2013 Fiscal Year Final Research Report
Development of the novel IBD treatment targeted S1P receptor
| Project/Area Number |
23590934
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUJII TOSHIMITSU 東京医科歯科大学, 医学部附属病院, 助教 (30547451)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Mamoru 東京医科歯科大学, 医歯学総合研究科, 教授 (10175127)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAISHI Takashi 東京医科歯科大学, 医学部附属病院, 助教 (60447464)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 炎症性腸疾患 / 慢性腸炎 / リンパ球動態制御 / FTY720 |
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| Research Abstract |
In inflammatory bowel diseases, it is thought that colitogenic memory CD4+ T cells are intermittently reactivated in regional lymphoid organs, and return to inflammatory tissues. Little is known about how FTY720 controls the migration property of memory T cells. We here demonstrated that FTY720 prevents the development of colitis induced by the adoptive transfer of naive CD4+ T cells into SCID mice. Also FTY720 prevents the colitis induced by the adoptive transfer of colitogenic effector-memory CD4+ T cells into SCID mice. In both model, cell number of CD4+ T cells was markedly decreased in peripheral blood of FTY720-treated mice, but conversely increased in lymph nodes. Notably, FTY720 treatment prevented the development of colitis in inflammatory bowel disease model by inhibition of T-cell egress from lymph nodes.
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