| Project/Area Number |
23590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTO Tadashi 東京大学, 医学部附属病院, 臨床登録医 (40444088)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
YOSHIDA Haruhiko 東京大学, 医学部附属病院, 臨床登録医 (60240305)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝臓学 / DDX20 / microRNA / 肝癌 / 肝細胞癌 / 国際情報交換 アメリカ |
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| Research Abstract |
DDX20 was previously identified as one of the causes of hepatocarcinogenesis. In this project, we identified that DDX20 is a component of RISC, which mediates microRNA maturation. By DDX20 decrease, microRNA140-5p amount was specifically decreased, which enhanced DNMT1 leading to the decrease of metallothionein expression, which is closely related to NFkB activities, a major cause of hepatocarcinogenesis. These phenomena were confirmed in miR140 knockout mice and chemically-induced hepatocarcinogenesis. Therefore, it willbe promising that based on these results, novel preventive methods against hepatocarcinogenesis are developed by further analyses.
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