| Project/Area Number |
23591270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TERAO Yasuo 東京大学, 医学部附属病院, 講師 (20343139)
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| Co-Investigator(Renkei-kenkyūsha) |
KITAZAWA Shigeru 大阪大学, 大学院生命機能研究科, 教授 (00251231)
UGAWA Yoshikazu 福島県立医大, 神経内科, 教授 (50168671)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 小脳機能検査 / 運動適応 / 脊髄小脳変性症 / 神経内科 / 神経シナプス可塑 / 神経シナプス可塑性 |
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| Research Abstract |
The cerebellar neuro-plasticity has an important role in sensori-motor adaptation tasks. To detect the cerebellar plasticity in humans, we established a clinically useful prism adaptation task using a touch panel monitor. We made normative data for several adaptation parameters by performing this examination in healthy volunteers. First, we applied this method to patients with pure cerebellar ataxia and showed adaptation abnormality, which confirmed that our method should detect cerebellar dysfunction in humans. The degree of the adaptation impairment did not correlated with the severity of clinical cerebellar symptoms, which suggests that our method may detect another aspect of cerebellar dysfunction.
Moreover, to modify the cerebellar neural plasticity, we apply repetitive transcranial magnetic stimulation (rTMS) over the cerebellum. Some cerebellar adaptation parameters tended to be affected by repetitive cerebellar stimulation.
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