| Project/Area Number |
23591063
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
DAIDA Hiroyuki 順天堂大学, 医学部, 教授 (40197596)
AMANO Atsushi 順天堂大学, 医学部, 教授 (70338440)
INABA Hirotaka 順天堂大学, 医学部, 准教授 (10511454)
KUWAKI Kenji 順天堂大学, 医学部, 准教授 (90398313)
YAMAMOTO Taira 順天堂大学, 医学部, 准教授 (70301504)
SUWA Satoru 順天堂大学, 医学部, 准教授 (90226613)
OKAZAKI Shinya 順天堂大学, 医学部, 准教授 (80317396)
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| Project Period (FY) |
2011-04-28 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 冠動脈疾患 / 冠インターベンション / バイパス手術 / 長期予後 / データベース |
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| Outline of Final Research Achievements |
Coronary intervention has evolved along with advances in the technology and medical therapy. However, there is no evidence regarding improvement in clinical outcome following PCI. Data from the Juntendo PCI Registry during 1984-2010 were analyzed. The patients were divided into 3 groups according to date of index PCI. A total of 3,831 patients were examined (POBA era, n=1,147; BMS era, n=1,180; DES era, n=1,504). Mean age was highest in the DES era. The prevalence of diabetes and hypertension was higher in the DES and BMS eras than in the POBA era. Unadjusted cumulative event-free survival rate for 2-year MACE was significantly different across the 3 eras. Adjusted relative risk reduction for 2-year MACE was 56% in the DES era and 34% in the BMS era, both compared with the POBA era. Age, ACS, and LVEF were associated with the incidence of MACE.
CONCLUSIONS: Clinical outcome of PCI improved across the 26-year study period, despite the higher patient risk profile in the recent era.
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