| Project/Area Number |
23591236
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
KAWACHI Izumi 新潟大学, 医歯学総合病院, 助教 (40432083)
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| Co-Investigator(Kenkyū-buntansha) |
TOYOSHIMA Yasuko 新潟大学, 脳研究所, 准教授 (20334675)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 視神経脊髄炎 / 多発性硬化症 / 自然免疫機構 / アクアポリン4水チャネル / 神経免疫病態学 / I型インターフェロン / アクアポリン4 / 自然免疫 |
|---|
| Research Abstract |
Neuromyelitis optica (NMO) and multiple sclerosis are the two main autoimmune, inflammatory and demyelinating syndromes of the central nervous system. The discovery of NMO immunoglobulin G autoantibody, which targets the water channel aquaporin-4 (AQP4) and is a specific marker of NMO, should revolutionize understanding of pathogenesis in the two diseases. Not only IL-17/IFN-gamma-producing cells, but also innate immune cells including neutrophils, antigen-presenting cells, plasma cells and plasmablasts were evident in NMO lesions. These data suggest that unique dynamics of innate immune cells might be present in NMO in situ.
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