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Role of thrombospondin and nicotine dependence in vascular damage from smoking

Research Project

Project/Area Number 23591056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOsaka City University

Principal Investigator

TAKEMOTO Yasuhiko  大阪市立大学, 医学(系)研究科(研究院), 准教授 (20364002)

Co-Investigator(Kenkyū-buntansha) YOSHIYAMA Minoru  大阪市立大学, 医学(系)研究科(研究院), 教授 (30240956)
HIROHASHI Kazuhiro  大阪市立大学, 医学(系)研究科(研究院), 教授 (00145799)
AZUMA Jyunichi  兵庫医療大学, 薬学部, 教授 (30144463)
FUJIO Yasushi  大阪大学, 薬学研究科(研究院), 教授 (20359839)
MAEDA Makiko  大阪大学, 薬学研究科(研究院), 講師 (70461168)
NONEN Shinpei  兵庫医療大学, 薬学部, 講師 (40467527)
Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords禁煙 / 血管障害 / ニコチン依存度 / トロンボスポンジン / 血管内皮機能 / 喫煙
Outline of Final Research Achievements

We evaluated alterations of flow-mediated dilation (FMD) in smokers during smoking cessation with varenicline therapy and found significant increases of FMD. Thrombospondin-1 increases nitric oxide (NO) and suggests the possibility of FMD improvements. However, there were no significant differences of thrombospondin-1 plasma levels between before and after smoking cessation with varenicline therapy. VEGF also increases nitric oxide (NO) and suggests the possibility of FMD improvements. IL-6 induces vascular inflammations and suggests the possibility of FMD deteriorations. However, there were no significant differences of VEGF and IL-6 levels between before and after smoking cessation with varenicline therapy.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (88 results)

All 2015 2014 2013 2012 2011

All Journal Article (41 results) (of which Peer Reviewed: 41 results,  Open Access: 3 results) Presentation (44 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy2015

    • Author(s)
      Kobayashi, M
    • Journal Title

      Osaka City Med J

      Volume: 印刷中

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outcomes of everolimus-eluting stent incomplete stent apposition: a serial optical coherence tomography analysis2015

    • Author(s)
      Shimamura, K
    • Journal Title

      Eur Heart J Cardiovasc Imaging

      Volume: 16 Issue: 1 Pages: 23

    • DOI

      10.1093/ehjci/jeu174

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Percutaneous Carbon Dioxide Treatment using a Gas Mist Generator Enhances the Collateral Blood Flow in the Ischemic Hindlimb2015

    • Author(s)
      Izumi, Y
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 22 Issue: 1 Pages: 38-51

    • DOI

      10.5551/jat.23770

    • NAID

      130004677973

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction2014

    • Author(s)
      Yamaguchi, T
    • Journal Title

      Int J Cardiol

      Volume: 30 Pages: 239-246

    • DOI

      10.1016/j.ijcard.2014.10.144

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hydrogen gas attenuates embryonic gene expression and prevents left ventricular remodeling induced by intermittent hypoxia in cardiomyopathic hamsters2014

    • Author(s)
      Kato R
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 307 Issue: 11 Pages: H1626-H1633

    • DOI

      10.1152/ajpheart.00228.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serial assessment of arterial stiffness by cardio-ankle vascular index for prediction of future cardiovascular events in patients with coronary artery disease2014

    • Author(s)
      Otsuka, K
    • Journal Title

      Hypertens Res

      Volume: 37 Issue: 11 Pages: 1014-1020

    • DOI

      10.1038/hr.2014.116

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig2014

    • Author(s)
      Yamaguchi, T
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 126 Issue: 2 Pages: 168-171

    • DOI

      10.1254/jphs.14171SC

    • NAID

      130004690915

    • ISSN
      1347-8613, 1347-8648
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.2014

    • Author(s)
      Sano, S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 2 Pages: 327-333

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genetic polymorphisms of CYP17A1 in steroidogenesis pathway are associated with risk of progression to castration-resistant prostate cancer in Japanese men receiving androgen deprivation therapy2013

    • Author(s)
      Yamada, T.
    • Journal Title

      Int. J. Clin. Oncol.

      Volume: 18 Pages: 711-717

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy2013

    • Author(s)
      Azuma, J.
    • Journal Title

      Eur. J. Clin. Pharmacol.

      Volume: 69 Pages: 1091-1101

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Minimal dose for effective clinical outcome and predictive factors for responsiveness to carvedilol: Japanese chronic heart failure (J-CHF) study2013

    • Author(s)
      Okamoto, H.
    • Journal Title

      Int. J. Cardiol.

      Volume: 164 Pages: 238-244

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cathelicidin antimicrobial peptide inhibits fibroblast migration via P2X7 receptor signaling.2013

    • Author(s)
      Kumagai, S.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 437 Pages: 609-614

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insulin resistance is associated with coronary plaque vulnerability: insight from optical coherence tomography analysis.2013

    • Author(s)
      Iguchi, T.
    • Journal Title

      Eur Heart J Cardiovasc Imaging.

      Volume: 15 Pages: 284-291

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous assessment of endothelial function and morphology in the brachial artery using a new semiautomatic ultrasound system2013

    • Author(s)
      Iguchi, T.
    • Journal Title

      Hypertens Res.

      Volume: 36 Pages: 691-697

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tolvaptan attenuates left ventricular fibrosis after acute myocardial infarction in rats.2013

    • Author(s)
      Yamazaki, T.
    • Journal Title

      J Pharmacol Sci.

      Volume: 123 Pages: 58-66

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic accuracy and cost-effectiveness of a pocket-sized transthoracic echocardiographic imaging device2013

    • Author(s)
      Kitada, R.
    • Journal Title

      Clin Cardiol.

      Volume: 36 Pages: 603-610

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of coronary flow reserve on long-term cardiovascular outcomes in patients with chronic kidney disease.2013

    • Author(s)
      Nakanishi, K.
    • Journal Title

      Am J Cardiol.

      Volume: 112 Pages: 928-932

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study.2013

    • Author(s)
      Kono, Y.
    • Journal Title

      Drug Des Devel Ther.

      Volume: 3 Pages: 369-374

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in serum cholesterol levels determine future risk of cardiovascular events in patients with acute coronary syndrome in the Japanese Coronary Artery Disease (JCAD) Study.2013

    • Author(s)
      Fukuda, S.
    • Journal Title

      J Cardiol.

      Volume: 6 Pages: 387-392

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Napkin-ring sign on coronary CT angiography for the prediction of acute coronary syndrome.2013

    • Author(s)
      Otsuka, K.
    • Journal Title

      JACC Cardiovasc Imaging.

      Volume: 6 Pages: 448-457

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Simultaneous assessment of endothelial function and morphology in the brachial artery using a new semiautomatic ultrasound system2013

    • Author(s)
      Iguchi, T
    • Journal Title

      Hypertension Research

      Volume: 未定

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Absence of Coronary Calcification With Normal Endothelial Function – A Unique Entity for Preemptive Medical Care -2012

    • Author(s)
      Takemoto, Y
    • Journal Title

      Circ J

      Volume: 76 Pages: 2544-2545

    • NAID

      10031078490

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multicenter study design to assess the clinical usefulness of semi-automatic measurement of flow-mediated vasodilatation of the brachial artery2012

    • Author(s)
      Tomiyama, H
    • Journal Title

      Int Heart J

      Volume: 53 Pages: 170-175

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] JAK/STAT signaling in cardiomyogenesis of cardiac stem cells2012

    • Author(s)
      Mohri, T
    • Journal Title

      JAK/STAT

      Volume: 1 Pages: 125-130

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Endothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation and atherosclerosis in apolipoprotein E knockout mice2012

    • Author(s)
      Higuchi, K
    • Journal Title

      Circ. J

      Volume: 76 Pages: 2031-2040

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Tolvaptan improves left ventricular dysfunction after myocardial infarction in rats2012

    • Author(s)
      Yamazaki, T
    • Journal Title

      Circ Heart Fail

      Volume: 5 Pages: 794-802

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Peri-atrial epicardial adipose tissue is associated with new-onset nonvalvular atrial fibrillation2012

    • Author(s)
      Nakanishi, K
    • Journal Title

      Circ J

      Volume: 76 Pages: 2748-2754

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Therapeutic administration of IL-11 exhibits the postconditioning effects against ischemia-reperfusion injury via STAT3 in the heart2012

    • Author(s)
      Obana, M
    • Journal Title

      Am J Physiol Heart Circ Physiol

      Volume: 303

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel device that produces carbon dioxide mist for myocardial infarction treatment in rats2012

    • Author(s)
      Yamazaki, T
    • Journal Title

      Circ J

      Volume: 76 Pages: 1203-1212

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The antifibrotic agent pirfenidone inhibits angiotensin II-induced cardiac hypertrophy in mice2012

    • Author(s)
      Yamazaki, T
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 34-40

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Circadian variation in coronary flow velocity reserve and its relation to alpha1-sympathetic activity in humans2012

    • Author(s)
      Fukuda, S
    • Journal Title

      Int J Caridol

      Volume: 157 Pages: 216-220

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cigarette smoke extract induces CYP2B6 through constitutive androstane receptor in hepatocytes2011

    • Author(s)
      Washio, I.
    • Journal Title

      Drug Metab. Dispos.

      Volume: 39 Pages: 1-3

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Docking protein Gab1 is an essential component of postnatal angiogenesis after ischemia via HGF/c-Met signaling2011

    • Author(s)
      Shioyama, W.
    • Journal Title

      Circ. Res.

      Volume: 108 Pages: 664-675

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between osteopontin promoter variants and diastolic dysfunction in hypertensive heart in the Japanese population2011

    • Author(s)
      Nakayama, H.
    • Journal Title

      Hypertension Res.

      Volume: 34 Pages: 1141-1146

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] STAT3/Pim-1 signaling pathway plays a crucial role in endothelial differentiation of cardiac resident stem cells both in vitro and in vivo2011

    • Author(s)
      Iwakura, T.
    • Journal Title

      J. Mol. Cell. Cardiol.

      Volume: 51 Pages: 207-214

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-6-mediated Th17 differentiation through RORγt is essential for the initiation of experimental autoimmune myocarditis2011

    • Author(s)
      Yamashita, T.
    • Journal Title

      Cardiovasc. Res.

      Volume: 91 Pages: 640-648

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gp130 cytokine signal as a therapeutic target against cardiovascular diseases2011

    • Author(s)
      Fujio, Y.
    • Journal Title

      J. Pharmacol. Sci.

      Volume: 117 Pages: 213-222

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Passive exercise using whole-body periodic acceleration enhances blood supply to ischemic hindlimb2011

    • Author(s)
      Rokutanda, T.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 12 Pages: 2872-2880

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of coronary microcirculation in female nurses after day-time versus night-time shifts2011

    • Author(s)
      Kubo, T.
    • Journal Title

      Am J Cardiol.

      Volume: 108 Pages: 1665-1668

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pocket-sized echo for evaluation of mitral and tricuspid regurgitation2011

    • Author(s)
      Kono, Y.
    • Journal Title

      JACC Cardiovasc Imaging.

      Volume: 8 Pages: 921-921

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Aromatherapy alleviates endothelial dysfunction of medical staff after night-shift work: preliminary observations2011

    • Author(s)
      Shimada, K.
    • Journal Title

      Hypertens Res.

      Volume: 34 Pages: 264-267

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 独歩で来院され、無痛性心筋梗塞に心室中隔穿孔を合併した一例2015

    • Author(s)
      衣畑成紀
    • Organizer
      日本病院総合診療医学会
    • Place of Presentation
      ホテル日航福岡(福岡県・福岡市)
    • Year and Date
      2015-02-27 – 2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 腹水量の変化に注目し診断に至った腹痛の一例2015

    • Author(s)
      小林正宜
    • Organizer
      日本病院総合診療医学会
    • Place of Presentation
      ホテル日航福岡(福岡県・福岡市)
    • Year and Date
      2015-02-27 – 2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 治療抵抗性の腰痛を主訴に来院した50代男性の1例2015

    • Author(s)
      並川浩己
    • Organizer
      日本病院総合診療医学会
    • Place of Presentation
      ホテル日航福岡(福岡県・福岡市)
    • Year and Date
      2015-02-27 – 2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 発熱精査にて受診した一例2015

    • Author(s)
      福本一夫
    • Organizer
      日本病院総合診療医学会
    • Place of Presentation
      ホテル日航福岡(福岡県・福岡市)
    • Year and Date
      2015-02-27 – 2015-02-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 全身倦怠感に食欲不振が加わって来院した中年男性の1例2014

    • Author(s)
      並川浩己
    • Organizer
      日本内科学会近畿地方会
    • Place of Presentation
      メルパルク京都(京都府・京都市)
    • Year and Date
      2014-12-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vascular Functional and Morphological Alterations in Smokers during Varenicline Therapy2014

    • Author(s)
      Kobayashi, M
    • Organizer
      European Society of Cardiology Congress 2014
    • Place of Presentation
      Fira Gran Via, Barcelona(Spain)
    • Year and Date
      2014-08-29 – 2014-09-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 医学部4年生を対象とした医療面接を取り入れた禁煙講義の試み2014

    • Author(s)
      小林正宜
    • Organizer
      日本医学教育学会
    • Place of Presentation
      和歌山県立医科大学(和歌山県・和歌山市)
    • Year and Date
      2014-07-18 – 2014-07-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内皮機能検査「FMD」の最新の知見:baIMTとFMD:どう使う?血管機能評価と血管形態評価2014

    • Author(s)
      竹本恭彦
    • Organizer
      日本動脈硬化学会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 医学部生に対する禁煙指導―ロールプレイシミュレーションによる成果―2014

    • Author(s)
      小林正宜
    • Organizer
      日本シミュレーション医療教育学会
    • Place of Presentation
      宮崎大学医学部(宮崎県・宮崎市)
    • Year and Date
      2014-06-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] 喫煙習慣・生活習慣は禁煙の妨げとなるか:禁煙達成成否要因の検討2014

    • Author(s)
      小林正宜
    • Organizer
      日本プライマリケア連合学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脱毛・味覚障害・下痢の多彩な症状を呈した1例2014

    • Author(s)
      並川浩己
    • Organizer
      日本プライマリケア連合学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 診断に難渋した右鎖骨上リンパ節腫大の一例2014

    • Author(s)
      幕内安弥子
    • Organizer
      日本プライマリケア連合学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2014-05-10 – 2014-05-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] High blood pressure is associated with the progression of aortic valve stenosis in chronic hemodialysis patients2014

    • Author(s)
      Norioka, N.
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo International Forum, Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Repeated remote ischemic conditioning attenuates left ventricular remodeling via exosome-mediated intercellular communication on chronic heart failure after myocardial infarction2014

    • Author(s)
      Yamaguchi, T.
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo International Forum, Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Assessment of left ventricular wall motion using echocardiography and ECG changes in serious cases with Takotsubo cardiomyopathy2014

    • Author(s)
      Norioka, N.
    • Organizer
      The 78th Annual Scientific Meeting of the Japanese Circulation Society
    • Place of Presentation
      Tokyo International Forum, Tokyo, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 禁煙による体重変化と代謝変化の関係2013

    • Author(s)
      小林正宣
    • Organizer
      第4回日本プライマリケア連合学会学術大会
    • Place of Presentation
      仙台国際センター、仙台、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] 大学病院総合診療科を受診した片頭痛患者の特徴2013

    • Author(s)
      福本一夫
    • Organizer
      第4回日本プライマリケア連合学会学術大会
    • Place of Presentation
      仙台国際センター、仙台、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] 発熱を主訴とした患者の赤血球沈降速度値の意義2013

    • Author(s)
      並川浩己
    • Organizer
      第4回日本プライマリケア連合学会学術大会
    • Place of Presentation
      仙台国際センター、仙台、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] A report from the Japanese pharmacogenomics clinical traial; CYP2A6 Gene Polymorphisms Influence Nicotine Dependence and Monoamine Oxidase Gene Polymorphism Does Smoking Cessation Behavior2013

    • Author(s)
      Maeda, M.
    • Organizer
      American Heart Association Scientific Session 2013
    • Place of Presentation
      Dallas Convention Center, Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] 葉酸欠乏性貧血による心不全から回復し、再発予防のため社会的支援まで介入できた一例2013

    • Author(s)
      幕内安弥子
    • Organizer
      第27回日本プライマリケア連合学会
    • Place of Presentation
      兵庫医療大学、神戸、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] 発熱、頭痛を主訴に来院した抗NMDA受容体脳炎の一例2013

    • Author(s)
      小林正宣
    • Organizer
      第27回日本プライマリケア連合学会
    • Place of Presentation
      兵庫医療大学、神戸、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] 四肢末梢浮腫が主訴であった好酸球性血管浮腫の一例2013

    • Author(s)
      並川浩己
    • Organizer
      第27回日本プライマリケア連合学会
    • Place of Presentation
      兵庫医療大学、神戸、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] 扁平上皮癌を伴った皮膚型結節性多発動脈炎の一例2013

    • Author(s)
      福本一夫
    • Organizer
      第27回日本プライマリケア連合学会
    • Place of Presentation
      兵庫医療大学、神戸、日本
    • Related Report
      2013 Research-status Report
  • [Presentation] Simultaneous Assessment of Endothelial Function and Morphology in Brachial Artery Using a New Semi-automatic Ultrasound System2013

    • Author(s)
      Iguchi, T
    • Organizer
      Scientific meeting of American College of Cardiology
    • Place of Presentation
      Moscone Center, San Franscisco, USA
    • Related Report
      2012 Research-status Report
  • [Presentation] Prognostic Significance of Combined Assessment of Brachial Intima-media Thickness and Flow-Mediated Dilatation in Patients with Atherosclerotic Risk Factors and No Coronary Heart Disease2013

    • Author(s)
      Iguchi, T
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜, 横浜, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Predictive Value of Combined Assessment of Atherosclerotic Risk with Brachial Arterial Flow-Mediated Dilatation, Intima-Media Thickness and Cardio-Ankle Vascular Index2013

    • Author(s)
      Iguchi, T
    • Organizer
      日本循環器学会学術集会
    • Place of Presentation
      パシフィコ横浜, 横浜, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 喫煙者におけるインターロイキン-6(IL-6)遺伝子プロモーター領域の遺伝子多型が肥満とニコチン依存に及ぼす影響2012

    • Author(s)
      前田真貴子
    • Organizer
      日本臨床薬理学会学術総会
    • Place of Presentation
      沖縄コンベンションセンター, 沖縄, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 禁煙成功率と禁煙に伴う変化:禁煙専門外来における検討2012

    • Author(s)
      小林正宜
    • Organizer
      日本タバコフリー学会学術大会
    • Place of Presentation
      兵庫医療大学, 神戸, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 禁煙外来における機能性消化管疾患の実態2012

    • Author(s)
      木幡幸恵
    • Organizer
      日本タバコフリー学会学術大会
    • Place of Presentation
      兵庫医療大学, 神戸, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 受動喫煙は非喫煙正常健常者の心臓冠動脈における血行を急速に障害する2012

    • Author(s)
      大塚亮
    • Organizer
      日本タバコフリー学会学術大会
    • Place of Presentation
      兵庫医療大学, 神戸, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 健常人の血管内皮機能に対する遠隔虚血コンディショニングの効果の検討2012

    • Author(s)
      井口 朋和
    • Organizer
      日本心臓病学会学術集会
    • Place of Presentation
      ANAクラウンプラザホテル金沢, 金沢, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 禁煙成功率と禁煙に伴う変化2012

    • Author(s)
      小林正宜
    • Organizer
      日本プライマリ・ケア連合学会学術大会
    • Place of Presentation
      福岡国際会議場, 福岡, 日本
    • Related Report
      2012 Research-status Report
  • [Presentation] 血管中内膜複合体厚と内皮依存性血管拡張反応の関連性2012

    • Author(s)
      井口 朋和
    • Organizer
      臨床高血圧フォーラム
    • Place of Presentation
      千里ライフサイエンスセンター, 大阪、日本
    • Related Report
      2012 Research-status Report
  • [Presentation] Alteration in subendocardial and subepicardial myocardial strain in patients with aortic valve stenosis-an early marker of left vetnricular dysfunction2012

    • Author(s)
      Eiichi Hyodo
    • Organizer
      Annual scientific meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Simultaneous functional and morphological assessment of the vascular endothelium:evaluation from the brachial artery with a validation study2012

    • Author(s)
      Tomokazu Iguchi
    • Organizer
      Annual scientific meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Significant differences by races in frequency and morphology of bicuspid aortic valve disease2012

    • Author(s)
      Satoshi Saito
    • Organizer
      Annual scientific meeting of the Japanese Circulation Society
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Effects of remote ischemic conditioning on vascular endothelial function in healthy subjects2012

    • Author(s)
      Tomokazu Iguchi
    • Organizer
      American college of cardiology annual scientific session
    • Place of Presentation
      Chicago
    • Related Report
      2011 Research-status Report
  • [Presentation] 新血管壁トラッキングシステムによる血管内腔径、中内膜複合体厚同時評価法:目視計測法との比較検討2011

    • Author(s)
      井口 朋和
    • Organizer
      日本心臓病学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 心サルコイドーシスの診断における局所壁運動異常評価の有用性ー核医学検査との比較ー2011

    • Author(s)
      武田 久輝
    • Organizer
      日本心臓病学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] 拡張型心筋症における心筋重量当たりの冠動脈長、冠動脈径、および冠動脈体積の特徴2011

    • Author(s)
      松本 健嗣
    • Organizer
      日本心臓病学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Research-status Report
  • [Presentation] ラット心筋梗塞モデル慢性期に対するバゾプレシンV2受容体拮抗薬トルバプタンの効果2011

    • Author(s)
      泉 康雄
    • Organizer
      日本高血圧学会
    • Place of Presentation
      宇都宮
    • Related Report
      2011 Research-status Report
  • [Presentation] II度以上未治療高血圧治療に対する高用量ARB投与とARB・CCB併用投与の降圧効果2011

    • Author(s)
      中村 泰浩
    • Organizer
      日本高血圧学会
    • Place of Presentation
      宇都宮
    • Related Report
      2011 Research-status Report
  • [Presentation] 血管中内膜厚と内皮依存性血管拡張反応の関連性:上腕動脈における同時測定による検討2011

    • Author(s)
      井口 朋和
    • Organizer
      日本高血圧学会
    • Place of Presentation
      宇都宮
    • Related Report
      2011 Research-status Report
  • [Presentation] 禁煙専門外来における禁煙成功率2011

    • Author(s)
      小林 正宣
    • Organizer
      日本プライマリケア連合学会
    • Place of Presentation
      大阪
    • Related Report
      2011 Research-status Report
  • [Book] 医師・薬剤師のための医薬品副作用ハンドブック2013

    • Author(s)
      竹本 恭彦、葭山 稔
    • Total Pages
      613
    • Publisher
      日本臨床社
    • Related Report
      2013 Research-status Report
  • [Book] 医薬品副作用学 薬剤性心筋炎、心筋症2012

    • Author(s)
      竹本 恭彦、葭山 稔
    • Total Pages
      4
    • Publisher
      日本臨床社
    • Related Report
      2012 Research-status Report
  • [Book] 循環器内科 心臓・血管リモデリングとは2012

    • Author(s)
      竹本 恭彦、葭山 稔
    • Total Pages
      5
    • Publisher
      科学評論社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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