| Project/Area Number |
23591282
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATTORI Nobutaka 順天堂大学, 医学部, 教授 (80218510)
YAMAMOTO Yorihiro 東京工科大学, 応用生物学, 教授 (60134475)
SATOU Shigeto 順天堂大学, 医学部, 准教授 (00445537)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | パーキンソン病 / コエンザイムQ10 / ミトコンドリア / ユビキノール / 酸化的ストレス / ウエアリングオフ / コエンザイムＱ10 / 酸化ストレス / 還元型コエンザイムQ10 / サプリメント / 無作為化二重盲検併行群間試験 / 二重盲検法 |
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| Outline of Final Research Achievements |
The reduced form of Coenzyme Q10 (ubiquinol-10) has shown better neuroprotective effects in animal models. Randomized, double-blind, placebo-controlled, parallel-group pilot trials were conducted to assess the efficacy of ubiquinol-10 in Japanese patients with PD. Participants were divided into two trial groups: PD experiencing wearing off (Group A), and early PD, without levodopa (Group B). Participants took 300 mg of ubiquinol-10 or placebo per day for 48 weeks (Group A) or 96 weeks (Group B). In Group A, total Unified Parkinson’s Disease Rating Scale (UPDRS) scores decreased in the ubiquinol-10 group (n = 14; mean ± SD [-4.2 ± 8.2]), indicating significant improvement (p < 0.05) in ubiquinol-10 group. In Group B, UPDRS increased in the ubiquinol-10 group, as well as in the placebo group. This is the first report indicating that ubiquinol-10 may significantly improve PD with wearing off, and that ubiquinol-10 is safe and well tolerated.
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