Analyses about the role of DDX20 in hepatocarcinogenesis
| Project/Area Number |
23590960
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
GOTO Tadashi 東京大学, 医学部附属病院, 臨床登録医 (40444088)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUKA Motoyuki 東京大学, 医学部附属病院消化器内科, 助教 (90518945)
YOSHIDA Haruhiko 東京大学, 医学部附属病院, 臨床登録医 (60240305)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 肝臓学 / DDX20 / microRNA / 肝癌 / 肝細胞癌 / 国際情報交換 アメリカ |
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| Research Abstract |
DDX20 was previously identified as one of the causes of hepatocarcinogenesis. In this project, we identified that DDX20 is a component of RISC, which mediates microRNA maturation. By DDX20 decrease, microRNA140-5p amount was specifically decreased, which enhanced DNMT1 leading to the decrease of metallothionein expression, which is closely related to NFkB activities, a major cause of hepatocarcinogenesis. These phenomena were confirmed in miR140 knockout mice and chemically-induced hepatocarcinogenesis. Therefore, it willbe promising that based on these results, novel preventive methods against hepatocarcinogenesis are developed by further analyses.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Intrahepatic bile duct dilatation after percutaneous radiofrequency ablation for hepatocellular carcinoma: impact on patient's prognosis.2011
Author(s)
Kondo Y, Shiina S, Tateishi R, Arano T, Uchino K, Enooku K, Goto E, Nakagawa H, Masuzaki R, Asaoka Y, Fujie H, Goto T, Omata M, Yoshida H, Koike K.
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Journal Title
Liver Int
Volume: 31(2)
Issue: 2
Pages: 197-205
DOI
Related Report
Peer Reviewed
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[Journal Article] Prediction of hepatocellular carcinoma development by plasma ADAMTS 13 in chronic hepatitis B and C2011
Author(s)
Ikeda H, Tateishi R, Enooku K, Yoshida H, nakagawa H, Masuzaki R, Kondo Y, Goto T, Shiina S, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Ono T, Koike K, Yatomi Y
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Journal Title
Cancer Epidemiol Biomarkers Prev.
Volume: 20
Issue: 10
Pages: 2204-11
DOI
Related Report
Peer Reviewed
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