Analysis of immune and metabolic responses of liver cells under inflammatory circumstances or viral infection
Project/Area Number |
23590970
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Nagoya University |
Principal Investigator |
ISHIKAWA TETSUYA 名古屋大学, 医学(系)研究科(研究院), 教授 (10288508)
|
Co-Investigator(Kenkyū-buntansha) |
ISHIGAMI Masatoshi 名古屋大学, 医学部附属病院, 講師 (90378042)
UEYAMA Jun 名古屋大学, 大学院医学系研究科, 准教授 (00397465)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 肝細胞 / サイトカイン / ケモカイン / 炎症応答 / 肝癌細胞株 / p53 / NFκB |
Research Abstract |
To elucidate the role of hepatic parencymal cells on the pathogenesis of hepatitis, the expression patterns of cytokines and chemokines by hepatoma cell lines under inflammatory circumstance were analyzed. In three hepatoma cell lines used, the expressions of inflammatory cytokines and chemokies were up-regulated after various inflammatory stimuli. The pathogenetic importance of hepatic parencymal cells in the formation of hepatic inflammation is confirmed, and in vitro hepatitis model used in the current study is thought to be useful for the detailed analysis of the pathogenesis of hepatitis.
|
Report
(4 results)
Research Products
(14 results)
-
[Journal Article] Ursodeoxycholic acid inhibits overexpression of P-glycoprotein induced bydoxorubicininHepG2 cells.2014
Author(s)
Komori Y, Arisawa A, Takai M, Yokoyama K, Honda M, Hayashi K, Ishigami M, Katano Y, Goto H, Ueyama J, Ishikawa T, Wakusawa Y.
-
Journal Title
Eur J Pharmacol
Volume: 724
Pages: 161-167
DOI
Related Report
Peer Reviewed
-
[Journal Article] A pediatric case of hepatitis B virus subgenotype A2 in Japan2013
Author(s)
Hayashi K, Ishigami M, Ishizu Y, Kuzuya T, Honda T, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Ito Y, Kimura H, Katano Y, Goto H
-
Journal Title
Clin J Gastroenterol
Volume: 6
Issue: 5
Pages: 383-385
DOI
Related Report
Peer Reviewed
-
[Journal Article] Pegylated interferon monotherapy in patients with chronic hepatitis C with low viremia and its relationship to mutations in the NS5A region and the single nucleotide polymorphism of interleukin-28B.2013
Author(s)
Hayashi K, Katano Y, Masuda H, Ishizu I, Kuzuya T, Honda T, Ishigami M, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H.
-
Journal Title
Hepatol Res
Volume: 43
Issue: 6
Pages: 580-588
DOI
NAID
Related Report
Peer Reviewed
-
[Journal Article] Comparison of the efficacy of ribavirin plus peginterferon alfa-2b for chronic hepatitis C infection in patients with and without coagulation disorders.2013
Author(s)
Honda T, Katano Y, Kuzuya T, Hayashi K, Ishigami M, Itoh A, Hirooka Y, Nakano I, Ishikawa T, Toyoda H, Kumada T, Yamamoto K, Matsushita T, Kojima T, Takamatsu J, Goto H
-
Journal Title
J Med Virol.
Volume: 85(2)
Issue: 2
Pages: 228-234
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin2012
Author(s)
Hayashi K, Katano Y, Kuzuya T, Tachi Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H
-
Journal Title
J Med Virol
Volume: 84
Pages: 438-444
Related Report
Peer Reviewed
-
-
[Journal Article] Prevalence of hepatitis C virus genotype 1a in Japan and correlation of mutations in the NS5A region and single-nucleotide polymorphism of interleukin-28B with the response to combination therapy with pegylated-interferon-alpha 2b and ribavirin.2012
Author(s)
Hayashi K, Katano Y, Kuzuya T, Tachi Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Urano F, Yoshioka K, Toyoda H, Kumada T, Goto H
-
Journal Title
J Med Virol
Volume: 84
Pages: 438-444
Related Report
Peer Reviewed
-
[Journal Article] Association of interleukin 28B and mutation in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy2011
Author(s)
Hayashi K, Katano Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Yoshioka Y, Toyoda H, Kumada T, Goto H
-
Journal Title
Liver Int
Volume: 31
Pages: 1359-1361
Related Report
Peer Reviewed
-
[Journal Article] Association of interleukin 28B and mutation in the core and NS5A region of hepatitis C virus with response to peg-interferon and ribavirin therapy.2011
Author(s)
Hayashi K, Katano Y, Honda T, Ishigami M, Itoh A, Hirooka Y, Ishikawa T, Nakano I, Yoshioka Y, Toyoda H, Kumada T, Goto H.
-
Journal Title
Liver Int
Volume: 31
Pages: 1359-1361
Related Report
Peer Reviewed
-
-
-
-