Development of genomics-based prophylaxis strategy for gastric mucosal injury induced by anti-platelet agents
Project/Area Number |
23590913
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
FURUTA TAKAHISA 浜松医科大学, 医学部附属病院, 准教授 (10303546)
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Co-Investigator(Kenkyū-buntansha) |
SUGIMOTO Mitsushige 浜松医科大学, 医学部附属病院, 助教 (80397398)
OGAWA Noriyoshi 浜松医科大学, 医学部附属病院, 講師 (80308618)
TAKEUCHI Kazuhiko 浜松医科大学, 医学部, 準教授 (00419425)
MATSUYAMA Yukihiro 浜松医科大学, 医学部, 教授 (20312316)
NANBA Hiroki 浜松医科大学, 医学部, 教授 (60198405)
UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
|
Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 低用量アスピリン / H. pylori / 胃粘膜傷害 / 遺伝子多型 / SLCO1B1 / Aspirin / CYP2C9 / UGT1A6 / アスピリン / 抗血小板薬 / クロピドグレル |
Research Abstract |
Pharmacogenomics associated with the gastric mucosal injury induced by low dose aspirin (LDA) was investigated. We measured the four SNPs associated with metabolism of aspirin in patients treated with LDA. We analyzed the association of such SNPs with gastric mucosal injury with reference to H. pylori infection. The relative risk of gastric ulcer in patients with SLCO1B1 (rs4149056) TT genotype was 3.2 folds as high as that of those with C allele. The results suggest that measurement of SNP of SLCO1B1 could be the predictive marker of gastric mucosa injury induced by LDA.
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Report
(4 results)
Research Products
(64 results)
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[Journal Article] Prevention ofgastricmucosal injuryinduced by anti-platelet drugs by famotidine2014
Author(s)
Uotani T, Sugimoto M, Nishino M, Ichikawa H, Sahara S, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
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Journal Title
J Clin Pharmacol
Volume: (Epub ahead of print)
Issue: 8
Pages: 858-864
DOI
Related Report
Peer Reviewed
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[Journal Article] Dosing Schemes of Amoxicillin on Eradication Rates of Helicobacter pylori With Amoxicillin-Based Triple Therapy2014
Author(s)
Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
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Journal Title
J Clin Pharmacol
Volume: 54
Issue: 3
Pages: 258-266
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Eradication of H. pylori infection in patients allergic to penicillin by the triple therapy with a PPI, metronidazole and sitafloxacin2014
Author(s)
Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Kagami T, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
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Journal Title
Intern Med.
Volume: 53
Pages: 571-575
Related Report
Peer Reviewed
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[Journal Article] Sitafloxacin-based third-line rescue regimens for Helicobacter pylori infection in Japan2014
Author(s)
Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani TSahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K.
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Journal Title
J Gastroenterol Hepatol
Volume: 29
Issue: 3
Pages: 487-493
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Induction of Murine TNBS Colitis Is Strictly Controlled by a Modified Method Using Continuous Inhalation Anesthesia with Sevoflurane2014
Author(s)
Terai T, Osawa S, Tani S, Oishi S, Arai Y, Yamada T, Sugimoto M, Furuta T, Kanaoka S, Miyajima H, Sugimoto K
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Journal Title
Dig Dis Sci
Volume: 1
Pages: 1-2
Related Report
Peer Reviewed
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[Journal Article] Rapid Automated Genotyping of CYP2C19 and the Helicobacter pylori 23S rRNA Gene in Gastric Juice2013
Author(s)
Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K
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Journal Title
Journal of GHR
Volume: 2
Pages: 403-407
Related Report
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[Journal Article] Association of gastric mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment2013
Author(s)
Nishino M, Sugimoto M, Uotani T, Yamade M, Sahara S, Ichikawa H, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
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Journal Title
Digestion
Volume: 88(2)
Pages: 79-86
Related Report
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[Journal Article] Antiplatelet drugs are a risk factor for esophageal mucosal injury2013
Author(s)
Sugimoto M, Uotani T, Nishino M, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Umemura K, Watanabe H, Miyajima H, Furuta T
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Journal Title
Digestion
Volume: 87(4)
Pages: 281-9
Related Report
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[Journal Article] Rapid Automated Genotyping of CYP2C19 and the Helicobacter pylori 23S rRNA Gene in Gastric Juice2013
Author(s)
Furuta T, Soya Y, Sugimoto M, Nishino M, Yamade M, Uotani T, Kodaira C, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Maekawa M, Watanabe H, Umemura K.
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Journal Title
Journal of GHR
Volume: 2
Pages: 403-407
Related Report
Peer Reviewed
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[Journal Article] Histology of symptomatic GERD:Is it predictive of response to proton pump inhibitors?2013
Author(s)
Miwa H, Takubo K, Shimatani T, Furuta T, Oshima T, Tanaka J, Aida J, Ito M, Kurosawa S, Joh T, Wada T, Habu Y, Watanabe Y, Hongo M, Chiba T, Kinoshita Y
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Journal Title
J Gastroenterol Hepatol
Volume: 28
Issue: 3
Pages: 479-487
DOI
Related Report
Peer Reviewed
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[Journal Article] Multi-center randomized controlled study to establish the standard third-line regimen for Helicobacter pylori eradication in Japan.2013
Author(s)
Murakami K, Furuta T, Ando T, Nakajima T, Inui Y, Oshima T, Tomita T, Mabe K, Sasaki M, Suganuma T, Nomura H, Satoh K, Hori S, Inoue S, Tomokane T, Kudo M, Inaba T, Take S, Ohkusa T, Yamamoto S, Mizuno S, Kamoshida T, Amagai K, Iwamoto J, Miwa J, Kodama M, Okimoto T, Kato M, Asaka M; For the Japan GAST Study Group.
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Journal Title
J Gastroenterol
Volume: 48
Issue: 10
Pages: 1128-1135
DOI
Related Report
Peer Reviewed
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[Journal Article] Randomised clinical trial: rabeprazole improves symptoms in patients with functional dyspepsia in Japan2013
Author(s)
Iwakiri R, Tominaga K, Furuta K, Inamori M, Furuta T, Masuyama H, Kanke K, Nagahara A, Haruma K, Kinoshita Y, Higuchi K, Takahashi S, Kusano M, Iwakiri K, Kato M, Hongo M, Hiraishi H, Watanabe S, Miwa H, Naito Y, Fujimoto K, Arakawa T
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Journal Title
Aliment Pharmacol Ther
Volume: 38
Issue: 7
Pages: 729-740
DOI
Related Report
Peer Reviewed
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[Journal Article] Twice-daily dosing of esomeprazole effectively inhibits acid secretion in CYP2C19 rapid metabolizers compared with twice-daily omeprazole, rabeprazole, or lansoprazole2013
Author(s)
Sahara S, Sugimoto M, Uotani T, Ichikawa H, Yamade M, Iwaizumi M, Yamada T, Osawa S, Sugimoto K< Umemura K, Miyajima H, Furuta T
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Journal Title
Aliment Pharmacol Ther.
Volume: 38
Issue: 9
Pages: 1129-1137
DOI
Related Report
Peer Reviewed
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[Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype2012
Author(s)
Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T
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Journal Title
ClinGastroenterolHepatol
Volume: 10(8)
Pages: 879-885
Related Report
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[Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype2012
Author(s)
Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T.
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Journal Title
Clin Gastroenterol Hepatol. 2012
Volume: 10
Pages: 879-885
Related Report
Peer Reviewed
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[Journal Article] Norepinephrine suppresses IFN-γ and TNF-α production by murine intestinal intraepithelial lymphocytes via the β(1) adrenoceptor.2012
Author(s)
Takayanagi Y, Osawa S, Ikuma M, Takagaki K, Zhang J, Hamaya Y, Yamada T, Sugimoto M, Furuta T, Miyajima H, Sugimoto K
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Journal Title
J Neuroimmunol
Volume: 245
Pages: 66-74
Related Report
Peer Reviewed
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[Journal Article] Trastuzumab has opposing effects on SN-38-induced double-strand breaks and cytotoxicity in HER2-positive gastric cancer cells depending on administration sequence2012
Author(s)
Yamade M, Sugimoto M, Nishino M, Uotani T, Sahara S, Iwaizumi M, Yamada T, Osawa S, Sugimoto K, Miyajima H, Furuta T
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Journal Title
Anticancer Res
Volume: 32
Pages: 105-114
Related Report
Peer Reviewed
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[Journal Article] Ability of Rabeprazole to Prevent Gastric Mucosal Damage from Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype.2012
Author(s)
Uotani T, Sugimoto M, Nishino M, Kodaira C, Yamade M, Sahara S, Yamada T, Osawa S, Sugimoto K, Tanaka T, Umemura K, Watanabe H, Miyajima H, Furuta T
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Journal Title
Clin Gastroenterol Hepatol.
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Preventive Effects of Lansoprazole and Famotidine on Gastric Mucosal Injury Induced by Low-Dose Aspirin in Helicobacter pylori-Negative Healthy Volunteers2011
Author(s)
Nishino M, Sugimoto M, Kodaira C, Yamade M, Uotani T, Shirai N, Ikuma M, Tanaka T, Sugimura H, Hishida A, Furuta T
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Journal Title
J Clin Pharmacol
Volume: 51(7)
Pages: 1079-86
Related Report
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[Presentation] Effect of dosing scheme of amoxicillin on eradication rates of H. pylori by triple therapy with PPI, amoxicillin and clarithromycin or metronidazole2014
Author(s)
Furuta T, Sugimoto M, Kodaira C, Nishino M, Yamade M, Uotani T, Sahara S, Watanabe H, Umemura K
Organizer
ASCPT
Place of Presentation
Atlanta, USA
Related Report
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[Presentation] Effect of dosing schedules of amoxicillin on eradication rates of H. pylori by triple therapy with PPI, amoxicillin and clarithromycin or metronidazole. Workshop 3. Treatment and Drug Resistance2013
Author(s)
Furuta T, Sugimoto M, Yamade M, Uotani T, Sahara S, Ichikawa H, Yamada T, Osawa S, Sugimoto K, Watanabe H, Umemura K
Organizer
The XXVIth International Workshop of the European Helicobacter Study Group
Place of Presentation
Madrid, Spain
Related Report
Invited
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[Presentation] Comparison of three third-line rescue triple regimens for Helicobacter pylori infection in Japan.2012
Author(s)
T. Furuta, M. Sugimoto, C. Kodaira, M. Nishino, M. Yamade, T. Uotani, S. Sahara, H. Ichikawa, T. Yamada, S. Osawa, K. Sugimoto, H. Watanabe, K. Umemura
Organizer
XXVth International Workshop on Helicobacter and related bacteria in chronic digestive inflammation and gastric cancer
Place of Presentation
リュブリャナ、スロベニア
Related Report
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