部, 教授 (20312316) ; NANBA Hiroki 浜松医科大学, 医学部, 教授 (60198405) ; UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 低用量アスピリン / H. pylori / 胃粘膜傷害 / 遺伝子多型 / SLCO1B1 / Aspirin / CYP2C9 / UGT1A6 / アスピリン / 抗血小板薬 / クロピドグレル

Research Abstract

Pharmacogenomics associated with the gastric mucosal injury induced by low dose aspirin (LDA) was investigated. We measured the four SNPs associated with metabolism of aspirin in patients treated with LDA. We analyzed the association of such SNPs with gastric mucosal injury with reference to H. pylori infection. The relative risk of gastric ulcer in patients with SLCO1B1 (rs4149056) TT genotype was 3.2 folds as high as that of those with C allele. The results suggest that measurement of SNP of SLCO1B1 could be the predictive marker of gastric mucosa injury induced by LDA.

Research Products

• [Journal Article] Prevention ofgastricmucosal injuryinduced by anti-platelet drugs by famotidine (2014)
  • Author(s): Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: J Clin Pharmacol Volume: (Epub ahead of print) Issue: 8 Pages: 858-864
  • DOI: 10.1002/jcph.284
  • Peer Reviewed
• [Journal Article] Dosing Schemes of Amoxicillin on Eradication Rates of Helicobacter pylori With Amoxicillin-Based Triple Therapy (2014)
  • Author(s): Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
  • Journal Title: J Clin Pharmacol Volume: 54 Issue: 3 Pages: 258-266
  • DOI: 10.1002/jcph.195
  • Peer Reviewed / Open Access
• [Journal Article] Eradication of H. pylori infection in patients allergic to penicillin by the triple therapy with a PPI, metronidazole and sitafloxacin (2014)
  • Author(s): Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
  • Journal Title: Intern Med. Volume: 53 Pages: 571-575
  • Peer Reviewed
• [Journal Article] Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan (2014)
  • Author(s): Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani TSahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
  • Journal Title: J Gastroenterol Hepatol Volume: 29 Issue: 3 Pages: 487-493
  • DOI: 10.1111/jgh.12442
  • Peer Reviewed / Open Access
• [Journal Article] Induction of Murine TNBS Colitis Is Strictly Controlled by a Modified Method Using Continuous Inhalation Anesthesia with Sevoflurane (2014)
  • Author(s): Terai T, Osawa S, Tani S, Oishi S, Arai Y, Yamada T, Sugimoto M, Furuta T, Kanaoka S, Miyajima H, Sugimoto K
  • Journal Title: Dig Dis Sci Volume: 1 Pages: 1-2
  • Peer Reviewed
• [Journal Article] アモキシシリン耐性の機序とその対策 (2014)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美、鏡卓馬
  • Journal Title: Helicobacter Research Volume: 18 Pages: 142-148
• [Journal Article] 除菌難渋例への対応 –薬剤耐性の実情と三次除菌、四次除菌レジメンの構築- (2014)
  • Author(s): 古田隆久
  • Journal Title: 日本ヘリコバクター学会誌 Volume: 15 Pages: 25-26
• [Journal Article] H. pylori胃炎診療の実際 –エキスパートからのアドバイス－ （3） H. pylori二次除菌失敗例に対する診療 (2014)
  • Author(s): 古田隆久、杉本光繁、魚谷貴洋、佐原秀、市川仁美、鏡卓馬
  • Journal Title: 臨床消化器内科 Volume: 29 Pages: 317-324
• [Journal Article] Rapid Automated Genotyping of CYP2C19 and the Helicobacter pylori 23S rRNA Gene in Gastric Juice (2013)
  • Author(s): Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K
  • Journal Title: Journal of GHR Volume: 2 Pages: 403-407
• [Journal Article] Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment (2013)
  • Author(s): Nishino M, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: Digestion Volume: 88(2) Pages: 79-86
• [Journal Article] Antiplatelet drugs are a risk factor for esophageal mucosal injury (2013)
  • Author(s): Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: Digestion Volume: 87(4) Pages: 281-9
• [Journal Article] Rapid Automated Genotyping of CYP2C19 and the Helicobacter pylori 23S rRNA Gene in Gastric Juice (2013)
  • Author(s): Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K.
  • Journal Title: Journal of GHR Volume: ２ Pages: 403-407
  • Peer Reviewed
• [Journal Article] 浜松医科大学における「ピロリ菌・胃癌リスク検診外来」における胃癌予防への取り組み (2013)
  • Author(s): 古田 隆久、佐原秀、市川仁美
  • Journal Title: 日本消化器がん検診学会雑誌 Volume: 5 Pages: 531-542
  • Peer Reviewed
• [Journal Article] Histology of symptomatic GERD:Is it predictive of response to proton pump inhibitors? (2013)
  • Author(s): Miwa H, Takubo K, Shimatani T, Furuta T, Oshima T, Tanaka J, Aida J, Ito M, Kurosawa S, Joh T, Wada T, Habu Y, Watanabe Y, Hongo M, Chiba T, Kinoshita Y
  • Journal Title: J Gastroenterol Hepatol Volume: 28 Issue: 3 Pages: 479-487
  • DOI: 10.1111/j.1440-1746.2012.07266.x
  • Peer Reviewed
• [Journal Article] Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan. (2013)
  • Author(s): Murakami K, Furuta T, Ando T, Nakajima T, Inui Y, Oshima T, Tomita T, Mabe K, Sasaki M, Suganuma T, Nomura H, Satoh K, Hori S, Inoue S, Tomokane T, Kudo M, Inaba T, Take S, Ohkusa T, Yamamoto S, Mizuno S, Kamoshida T, Amagai K, Iwamoto J, Miwa J, Kodama M, Okimoto T, Kato M, Asaka M; For the Japan GAST Study Group.
  • Journal Title: J Gastroenterol Volume: 48 Issue: 10 Pages: 1128-1135
  • DOI: 10.1007/s00535-012-0731-8
  • Peer Reviewed
• [Journal Article] Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan (2013)
  • Author(s): Iwakiri R, Tominaga K, Furuta K, Inamori M, Furuta T, Masuyama H, Kanke K, Nagahara A, Haruma K, Kinoshita Y, Higuchi K, Takahashi S, Kusano M, Iwakiri K, Kato M, Hongo M, Hiraishi H, Watanabe S, Miwa H, Naito Y, Fujimoto K, Arakawa T
  • Journal Title: Aliment Pharmacol Ther Volume: 38 Issue: 7 Pages: 729-740
  • DOI: 10.1111/apt.12444
  • Peer Reviewed
• [Journal Article] Statins directly suppress cytokine production in murine intraepithelial lymphocytes (2013)
  • Author(s): Zhang J
  • Journal Title: Cytokine Volume: 61 Issue: 2 Pages: 540-545
  • DOI: 10.1016/j.cyto.2012.12.006
  • Peer Reviewed
• [Journal Article] Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolizers compared with twice-daily omeprazole, rabeprazole, or lansoprazole (2013)
  • Author(s): Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K< Umemura K, Miyajima H, Furuta T
  • Journal Title: Aliment Pharmacol Ther. Volume: 38 Issue: 9 Pages: 1129-1137
  • DOI: 10.1111/apt.12492
  • Peer Reviewed
• [Journal Article] Pharmacokinetics, Pharmacodynamics and Pharmacogenomics of proton pump inhibitors (2013)
  • Author(s): Furuta T, Sugimoto M, Shirai N
  • Journal Title: Front Gastrointest Res Volume: 32 Pages: 18-33
• [Journal Article] 本邦におけるピロリ菌三次除菌療法の現況と課題 (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美
  • Journal Title: 日本ヘリコバクター学会誌 Volume: 14 Pages: 95-100
• [Journal Article] ペプシノゲンを用いたHelicobacter pylori除菌判定の可能生 (2013)
  • Author(s): 古田隆久、杉本光繁、小平知世、西野眞史、山出美穂子、魚谷貴洋、佐原秀、白井直人
  • Journal Title: Helicobacter Research Volume: 17 Pages: 40-45
• [Journal Article] 血清ペプシノゲンによるH. pyloriの除菌判定 (2013)
  • Author(s): 古田隆久、杉本光繁、小平知世、西野眞史、山出美穂子、魚谷貴洋、佐原秀、市川仁美、山田貴教、杉本健、大澤恵、白井直人
  • Journal Title: 日本消化器病学会誌 Volume: 112 Pages: 210-217
• [Journal Article] クロピドグレルとPPI (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美、西野眞史
  • Journal Title: 消化器内科 Volume: 56 Pages: 184-189
• [Journal Article] 現状のH. pylori検査方法と抗H. pylori IgG抗体の低抗体価に関して (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美. 診断方法の進歩
  • Journal Title: Helicobacter Research Volume: 17 Pages: 100-103
• [Journal Article] H. pyloriの除菌方法 (2013)
  • Author(s): 古田隆久、村上一成
  • Journal Title: 日本ヘリコバクター学会雑誌 Volume: Suppl Pages: 31-38
• [Journal Article] PPIを題材にしたこれまでの研究報告 (2013)
  • Author(s): 古田隆久、杉本光繁
  • Journal Title: 日本臨床薬理学会雑誌 Volume: 44 Pages: 263-265
  • NAID: 10031178001
• [Journal Article] 胃癌予防を見据えたH. pylori除菌へのPGxの応用 (2013)
  • Author(s): 古田隆久、杉本光繁
  • Journal Title: 日本臨床薬理学会雑誌 44(3): 95-100, 2013. Volume: 44 Pages: 95-100
  • NAID: 10031165670
• [Journal Article] H. pylori三次除菌療法の現況と展望 (2013)
  • Author(s): 古田隆久、杉本光繁、魚谷貴洋、佐原秀、市川仁美.
  • Journal Title: 日本臨床 Volume: 71 Pages: 1404-1412
• [Journal Article] 併症を有する患者、併用薬のある患者に対するHelicobacter pylori除菌療法 (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美
  • Journal Title: Helicobacter Research Volume: 17 Pages: 284-290
• [Journal Article] ヘリコバクター・ピロリ除菌治療の最前線 (2013)
  • Author(s): 古田隆久
  • Journal Title: CLINICIAN Volume: 60 Pages: 718-728
• [Journal Article] ペニシリンアレルギー患者でのH. pylori除菌療法 (2013)
  • Author(s): 古田隆久
  • Journal Title: 日本医事新報 Volume: 4659 Pages: 60-61
• [Journal Article] 一次から三次除菌療法の実際と課題 (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美
  • Journal Title: 消化器の臨床 Volume: 16 Pages: 372-381
• [Journal Article] 感染症トピックス 1）細菌 （2）ヘリコバクター・ピロリ (2013)
  • Author(s): 古田隆久
  • Journal Title: MEDICAL TECHNOLOGY Volume: 41 Pages: 1264-1267
• [Journal Article] 除菌レジメン（三次除菌も含めて） (2013)
  • Author(s): 古田隆久
  • Journal Title: 消化器内視鏡 Volume: 25 Pages: 2018-2019
• [Journal Article] 24時間を通じた酸分泌抑制のためのPPI分割投与の有用性 (2013)
  • Author(s): 杉本光繁、魚谷貴洋、佐原秀、市川仁美、古田隆久
  • Journal Title: 消化器内科 Volume: 56 Pages: 159-166
• [Journal Article] 低用量アスピリン起因性胃粘膜傷害におけるHelicobacter pylori感染の影響 (2013)
  • Author(s): 魚谷 貴洋, 杉本 光繁, 市川 仁美, 佐原 秀, 山出 美穂子, 古田 隆久
  • Journal Title: 消化器内科 Volume: 55 Pages: 287-291
• [Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype (2012)
  • Author(s): Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: ClinGastroenterolHepatol Volume: 10(8) Pages: 879-885
• [Journal Article] Impactofacidinhibitiononesophagealmucosalinjury inducedbylow-doseaspirin (2012)
  • Author(s): Sugimoto M,NishinoM,KodairaC,YamadeM,UotaniT,Ikuma M,Furuta T
  • Journal Title: Digestion Volume: 85(1)(Epub2011 Nov24) Pages: 9-17
• [Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype (2012)
  • Author(s): Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T.
  • Journal Title: Clin Gastroenterol Hepatol. 2012 Volume: 10 Pages: 879-885
  • Peer Reviewed
• [Journal Article] Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β(1) adrenoceptor. (2012)
  • Author(s): Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto K
  • Journal Title: J Neuroimmunol Volume: 245 Pages: 66-74
  • Peer Reviewed
• [Journal Article] Trastuzumab has opposing effects on SN-38-induced double-strand breaks and cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence (2012)
  • Author(s): Yamade M, Sugimoto M, Nishino M, Uotani T, Sahara S, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Furuta T
  • Journal Title: Anticancer Res Volume: 32 Pages: 105-114
  • Peer Reviewed
• [Journal Article] Role of Helicobacter pylori cagA EPIYA motif and vacA genotypes for the development of gastrointestinal diseases in Southeast Asian countries: a meta-analysis (2012)
  • Author(s): Sahara S, Sugimoto M, Vilaichone RK, Mahachai V, Miyajima H, Furuta T, Yamaoka
  • Journal Title: BMC Infect Dis Volume: 12 Pages: 223-223
  • Peer Reviewed
• [Journal Article] Individualized Therapy for Gastroesophageal Reflux Disease: Potential Impact of Pharmacogenetic Testing Based on CYP2C19 (2012)
  • Author(s): Furuta T, Sugimoto M
  • Journal Title: Mol Diagn Ther Volume: 16 Pages: 223-34
  • Peer Reviewed
• [Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype. (2012)
  • Author(s): Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T
  • Journal Title: Clin Gastroenterol Hepatol. Volume: in press
  • Peer Reviewed
• [Journal Article] The Acid-Related Symptoms Research Group. Investigation of Pretreatment Prediction of Proton Pump Inhibitor (PPI)-Resistant Patients with Gastroesophageal Reflux Disease and the Dose Escalation Challenge of PPIs :-TORNADO study-a Multicenter Prospective Study by the ARS (Acid-Related Symptoms) Research Group in Japan (2011)
  • Author(s): Furuta T, ShimataniT, Sugimoto M, IshiharaS, FujiwaraY, Kusano M, Koike T, Hongo M, Chiba T, Kinoshita Y
  • Journal Title: J Gastroenterol Volume: 46(11) Pages: 1273-1283
• [Journal Article] Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy (2011)
  • Author(s): Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Umemura K, Furuta T
  • Journal Title: World J Gastroenterol Volume: 17(14) Pages: 1858-65
• [Journal Article] Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers (2011)
  • Author(s): Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T
  • Journal Title: J Clin Pharmacol Volume: 51(7) Pages: 1079-86
• [Journal Article] Impact of Acid Inhibition on Esophageal Mucosal Injury Induced by Low-Dose Aspirin (2011)
  • Author(s): Sugimoto M, Nishino M, Kodaira C, Yamade M, Uotani T, Ikuma M, Furuta T
  • Journal Title: Digestion Volume: 85(1) Pages: 9-17
• [Presentation] Effect of dosing scheme of amoxicillin on eradication rates of H. pylori by triple therapy with PPI, amoxicillin and clarithromycin or metronidazole (2014)
  • Author(s): Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Watanabe H, Umemura K
  • Organizer: ASCPT
  • Place of Presentation: Atlanta, USA
• [Presentation] Effect of dosing schedules of amoxicillin on eradication rates of H. pylori by triple therapy with PPI, amoxicillin and clarithromycin or metronidazole. Workshop 3. Treatment and Drug Resistance (2013)
  • Author(s): Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
  • Organizer: The XXVIth International Workshop of the European Helicobacter Study Group
  • Place of Presentation: Madrid, Spain
  • Invited
• [Presentation] Individualized eradication therapy for H. pylori infection based on genetic testing by the automated SNP analyzer (2013)
  • Author(s): Furuta T
  • Organizer: 2013 Chinese annual symposium on Gastroenterology
  • Place of Presentation: Beijing, China.
  • Invited
• [Presentation] ABC検診における血清ペプシノゲンのH. pylori感染症診療への応用の有用性 (2013)
  • Author(s): 古田隆久、杉本光繁、魚谷貴洋、佐原秀、市川仁美
  • Organizer: .第19回日本ヘリコバクター学会
  • Place of Presentation: 長崎
• [Presentation] 高用量3剤PPI/AMPC/Ecabet sodium療法よるHp救済療養 (2013)
  • Author(s): 古田隆久、杉本光繁、魚谷貴洋、佐原秀、市川仁美
  • Organizer: 第19回日本ヘリコバクター学会
  • Place of Presentation: 長崎
• [Presentation] 遺伝子多型に基づくH. pylori除菌療法の成果 (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美、山田貴教、大澤恵、杉本健.
  • Organizer: 第9回日本消化管学会学術集会
  • Place of Presentation: 東京
• [Presentation] 消化器疾患の薬物治療の問題点 - 治療効果の個体間格差、薬物間相互作用を中心に - (2012)
  • Author(s): 古田隆久
  • Organizer: 日本消化器病学会東海支部第116回例会 第27回教育講演会
  • Place of Presentation: 津
  • Invited
• [Presentation] Impact of pharmacogenomics on Helicobacter eradication. (2012)
  • Author(s): Furuta T.
  • Organizer: ASIAN PACIFIC DIGESTIVE WEEK 2012
  • Place of Presentation: BANHKOK, THAILAND
  • Invited
• [Presentation] Comparison of three third-line rescue triple regimens for Helicobacter pylori infection in Japan. (2012)
  • Author(s): T. Furuta, M. Sugimoto, C. Kodaira, M. Nishino, M. Yamade, T. Uotani, S. Sahara, H. Ichikawa, T. Yamada, S. Osawa, K. Sugimoto, H. Watanabe, K. Umemura
  • Organizer: XXVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
  • Place of Presentation: リュブリャナ、スロベニア
• [Presentation] PPIを題材にしたこれまでの研究報告 (2012)
  • Author(s): 古田隆久、杉本光繁、梅村和夫
  • Organizer: 第33回日本臨床薬理学会学術総会
  • Place of Presentation: 宜野湾市、沖縄
• [Presentation] 胃癌予防を見据えたH. pylori除菌へのPGxの応用 (2012)
  • Author(s): 古田隆久、杉本光繁
  • Organizer: 第33回日本臨床薬理学会学術総会
  • Place of Presentation: 宜野湾市、沖縄
• [Presentation] クロピドグレルとプロトンポンプ阻害薬の効果とCYP2C19遺伝子多型の影響 (2012)
  • Author(s): 古田隆久
  • Organizer: 日本人類遺伝学会第57回大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 低用量アスピリン起因性胃粘膜障害におけるH. pylori感染の影響 (2011)
  • Author(s): 魚谷貴洋、杉本光繁、古田隆久
  • Organizer: シンポジウム7 低用量アスピリンによる消化管粘膜障害のUp tp date 第53回日本消化器病学会大会 JDDW2011
  • Place of Presentation: 福岡
• [Book] 最新医学・別冊 新しい診断と治療のABC 6. (2013)
  • Author(s): 古田隆久、杉本光繁、山出美穂子、魚谷貴洋、佐原秀、市川仁美
  • Total Pages: 14
  • Publisher: 最新医学
• [Book] 胃・十二指腸潰瘍. 臨床検査のガイドライン JSLM2012 検査値アプローチ/症候/疾患 日本臨床検査医学会ガイドライン作成委員会編 (2012)
  • Author(s): 古田隆久
  • Total Pages: 5
  • Publisher: 宇宙堂八木書店
• [Book] NSAIDs潰瘍の治療の実際を知る. 整形外科診療のためのNSAIDs処方ハンドブック (2012)
  • Author(s): 古田隆久
  • Total Pages: 8
  • Publisher: 先端医学社