To overcome intractable chronic cough: disclosure of mechanism of cough response to bronchoconstiction to conrol of the cough
| Project/Area Number |
23591142
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Haruhiko 金沢大学, 医学系, 協力研究員 (70401908)
OHKURA Noriyuki 金沢大学, 医学系, 協力研究員 (80397215)
片山 伸幸 金沢大学, 医学系, 研究員 (30334767)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 慢性咳嗽 / 咳喘息 / 気管支平滑筋収縮 / 気管支平滑筋 / 難治性 / 咳嗽反応 |
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| Research Abstract |
Basic study: Beta2-agonists abolished both the methacholine-induced bronchoconstriction and cough. Capsaicin desensitization had no effect on the bronchoconstriction or the number of coughs. Moguisteine inhibited the number of coughs but not the bronchoconstriction. It is concluded that bronchoconstriction causes cough via RARs, but not C-fibers. Furthermore, prostaglandin E2 takes a role to enhance the methacholine-induced cough response as protection of bronchoconstriction.
Clinical study: Cough response to bronchoconstriction induced by Meth was heightened in cough variant asthma patients. The increased cough response recovered to normal range after treatment. Thus, we identified heightened cough response to bronchoconstriction as a fundamental physiologic feature of cough variant asthma. Sensitivity and specificity of cough responsiveness to Mch for discrimination of cough variant asthma from chronic non-productive cough were 81.0% and 89.7%, respectively.
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Report
(4 results)
Research Products
(67 results)
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[Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids2014
Author(s)
Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
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Journal Title
Allergy
Volume: (Epub ahead of print)
Related Report
Peer Reviewed
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[Journal Article] Exacerbation of daily cough and allergic symptoms in adult patients with chronic cough by Asian Dust : A hospital-based study in Kanazawa2014
Author(s)
Higashi T, Kambayashi Y, Ohkura N, Fujimura M, Nakanishi S, Yoshizaki T, Saijoh K, Hayakawa K, Kobayashi F, Michigami Y, Hitomi Y, Nakamura H
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Journal Title
Atmospheric Environment
Volume: (in press)
NAID
Related Report
Peer Reviewed
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[Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids.2014
Author(s)
Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M.
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Journal Title
Allergy
Volume: 69
Issue: 5
Pages: 668-73
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes.2014
Author(s)
Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
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Journal Title
J Allergy Clin Immunol
Volume: 133
Issue: 5
Pages: 1474-1477
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids2013
Author(s)
Kanematsu Y, Matsumoto H, Izubara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
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Journal Title
J Allergy Clin Immunol
Volume: 132(2)
Pages: 305-12
NAID
Related Report
Peer Reviewed
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[Journal Article] J Thorac Oncol2012
Author(s)
Sakai A, Kasahara K, Ohmori T, Kimura H, Sone T, Fujimura M, Nakao S
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Journal Title
J Thorac Oncol
Volume: 7(9)
Pages: 1337-44
Related Report
Peer Reviewed
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[Journal Article] Association between episodes of upper respiratory infection and exacerbations in adult patients with asthma2012
Author(s)
Tomita K, Sano H, Iwanaga T, Ishihara K, Ichinose M, Kawase I, Kimura H, Hirata K, Fujimura M, Mishima M, Tohda Y
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Journal Title
Journal of Asthma
Volume: 49(3)
Pages: 253-259
Related Report
Peer Reviewed
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