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Investigation of the role of mucosal inductive site and indigenous bacteria on the NSAID-induced enteropathy

Research Project

Project/Area Number 23590941
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionOsaka University

Principal Investigator

IIJIMA Hideki  大阪大学, 医学(系)研究科(研究院), 講師 (90444520)

Co-Investigator(Kenkyū-buntansha) MASAHIKO Tsujii  大阪大学, 医学系研究科, 准教授 (40303937)
TSUTOMU Nishida  大阪大学, 医学系研究科, 助教 (20467575)
SHINICHIRO Shinzaki  大阪大学, 医学系研究科, 助教 (60546860)
Co-Investigator(Renkei-kenkyūsha) HIROSHI Kiyono  東京大学, 医科学研究所, 教授 (10271032)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords小腸粘膜傷害 / NSAID / 粘膜免疫 / パイエル板 / 樹状細胞 / NSAID / 小腸粘膜障害 / NSAIDs / CD103陽性樹状細胞 / NSAIDs
Research Abstract

We investigated the role of Peyer's patches (PPs) in mouse model of non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy. We found PP-null mice showed greater indomethacin-induced enteropathy than the wild type mice. The proportion of CD103+ DCs and IL-10 expressing CD4+ T cells of PPs increased after indomethacin treatment. Protective effect was not associated with commensal bacteria. These results indicate that PPs play a protective role in NSAID-induced enteropathy, and this protection is associated with an increase in CD103+ DCs and IL-10 producing CD4+ T cells in the intestine. PPs are considered to be a target for digestive inflammatory diseases.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2014 2013 2012 2011 Other

All Journal Article (17 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Peyer's patches play a protective role in nonsteroidal anti-inflammatory drug-induced enteropathy in mice.2014

    • Author(s)
      Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 5 Issue: 5 Pages: 790-9

    • DOI

      10.1097/mib.0000000000000017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Narrow Band Imaging with Magnifying Endoscopy for Peyer's Patches in Patients with Inflammatory Bowel Disease2013

    • Author(s)
      Hiyama S, Iijima H, Shinzaki S, Mukai A, Inoue T, Shiraishi E, Kawai S, Yamada T, Nishida T, Tsujii M, Takehara T
    • Journal Title

      Digestion

      Volume: 87(4) Pages: 269-80

    • Related Report
      2013 Final Research Report
  • [Journal Article] Lectin-based Immunoassay for Aberrant IgG Glycosylation as the Biomarker for Crohn's Disease2013

    • Author(s)
      Shinzaki S, Kuroki E, Iijima H, Tatsunaka N, Ishii M, Fujii H, Kamada Y, Kobayashi T, Shibukawa N, Inoue T, Tsujii M, Takeishi S, Mizushima T, Ogata A, Naka T, Plevy SE, Takehara T, Miyoshi E
    • Journal Title

      Inflamm Bowel Dis

      Volume: 19(2) Pages: 321-31

    • Related Report
      2013 Final Research Report
  • [Journal Article] CagA mediates epigenetic regulation to attenuate let-7 expression in Helicobacter pylori-related carcinogenesis2013

    • Author(s)
      Hayashi Y, Tsujii M, Wang J, Kondo J, Akasaka T, Jin Y, Li W, Nakamura T, Nishida T, Iijima H, Tsuji S, Kawano S, Hayashi N, Takehara T
    • Journal Title

      Gut

      Volume: 62(11) Pages: 1536-46

    • Related Report
      2013 Final Research Report
  • [Journal Article] Amelioration of Small Bowel Injury by Switching from Nonselective Nonsteroidal Anti-Inflammatory Drugs to Celecoxib in Rheumatoid Arthritis Patients: A Pilot Study2013

    • Author(s)
      Inoue, T., Iijima, H., Arimitsu, J., Hagihara, K., Kawai, S., Shiraishi, E., Hiyama, S., Mukai, A., Shinzaki, S., Nishida, T., Ogata, A., Tsujii, M., Takehara, T.
    • Journal Title

      Digestion

      Volume: 89 Issue: 2 Pages: 124-132

    • DOI

      10.1159/000357229

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Narrow Band Imaging with Magnifying Endoscopy for Peyer's Patches in Patients with Inflammatory Bowel Disease2013

    • Author(s)
      Hiyama, S., Iijima, H., Shinzaki, S., Mukai, A., Inoue, T., Shiraishi, E., Kawai, S., Yamada, T., Nishida, T., Tsujii, M., Takehara, T.
    • Journal Title

      Digestion

      Volume: 87 Issue: 4 Pages: 269-80

    • DOI

      10.1159/000349953

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lectin-based immunoassay for aberrant IgG glycosylation as the biomarker for Crohn's disease.2013

    • Author(s)
      Shinzaki S, 他13名, Naka T, Plevy S E, Takehara T, Miyoshi E.
    • Journal Title

      Inflamm Bowel Dis.

      Volume: 19(2) Issue: 2 Pages: 321-31

    • DOI

      10.1097/mib.0b013e318280eade

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Narrow Band Imaging with Magnifying Endoscopy for Peyer’s Patches in Patients with Inflammatory Bowel Disease2013

    • Author(s)
      S. Hiyama, H. Iijima, S. Shinzaki, A. Mukai, T. Inoue, Eri Shiraishi, S. Kawai, T. Yamada, T. Nishida, M. Tsujii and T. Takehara
    • Journal Title

      Digestion

      Volume: -

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Serum leucine-rich alpha-2 glycoprotein is a disease activity biomarker in ulcerative colitis2012

    • Author(s)
      Serada S, Fujimoto M, Terabe F, Iijima H, Shinzaki S, Matsuzaki S, Ohkawara T, Nezu R, Nakajima S, Kobayashi T, Plevy SE, Takehara T, Naka T
    • Journal Title

      Inflamm Bowel Dis

      Volume: 18(11) Pages: 2169-79

    • Related Report
      2013 Final Research Report
  • [Journal Article] Extracellular ATP mediates mast cell-dependent intestinal inflammation through P2X7 purinoceptors2012

    • Author(s)
      Kurashima Y, Amiya T, Nochi T, Fujisawa K, Haraguchi T, Iba H, Tsutsui H, Sato S, Nakajima S, Iijima H, Kubo M, Kunisawa J, Kiyono H
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 1034-1034

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantitative change of IgA hinge O-glycan composition is a novel marker of therapeutic responses of IgA nephropathy2012

    • Author(s)
      Iwatani H, Inoue T, Wada Y, Nagasawa Y, Yamamoto R, Iijima H, Takehara T, Imai E, Rakugi H, Isaka Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 428(3) Pages: 339-42

    • Related Report
      2013 Final Research Report
  • [Journal Article] Deficiency of N-acetylgalactosamine in O-linked oligosaccharides of IgA is a novel biologic marker for Crohn's disease2012

    • Author(s)
      Inoue T, Iijima H, Tajiri M, Shinzaki S, Shiraishi E, Hiyama S, Mukai A, Nakajima S, Iwatani H, Nishida T, Mizushima T, Yasui T, Isaka Y, Kanto T, Tsujii M, Miyoshi E, Wada Y, Takehara T
    • Journal Title

      Inflamm Bowel Dis

      Volume: 18(9) Pages: 1723-34

    • Related Report
      2013 Final Research Report
  • [Journal Article] Functional analysis of agalactosyl IgG in inflammatory bowel disease patients2011

    • Author(s)
      Nakajima, S., H. Iijima, S. Shinzaki, S. Egawa, T. Inoue, A. Mukai, Y. Hayashi, J. Kondo, T. Akasaka, T. Nishida, T. Kanto, E. Morii, T. Mizushima, E. Miyoshi, M. Tsujii, N. Hayashi
    • Journal Title

      Inflamm Bowel Dis

      Volume: 17 Pages: 927-936

    • NAID

      10028268520

    • Related Report
      2013 Final Research Report
  • [Journal Article] Comparative analysis of the effects of anti-IL-6 receptor mAb and anti-TNF mAb treatment on CD4(+) T-cell responses in murine colitis2011

    • Author(s)
      Terabe, F., M. Fujimoto, S. Serada, S. Shinzaki, H. Iijima, M. Tsujii, N. Hayashi, S. Nomura, H. Kawahata, M.H. Jang, M. Miyasaka, M. Mihara, Y. Ohsugi, T. Kishimoto, and T. Naka
    • Journal Title

      Inflamm Bowel Dis

      Volume: 17 Pages: 491-502

    • Related Report
      2013 Final Research Report
  • [Journal Article] COX-2選択的阻害薬によるNSAID起因性小腸粘膜傷害の治療・予防2011

    • Author(s)
      井上隆弘、 飯島英樹、 白石衣里、 日山智史、 他
    • Journal Title

      消化器内科

      Volume: 53 Pages: 29-34

    • Related Report
      2011 Research-status Report
  • [Journal Article] Peyer's patches play a protective role in non-steroidal anti-inflammatory drug-induced enteropathy in mice

    • Author(s)
      Hiyama S, Iijima H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Kato M, Hayashi Y, Nishida T, Fujii H, Mukai A, Shibata N, Sato S, Kiyono H, Gotoh K, Motooka D, Nakamura S, Iida T, Tsujii M, Takehara T
    • Journal Title

      Inflamm Bowel Dis

      Volume: (In press)

    • Related Report
      2013 Final Research Report
  • [Journal Article] Regulation of anergy-related ubiquitin E3 ligase, GRAIL, in murine models of colitis and patients with Crohn's disease

    • Author(s)
      Mukai A, Iijima H, Hiyama S, Fujii H, Shinzaki S, Inoue T, Shiraishi E, Kawai S, Araki M, Hayashi Y, Kondo J, Mizushima T, Kanto T, Egawa S, Nishida T, Tsujii M, Takehara T
    • Journal Title

      J Gastroenterol

      Volume: (In press)

    • Related Report
      2013 Final Research Report
  • [Presentation] Observation of Peyer's patch using narrow band imaging with magnifying endoscopy is useful in predicting the recurrence in ulcerative colitis patients2013

    • Author(s)
      Hiyama, S., H. Iijima, S. Shinzaki, T. Inoue, E. Shiraishi, S. Kawai, M. Araki, T. Nishida, M. Tsujii, and T. Takehara
    • Organizer
      UEGW
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Final Research Report
  • [Presentation] Peyer's Patches Play a Protective Role in NSAIDs-Induced Enteropathy2013

    • Author(s)
      Hiyama, S., H. Iijima, S. Kawai, E. Shiraishi, A. Mukai, T. Inoue, S. Shinzaki, M. Tsujii, and T. Takehara
    • Organizer
      DDW
    • Place of Presentation
      Orland
    • Related Report
      2013 Final Research Report
  • [Presentation] Peyer's patches play a protective role in NSAIDs-induced small bowel injury2013

    • Author(s)
      Hiyama, S., Iijima, H., Shinzaki, S., Shibata, N., Sato S., Tsujii, M., Kiyono, H., Takehara, T
    • Organizer
      第42回日本免疫学会
    • Place of Presentation
      幕張メッセ
    • Related Report
      2013 Final Research Report
  • [Presentation] Observation of Peyer's patch using narrow band imaging with magnifying endoscopy is useful in predicting the recurrence in ulceratie colitis patients2013

    • Author(s)
      Hiyama, S., H. Iijima, S. Kawai, E. Shiraishi, A. Mukai, T. Inoue, S. Shinzaki, M. Tsujii, and T. Takehara.
    • Organizer
      UEGW
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2013 Annual Research Report
  • [Presentation] Peyer's Patches Play a Protective Role in NSAIDs-Induced Enteropathy2013

    • Author(s)
      Hiyama, S., H. Iijima, S. Shinzaki, T. Inoue, E. Shiraishi, S. Kawai, M. Araki, T. Nishida, M. Tsujii, and T. Takehara.
    • Organizer
      DDW
    • Place of Presentation
      Orland, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 関節リウマチ患者におけるNSAIDs小腸粘膜傷害に対するメサラジンの有用性および粘膜傷害のリスク因子に関する検討2013

    • Author(s)
      井上隆弘, 飯島英樹, 有光潤介, 萩原圭祐, 川井翔一朗, 白石衣里, 日山智史, 向井章, 新崎信一郎, 西田勉, 緒方篤, 辻井正彦, 竹原徹郎
    • Organizer
      JDDW2013
    • Place of Presentation
      グランドプリンスホテル新高輪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Alteration of Peyer's patch in patients with inflammatory bowel disease observed in using narrow band imaging with magnifying endoscopy2012

    • Author(s)
      Hiyama, S., H. Iijima, S. Shinzaki, A. Mukai, T. Inoue, S. Kawai, E. Shiraishi, T. Yamada, T. Nishida, M. Tsujii, and T. Takehara
    • Organizer
      UEGW
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of balloon dilation using double-balloon enteroscopy for small-bowel strictures in patients with symptomatic Crohn's disease2012

    • Author(s)
      Inoue, T., H. Iijima, and T. Takehara
    • Organizer
      ASIBD 2012
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
  • [Presentation] Narrow Band Imaging With Magnifying Endoscopy for Peyer's Patches in Patients With Inflammatory Bowel Disease2012

    • Author(s)
      Hiyama, S., H. Iijima, S. Shinzaki, A. Mukai, S. Nakajima, T. Inoue, E. Shiraishi, T. Yamada, T. Nishida, M. Tsujii, and T. Takehara
    • Organizer
      DDW 2012
    • Place of Presentation
      San Diego
    • Related Report
      2013 Final Research Report
  • [Presentation] Efficacy of balloon dilation using double-balloon enteroscopy for small-bowel strictures in patients with symptomatic Crohn's disease2012

    • Author(s)
      Inoue, T., H. Iijima, S. Yamaguchi, S. Egawa, Y. Arimoto, K. Tominaga, A. Maekawa, S. Hiyama, S. Shinzaki, M. Komori, T. Nishida, H. Hagiwara, M. Oshita, M. Tsujii, M. Kubo, and T. Takehara
    • Organizer
      UEGW
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2013 Final Research Report
  • [Presentation] パイエル板はNSAIDs起因性小腸粘膜傷害に保護的に働く2012

    • Author(s)
      日山智史, 飯島英樹, 白石衣里, 向井章, 井上隆弘, 中島佐知子, 新﨑信一郎, 辻井正彦, 竹原徹郎
    • Organizer
      JDDW2012(消化器病学会)
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] ALTERNATION OF PEYER’S PATCH IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE: OBSERVATION USING NARROW BAND IMAGING WITH MAGNIFYING ENDOSCOPY.2012

    • Author(s)
      Satoshi Hiyama,Hideki Iijima,Shinichiro Shinzaki,Akira Mukai,Takahiro Inoue,Syouichirou Kawai,Eri Shiraishi,Takuya Yamada,Tsutomu Nishida,Masahiko Tsujii,Tetsuo Takehara
    • Organizer
      United European Gastroenterology: UEG Week 2012
    • Place of Presentation
      Amsterdam, Netherland
    • Related Report
      2012 Research-status Report
  • [Presentation] NSAID起因性小腸粘膜障害に対するバイエル板の関与2011

    • Author(s)
      日山智史, 飯島英樹, 竹原徹郎
    • Organizer
      第53回日本消化器病学会大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] Narrow Band Imaging With Magnifying Endoscopy for Peyer's Patches in Patients With Inflammatory Bowel Disease

    • Author(s)
      Satoshi Hiyama, Hideki Iijima, Shinichiro Shinzaki, Akira Mukai, Sachiko Nakajima, Takahiro Inoue, Eri Shiraishi, Takuya Yamada, Tsutomu Nishida, Masahiko Tsujii,Tetsuo Takehara
    • Organizer
      Digestive Disease Week 2012
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] IBD患者におけるパイエル板NBI拡大観察

    • Author(s)
      日山智史、飯島英樹、川井翔一郎、白石衣里、向井章、井上隆弘、新崎信一郎、辻井正彦、竹原徹郎
    • Organizer
      第50回小腸研究会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
  • [Presentation] パイエル板はNSAIDs起因性小腸粘膜傷害に保護的に働く

    • Author(s)
      日山智史、飯島英樹、白石衣里、向井章、井上隆弘、中島佐知子、新﨑信一郎、辻井正彦、竹原徹郎
    • Organizer
      JDDW2012(消化器病学会)
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Remarks]

    • URL

      http://www.med.osaka-u.ac.jp/pub/gh/index.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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