| Project/Area Number |
23591056
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Osaka City University |
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Principal Investigator |
TAKEMOTO Yasuhiko 大阪市立大学, 医学(系)研究科(研究院), 准教授 (20364002)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIYAMA Minoru 大阪市立大学, 医学(系)研究科(研究院), 教授 (30240956)
HIROHASHI Kazuhiro 大阪市立大学, 医学(系)研究科(研究院), 教授 (00145799)
AZUMA Jyunichi 兵庫医療大学, 薬学部, 教授 (30144463)
FUJIO Yasushi 大阪大学, 薬学研究科(研究院), 教授 (20359839)
MAEDA Makiko 大阪大学, 薬学研究科(研究院), 講師 (70461168)
NONEN Shinpei 兵庫医療大学, 薬学部, 講師 (40467527)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 禁煙 / 血管障害 / ニコチン依存度 / トロンボスポンジン / 血管内皮機能 / 喫煙 |
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| Outline of Final Research Achievements |
We evaluated alterations of flow-mediated dilation (FMD) in smokers during smoking cessation with varenicline therapy and found significant increases of FMD. Thrombospondin-1 increases nitric oxide (NO) and suggests the possibility of FMD improvements. However, there were no significant differences of thrombospondin-1 plasma levels between before and after smoking cessation with varenicline therapy. VEGF also increases nitric oxide (NO) and suggests the possibility of FMD improvements. IL-6 induces vascular inflammations and suggests the possibility of FMD deteriorations. However, there were no significant differences of VEGF and IL-6 levels between before and after smoking cessation with varenicline therapy.
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