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Role of xanthine oxidoreductase enzyme and uric acid in ischemic renal damage and metabolic syndrome

Research Project

Project/Area Number 23591195
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionKyushu University

Principal Investigator

OHTSUBO Toshio  九州大学, 大学病院, 講師 (30423974)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords尿酸産生酵素 / 肥満 / メタボリックシンドローム / キサンチンオキシドリダクターゼ / 白色脂肪細胞 / インスリン抵抗性 / 国際情報交換 USA / 国際情報交流 USA
Research Abstract

The aim of this study was to examine the roles of XOR in various tissues using XOR genetically modified mice. 1. Treatment with NOS inhibitor showed the increase in systolic blood pressure and the decrease in endothelium-dependent vasodilation in aorta of XOR heterozygous (XOR+/-) mice compared to WT mice. 2. In the model of renal ischemic-reperfusion, renal damage level was higher in WT mice than XOR+/- mice. 3. Experiments with high-fat diet exhibited that body weight, visceral fat, fat storage in hepatic cells and insulin resistance were significantly higher in XOR+/- mice than WT mice. 4. XOR+/- mice exhibited significantly increased body weight with aging, and also showed higher rates of insulin resistance and higher blood pressure levels compared to WT mice.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (23 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (15 results) Remarks (1 results)

  • [Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.2014

    • Author(s)
      Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K., and Kitazono, T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 34 Issue: 1 Pages: 44-51

    • DOI

      10.1161/atvbaha.113.302214

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mice heterozygous for the Xanthine Oxidoreductase Gene Facilitate Lipid Accumulation in Adipocytes.2014

    • Author(s)
      Murakami N, Ohtsubo T, Kansui Y, Goto K, Noguchi H, Haga Y, Nakabeppu Y, Matsumura K, Kitazono T
    • Journal Title

      Arteriosclerosis, Thrombosis, and Vascular Biology

      Volume: 34 Pages: 44-51

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of the Superoxide Dismutase Mimetic Tempol on Impaired Endothelium-Dependent and Endothelium-Independent Relaxations in Type II Diabetic Rats.2012

    • Author(s)
      Oniki H, Goto K, Fujii K, Kansui Y, Murakami N, Ohtsubo T, Matsumura K, Kitazono T.
    • Journal Title

      Clin Exp Hypertens

      Volume: 35 Pages: 112-119

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Facilitation of sympathetic neurotransmission by phosphatidylinositol-4,5-bisphosphate-dependent regulation of KCNQ channels in rat mesenteric arteries.2012

    • Author(s)
      Kansui Y, Goto K, Ohtsubo T, Murakami N, Ichishima K, Matsumura K, Kitazono T.
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 909-916

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Upregulation of endothelium-derived hyperpolarizing factor compensates for the loss of nitric oxide in mesenteric arteries of dahl salt-sensitive hypertensive rats.2012

    • Author(s)
      Goto K, Kansui Y, Oniki H, Ohtsubo T, Matsumura K, Kitazono T
    • Journal Title

      Hypertens Res

      Volume: 35 Pages: 849-854

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] for the COMFORT Investigators. Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?2012

    • Author(s)
      Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T
    • Journal Title

      Circ J.

      Volume: 76 Pages: 1415-1422

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Body Mass Index with Glomerular Filtration Rate in Japanese: A Cross-Sectional Study in Work-Site Population.2012

    • Author(s)
      Kansui Y, Ohtsubo T, Goto K, Oniki H, Yamasaki T, Fukuhara M, Ohta Y, Matsumura K.
    • Journal Title

      Clin Exp Hypertens.

      Volume: 34 Pages: 140-144

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Xanthine Oxidoreductaseは、酸化ストレスを介して腎臓の虚血再灌流障害を引き起こす2013

    • Author(s)
      芳賀祥江、村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] Xanthine Oxidoreductaseは、酸化ストレスを介して腎臓の虚血再灌流障害を引き起こす2013

    • Author(s)
      芳賀芳江、村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
    • Organizer
      第36回日本高血圧学会総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] Heterozygous deletion of xanthine oxidoreducatase augments adipogenesis in white adipose tissue and induces obesity with insulin resistance2012

    • Author(s)
      Noboru Murakami, Toshio Ohtsubo, Yasuo Kansui, Kenichi Goto , Kiyoshi Matsumura and Takanari Kitazono
    • Organizer
      The 24th Scientific Meeting of the international Society of Hypertension
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2013 Final Research Report
  • [Presentation] 加齢におけるxanthine oxidoreductaseの役割:XOR遺伝子改変マウスを用いた検討2012

    • Author(s)
      村上昇、大坪俊夫、土橋卓也
    • Organizer
      第45回日本痛風・核酸代謝学会総会
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2013 Final Research Report
  • [Presentation] Heterozygous deletion of xanthine oxidoreducatase augments adipogenesis in white adipose tissue and induces obesity with insulin resistance.2012

    • Author(s)
      Noboru Murakami, Toshio Ohtsubo, Yasuo Kansui, Kenichi Goto , Kiyoshi Matsumura and Takanari Kitazono
    • Organizer
      International Society of Hypertension
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2012 Research-status Report
  • [Presentation] Reduced activity of SKCa channels accounts for the impaired EDHF-mediated relaxation in mesenteric arteries of stroke-prone spontaneously hypertensive rats2012

    • Author(s)
      Kenichi Goto, Yasuo Kansui, Toshio Ohtsubo, Kiyoshi Matsumura, Takanari Kitazono
    • Organizer
      International Society of Hypertension
    • Place of Presentation
      Sydney, Australia
    • Related Report
      2012 Research-status Report
  • [Presentation] Xanthine oxidoreductaseの発現低下は白色脂肪組織における脂肪合成促進を来し、インスリン抵抗性を伴う肥満を促進する:XOR遺伝子改変マウスを用いた検討2012

    • Author(s)
      村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] COMFORT試験グループ 服薬アドヒアランスが血圧コントロールに及ぼす影響:COMFORT試験サブ解析2012

    • Author(s)
      寒水康雄、松村潔、貴田春子、大坪俊夫、笹栗俊之、藤井弘二、福原正代、上園慶子、守永友希、大田祐子、乙成孝俊、川崎純也、土橋卓也、
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 血管周囲脂肪組織はGuanylate Cyclaseを抑制して一酸化窒素に対する血管弛緩作用を減弱させる2012

    • Author(s)
      寒水康雄、後藤健一、大坪俊夫、村上昇、市島久仁彦、松村潔、北園孝成
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
  • [Presentation] 加齢におけるxanthine oxidoreductaseの役割:XOR遺伝子改変マウスを用いた検討2012

    • Author(s)
      村上昇、大坪俊夫、土橋卓也
    • Organizer
      第45回日本痛風・核酸代謝学会総会
    • Place of Presentation
      奈良県新公会堂
    • Related Report
      2011 Research-status Report
  • [Presentation] 長期高脂肪食負荷による脂肪性肝障害の進行におけるキサンチンオキドリダクターゼ(XOR)の役割2011

    • Author(s)
      村上昇、大坪俊夫、土橋卓也東京
    • Organizer
      第44回日本痛風・核酸代謝学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 一酸化窒素合成阻害による血圧上昇におけるキサンチンオキシドリダクターゼ(XOR)の役割:XOR遺伝子改変マウスを用いた検討2011

    • Author(s)
      村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Related Report
      2013 Final Research Report
  • [Presentation] 一酸化窒素合成阻害による血圧上昇におけるキサンチンオキシドリダクターゼ(XOR)の役割2011

    • Author(s)
      村上昇、大坪俊夫、寒水康雄、後藤健一、松村潔、北園孝成
    • Organizer
      第34回日本高血圧学会総会
    • Place of Presentation
      宇都宮
    • Related Report
      2011 Research-status Report
  • [Presentation] Role of xanthine oxidoreductase in high fat diet-induced obesity mice2010

    • Author(s)
      Toshio Ohtsubo, Kiyoshi Matsumura, Kenichi Goto, Hideyuki Oniki, Tomoko Ymasaki, Masayo Fukuhara, Yuko Ohta and Mitsuo Iida
    • Organizer
      The 23rd Scientific Meeting of the international Society of Hypertension
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] The association between serum uric acid and blood pressure in Japanese men2010

    • Author(s)
      Toshio Ohtsubo, Kiyoshi Matsumura, Kenichi Goto, Hideko Noguchi, Hideyuki Oniki, and Mitsuo Iida
    • Organizer
      The 23rd Scientific Meeting of the international Society of Hypertension
    • Place of Presentation
      Vancouver, Canada
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://hyoka.ofc.kyushu-u.ac.jp/search/details/K002991/research.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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