Role of xanthine oxidoreductase enzyme and uric acid in ischemic renal damage and metabolic syndrome
| Project/Area Number |
23591195
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 尿酸産生酵素 / 肥満 / メタボリックシンドローム / キサンチンオキシドリダクターゼ / 白色脂肪細胞 / インスリン抵抗性 / 国際情報交換 USA / 国際情報交流 USA |
|---|
| Research Abstract |
The aim of this study was to examine the roles of XOR in various tissues using XOR genetically modified mice. 1. Treatment with NOS inhibitor showed the increase in systolic blood pressure and the decrease in endothelium-dependent vasodilation in aorta of XOR heterozygous (XOR+/-) mice compared to WT mice. 2. In the model of renal ischemic-reperfusion, renal damage level was higher in WT mice than XOR+/- mice. 3. Experiments with high-fat diet exhibited that body weight, visceral fat, fat storage in hepatic cells and insulin resistance were significantly higher in XOR+/- mice than WT mice. 4. XOR+/- mice exhibited significantly increased body weight with aging, and also showed higher rates of insulin resistance and higher blood pressure levels compared to WT mice.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Mice heterozygous for the xanthine oxidoreductase gene facilitate lipid accumulation in adipocytes.2014
Author(s)
Murakami, N., Ohtsubo, T., Kansui, Y., Goto, K., Noguchi, H., Haga, Y., Nakabeppu, Y., Matsumura, K., and Kitazono, T.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 34
Issue: 1
Pages: 44-51
DOI
Related Report
Peer Reviewed
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[Journal Article] Mice heterozygous for the Xanthine Oxidoreductase Gene Facilitate Lipid Accumulation in Adipocytes.2014
Author(s)
Murakami N, Ohtsubo T, Kansui Y, Goto K, Noguchi H, Haga Y, Nakabeppu Y, Matsumura K, Kitazono T
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Journal Title
Arteriosclerosis, Thrombosis, and Vascular Biology
Volume: 34
Pages: 44-51
Related Report
Peer Reviewed
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[Journal Article] for the COMFORT Investigators. Does a Combination Pill of Antihypertensive Drugs Improve Medication Adherence in Japanese?2012
Author(s)
Matsumura K, Arima H, Tominaga M, Ohtsubo T, Sasaguri T, Fujii K, Fukuhara M, Uezono K, Morinaga Y, Ohta Y, Otonari T, Kawasaki J, Kato I, Tsuchihashi T
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Journal Title
Circ J.
Volume: 76
Pages: 1415-1422
Related Report
Peer Reviewed
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