| Project/Area Number |
23591280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
MURATA Kenya 和歌山県立医科大学, 医学部, 准教授 (90264853)
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| Co-Investigator(Kenkyū-buntansha) |
MIWA Hideto 順天堂大学, 医学部, 准教授 (50231626)
NAKANISHI Ichiro 和歌山県立医科大学, 医学部, 助教 (40364088)
HIWATANI Yasuhiro 和歌山県立医科大学, 医学部, 助教 (40405452)
KOUDA Ken 和歌山県立医科大学, 医学部, 非常勤講師 (20433352)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 筋病理 / 傍脊柱筋萎縮 / パーキンソン病 / 腰曲がり / NIRS / 筋生検 / 国際情報交換 / 国際研究者交流 |
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| Outline of Final Research Achievements |
Approximately 70% of the Parkinson's disease patients showed scoliosis. Fat in the erector spinae muscles were diffusely infiltrated in the half of the scoliosis patients. Paraspinal muscle atrophy, in the middle portion of the longissimus muscles, was remarkable in Parkinson's disease patients with scoliosis. The degree of fat infiltration and atrophy of the paraspinal muscles correlated with the severity of ADL disturbance in Parkinson's disease patients with scoliosis.
Various mechanisms may contribute to the development of Parkinsonian scoliosis. Dopaminergic depletion in Parkinson's disease may induce functional changes in the organization of the corticospinal and reticulospinal tracts, and dysfunction may contribute to axial rigidity. To prevent the scoliosis, treatment interventions such as an appropriate pharmacotherapy and rehabilitation at the early stage of Parkinson's disease is very important.
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