Study for plastic change in human cerebellar neurons

• Project/Area Number: 23591270
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurology
• Research Institution: The University of Tokyo
• Principal Investigator: HANAJIMA Ritsuko 東京大学, 医学部附属病院, 助教 (80396738)
• Co-Investigator(Kenkyū-buntansha): TERAO Yasuo 東京大学, 医学部附属病院, 講師 (20343139)
• Co-Investigator(Renkei-kenkyūsha): KITAZAWA Shigeru 大阪大学, 大学院生命機能研究科, 教授 (00251231) ; UGAWA Yoshikazu 福島県立医大, 神経内科, 教授 (50168671)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 小脳機能検査 / 運動適応 / 脊髄小脳変性症 / 神経内科 / 神経シナプス可塑 / 神経シナプス可塑性

Research Abstract

The cerebellar neuro-plasticity has an important role in sensori-motor adaptation tasks. To detect the cerebellar plasticity in humans, we established a clinically useful prism adaptation task using a touch panel monitor. We made normative data for several adaptation parameters by performing this examination in healthy volunteers. First, we applied this method to patients with pure cerebellar ataxia and showed adaptation abnormality, which confirmed that our method should detect cerebellar dysfunction in humans. The degree of the adaptation impairment did not correlated with the severity of clinical cerebellar symptoms, which suggests that our method may detect another aspect of cerebellar dysfunction.
Moreover, to modify the cerebellar neural plasticity, we apply repetitive transcranial magnetic stimulation (rTMS) over the cerebellum. Some cerebellar adaptation parameters tended to be affected by repetitive cerebellar stimulation.

Research Products

• [Journal Article] Triad-conditioning Transcranial Magnetic Stimulation in Parkinson's Disease (2014)
  • Author(s): Hanajima R, Terao Y, Shirota Y, Ohminami S, Tsutsumi R, Shimizu T, Tanaka N, Okabe S, Tsuji S, Ugawa Y
  • Journal Title: Brain Stimul Volume: 7 Pages: 74-79
• [Journal Article] Effects of the motor cortical quadripulsetranscranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions (2014)
  • Author(s): Tsutsumi R, Hanajima R, Terao Y, Shirota Y, Ohminami S, Shimizu T, Tanaka N, Ugawa Y
  • Journal Title: J Neurophysiol Volume: 111 Pages: 26-35
• [Journal Article] Triad-conditioning transcranial magnetic stimulation in Parkinson's disease. (2014)
  • Author(s): Hanajima R, Terao Y, Shirota Y, Ohminami S, Tsutsumi R, Shimizu T, Tanaka N, Okabe S, Tsuji S, Ugawa Y.
  • Journal Title: Brain Stimul Volume: 7 Issue: 1 Pages: 74-9
  • DOI: 10.1016/j.brs.2013.09.013
  • Peer Reviewed
• [Journal Article] Effects of the motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral motor cortex and interhemispheric interactions. (2014)
  • Author(s): Tsutsumi R, Hanajima R, Terao Y, Shirota Y, Ohminami S, Shimizu T, Tanaka N, Ugawa Y.
  • Journal Title: J Neurophysiol Volume: 111 Issue: 1 Pages: 26-35
  • DOI: 10.1152/jn.00515.2013
  • Peer Reviewed / Open Access
• [Journal Article] Bidirectional effects on interhemispheric resting-state functional connectivity induced by excitatory and inhibitory repetitive transcranial magnetic stimulation (2013)
  • Author(s): Watanabe T, Hanajima R, Shirota Y, Ohminami S, Tsutsumi R, Terao Y, Ugawa Y, Hirose S, Miyashita Y, Konishi S, Kunimatsu A, Ohtomo K
  • Journal Title: Hum Brain Mapp Volume: 35(5) Pages: 1896-905
• [Journal Article] A conduction block in sciatic nerves can be detected by magnetic motor root stimulation (2013)
  • Author(s): Matsumoto H, Konoma Y, Fujii K, Hanajima R, Terao Y, Ugawa Y
  • Journal Title: J Neurol Sci Volume: 331 Pages: 174-6
• [Journal Article] Magnetic-motor-root stimulation : review (2013)
  • Author(s): Matsumoto H, Hanajima R, Terao Y, Ugawa Y
  • Journal Title: ClinNeurophysiol Volume: 124 Pages: 1055-67
• [Journal Article] Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation : a near-infrared spectroscopy study (2013)
  • Author(s): Furubayashi T, Mochizuki H, Terao Y, Arai N, Hanajima R, Hamada M, Matsumoto H, Nakatani-Enomoto S, Okabe S, Yugeta A, Inomata-Terada S, Ugawa Y
  • Journal Title: J Neurophysiol Volume: 109 Pages: 1626-37
• [Journal Article] Focal lesion in upper part of brachial plexus can be detected by magnetic cervical motor root stimulation (2013)
  • Author(s): Matsumoto H, Tokushige S, Hashida H, Hanajima R, Terao Y, Ugawa Y
  • Journal Title: Brain Stimul Volume: 6 Pages: 538-40
• [Journal Article] A conduction block in sciatic nerves can be detected by magnetic motor root stimulation. (2013)
  • Author(s): Matsumoto H, Konoma Y, Fujii K, Hanajima R, Terao Y, Ugawa Y.
  • Journal Title: J Neurol Sci Volume: 331 Issue: 1-2 Pages: 174-6
  • DOI: 10.1016/j.jns.2013.06.005
  • Peer Reviewed
• [Journal Article] Cortical hemoglobin concentration changes underneath the coil after single-pulse transcranial magnetic stimulation: a near-infrared spectroscopy study. (2013)
  • Author(s): Furubayashi T, Mochizuki H, Terao Y, Arai N, Hanajima R, Hamada M, Matsumoto H, Nakatani-Enomoto S, Okabe S, Yugeta A, Inomata-Terada S, Ugawa Y.
  • Journal Title: J Neurophysiol Volume: 109 Issue: 6 Pages: 1626-1637
  • DOI: 10.1152/jn.00980.2011
  • Peer Reviewed
• [Journal Article] Deterioration of horizontal saccades in progressive supranuclear palsy. (2013)
  • Author(s): Terao Y, Fukuda H, Shirota Y, Yugeta A, Yoshioka M, Suzuki M et al.
  • Journal Title: Clin Neurophysiol Volume: 124(2) Issue: 2 Pages: 354-63
  • DOI: 10.1016/j.clinph.2012.07.008
  • Peer Reviewed
• [Journal Article] Reduced interhemispheric inhibition in mild cognitive impairment (2012)
  • Author(s): Tsutsumi R,Hanajima R, Hamada M, Shirota Y, Matsumoto H, Terao Y, Ohminami S, Yamakawa Y, Shimada H, Tsuji S, Ugawa Y
  • Journal Title: Exp Brain Res Volume: 218 Pages: 21-6
• [Journal Article] Conditioning intensity-dependent interaction between short-latency interhemispheric inhibition and short-latency afferent inhibition (2012)
  • Author(s): Tsutsumi R, Shirota Y, Ohminami S, Terao Y, Ugawa Y,Hanajima R
  • Journal Title: J Neurophysiol Volume: 108 Pages: 1130-7
• [Journal Article] Increased primary motor cortical excitability by a single-pulse transcranial magnetic stimulation over the supplementary motor area (2012)
  • Author(s): Shirota Y, Hamada M, Terao Y, Ohminami S, Tsutsumi R, Ugawa Y, Hanajima R
  • Journal Title: Exp Brain Res Volume: 219 Pages: 339-49
• [Journal Article] Bidirectional modulation of sensory cortical excitability by quadripulsetranscranial magnetic stimulation (QPS) in humans (2012)
  • Author(s): Nakatani-Enomoto S, Hanajima R, Hamada M, Terao Y, Matsumoto H, Shirota Y, Okabe S, Hirose M, Nakamura K, Furubayashi T, Kobayashi S, Mochizuki H, Enomoto H, Ugawa Y
  • Journal Title: Clin Neurophysiol Volume: 123 Pages: 1415-21
• [Journal Article] Reduced interhemispheric inhibition in mild cognitive impairment. (2012)
  • Author(s): Tsutsumi R, Hanajima R et al.
  • Journal Title: Exp Brain Res Volume: 218 Issue: 1 Pages: 21-26
  • DOI: 10.1007/s00221-011-2997-0
  • Peer Reviewed
• [Journal Article] Bidirectional modulation of sensory cortical excitability by quadripulse transcranial magnetic stimulation (QPS) in humans. (2012)
  • Author(s): Nakatani-Enomoto S
  • Journal Title: Clinical Neurophysiology Volume: 123(7) Issue: 7 Pages: 1415-1421
  • DOI: 10.1016/j.clinph.2011.11.037
  • Peer Reviewed
• [Journal Article] Increased primary motor cortical excitability by a single-pulse transcranial magnetic stimulation over the supplementary motor area (2012)
  • Author(s): Y Shirota, et al.
  • Journal Title: Experimental Brain Research Volume: 219 Issue: 3 Pages: 339-349
  • DOI: 10.1007/s00221-012-3095-7
  • Peer Reviewed
• [Journal Article] Conditioning intensity-dependent interaction between short-latency interhemispheric inhibition and short-latency afferent inhibition. (2012)
  • Author(s): Tsutsumi R et al.
  • Journal Title: J Neurophysiol. Volume: 108 Issue: 4 Pages: 1130-1137
  • DOI: 10.1152/jn.00300.2012
  • Peer Reviewed
• [Journal Article] Aging influences central motor conduction less than peripheral motor conduction: a transcranial magnetic stimulation study (2012)
  • Author(s): Matsumoto H et al.
  • Journal Title: Muscle Nerve Volume: 46 Issue: 6 Pages: 932-966
  • DOI: 10.1002/mus.23430
  • Peer Reviewed
• [Journal Article] Reduced interhemispheric inhibition in-- (2012)
  • Author(s): Tsutsumi R, Hanajima Ret al
  • Journal Title: Exp Brain Res Volume: 218 Pages: 21-26
  • Peer Reviewed
• [Journal Article] Some evidence supporting the safety of quadripulse stimulation (QPS) (2011)
  • Author(s): Nakatani-Enomoto S, Hanajima R, Hamada M, Mochizuki H, Kobayashi S, Enomoto H, Sugiura Y, Matsumoto H, Furubayashi T, Terao Y, Sato F, Ugawa Y
  • Journal Title: Brain Stimul Volume: 4 Pages: 303-5
• [Journal Article] Short-interval intracortical inhibition in Parkinson's disease using anterior-posterior directed currents (2011)
  • Author(s): Hanajima R, Terao Y, Shirota Y, Ohminami S, Nakatani-Enomoto S, Okabe S, Matsumoto H, Tsutsumi R, Ugawa Y
  • Journal Title: Exp Brain Res Volume: 214 Pages: 317-21
• [Journal Article] Short-interval intracortical inhibition in-- (2011)
  • Author(s): Hanajima R, Terao Y et al
  • Journal Title: Exp Brain Res Volume: 214 Pages: 317-321
  • Peer Reviewed
• [Journal Article] Inter-individual variation in the efficient -- (2011)
  • Author(s): Shirota Y, Hanajima R et al
  • Journal Title: Clin Neurophysiol Volume: 122 Pages: 2044-2048
  • Peer Reviewed
• [Journal Article] Initiation and inhibitory control of saccades-- (2011)
  • Author(s): Terao Y Hanajima R et al
  • Journal Title: Neuropsychologia Volume: 49 Pages: 1794-1806
  • Peer Reviewed
• [Journal Article] Small saccades restrict visual scanning -- (2011)
  • Author(s): Matsumoto H, Terao Y, Hanajima R et al
  • Journal Title: Mov Disord Volume: 26 Pages: 1619-1626
  • Peer Reviewed
• [Journal Article] Some evidence supporting the safety-- (2011)
  • Author(s): Nakatani-Enomoto S, Hanajima Ret al
  • Journal Title: Brain Stimul Volume: 4 Pages: 303-305
  • Peer Reviewed
• [Presentation] 脊髄小脳変性症患者（Spino-cerebellar degeneration: SCD）におけるプリズム順応障害と古典的運動失調症状との関連 (2014)
  • Author(s): 花島律子、内村元昭、北澤茂、大南伸也、堤涼介、清水崇弘、田中信行、寺尾安生、宇川義一
  • Organizer: 第５５回 神経学会総会
  • Place of Presentation: 福岡（福岡国際会議場）
• [Presentation] 反復4連続磁気刺激法による皮質興奮性変化に抗パーキンソン病薬が与える影響の検討 (2013)
  • Author(s): 榎本博之、門脇傑、守谷新、村上丈伸、中村耕一郎、榎本(中谷)雪、小林俊輔、花島律子、寺尾安生、宇川義一
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] 4連発磁気刺激(QPS)を用いたLDOPAおよびゾニサミドの大脳皮質可塑性変化への影響の検討 (2013)
  • Author(s): 田中信行、堤涼介、松田俊一、大南伸也、寺田さとみ、代田悠一郎、花島律子、寺尾安生、宇川義一
  • Organizer: 第7回日本パーキンソン病・運動障害疾患学会
  • Place of Presentation: 東京
• [Presentation] ヒト脊髄前核細胞における興奮性シナプス後電位(EPSP)の形状推定:2連発脳幹磁気刺激法での検討 (2013)
  • Author(s): 松本英之、花島律子、濱田雅、寺尾安生、弓削田晃弘、寺田さとみ、榎本雪、辻省次、宇川義一
  • Organizer: 第15回日本ヒト脳機能マッピング学会
  • Place of Presentation: 東京
• [Presentation] 一次運動野の反復単相性4連発経頭蓋磁気刺激QPSによる対側一次運動野への可塑性誘導 (2013)
  • Author(s): 堤涼介、花島律子、寺尾安生、代田悠一郎、清水崇宏、田中信行、宇川義一
  • Organizer: 第15回日本ヒト脳機能マッピング学会
  • Place of Presentation: 東京
• [Presentation] 前補足運動野に対する4連発経頭蓋反復磁気刺激がヒト逐次運動系列学習に与える影響 (2013)
  • Author(s): 清水崇宏、花島律子、堤涼介、代田悠一郎、大南伸也、田中信行、寺尾安生、宇川義一
  • Organizer: 第15回日本ヒト脳機能マッピング学会
  • Place of Presentation: 東京
• [Presentation] Quadripulse transcranial magnetic stimulation (QPS)の難治性てんかんに対する影響 (2013)
  • Author(s): 榎本雪、花島律子、浜田雅、松本英之、町井克行、寺尾安生、川井謙介、管るみ子、丹羽真一、榎本博之、宇川義一
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
• [Presentation] 前運動野に対する4連発経頭蓋反復磁気刺激がヒトの逐次運動系列学習に与える影響 (2013)
  • Author(s): 清水崇宏、花島律子、堤涼介、代田悠一郎、松田俊一、田中信行、寺尾安生、宇川義一
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
• [Presentation] 小脳疾患における衝動性眼球運動異常の検討―小脳遠心系と求心系の障害の比較― (2013)
  • Author(s): 寺尾安生、福田秀樹、松田俊一、弓削田晃弘、花島律子、野村芳子、瀬川昌也、宇川義一
  • Organizer: 第43回日本臨床神経生理学会学術大会
  • Place of Presentation: 高知
• [Presentation] Intrinsic rhythm of the primary motor cortex in Parkinson's disease (2013)
  • Author(s): Hanajima R, Shirota Y, Ohminami S, Tsutsumi R , Shimizu T, Tanaka N, Terao Y, Tsuji S, Ugawa Y
  • Organizer: 17^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Sydney
• [Presentation] Effects of motor cortical quadripulse transcranial magnetic stimulation (QPS) on the contralateral primary motor cortex (2013)
  • Author(s): Tsutsumi R, Hanajima R, Terao Y, Shirota Y, Shimizu T, Tanaka N, Ugawa Y
  • Organizer: 17^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Sydney
• [Presentation] Difference in the modulation of quadripulse transcranial magnetic stimulation (QPS) effect between L-DOPA and zonisamide (2013)
  • Author(s): Tanaka N, Tsutsumi R, S. Matsuda, Ohminami S, Inomata-Terada S, Shirota Y, Hanajima R, Terao Y, Ugawa Y
  • Organizer: 17^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Sydney
• [Presentation] Effects of quadripulse stimulation over medial frontal cortex on human visuomotor sequence learning (2013)
  • Author(s): Shimizu T, Hanajima R, Tsutsumi R, Shirota Y, Tanaka N, S. Matsuda, Terao Y, Ugawa Y
  • Organizer: 17^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Sydney
• [Presentation] 不随意運動の病態生理 振戦の病態生理 (2013)
  • Author(s): 花島律子
  • Organizer: 第５4回 神経学会総会
  • Place of Presentation: 東京(東京国際フォーラム）
  • Invited
• [Presentation] Motor excitability in myoclonus and focal dystonia (2013)
  • Author(s): Hanajima R
  • Organizer: 5th Asia Oceanian Congress of Clinical Neurophysiology
  • Place of Presentation: Bali、Ｉｎｄｏｎｅｓｉａ
  • Invited
• [Presentation] Paired TMS in clinical neurology. GABA function and cerebellar function (2013)
  • Author(s): Hanajima R
  • Organizer: Workshop Transcranial Magnetic Stimulation Clinical Applications. 5th Asia Oceanian Congress of Clinical Neurophysiology
  • Place of Presentation: Bali、Ｉｎｄｏｎｅｓｉａ
  • Invited
• [Presentation] 基底核疾患における運動野興奮リズムの変化 (2012)
  • Author(s): 花島律子,寺尾安生,代田悠一郎,大南伸也,堤涼介,岡部慎吾,宇川義一
  • Organizer: 第53回神経学会総会
  • Place of Presentation: 東京(臨床神経学52:1434)
• [Presentation] プリズム順応課題を用いた脊髄小脳変性症の生理学的解析 (2012)
  • Author(s): 大南伸也,代田悠一郎,堤涼介,北澤茂,内村元昭,井上雅仁,松田俊一,市川弥生子,後藤順,辻省次,宇川義一,寺尾安生,花島律子
  • Organizer: 第53回神経学会総会
  • Place of Presentation: 東京(臨床神経学52:1513)
• [Presentation] 経頭蓋磁気刺激法を用いた一次運動野抑制機能への年齢の影響 (2012)
  • Author(s): 堤涼介,花島律子,代田悠一郎,大南伸也,寺尾安生,辻省次,宇川義一
  • Organizer: 第53回神経学会総会
  • Place of Presentation: 東京(臨床神経学52巻12:1411)
• [Presentation] 脊髄小脳変性症におけるプリズム順応課題 (2012)
  • Author(s): 大南伸也,代田悠一郎,堤涼介,北澤茂,内村元昭,井上雅仁,松田俊一,市川弥生子,後藤順,辻省次,宇川義一,寺尾安生,花島律子
  • Organizer: 第42回臨床神経生理学会
  • Place of Presentation: 東京(臨床神経生理学40:501)
• [Presentation] パーキンソン病における短潜時皮質内抑制・促通 (2012)
  • Author(s): 代田悠一郎,寺尾安生,大南伸也,堤涼介,宇川義一,花島律子
  • Organizer: 第42回臨床神経生理学会
  • Place of Presentation: 東京(臨床神経生理学40:495)
• [Presentation] 運動野刺激のQPSが感覚皮質に与える影響 (2012)
  • Author(s): 榎本雪,花島律子,濱田雅,松本英之,代田悠一郎,大南伸也,岡部慎吾,古林俊晃,門脇傑,中村耕一郎,小林俊輔,望月仁志,榎本博之,宇川義一
  • Organizer: 第42回臨床神経生理学会
  • Place of Presentation: 東京(臨床神経生理学40:444)
• [Presentation] 一次運動野の反復単相性4連発経頭蓋磁気刺激QPSによる対側一次運動野への可塑性誘導 (2012)
  • Author(s): 堤涼介,花島律子,寺尾安生,代田悠一郎,大南伸也,清水崇宏,田中信行,宇川義一
  • Organizer: 第42回臨床神経生理学会
  • Place of Presentation: 東京(臨床神経生理学40:444)
• [Presentation] 脊髄小脳変性症におけるプリズム順応課題 (2012)
  • Author(s): 大南伸也,代田悠一郎,堤涼介,北澤茂,内村元昭,井上雅仁,松田俊一,市川弥生子,後藤順,辻省次,宇川義一,寺尾安生,花島律子
  • Organizer: 第6回日本パーキンソン病・運動障害疾患学会
  • Place of Presentation: 京都
• [Presentation] Intrinsic rhythm of the primary motor cortex in cortical myoclonus (2012)
  • Author(s): Hanajima R, Terao Y, Okabe S, Nakatani-Enomoto S, Furubayashi T , Hamada M, Yugeta A, Matsumoto H, Shirota Y, Tsuji S, Ugawa Y
  • Organizer: 1st Workshop on Synaptic plasticity from Bench to Bed Side
  • Place of Presentation: Tarmina
• [Presentation] Difference in facilitation with triad-conditioning TMS technique between Parkinson's disease and focal hand dystonia (2012)
  • Author(s): Hanajima R, Terao Y, Shirota Y, Ohminami S, Tsutsumi R, Ugawa Y
  • Organizer: 16^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Dublin
• [Presentation] Prism adaptation in spinocerebellar ataxiaThe movement disorder society's (2012)
  • Author(s): Ohminami S , Shirota Y, Tsutsumi R, Kitazawa,M. Uchimura, M. Inoue, S. Matsuda, Y. Ichikawa, J. Goto, Tsuji S, Ugawa Y, Terao Y, Hanajima R
  • Organizer: 16^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Dublin
• [Presentation] Electrophysiological analyses of anti-NMDA receptor encephalitis (2012)
  • Author(s): Shimizu T, Hanajima R, Tsutsumi R, Shirota Y, Ohminami S, S. Matsuda, T. Yamamoto, J. Goto, J. Shimizu, Terao Y, Ugawa Y, Tsuji S
  • Organizer: 16^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Dublin
• [Presentation] Conditioning intensity dependent interaction between interhemispheric inhibition and short-latency afferent inhibition (2012)
  • Author(s): Tsutsumi R, Hanajima R, Shirota Y, Ohminami S, Terao Y, Ugawa Y
  • Organizer: 16^<th> international congress of Parkinson's disease and movement disorders
  • Place of Presentation: Dublin
• [Presentation] Intrinsic rhythm within the primary motor cortex in cortical myoclonus (2012)
  • Author(s): Hanajima R Terao Y, Okabe S, Nakatani-Enomoto S, Furubayashi T, Hamada M Yugeta A, Matsumoto H, Shirota Y, Tsuji S, Ugawa Y
  • Organizer: 2^<nd> Workshop on Synaptic plasticity from Bench to Bed Side
  • Place of Presentation: Tarmina
• [Presentation] Prism adaptation in spinocerebellar ataxia (2012)
  • Author(s): Ohminami S , Shirota Y, Tsutsumi R, Kitazawa,M. Uchimura, M. Inoue, S. Matsuda, Y. Ichikawa, J. Goto,Tsuji S, Ugawa Y, Terao Y, Hanajima R
  • Organizer: 2^<nd> Workshop on Synaptic plasticity from Bench to Bed Side
  • Place of Presentation: Tarmina
• [Presentation] 運動失調の臨床再考 プリズム適応の応用によるヒト小脳入力系機能障害の検出 (2012)
  • Author(s): 花島律子
  • Organizer: 第6回 パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都
  • Invited
• [Presentation] プリズム順応課題を用いた脊髄小脳変性症の生理学的解析 (2012)
  • Author(s): 大南伸也他
  • Organizer: 第6回 パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 京都
• [Presentation] プリズム順応課題を用いた脊髄小脳変性症の生理学的解析 (2012)
  • Author(s): 大南伸也他
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] プリズム順応課題を用いた脊髄小脳変性症の生理学的解析 (2012)
  • Author(s): 大南伸也他
  • Organizer: 第42回日本臨床神経生理学会・学術大会
  • Place of Presentation: 東京
• [Presentation] Prism adaptation in spinocerebellar ataxia (2012)
  • Author(s): S Ohminami,et al.
  • Organizer: The movement disorder society’s 16th international congress of Parkinson’s disease and movement disorders
  • Place of Presentation: Dublin, Ireland
• [Presentation] Prism adaptation in spinocerebellar ataxia (2012)
  • Author(s): S Ohminami,et al.
  • Organizer: 2nd Workshop on Synaptic plasticity from Bench to Bed Side
  • Place of Presentation: Tarmina, Italy
• [Presentation] パーキンソン病における後ろ向き誘導電流による皮質内抑制 (2011)
  • Author(s): 花島律子,寺尾安生,代田悠一郎,大南伸也,堤涼介,松田俊一,松本英之,岡部慎吾,辻省次,宇川義一
  • Organizer: 第52回神経学会総会
  • Place of Presentation: 名古屋(臨床神経学51:1398)
• [Presentation] 脳幹磁気刺激検査におけるコイル位置に関する検討 (2011)
  • Author(s): 代田悠一郎,濱田雅,花島律子,寺尾安生,松本英之,大南伸也,辻省次,宇川義一
  • Organizer: 第52回神経学会総会
  • Place of Presentation: 名古屋(臨床神経学51:1447)
• [Presentation] 強力な新規可塑性誘導法であるquadripulse stimulation(QPS)のHuntington病における反応性 (2011)
  • Author(s): 大南伸也,寺尾安生,代田悠一郎,堤涼介,後藤順,市川弥生子,辻省次,宇川義一,花島律子
  • Organizer: 第52回神経学会総会
  • Place of Presentation: 名古屋(臨床神経学5:1436)
• [Presentation] アルツハイマー病における運動野調節機能 (2011)
  • Author(s): 堤涼介,花島律子,濱田雅,代田悠一郎,松本英之,寺尾安生,大南伸也,山川義宏,嶋田裕之,辻省次,宇川義一
  • Organizer: 第52回神経学会総会
  • Place of Presentation: 名古屋(臨床神経学51:1340)
• [Presentation] 経頭蓋磁気刺激を用いた運動野内調節機能の相互作用に関する検討 (2011)
  • Author(s): 堤涼介,花島律子,代田悠一郎,大南伸也,寺尾安生,宇川義一
  • Organizer: 第41回臨床神経生理学会
  • Place of Presentation: 静岡(臨床神経生理学39:463)
• [Presentation] Huntington病患者におけるQuadripulse stimulationによる可塑性誘導 (2011)
  • Author(s): 大南伸也,寺尾安生,代田悠一郎,堤涼介,後藤順,市川弥生子,辻省次,宇川義一,花島律子
  • Organizer: 第41回臨床神経生理学会
  • Place of Presentation: 静岡(臨床神経生理学39:459)
• [Presentation] 皮質性ミオクローヌスにおける運動野興奮リズムの変化 (2011)
  • Author(s): 花島律子、寺尾安生、榎本雪、岡部慎吾、代田悠一郎、大南伸也、松本英之、宇川義一
  • Organizer: 第5回日本パーキンソン病・運動障害疾患学会
  • Place of Presentation: 東京
• [Presentation] 多系統委縮症患者における小脳抑制 (2011)
  • Author(s): 代田悠一郎、花島律子、大南伸也、堤涼介、寺尾安生、辻省次、宇川義一
  • Organizer: 第5回日本パーキンソン病・運動障害疾患学会
  • Place of Presentation: 東京
• [Presentation] 瀬川病における衝動性眼球運動の異常と臨床型による違い (2011)
  • Author(s): 寺尾安生,福田秀樹,弓削田晃弘,松田俊一,花島律子,宇川義一,野村芳子,瀬川昌也
  • Organizer: 第5回日本パーキンソン病・運動障害疾患学会
  • Place of Presentation: 東京
• [Presentation] Normal SICI in Parkinon's disease : SICI using anterior-posterior directed induced currents in the brain (2011)
  • Author(s): Hanajima R, Terao Y, Shirota Y, Ohminami S, Nakatani-Enomoto S, Okabe S, Matsumoto H, Tsutsumi R, Ugawa Y
  • Organizer: 14th European Congress on Clinical Neuropysiology
  • Place of Presentation: Rome
• [Presentation] Long term effects induced by quadripulse stimulation in Huntington's disease (2011)
  • Author(s): Ohminami S, Terao Y, Shirota Y, Tustsumi R, GotoJ, Ichikawa Y, Tsuji S, Ugawa Y, Hanajima R
  • Organizer: 14th European Congress on Clinical Neuropysiology
  • Place of Presentation: Rome
• [Presentation] Inter-individual variation in the efficient stimulation site for magnetic brainstem stimulation (2011)
  • Author(s): Shirota Y, Hanajima R, Hamada M, Terao Y, Matsumoto H, Ohminami S, Tsutsumi R, Furubayashi T, Ugawa Y
  • Organizer: 14th European Congress on Clinical Neuropysiology
  • Place of Presentation: Rome
• [Presentation] Abnormal motor cortex inhibitory circuits in mild cognitive impairement (2011)
  • Author(s): Tsutsumi R, Hanajima R, Hamada M, Shirota Y, Matsumoto H, Terao Y, Ohminami S, Yamakawa H, Shimada H, Tsuji S, Ugawa Y
  • Organizer: 14th European Congress on Clinical Neuropysiology
  • Place of Presentation: Rome
• [Presentation] Intrisic rhythm of the primary motor cortex in cortical myoclonus (2011)
  • Author(s): Hanajima R, Terao Y, Nakatani-Enomoto S, Okabe S, Shirota Y, Ohminami S, Matusmoto H, Tsutsumi R, Tsuji S, Ugawa Y
  • Organizer: 15th International Congress of Parkinson's disease and movement disorders
  • Place of Presentation: Toronto
• [Presentation] Cerebellar inhibition in multiple system atrophy patients (2011)
  • Author(s): Shirota Y, Hanajima R, Hamada M, Terao Y, Matsumoto H, Ohminami S, Tsutsumi R , Ugawa Y
  • Organizer: 15th International Congress of Parkinson's disease and movement disorders
  • Place of Presentation: Toronto
• [Presentation] Long term effects induced by quadripulse stimulation in Huntington's disease (2011)
  • Author(s): Ohminami S, Terao Y, Shirota Y, Tsutsumi R , Goto, J, Ichikawa Y, Tsuji S, Ugawa Y, Hanajima R
  • Organizer: 15th International Congress of Parkinson's disease and movement disorders
  • Place of Presentation: Toronto
• [Presentation] Saccade abnormalities in hereditary progressive dystonia (2011)
  • Author(s): Terao Y, Fukuda H, Yugeta A, Hanajima R, Ugawa Y, Nomura Y, Segawa M
  • Organizer: 15th International Congress of Parkinson's disease and movement disorders
  • Place of Presentation: Toronto
• [Presentation] Abnormal motor cortex inhibitory circuits in mild cognitive impairment (2011)
  • Author(s): Tsutsumi R, Hanajima R, Hamada M, Shirota Y, Matsumoto H, Terao Y, Ohminami S, Yamakawa Y, Shimada, H Tsuji S, Ugawa Y
  • Organizer: 15th International Congress of Parkinson's disease and movement disorders
  • Place of Presentation: Toronto
• [Presentation] Transcranial magnetic stimulatoin over the cerebellumm in ataxic and non-ataxic patients with progressive supranuclearpasy (2011)
  • Author(s): Shirota Y, Hanajima R, Terao Y, Tsuji S, Ugawa Y
  • Organizer: 4th International Symposium of the Society for Researcn on the Cerebellum
  • Place of Presentation: Tokyo
• [Presentation] Normal SICI in Parkinson’s disease:-- (2011)
  • Author(s): R Hanajima, Y Terao et al
  • Organizer: ＥＣＣＮ 2011ＴＭＳｔＤＣ symposium
  • Place of Presentation: Roma
• [Presentation] Inter-individual variation in the efficient -- (2011)
  • Author(s): Y Shirota, R Hanajima et al
  • Organizer: ＥＣＣＮ 2011ＴＭＳｔＤＣ symposium
  • Place of Presentation: Roma
• [Presentation] Intrinsic rhythm of the primary motor cortex in-- (2011)
  • Author(s): R Hanajima, Y Terao et al
  • Organizer: 15th International Congress of PD and MD
  • Place of Presentation: Toronto
• [Presentation] 皮質性ミオクローヌスにおける運動野興奮リズムの変化 (2011)
  • Author(s): 花島律子、寺尾安生ら
  • Organizer: 第5回パーキンソン病・運動障害疾患コングレス
  • Place of Presentation: 東京
• [Presentation] パーキンソン病における後ろ向き誘導電流による皮質内抑制 (2011)
  • Author(s): 花島律子、寺尾安生ら
  • Organizer: 第52回日本神経学会総会
  • Place of Presentation: 名古屋
• [Presentation] 随意運動の正常と異常 (2011)
  • Author(s): 花島律子
  • Organizer: 第5回motor control研究会(招待講演)
  • Place of Presentation: 岡崎
• [Presentation] Transcranial magnetic stimulation over -- (2011)
  • Author(s): Y. Shirota, R. Hanajima et al
  • Organizer: 第4回小脳シンポジウム
  • Place of Presentation: 東京
• [Presentation] 反復磁気刺激法（rTMS）臨床応用の将来的展望 (2011)
  • Author(s): 花島律子
  • Organizer: 第３３回生物学的精神医学会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 経頭蓋磁気刺激を用いた皮質抑制機能の相互作用に関する検討 (2011)
  • Author(s): 堤涼介、花島律子ら
  • Organizer: 第41回日本臨床神経生理学会・学術大会
  • Place of Presentation: 静岡
• [Presentation] Huntington病患者におけるQuadripulse stimulationによる可塑性誘導 (2011)
  • Author(s): 大南伸也、寺尾安生、花島律子ら
  • Organizer: 第41回日本臨床神経生理学会・学術大会
  • Place of Presentation: 静岡