| Project/Area Number |
23591092
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Meiji University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Michiyo 明治大学, 農学部, 講師 (20445860)
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| Co-Investigator(Renkei-kenkyūsha) |
KAMIYA Chizuko 独立行政法人国立循環器病研究センター, 周産期・婦人科部, 医師 (10551301)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 周産期心筋症 / プロラクチン / バソインヒビン |
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| Research Abstract |
It is well known that prolactin (PRL) has modified into several variants. One of these variants, N-terminal PRL which is cleaved by cathepsinD (CathD), is named vasoinhibins (Vi) because of its anti-angiogenic and pro-apototic properties. Vi has been reported the possibility to cause for peripartum cardiomyopathy (PPCM) and pregnancy induced hypertension (PIH) syndrome. In order to clarify these pathogenic mechanisms, we tried to detect Vi value and CathD activity in patient's blood and determine the relationship between these factors and diseases.
Vi content and CathD activity in PPCM and PIH patients are higher than these of control healthy pregnant women. These results seem to suggest that measurement of Vi content and CathD activity is useful for early detection of PPCM and PIH in pregnant women.
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