the impact of epicardial adipose tissue on the development of atherosclerotic coronary artery disease

• Project/Area Number: 23591028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Yamagata University
• Principal Investigator: NITOBE joji 山形大学, 医学部, 非常勤講師 (30400542)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: メタボリック症候群 / 心外膜脂肪 / 動脈硬化 / マルチスライスCT

Research Abstract

We investigated the impact of epicardial adipose tissue(EAT) volume measured by multi-detector CT and adiponectin level in pericardial fluid on the development of CAD in obese and non-obese patients. EAT volume was significantly higher in CAD patients compared to non CAD patients. EAT volume was not significantly different between obese patients with and without CAD. EAT was significantly higher in non-obese patients with CAD compared to those without CAD (35.0 + 18.8 mL vs. 16.9 + 10.5 mL, p < 0.01). Adiponectin concentration in pericardial fluid was significantly lower in non-obese patients with CAD compared to those without CAD. Multiple logistic regression analysis showed that increment of EAT volume correlated independently with the progression of CAD in non-obese patients.
EAT may be associated with the development of CAD in non-obese patients. The decreased secretion of adiponectin from EAT may contribute to the development of coronary atherosclerosis.

Research Products

• [Journal Article] The Role of Epicardial Adipose Tissue
  • Author(s): Iwayama T, Nitobe J, Watanabe T, Ishino M, Tamura H, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyashita T, Miyamoto T, Toyama S, Sadahiro M, Kubota I.
• [Presentation] Impact of plasma estradiol level on the development of coronary artery disease in men (2012)
  • Author(s): Yashiro Y, Nitobe J, et al
  • Organizer: Japanese Circulation Society
  • Place of Presentation: 福岡市 福岡国際会議場