Identification of novel disease-specific diagnostic markers and therapeutic targets for interstitial pneumonias
Project/Area Number |
23591148
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Respiratory organ internal medicine
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Research Institution | Hiroshima University |
Principal Investigator |
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Project Period (FY) |
2011 – 2013
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Project Status |
Completed (Fiscal Year 2013)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 間質性肺炎 / マイクロアレイ / バイオマーカー / 分子標的治療薬 / 国際情報交換 / KL-6 / SP-A / SP-D |
Research Abstract |
Idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) are subtypes of idiopathic interstitial pneumonia (IIP), which is characterized by alveolar epithelial damage, activation of fibroblast proliferation, and loss of normal pulmonary architecture and function. Clinical differentiation between IPF and NSIP is difficult, and the molecular basis for IIP remains unclear. The study included 12 patients with IIP (IPF, n = 7; NSIP, n = 5). RNA extracted from lung specimens was profiled using Illumina Human WG-6 v3 BeadChips, and an Ingenuity Pathway Analysis was performed to identify altered functional and canonical signaling pathways. Genes and pathways related to cancer, cell death and survival, and cellular growth and proliferation were differentially expressed in IIP patients. These data provide valuable information on the possible mechanisms underlying pulmonary fibrosis, and reveal several potential biomarkers for IIP diagnosis and therapeutic targeting.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels2013
Author(s)
Horimasu Y, Hattori N, Ishikawa N, Kawase S, Tanaka S, Yoshioka K, Yokoyama A, Kohno N, Bonella F, Guzman J, Ohshimo S, Costabel U
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Journal Title
Respir Med
Volume: 106
Pages: 1756-64
Related Report
Peer Reviewed
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[Journal Article] SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis.2013
Author(s)
Masuda T, Hattori N, Senoo T, Akita S, Ishikawa N, Fujitaka K, Haruta Y, Murai H, Kohno N.
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Journal Title
Mol Cancer Ther
Volume: 12
Issue: 11
Pages: 2378-88
DOI
Related Report
Peer Reviewed
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[Journal Article] Characteristics of inspiratory and expiratory reactance in interstitial lung disease.2013
Author(s)
Sugiyama A, Hattori N, Haruta Y, Nakamura I, Nakagawa M, Miyamoto S, Onari Y, Iwamoto H, Ishikawa N, Fujitaka K, Murai H, Kohno N.
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Journal Title
Respir Med
Volume: 107
Issue: 6
Pages: 875-82
DOI
Related Report
Peer Reviewed
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[Journal Article] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected non-small cell lung cancer2012
Author(s)
Tanaka S, Hattori N, Ishikawa N, Shoda H, Takano A, Nishino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyama A, Kohno N
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Journal Title
Int J Cancer
Volume: 130
Pages: 377-87
Related Report
Peer Reviewed
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[Journal Article] Interferon (alpha, Beta and omega) receptor 2 is a prognostic biomarker for lung cancer2012
Author(s)
Tanaka S, Hattori N, Ishikawa N, Horimasu Y, Deguchi N, Takano A, Tomoda Y, Yoshioka K, Fujitaka K, Arihiro K, Okada M, Yokoyama A, Kohno N
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Journal Title
Pathobiology
Volume: 79
Pages: 24-33
Related Report
Peer Reviewed
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[Journal Article] Different MUC1 gene polymorphisms in German and Japanese ethnicities affect serum KL-6 levels.2012
Author(s)
Horimasu Y, Hattori N, Ishikawa N, Kawase S, Tanaka S, Yoshioka K, Yokoyama A, Kohno N, Bonella F, Guzman J, Ohshimo S, Costabel U.
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Journal Title
Respir Med
Volume: 106
Pages: 1756-64
Related Report
Peer Reviewed
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[Journal Article] Interferon (alpha, beta and omega) receptor 2 is a prognostic biomarker for lung cancer.2012
Author(s)
Tanaka S, Hattori N, Ishikawa N, Horimasu Y, Deguchi N, Takano A, Tomoda Y, Yoshioka K, Fujitaka K, Arihiro K, Okada M, Yokoyama A, Kohno N
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Journal Title
Pathobiology
Volume: 79
Pages: 24-33
Related Report
Peer Reviewed
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[Journal Article] Krebs von den Lungen-6 (KL-6) is a prognostic biomarker in patients with surgically resected nonsmall cell lung cancer.2012
Author(s)
Tanaka S, Hattori N, Ishikawa N, Shoda H, Takano A, Nishino R, Okada M, Arihiro K, Inai K, Hamada H, Yokoyama A, Kohno N
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Journal Title
Int J Cancer
Volume: 130
Pages: 377-87
Related Report
Peer Reviewed
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[Journal Article] Identification of Epstein-Barr virus-induced gene 3 as a novel serum and tissue biomarker and a therapeutic target for lung cancer2011
Author(s)
Nishino R, Takano A, Oshita H, Ishikawa N, Akiyama H, Ito H, Nakayama H, Miyagi Y, Tsuchiya E, Kohno N, Nakamura Y, Daigo Y
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Journal Title
Clin Cancer Res
Volume: 17
Pages: 6272-86
Related Report
Peer Reviewed
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[Journal Article] Change in serum KL-6 level from baseline is useful for predicting life-threatening EGFR-TKIs induced interstitial lung disease2011
Author(s)
Kawase S, Hattori N, Ishikawa N, Horimasu Y, Fujitaka K, Furonaka O, Isobe T, Miyoshi S, Hamada H, Yamane T, Yokoyama A, Kohno N
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Journal Title
Respir Res
Volume: 12
Pages: 97-97
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Peer Reviewed
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[Journal Article] A comprehensive peptidome profiling technology for the identification of early detection biomarkers for lung adenocarcinoma2011
Author(s)
Ueda K, Saichi N, Takami S, Kang D, Toyama A, Daigo Y, Ishikawa N, Kohno N, Tamura K, Shuin T, Nakayama M, Sato TA, Nakamura Y, Nakagawa H
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[Presentation] Comparison of KL-6, SP-A, SP-D, 8-isoprostane, MMP-9,and TIMP-1 as serum biomarkers for patients with combined pulmonary fibrosis and emphysema2013
Author(s)
Ishikawa N, Matsuda T, Nakashima T, Iwamoto H, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N, Kohno N
Organizer
18th Congress of the Asian Pacific Society of Respirology
Place of Presentation
Yokohama
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[Presentation] Gene expression profiles of chronic hypersensitivity pneumonitis : Molecular signatures of pulmonary fibrosis2013
Author(s)
Ishikawa N, Taniwaki M, Horimasu Y, Iwamoto H, Ohshimo S, Fujitaka K, Haruta Y, Murai H, Hattori N, Kohno N
Organizer
American Thoracic Society International Conference
Place of Presentation
Philadelphia, USA
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[Book] 臨床病態学2013
Author(s)
石川暢久,河野修興
Total Pages
641
Publisher
NOUVELLE HIROKAWA
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