To overcome intractable chronic cough: disclosure of mechanism of cough response to bronchoconstiction to conrol of the cough

• Project/Area Number: 23591142
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: FUJIMURA Masaki 金沢大学, 医学系, 協力研究員 (90190066)
• Co-Investigator(Kenkyū-buntansha): OGAWA Haruhiko 金沢大学, 医学系, 協力研究員 (70401908) ; OHKURA Noriyuki 金沢大学, 医学系, 協力研究員 (80397215) ; 片山 伸幸 金沢大学, 医学系, 研究員 (30334767)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 慢性咳嗽 / 咳喘息 / 気管支平滑筋収縮 / 気管支平滑筋 / 難治性 / 咳嗽反応

Research Abstract

Basic study: Beta2-agonists abolished both the methacholine-induced bronchoconstriction and cough. Capsaicin desensitization had no effect on the bronchoconstriction or the number of coughs. Moguisteine inhibited the number of coughs but not the bronchoconstriction. It is concluded that bronchoconstriction causes cough via RARs, but not C-fibers. Furthermore, prostaglandin E2 takes a role to enhance the methacholine-induced cough response as protection of bronchoconstriction.
Clinical study: Cough response to bronchoconstriction induced by Meth was heightened in cough variant asthma patients. The increased cough response recovered to normal range after treatment. Thus, we identified heightened cough response to bronchoconstriction as a fundamental physiologic feature of cough variant asthma. Sensitivity and specificity of cough responsiveness to Mch for discrimination of cough variant asthma from chronic non-productive cough were 81.0% and 89.7%, respectively.

Research Products

• [Journal Article] It is time to call attention to the clinical significance of fungal colonization in chronic cough (2014)
  • Author(s): Ogawa H, Fujimura M
  • Journal Title: Allergology International Volume: (in press)
  • NAID: 130004705223
  • Peer Reviewed
• [Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids (2014)
  • Author(s): Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
  • Journal Title: Allergy Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian Dust : A hospital-based study in Kanazawa (2014)
  • Author(s): Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, Nakamura H
  • Journal Title: Atmospheric Environment Volume: (in press)
  • NAID: 120005418493
  • Peer Reviewed
• [Journal Article] Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes (2014)
  • Author(s): Matsumoto H, Fujimura M
  • Journal Title: J Allergy Clin Immunol Volume: (in press)
  • Peer Reviewed
• [Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (2014)
  • Author(s): Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 69 Issue: 5 Pages: 668-73
  • DOI: 10.1111/all.12400
  • Peer Reviewed / Open Access
• [Journal Article] Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. (2014)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
  • Journal Title: J Allergy Clin Immunol Volume: 133 Issue: 5 Pages: 1474-1477
  • DOI: 10.1016/j.jaci.2013.12.1084
  • Peer Reviewed / Open Access
• [Journal Article] Is bjerkandera allergy affected by the arrival of yellow sand dust? (2013)
  • Author(s): Ogawa H, Fujimura M, Satoh K, Makimura K
  • Journal Title: Allergol Int Volume: 62(4) Pages: 517-8
  • NAID: 130004873085
  • Peer Reviewed
• [Journal Article] Effects of pirfenidone on increased cough reflex sensitivity in guinea pigs (2013)
  • Author(s): Okazaki A, Ohkura N, Fujimura M, Katayama N, Kasahara K
  • Journal Title: Pulm Pharmacol Ther Volume: 26(5) Pages: 603-8
  • Peer Reviewed
• [Journal Article] Impact of Schizophyllum sensitization on decline of lung function in asthma (2013)
  • Author(s): Ogawa H, Fujimura M, Takeuchi Y, Makimura K
  • Journal Title: J Asthma Volume: 50(7) Pages: 764-8
  • Peer Reviewed
• [Journal Article] 非小細胞肺癌外来化学療法患者のQOLに対する補中益気湯の効 (2013)
  • Author(s): 石浦嘉久、山本宏樹、芝靖貴、寺崎靖、石田陽一、谷川二美子、早瀬秀子、丸山和美、小幡智恵美、石川見佳、廣上典和、笠原寿郎、藤村政樹
  • Journal Title: 癌と化学療法 Volume: 40(7) Pages: 913-916
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanematsu Y, Matsumoto H, Izubara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
  • Journal Title: J Allergy Clin Immunol Volume: 132(2) Pages: 305-12
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Increase in PEF40 by SABA predicts efficacy of bronchodilator therapy for chronic cough (2013)
  • Author(s): Nakade Y, Fujimura M, Ohkura N, Nakata M, Nanbu Y, Oe H, Horita H, Sakai Y, Wada T
  • Journal Title: Intern Med Volume: 52(18) Pages: 2017-23
  • Peer Reviewed
• [Journal Article] Anti-tumor effects of inductive hyperthermia using magnetic nanoparticles (ferucarbotran) on human lung cancer xenografts in nude mice (2013)
  • Author(s): Araya T, Kasahara K, Sone T, Kimura H, Nishikawa S, Nagae H, Nagano I, Fujimura M, Nakao S
  • Journal Title: OncoTargets and Therapy Volume: 6 Pages: 237-242
  • Peer Reviewed
• [Journal Article] Clinical experience with low-dose itraconazole in chronic idiopathic cough (2013)
  • Author(s): Ogawa H, Fujimura M, Makimura K Takeuchi
  • Journal Title: Cough Volume: (in press)
  • Peer Reviewed
• [Journal Article] Modulating effects of carbocystein on the membrane expression of toll-like receptor 4 in human bronchial epithelial cells (2013)
  • Author(s): Sakuramachi A, Fujimura M, Katayama N, Okura N, Furusho S, Abo M
  • Journal Title: J. New. Rem. & Clin Volume: 62(4) Pages: 26-37
  • Peer Reviewed
• [Journal Article] Influenza vaccine-induced interstitial lung disease (2013)
  • Author(s): Watanabe S, Waseda Y, Takato H, Inuzuka K, Katayama N, Kasahara K, Fujimura M
  • Journal Title: Eur Respir J Volume: 41(2) Pages: 474-7
  • Peer Reviewed
• [Journal Article] Pulmonary manifestations of anti-ARS antibody positive interstitial pneumonia–With or without PM/DM (2013)
  • Author(s): Takato H, Waseda Y, Watanabe S,Inuzuka K, Katayama N, Ichikawa Y, Yasui M, Fujimura M
  • Journal Title: Respir Med Volume: 107(1) Pages: 128-33
  • Peer Reviewed
• [Journal Article] Asthma exacerbations after the East Japan Disaster (2013)
  • Author(s): Ishiura Y, Fujimura M, Yamamoto H, Myou S, Ohkura N, Ishida Y
  • Journal Title: The Journal of Medical Investigation Volume: 60(1, 2) Pages: 61-65
  • NAID: 130004465295
  • Peer Reviewed
• [Journal Article] Modulating effects of carbocystein on the membrane expression of toll-like receptor 4 in human bronchial epithelial cells (2013)
  • Author(s): Sakuramachi A, Fujimura M, Katayama N, Okura N, Furusho S, Abo M
  • Journal Title: J. New. Rem. & Clin. Volume: 62 (4) Pages: 26-37
  • Peer Reviewed
• [Journal Article] 非小細胞肺癌外来化学療法患者のQOLに対する補中益気湯の効果 (2013)
  • Author(s): 石浦嘉久、山本宏樹、芝靖貴、寺崎靖、石田陽一、谷川二美子、早瀬秀子、丸山和美、小幡智恵美、石川見佳、廣上典和、笠原寿郎、藤村政樹
  • Journal Title: 癌と化学療法 Volume: 40 (7) Pages: 913-916
  • Peer Reviewed
• [Journal Article] Increase in PEF40 by SABA predicts efficacy of bronchodilator therapy for chronic cough. (2013)
  • Author(s): Nakade Y, Fujimura M, Ohkura N, Nakata M, Nanbu Y, Oe H, Horita H, Sakai Y, Wada T.
  • Journal Title: Intern Med. Volume: 52(18) Pages: 2017-2023
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu Y, Mishima M,et al.
  • Journal Title: J Allergy Clin Immunol Volume: 132 Issue: 2 Pages: 305-312
  • DOI: 10.1016/j.jaci.2013.04.050
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Impact of Schizophyllum sensitization on decline of lung function in asthma (2013)
  • Author(s): Ogawa H, Fujimura M, Takeuchi Y, Makimura K. Impact of Schizophyllum sensitization on decline of lung function in asthma.
  • Journal Title: J Asthma. Volume: 50 Issue: 7 Pages: 764
  • DOI: 10.3109/02770903.2013.803573
  • Peer Reviewed
• [Journal Article] Effects of pirfenidone on increased cough reflex sensitivity in guinea pigs. (2013)
  • Author(s): Okazaki A, Ohkura N, Fujimura M, Katayama N, Kasahara K.
  • Journal Title: Pulm Pharmacol Ther. Volume: 26(5) Issue: 5 Pages: 603-608
  • DOI: 10.1016/j.pupt.2013.06.009
  • Peer Reviewed
• [Journal Article] Is <i>Bjerkandera</i> Allergy Affected by the Arrival of Yellow Sand Dust? (2013)
  • Author(s): Ogawa H, Fujimura M, Satoh K, Makimura K.
  • Journal Title: Allergology International Volume: 62 Issue: 4 Pages: 517-518
  • DOI: 10.2332/allergolint.13-LE-0573
  • NAID: 130004873085
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] Successful treatment with chemotherapy and corticosteroids of pulmonary Mycobacterium abscessus infection accompanied by pleural effusion. (2013)
  • Author(s): Okazaki A, Takato H, Fujimura M, Ohkura N, Katayama N, Kasahara K.
  • Journal Title: J Infect Chemother. Volume: 19(5) Issue: 5 Pages: 964-968
  • DOI: 10.1007/s10156-012-0539-8
  • Peer Reviewed
• [Journal Article] 私はこう治療する：遷延性咳嗽. 特集：COPDの診断と治療. (2013)
  • Author(s): 藤村政樹
  • Journal Title: 診断と治療 Volume: 101 (6) Pages: 935-938
  • Peer Reviewed
• [Journal Article] 成人の慢性咳嗽の診療ー「咳嗽に関するガイドライン」を中心に-特集：地域で慢性咳嗽を診る. (2013)
  • Author(s): 藤村政樹
  • Journal Title: 月刊 地域医学 Volume: 27 (8) Pages: 674-678
  • NAID: 40019784520
  • Peer Reviewed
• [Journal Article] 好酸球と咳. 特集：長引く咳の診断と治療. (2013)
  • Author(s): 藤村政樹
  • Journal Title: 日本医師会雑誌 Volume: 142 (6) Pages: 1254-1254
  • Peer Reviewed
• [Journal Article] Prediction Formulas for Interrupter Respiratory Resistance in Healthy Japanese (2012)
  • Author(s): Nakade Y, Fujimura M, Ohkura N, Okuizumi Y, Nakata M, Nanbu Y, Oe H, Takamura T, Sakai Y, Wada T
  • Journal Title: Rinsho Byori Volume: 60(8) Pages: 725-33
  • Peer Reviewed
• [Journal Article] J Thorac Oncol (2012)
  • Author(s): Sakai A, Kasahara K, Ohmori T, Kimura H, Sone T, Fujimura M, Nakao S
  • Journal Title: J Thorac Oncol Volume: 7(9) Pages: 1337-44
  • Peer Reviewed
• [Journal Article] Frequency of Persistent Cough and Trends in Seeking Medical Care and Treatment -- Results of an Internet Survey in Japan (2012)
  • Author(s): Fujimura M
  • Journal Title: Allergology International Volume: 61(4) Pages: 573-581
  • Peer Reviewed
• [Journal Article] Heightened cough response to bronchoconstriction in cough variant asthma (2012)
  • Author(s): Ohkura N, Fujimura M, Nakade Y, Katayama N
  • Journal Title: Respirology Volume: 17(6) Pages: 964-968
  • Peer Reviewed
• [Journal Article] Association between episodes of upper respiratory infection and exacerbations in adult patients with asthma (2012)
  • Author(s): Tomita K, Sano H, Iwanaga T, Ishihara K, Ichinose M, Kawase I, Kimura H, Hirata K, Fujimura M, Mishima M, Tohda Y
  • Journal Title: Journal of Asthma Volume: 49(3) Pages: 253-259
  • Peer Reviewed
• [Journal Article] Pulmonary veno-occlusive disease following reduced-intensity allogeneic bone marrow transplantation for acute myeloid leukemia (2012)
  • Author(s): Hosokawa K, Yamazaki H, Nishitsuji M, Kobayashi S, Takami A, Fujimura M, Nakao S
  • Journal Title: Intern Med Volume: 51(2) Pages: 195-198
  • NAID: 130002062063
  • Peer Reviewed
• [Journal Article] Chronic cough in a tsunami-affected town (2012)
  • Author(s): Ogawa H, Fujimura M, Takeuchi Y, Makimura K
  • Journal Title: Pulmonary Pharmacology and Therapeutics Volume: 25(1) Pages: 11-11
  • NAID: 120003779565
  • Peer Reviewed
• [Journal Article] Heightened cough response to bronchoconstriction in cough variant (2012)
  • Author(s): Ohkura N, Fujimura M, Nakade Y, Katayama N
  • Journal Title: Respirology Volume: 17 (6) Pages: 964-968
  • Peer Reviewed
• [Journal Article] Prediction Formulas for Interrupter Respiratory Resistance in Healthy Japanese (2012)
  • Author(s): Nakade Y, Fujimura M, Ohkura N, Okuizumi Y, Nakata M, Nanbu Y, Oe H, Takamura
  • Journal Title: Rinsho Byori Volume: 60 (8) Pages: 725-733
  • Peer Reviewed
• [Journal Article] Allergic fungal cough (AFC): A more severe type of fungus-associated chronic cough (FACC) (2011)
  • Author(s): Ogawa H, Fujimura M
  • Journal Title: Pulm Pharmacol Ther Volume: 24
  • Peer Reviewed
• [Journal Article] Involvement of nitric oxide (NO) in cough reflex sensitivity between non-sensitized and OVA-sensitized guinea pigs (2011)
  • Author(s): Hori A, Fujimura M, Ohkura N, Tokuda A.
  • Journal Title: Cough Volume: 7 Pages: 5-5
  • NAID: 120003913342
  • Peer Reviewed
• [Journal Article] Sensitization to Bjerkandera adusta enhances severity of cough symptom in patients with fungus-associated chronic cough (FACC) (2011)
  • Author(s): Ogawa H, Fujimura M, Takeuchi Y, Makimura K
  • Journal Title: Medical Mycology Journal Volume: 52 Pages: 205-212
  • NAID: 10029466225
  • Peer Reviewed
• [Presentation] アレルギー性呼吸器疾患における担子菌の重要性について (2013)
  • Author(s): 小川晴彦
  • Organizer: 石川県耳鼻咽喉科医会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2013-10-19
• [Presentation] Schizophyllum allergyと気管支喘息 (2013)
  • Author(s): 小川晴彦,藤村政樹:
  • Organizer: 臨床喘息研究会
  • Place of Presentation: 鳥羽
  • Year and Date: 2013-10-09
• [Presentation] 慢性咳嗽とBjerkandera allergy (2013)
  • Author(s): 小川晴彦
  • Organizer: 第34回関東医真菌懇話会
  • Place of Presentation: 東京
  • Year and Date: 2013-06-01
• [Presentation] The Measurement Of Cough Sensitivity To Methacholine For Discrimination Of Cough Variant Asthma (2013)
  • Author(s): 大倉徳幸、 他
  • Organizer: 18 th congress of the Asian Pacific Society of Respirology
  • Place of Presentation: Pacifico Yokohama
• [Presentation] It's time to call attention to clinical significance of basidiomycetous fungi in chronic cough (2013)
  • Author(s): Ogawa H, Fujimura M
  • Organizer: The 18^<th> Congress of the Asian Pacific Respirology
  • Place of Presentation: Yokohama
• [Presentation] Atopic cough and fungal allergy (2013)
  • Author(s): Ogawa H
  • Organizer: The 1^st International Cough Conference
  • Place of Presentation: China
• [Presentation] FACS-JAPAN projectA II-2-c気管支喘息患者に合併したMIBの診断と治療を考える(一例報告) (2013)
  • Author(s): 小川晴彦,藤村政樹:
  • Organizer: 第36回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 大宮
• [Presentation] 咳喘息維持治療におけるロイコトリエン受容体拮抗薬と吸入ステロイド薬の比較試験 (2013)
  • Author(s): 大倉徳幸, 他
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] FACS-JAPAN project I-1-b黄砂の飛来はアレルギー性真菌性咳嗽の増悪に影響するか? (2013)
  • Author(s): 小川晴彦,藤村政樹
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] Relation between bronchoconstriction-triggered cough and protective reaction against bronchoconstriction (2013)
  • Author(s): 大倉徳幸, 他
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] English Mini- Symposium; Impact of Schizophyllum sensitization on decline of lung function in asthma (FACS-JAPAN project II-1-a-ii) (2013)
  • Author(s): Ogawa H,Fujimura M
  • Organizer: The 53rd annual meeting of J Resp Soc
  • Place of Presentation: Tokyo
• [Presentation] 咳喘息の診断におけるメサコリン誘発咳嗽測定の有用性に関する検討 (2013)
  • Author(s): 大倉徳幸, 他
  • Organizer: 第110回内科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] Relation between bronchoconstriction-triggered cough and protective reaction against bronchoconstriction (2013)
  • Author(s): Noriyuki Ohkura，Masaki Fujimura，Mayuko Tani，Akihito Okazaki，Nobuyuki Katayama，Kazuo Kasahara
  • Organizer: 第53回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] English Mini-Symposium; Impact of Schizophyllum sensitization on decline of lung function in asthma (FACS-JAPAN project II-1-a-ii). (2013)
  • Author(s): Ogawa H, Fujimura M.
  • Organizer: The 53rd annual meeting of J Resp Soc.
  • Place of Presentation: Tokyo international Forum
• [Presentation] FACS-JAPAN project I-1-b黄砂の飛来はアレルギー性真菌性咳嗽の増悪に影響するか？ (2013)
  • Author(s): 小川晴彦、藤村政樹
  • Organizer: 第25回日本アレルギー学会春季臨床大会
  • Place of Presentation: パシフィコ横浜
• [Presentation] FACS-JAPAN projectA II-2-c 気管支喘息患者に合併したMIBの診断と治療を考える (2013)
  • Author(s): 小川晴彦、藤村政樹
  • Organizer: 第36 回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 大宮ソニックシティ・パレスホテル大宮
• [Presentation] It’s time to call attention to clinical significance of basidiomycetous fungi in chronic cough. (2013)
  • Author(s): Ogawa H, Fujimura M.
  • Organizer: The 18th Congress of the Asian Pacific Respirology.
  • Place of Presentation: Pacifico Yokohama
• [Presentation] Predicting performance of cough reflex sensitivity, exhaled nitric oxide (eNO) and bronchial responsiveness for efficacy of bronchodilator therapy on isolated chronic non-productive cough (2011)
  • Author(s): Fujimura M, Ohkura N, Tokuda A, Waseda Y
  • Organizer: 21st ERS Annual Congress
  • Place of Presentation: オランダ, アムステルダムRAIコングレスセンター
• [Presentation] 喘息治療の課題：One Airway, One Diseaseの観点からみた喘息治療 (2011)
  • Author(s): 藤村政樹
  • Organizer: 第23回日本アレルギー学会春季臨床大会
  • Place of Presentation: 千葉県幕張メッセ
• [Book] 遷延性咳嗽-今日の治療指針2013年版 (2013)
  • Author(s): 藤村政樹
  • Publisher: 医学書院
• [Book] 今日の治療指針2013年版 遷延性咳嗽 (2013)
  • Author(s): 藤村政樹
  • Total Pages: 2
  • Publisher: 医学書院
• [Book] 咳喘息とアトピー咳嗽-今日の治療指針2012年版 (2012)
  • Author(s): 藤村政樹
  • Publisher: 医学書院
• [Book] 咳嗽-症状からアプローチするプライマリケア (2011)
  • Author(s): 藤村政樹 (日本医師会編)
  • Publisher: 医師薬出版株式会社
• [Book] 慢性咳嗽-診療ガイドダイジェスト (2011)
  • Author(s): 藤村政樹 (前沢政次、坂東浩編集)
  • Publisher: 南山堂
• [Book] 咳喘息の診断・治療の意義を探る-気管支喘息治療の新たなストラテジー (2011)
  • Author(s): 藤村政樹 (大田健編集)
  • Publisher: 先端医学社
• [Book] 咳喘息とアトピー咳嗽 (2011)
  • Author(s): 藤村政樹
  • Total Pages: 3
  • Publisher: 医師薬出版株式会社、東京