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Development of the novel IBD treatment targeted S1P receptor

Research Project

Project/Area Number 23590934
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

FUJII TOSHIMITSU  東京医科歯科大学, 医学部附属病院, 助教 (30547451)

Co-Investigator(Kenkyū-buntansha) WATANABE Mamoru  東京医科歯科大学, 医歯学総合研究科, 教授 (10175127)
永石 宇司  東京医科歯科大学, 医学部附属病院, 助教 (60447464)
Co-Investigator(Renkei-kenkyūsha) NAGAISHI Takashi  東京医科歯科大学, 医学部附属病院, 助教 (60447464)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords炎症性腸疾患 / 慢性腸炎 / リンパ球動態制御 / FTY720 / S1P受容体
Research Abstract

In inflammatory bowel diseases, it is thought that colitogenic memory CD4+ T cells are intermittently reactivated in regional lymphoid organs, and return to inflammatory tissues. Little is known about how FTY720 controls the migration property of memory T cells. We here demonstrated that FTY720 prevents the development of colitis induced by the adoptive transfer of naive CD4+ T cells into SCID mice. Also FTY720 prevents the colitis induced by the adoptive transfer of colitogenic effector-memory CD4+ T cells into SCID mice. In both model, cell number of CD4+ T cells was markedly decreased in peripheral blood of FTY720-treated mice, but conversely increased in lymph nodes. Notably, FTY720 treatment prevented the development of colitis in inflammatory bowel disease model by inhibition of T-cell egress from lymph nodes.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (111 results)

All 2014 2013 2012 2011 Other

All Journal Article (53 results) (of which Peer Reviewed: 41 results) Presentation (45 results) Book (11 results) Remarks (2 results)

  • [Journal Article] Advancing MR imaging in Crohn's disease2014

    • Author(s)
      Fujii T, Watanabe M(他5名)
    • Journal Title

      Digestion

      Volume: 89(1) Pages: 24-30

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Myosin light chain kinase expression induced via tumor necrosis factor receptor 2 signaling in the epithelial cells regulates the development of colitis-associated carcinogenesis2014

    • Author(s)
      Suzuki M, Nagaishi T, Watanabe M(他12名)
    • Journal Title

      PLoS One

      Volume: 9(2)

    • Related Report
      2013 Final Research Report
  • [Journal Article] 炎症性腸疾患の画像診断modality IV. MRI?腸管評価の新たなモダリティーはIBD診療を変えるかー2014

    • Author(s)
      藤井俊光
    • Journal Title

      INTESTINE

      Volume: Vol.18 No.2 Pages: 159-166

    • Related Report
      2013 Final Research Report
  • [Journal Article] Advancing magnetic resonance imaging in Crohn's disease.2014

    • Author(s)
      Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M.
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 24-30

    • DOI

      10.1159/000356210

    • NAID

      130005084744

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of salvage therapy and its effect on operative outcomes in patients with ulcerative colitis.2014

    • Author(s)
      Saito E, Nagahori M, Fujii T, Otsuka K, Watanabe M
    • Journal Title

      Digestion

      Volume: 89 Issue: 1 Pages: 55-60

    • DOI

      10.1159/000356221

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of Magnetic Resonance and Balloon Enteroscopic Examination of Deep Small Intestine in Patients with Crohn's Disease.2014

    • Author(s)
      Takenaka K, Ohtsuka K,Watanabe M et al
    • Journal Title

      Gastroenterology

      Volume: [Epub ahead of print] Issue: 2 Pages: 334-342

    • DOI

      10.1053/j.gastro.2014.04.008

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD2013

    • Author(s)
      Naganuma M, Fujii T, Watanabe M(他3名)
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19 Pages: 418-22

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients2013

    • Author(s)
      Naganuma M, Fujii T, Watanabe M(他9名)
    • Journal Title

      J Crohns Colitis

      Volume: 7 Pages: 308-313

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of Fetal Enteric Progenitors as a Source for Transplantation2013

    • Author(s)
      Fordham RP, Watanabe M(他7名)
    • Journal Title

      Cell Stem Cell

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific expression of Bestrophin-2 and Bestrophin-4 in human intestinal epithelial cells2013

    • Author(s)
      Ito G, Watanabe M(他15名)
    • Journal Title

      PloS One

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Th1/Th7-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota2013

    • Author(s)
      Nemoto Y, Watanabe M(他6名)
    • Journal Title

      J Immunol

      Volume: 190 Pages: 6616-6625

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein2013

    • Author(s)
      Kano Y, Watanabe M(他12名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 432 Pages: 175-181

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells2013

    • Author(s)
      Nemoto Y, Watanabe M(他6名)
    • Journal Title

      Gut

      Volume: 62 Pages: 1142-1152

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【潰瘍性大腸炎診療のトピックス】潰瘍性大腸炎に対する生物学的製剤による治療2013

    • Author(s)
      長堀正和,藤井俊光,渡辺守
    • Journal Title

      日本消化器病学会雑誌

      Volume: (0446-6586), 110巻11号 Pages: 1909-1915

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【抗体医薬による消化器治療のパラダイムシフト】【炎症性腸疾患(IBD)に対する生物学的製剤治療】生物学的製剤によるIBD治療戦略の進歩どう変わっていくか2013

    • Author(s)
      藤井俊光,渡辺守
    • Journal Title

      消化器の臨床

      Volume: (1344-3070), 16巻5号 Pages: 454-459

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【小腸疾患の臨床-最近の進歩】クローン病に対するMREC(MR enterocolonography)の有用性2013

    • Author(s)
      藤井俊光,渡辺守他
    • Journal Title

      臨床消化器内科

      Volume: (0911-601X), 28巻7号 Pages: 1069-1075

    • Related Report
      2013 Final Research Report
  • [Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum : a case report2013

    • Author(s)
      Araki A, Fujii T, Watanabe M(他6名)
    • Journal Title

      J Med Case Rep

      Volume: 6 Pages: 328-328

    • Related Report
      2013 Final Research Report
  • [Journal Article] Bone marrow-mesenchymal stem cells are a major source of interleukin-7 and sustain colitis by forming the niche for colitogenic CD4+ memory T cells.2013

    • Author(s)
      Nemoto Y, Nakamura T, Watanabe M et al
    • Journal Title

      Gut.

      Volume: 62 Issue: 8 Pages: 1142-1152

    • DOI

      10.1136/gutjnl-2012-302029

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transplantation of expanded fetal intestinal progenitors contributes to colon regeneration after injury.2013

    • Author(s)
      Fordham RP, Yui S, Nakamura T, Watanabe M et. al
    • Journal Title

      Cell Stem Cell

      Volume: 13 Issue: 6 Pages: 734-744

    • DOI

      10.1016/j.stem.2013.09.015

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Randomised clinical trial: evaluation of the efficacy of mesalazine (mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation -- a placebo-controlled study.2013

    • Author(s)
      Watanabe M, Nishino H, Sameshima Y, Ota A, Nakamura S, Hibi T
    • Journal Title

      Aliment pharmacol ther

      Volume: 38 Issue: 3 Pages: 264-273

    • DOI

      10.1111/apt.12362

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of QD and TID oral mesalazine for maintenance of remission in quiescent ulcerative colitis: a double-blind, double-dummy, randomized multicenter study.2013

    • Author(s)
      Watanabe M, Hanai H, Nishino H, Yokoyama T, Terada T, Suzuki Y
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19 Issue: 8 Pages: 1681-90

    • DOI

      10.1097/mib.0b013e318286fa3d

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Th1/Th17-Mediated Interstitial Pneumonia in Chronic Colitis Mice Independent of Intestinal Microbiota.2013

    • Author(s)
      Nemoto Y, Watanabe M et al
    • Journal Title

      J Immunol.

      Volume: 190 Issue: 12 Pages: 6616-6625

    • DOI

      10.4049/jimmunol.1202930

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] クローン病に対するMREC(MR enterocolonography)の有用性2013

    • Author(s)
      藤井 俊光, 北詰 良雄, 長沼 誠, 齊藤 詠子, 長堀 正和, 大塚 和朗, 渡辺 守
    • Journal Title

      臨床消化器内科

      Volume: 28 Pages: 1069-1075

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 生物学的製剤によるIBD治療戦略の進歩 どう変わっていくか2013

    • Author(s)
      藤井 俊光, 渡辺 守
    • Journal Title

      消化器の臨床

      Volume: 16 Pages: 454-459

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 潰瘍性大腸炎に対する生物学的製剤による治療2013

    • Author(s)
      長堀 正和, 藤井 俊光, 齊藤 詠子, 大塚 和朗, 渡辺 守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 110 Pages: 1909-1915

    • NAID

      130003383310

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Poor recall of prior exposure to varicella zoster, rubella, measles, or mumps in patients with IBD2013

    • Author(s)
      Naganuma M, Nagahori M, Fujii T, Morio J, Saito E, Watanabe M
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19 Issue: 2 Pages: 418-422

    • DOI

      10.1002/ibd.23027

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Incidence and characteristics of the 2009 influenza (H1N1) infections in inflammatory bowel disease patients.2013

    • Author(s)
      Naganuma M, Fujii T, Watanabe M. et al
    • Journal Title

      J Crohns Colitis.

      Volume: 7 Issue: 4 Pages: 308-13

    • DOI

      10.1016/j.crohns.2012.06.019

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction2012

    • Author(s)
      Chen L, Nagaishi T(他20名)
    • Journal Title

      Immunity

      Volume: 37 Pages: 930-946

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell2012

    • Author(s)
      Yui S, Nagaishi T, Watanabe M(他9名)
    • Journal Title

      Nat Med

      Volume: 18 Pages: 618-623

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012

    • Author(s)
      Nagaishi T, Watanabe M(他11名)
    • Journal Title

      J Immunol

      Volume: 188 Pages: 2524-2536

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nagaishi T, Watanabe M(他11名)
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Pages: 238-243

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type-I interferon-dependent innate immunity2012

    • Author(s)
      Nitta S, Watanabe M(他13名)
    • Journal Title

      Hepatology

      Volume: 57 Pages: 46-58

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] T-helper 17 and interleukin-17-producing lymphoid tissue inducer-like cells make different contributions to colitis in mice2012

    • Author(s)
      Ono Y, Watanabe M(他12名)
    • Journal Title

      Gastroenterology

      Volume: 143 Pages: 1288-1297

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A prospective analysis of the incidence of and risk factors for opportunistic infections in patients with inflammatory bowel disease2012

    • Author(s)
      Naganuma M, Watanabe M(他3名)
    • Journal Title

      J Gastroenterol

      Volume: 48 Pages: 595-600

    • NAID

      10031177010

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The use of traditional and newer calcineurin inhibitors in inflammatory bowel disease2012

    • Author(s)
      Naganuma M, Fujii T, Watanabe M
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 129-37

    • NAID

      10029026934

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+stem cell2012

    • Author(s)
      Yui S, Nakamura T, Sato T, Nemoto Y, Mizutani T, Zheng X, Ichinose S, Nagaishi T, Okamoto R, Tsuchiya K, Clevers H, and Watanabe M
    • Journal Title

      Nature Medicine

      Volume: 18 Issue: 4 Pages: 618-623

    • DOI

      10.1038/nm.2695

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The development of colitogenic CD4+ T cells is regulated by IL-7 in collaboration with natural killer cell function in a murine model of colitis2012

    • Author(s)
      Yamaji O, Totsuka T
    • Journal Title

      J Immunol

      Volume: 188 Issue: 6 Pages: 2524-2536

    • DOI

      10.4049/jimmunol.1100371

    • Related Report
      2012 Research-status Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro2012

    • Author(s)
      Mizutani T, Nakamura T, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 419 Issue: 2 Pages: 238-243

    • DOI

      10.1016/j.bbrc.2012.01.155

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel'sdiverticulum: a case report2012

    • Author(s)
      Araki A, Tsuchiya K, Oshima S, Okada E,Suzuki S, Akiyama JM, Fujii T, OkamotoR, Watanabe M
    • Journal Title

      J Med Case Rep

      Volume: 6(1) Issue: 1 Pages: 328-328

    • DOI

      10.1186/1752-1947-6-328

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction2012

    • Author(s)
      Chen L, Chen Z, Baker K, Halvorsen EM, da Cunha AP, Flak MB, Gerber G, Huang YH, Hosomi S, Arthur JC, Dery KJ, Nagaishi T, Beauchemin N, Holmes KV, Ho JW, Shively JE, Jobin C, Onderdonk AB, Bry L, Weiner HL, Higgins DE, Blumberg RS
    • Journal Title

      Immunity

      Volume: 37 Issue: 5 Pages: 930-946

    • DOI

      10.1016/j.immuni.2012.07.016

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 免疫調節薬/分子生物製剤を用いた難治性潰瘍性大腸炎に対する治療戦略2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      消化器内科

      Volume: 54 Pages: 28-33

    • Related Report
      2012 Research-status Report 2011 Research-status Report
  • [Journal Article] 【炎症性腸疾患-病因解明と診断・治療の最新知見-】 総論 炎症性腸疾患の疾患概念と変遷2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      日本臨床

      Volume: 70 Pages: 5-9

    • Related Report
      2012 Research-status Report
  • [Journal Article] 特集 図説 胃と腸用語集2012 MREC(MR entero-colonography)2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      胃と腸

      Volume: 47 Pages: 668-668

    • Related Report
      2012 Research-status Report
  • [Journal Article] 粘膜治癒・長期予後の面からみた難治性炎症性腸疾患の治療戦略2012

    • Author(s)
      長沼誠, 藤井俊光, 渡辺守
    • Journal Title

      日本臨床免疫学会会誌

      Volume: 35 Pages: 99-106

    • NAID

      10030573724

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] 炎症性腸疾患の疾患概念と変遷2012

    • Author(s)
      藤井俊光, 渡辺守
    • Journal Title

      日本臨床

      Volume: 70 Pages: 5-9

    • Related Report
      2011 Research-status Report
  • [Journal Article] Luminal CD4+ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation2011

    • Author(s)
      Nemoto Y, Watanabe M(他8名)
    • Journal Title

      Gastroenterology

      Volume: 141 Pages: 2130-2139

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis2011

    • Author(s)
      Zheng X, Watanabe M(他6名)
    • Journal Title

      Inflamm Bowel Dis

      Volume: 11 Pages: 2251-2260

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Upregulated IL-7Rαexpression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis2011

    • Author(s)
      Shinohara T, Watanabe M(他8名)
    • Journal Title

      J Immunol

      Volume: 186 Pages: 2623-2632

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 912011

    • Author(s)
      Funaoka Y, Watanabe M(他11名)
    • Journal Title

      J Virol

      Volume: 85 Pages: 5986-5994

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【クローン病の長期予後改善をめざして】長期予後の面からみたクローン病に対する免疫調節薬の有用性2011

    • Author(s)
      長沼誠,藤井俊光,渡辺守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108巻3号 Pages: 388-400

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] MR enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease2011

    • Author(s)
      Hyun SB, Kitazume Y, Suzuki S, Watanabe M, et al
    • Journal Title

      Inflam Bowel Dis

      Volume: 17 Issue: 5 Pages: 1063-1072

    • DOI

      10.1002/ibd.21510

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] The use of traditional and newer calcineurin inhibitors in inflammatory bovvel disease2011

    • Author(s)
      Naganuma M, Watanabe M, Hibi T
    • Journal Title

      J Gastroenterol

      Volume: 46 Issue: 2 Pages: 129-137

    • DOI

      10.1007/s00535-010-0352-z

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 長期予後の面からみたクローン病に対する免疫調節薬の有用性2011

    • Author(s)
      長沼誠, 藤井俊光, 渡辺守
    • Journal Title

      日本消化器病学会雑誌

      Volume: 108 Pages: 388-400

    • NAID

      10030296443

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] AJM300, an oralα4 integrin antagonist, for active ulcerative colitis : a multicenter, randomized, doubleblind, placebo-controlled phase 2a study.2014

    • Author(s)
      Watanabe M, et al
    • Organizer
      DDW/AGA 2014 Chicago ASGE/AGA Joint Presidential Plenary
    • Place of Presentation
      Chicago
    • Year and Date
      2014-05-05
    • Related Report
      2013 Final Research Report
  • [Presentation] The consecutive salvage therapy of tacrolimus and infliximab is effective in patients with refractory ulcerative colitis accompanied by acceptable adverse operative outcomes2014

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      DDW/AGA 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-05-04
    • Related Report
      2013 Final Research Report
  • [Presentation] MR enterocolonography is useful to predict clinical recurrence of Crohn's disease and identify patients who need more aggressive treatment2013

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      UEG Week 2013
    • Place of Presentation
      Berlin
    • Year and Date
      2013-10-14
    • Related Report
      2013 Final Research Report
  • [Presentation] Morning Seminar 2 Case Discussion - Crohn's Disease2013

    • Author(s)
      Toshimitsu Fujii
    • Organizer
      AOCC(Asian Organization for Crohn's & Colitis) 2013
    • Place of Presentation
      Tokyo
    • Year and Date
      2013-06-14
    • Related Report
      2013 Final Research Report
  • [Presentation] MR enterocolonography can predict clinical recurrence of Crohn's disease2013

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      DDW/AGA 2013
    • Place of Presentation
      Orlando
    • Year and Date
      2013-05-20
    • Related Report
      2013 Final Research Report
  • [Presentation] クローン病の再燃予測におけるMR enterocolonography (MREC)の有用性2013

    • Author(s)
      藤井俊光、長堀正和、渡辺守
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis2013

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      8^<th> Congress of ECCO
    • Place of Presentation
      Vienna
    • Year and Date
      2013-02-14
    • Related Report
      2013 Final Research Report
  • [Presentation] MR enterocolonography (MREC)のクローン病小腸大腸病変の評価および再燃予測における有用性2013

    • Author(s)
      藤井俊光、齊藤詠子、長堀正和、長沼誠、大塚和朗、渡辺守
    • Organizer
      第9回消化管学会総会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-01-26
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis2012

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      EUG Week 2012
    • Place of Presentation
      Amsterdam
    • Year and Date
      2012-10-22
    • Related Report
      2013 Final Research Report
  • [Presentation] クローン病小腸大腸病変の評価および再燃予測におけるMRエンテロコロノグラフィー(MREC)の有用性2012

    • Author(s)
      藤井俊光、長堀正和、渡辺守
    • Organizer
      JDDW2012第54回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-12
    • Related Report
      2013 Final Research Report
  • [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis2012

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      DDW/AGA 2012
    • Place of Presentation
      San Diego
    • Year and Date
      2012-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 難治性潰瘍性大腸炎に対するTacrolimus静注療法の有用性と安全性の検討2012

    • Author(s)
      藤井俊光、齊藤詠子、森尾純子、長堀正和、長沼誠、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗体製剤使用炎症性腸疾患患者における血中濃度測定と中和抗体測定の意義2012

    • Author(s)
      藤井俊光、長沼誠、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] クローン病粘膜治癒の評価に対するMREC(MR enterocolonography)の有用性と限界2012

    • Author(s)
      藤井俊光
    • Organizer
      第11回大腸画像アカデミー
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] Serological test and vaccinations for measles, mumps, rubella, and varicella zoster deserve considerations as early as possible after diagnosis of inflammatory bowel disease2011

    • Author(s)
      Makoto Naganuma, Toshimitsu Fujii, Mamoru Watanabe et al
    • Organizer
      UEGW 2011
    • Place of Presentation
      Stockholm
    • Year and Date
      2011-10-25
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] 重症潰瘍性大腸炎に対するHybrid tacrolimus療法の試み2011

    • Author(s)
      藤井俊光,渡辺守
    • Organizer
      JDDW2011第53回日本消化器病学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-23
    • Related Report
      2013 Final Research Report
  • [Presentation] Natural killer cells suppress a murine model of colitis by targeting the early stage of T cell development2011

    • Author(s)
      Takashi Nagaishi, Mamoru Watanabe et al
    • Organizer
      International Congress of Mucosal Immunology
    • Place of Presentation
      Paris
    • Year and Date
      2011-07-11
    • Related Report
      2013 Final Research Report
  • [Presentation] 免疫調整剤/分子生物製剤を用いた難治性潰瘍性大腸炎の対する治療戦略2011

    • Author(s)
      藤井俊光,渡辺守
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Prevalence of influenza infection and safety of human infection with influenza A (H1N1) vaccine in patients with IBD patients treated with immunomodulators and biologics2011

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe et al
    • Organizer
      DDW/AGA 2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-10
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] NK cells regulate CD62L-CD44- T cell subset in the development of pathogenic T cells in a murine model of colitis2011

    • Author(s)
      Osamu Yamaji, Takashi Nagaishi, Mamoru Watanabe et al
    • Organizer
      DDW/AGA 2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-08
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Regeneration of damaged colonic tissue by transplantation of colonic epithelial stem cells maintained and expanded in vitro2011

    • Author(s)
      Shiro Yui, Takashi Nagaishi, Mamoru Watanabe et al
    • Organizer
      DDW/AGA 2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-08
    • Related Report
      2013 Final Research Report
  • [Presentation] MR enterocolonography demonstrates comparative ability to double-balloon endoscopy for the simultaneous assessment of small and large intestinal lesions in Crohn's disease2011

    • Author(s)
      Hyun Sea Bong, Toshimitsu Fujii, Mamoru Watanabe et al
    • Organizer
      DDW/AGA 2011
    • Place of Presentation
      Chicago
    • Year and Date
      2011-05-08
    • Related Report
      2013 Final Research Report
  • [Presentation] MR enterocolonography demonstrates comparative ability to double-balloon endoscopy for the simultaneous assessment of small and large intestinal lesions in Crohn’s disease2011

    • Author(s)
      Hyun Sea Bong, Toshimitsu Fujii, Mamoru Watanabe et al
    • Organizer
      DDW/AGA 2011
    • Place of Presentation
      Chicago
    • Related Report
      2011 Research-status Report
  • [Presentation] Regeneration of damaged colonic tissue by transplantation of colonic epithelial stem cells maintained and expanded in vitro.2011

    • Author(s)
      Shiro Yui, Takashi Nagaishi, Mamoru Watanabe et al
    • Organizer
      DDW/AGA 2011
    • Place of Presentation
      Chicago
    • Related Report
      2011 Research-status Report
  • [Presentation] Natural killer cells suppress a murine model of colitis by targeting2011

    • Author(s)
      Takashi Nagaishi, Mamoru Watanabe et al
    • Organizer
      International Congress of Mucosal Immunology 2011
    • Place of Presentation
      Paris
    • Related Report
      2011 Research-status Report
  • [Presentation] W-4-5.免疫調整剤/分子生物製剤を用いた難治性潰瘍性大腸炎の対する治療戦略2011

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] S25-3 重症潰瘍性大腸炎に対するHybrid tacrolimus療法の試み2011

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      JDDW2011 第53回日本消化器病学会大会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] クローン病診療におけるMREC(MR enterocolonographyの役割2011

    • Author(s)
      藤井俊光
    • Organizer
      第23回千葉消化管フォーラム
    • Place of Presentation
      千葉
    • Related Report
      2011 Research-status Report
  • [Presentation] Analysis of indication and volume of colonoscopy for ulcerative colitis patients in the era of mucosal healing.

    • Author(s)
      Nagahori M,Saito E, Fujii T, Otsuka K, Watanabe M
    • Organizer
      1st Annual Meeting of AOCC
    • Place of Presentation
      東京 日本
    • Related Report
      2013 Annual Research Report
  • [Presentation] MR enterocolonography is useful to predict clinical recurrence of Crohn's disese and identify patients who need more aggressive treatment.

    • Author(s)
      Fujii T, Naganuma M, Kitazume Y, Saito E, Nagahori M, Ohtsuka K, Watanabe M
    • Organizer
      United European Gastoroenterology week( UEGW)2013
    • Place of Presentation
      ベルリン ドイツ
    • Related Report
      2013 Annual Research Report
  • [Presentation] MR enterocolonography can predict clinical recurrence of Crohn’s disease.

    • Author(s)
      Toshimitsu Fujii, Makoto Naganuma, Yoshio Kitazume, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      DDW/AGA 2013
    • Place of Presentation
      オーランド アメリカ
    • Related Report
      2013 Annual Research Report
  • [Presentation] Morning Seminar 2 Case Discussion - Crohn's Disease

    • Author(s)
      Toshimitsu Fujii
    • Organizer
      1st Annual Meeting of AOCC
    • Place of Presentation
      東京 日本
    • Related Report
      2013 Annual Research Report
  • [Presentation] The consecutive salvage therapy of tacrolimus and infliximab is effective in patients with refractory ulcerative colitis accompanied by acceptable adverse operative outcomes.

    • Author(s)
      Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
    • Organizer
      DDW/AGA 2014
    • Place of Presentation
      シカゴ アメリカ
    • Related Report
      2013 Annual Research Report
  • [Presentation] クローン病における小腸病変に対するバルーン内視鏡所見とMR所見の比較

    • Author(s)
      竹中健人、大塚和朗、藤井俊光、長堀正和、齊藤詠子、荒木昭博、新田沙由梨、鈴木雅博、渡辺守
    • Organizer
      第97回日本消化器内視鏡学会関東地方会
    • Place of Presentation
      東京 日本
    • Related Report
      2013 Annual Research Report
  • [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis.

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      DDW/AGA 2012
    • Place of Presentation
      San Diego
    • Related Report
      2012 Research-status Report
  • [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis.

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      EUG Week 2012
    • Place of Presentation
      Amsterdam
    • Related Report
      2012 Research-status Report
  • [Presentation] Intravenous tacrolimus therapy can rapidly induce remission in refractory ulcerative colitis.

    • Author(s)
      Toshimitsu Fujii, Mamoru Watanabe, et al
    • Organizer
      8th Congress of ECCO
    • Place of Presentation
      Vienna
    • Related Report
      2012 Research-status Report
  • [Presentation] 抗体製剤使用炎症性腸疾患患者における血中濃度測定と中和抗体測定の意義

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 難治性潰瘍性大腸炎に対するTacrolimus静注療法の有用性と安全性の検討

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 難治性潰瘍性大腸炎に対するインフリキシマブ(IFX)の中長期予後の検討

    • Author(s)
      齊藤詠子、藤井俊光, 渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] 炎症性腸疾患患者における抗TNFα受容体拮抗薬の選択に関する研究

    • Author(s)
      長堀正和、藤井俊光, 渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] Virtual colonographyとカプセル内視鏡 MR enterocolonography (MREC) の実際とクローン病小腸大腸病変の評価における有用性

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      第30回大腸検査学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] クローン病小腸大腸病変の評価および再燃予測におけるMRエンテロコロノグラフィー(MREC)の有用性

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      JDDW2012 第54回日本消化器病学会大会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] MR enterocolonography (MREC) のクローン病小腸大腸病変の評価および再燃予測における有用性

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      第9回消化管学会総会学術集会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] クローン病の再燃予測におけるMR enterocolonography (MREC) の有用性

    • Author(s)
      藤井俊光, 渡辺守
    • Organizer
      第99回日本消化器病学会総会
    • Place of Presentation
      鹿児島
    • Related Report
      2012 Research-status Report
  • [Book] これで納得!画像で見ぬく消化器疾患vol.3小腸2014

    • Author(s)
      渡辺守
    • Total Pages
      168
    • Publisher
      医学出版
    • Related Report
      2013 Final Research Report
  • [Book] 今日の治療指針20142014

    • Author(s)
      渡辺守
    • Total Pages
      2128
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] 実践!IBD診療2014

    • Author(s)
      渡辺守、藤井俊光
    • Total Pages
      224
    • Publisher
      医学出版
    • Related Report
      2013 Final Research Report
  • [Book] 実践!IBD診療2014

    • Author(s)
      藤井 俊光、渡辺 守
    • Total Pages
      224
    • Publisher
      医学出版
    • Related Report
      2013 Annual Research Report
  • [Book] これで納得!画像で見ぬく消化器疾患 vol.3小腸2014

    • Author(s)
      藤井俊光、大塚和朗
    • Total Pages
      168
    • Publisher
      医学出版
    • Related Report
      2013 Annual Research Report
  • [Book] 今日の治療指針20142014

    • Author(s)
      渡辺守、山口徹・北原光夫
    • Total Pages
      2128
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 病態と治療戦略がみえる免疫・アレルギー疾患イラストレイテッド, 2013年臨床編II臓器特異的自己免疫疾患クローン病2013

    • Author(s)
      大島茂、藤井俊光、渡辺守
    • Total Pages
      359
    • Publisher
      羊土社
    • Related Report
      2013 Final Research Report
  • [Book] 病態と治療戦略がみえる 免疫・アレルギー疾患イラストレイテッド2013

    • Author(s)
      大島 茂、藤井 俊光、渡辺 守
    • Total Pages
      359
    • Publisher
      羊土社
    • Related Report
      2013 Annual Research Report
  • [Book] IBD炎症性腸疾患を究める2011

    • Author(s)
      渡辺守
    • Total Pages
      304
    • Publisher
      メジカルレビュー社
    • Related Report
      2013 Final Research Report
  • [Book] これでわかるIBD診療のすべて2011

    • Author(s)
      渡辺守
    • Total Pages
      140
    • Publisher
      南江堂
    • Related Report
      2013 Final Research Report
  • [Book] これでわかるIBD診療のすべて2011

    • Author(s)
      藤井俊光, 渡辺守
    • Publisher
      南江堂
    • Related Report
      2011 Research-status Report
  • [Remarks] 今日の臨床サポート エルゼビア・ジャパン 潰瘍性大腸炎

    • URL

      http://clinicalsup.jp/

    • Related Report
      2013 Annual Research Report
  • [Remarks] Care Net 希少疾患ライブラリ 潰瘍性大腸炎

    • URL

      http://www.carenet.com/report/library/general/rare/index.html

    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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