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Development of inter-organ network-mediated beta-cell mass increasing strategies

Research Project

Project/Area Number 23591294
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionTohoku University

Principal Investigator

IMAI Junta  東北大学, 大学病院, 講師 (80431500)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords糖尿病 / 膵β細胞 / インスリン / 臓器間ネットワーク / 自律神経
Research Abstract

We tested the effects of previously reported pancreatic vagal nerve-derived peptides on proliferation of pancreatic islet cells using isolated pancreatic islets from rats and mice. We found vagal nerve derived factors to induce proliferation of pancreatic islet cells.
We also examined gene expressions of pancreatic islets from hepatic ERK- activated mice by microarray analysis, and identified the transcription factor which plays an important role in inducing proliferation of pancreatic beta-cells. In addition, we found that the activity of the transcription factor is up-regulated in isolated pancreatic islets from rats and mice stimulated by aforementioned vagal nerve-derived peptides.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (34 results)

All 2013 2012 2011

All Journal Article (17 results) (of which Peer Reviewed: 15 results) Presentation (13 results) (of which Invited: 3 results) Book (3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Bach1 deficiency protects pancreatic β-cells from oxidative stress injury.2013

    • Author(s)
      Kondo K, Ishigaki Y, Gao J, Yamada T, Imai J, Sawada S, Muto A, Oka Y, Igarashi K, Katagiri H.
    • Journal Title

      Am J Physiol Endocrinol Metab.

      Volume: 305(5) Issue: 5 Pages: E641-E648

    • DOI

      10.1152/ajpendo.00120.2013

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: A case-control study2013

    • Author(s)
      Takagi M, Ishigaki Y, Uno K, Sawada S, Imai J, Kaneko K, Hasegawa Y, Yamada T, Tokita A, Iseki K, Kanno S, Nishio Y, Katagiri H and Mori E
    • Journal Title

      BMC Neurol

      Volume: 13 Issue: 1 Pages: 76-76

    • DOI

      10.1186/1471-2377-13-76

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臓器間ネットワークによる膵β細胞の機能と量の調節2013

    • Author(s)
      今井 淳太、片桐 秀樹
    • Journal Title

      Diabetes Frontier

      Volume: 24 Pages: 513-518

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Chronic mild stress alters circadian expressions of molecular clock genes in the liver.2013

    • Author(s)
      Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J et al.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 304

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Chronic mild stress alters circadian expressions of molecular clock genes in the liver2012

    • Author(s)
      Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J, Uno K, Hasegawa Y, Sawada S, Oka Y, Katagiri H.
    • Journal Title

      Am J Physiol Endocrinol Metab

      Volume: 304 Issue: 3 Pages: E301-E309

    • DOI

      10.1152/ajpendo.00388.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals2012

    • Author(s)
      Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, Oka Y, Katagiri H.
    • Journal Title

      Cell Metab

      Volume: 16 Issue: 6 Pages: 825

    • DOI

      10.1016/j.cmet.2012.11.006

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of slowly progressive type 1 diabetes with insulin independence maintained for 10 years with alpha-glucosidase inhibitor monotherapy2012

    • Author(s)
      Munakata Y, Yamada T, Takahashi K, Tsukita S, Sawada S, Imai J, Ishigaki Y, Oka Y, Katagiri H
    • Journal Title

      Intern Med

      Volume: 51 Pages: 3391-3394

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of pancreatic beta-cells by inter-organ networks2012

    • Author(s)
      Imai J, Katagiri H
    • Journal Title

      Nihon Rinsho

      Volume: 70 Suppl 3 Pages: 109-112

    • NAID

      40019323633

    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Journal Article] Importance of endothelial NF-κB signaling in vascular remodeling and aortic aneurysm formation2012

    • Author(s)
      Saito T, Hasegawa Y, Ishigaki Y, Yamada T, Gao J, Imai J, Uno K, Kaneko K, Ogihara T, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H.
    • Journal Title

      Cardiovascular Research

      Volume: 97(1) Issue: 1 Pages: 106-114

    • DOI

      10.1093/cvr/cvs298

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Blockade of the nuclear factor-kappaB pathway in the endothelium prevents insulin resistance and prolongs life spans2012

    • Author(s)
      Hasegawa Y, Saito T, Ogihara T, Ishigaki Y, Yamada T, Imai J, Uno K, Gao J, Kaneko K, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H
    • Journal Title

      Circulation

      Volume: 125 Pages: 1122-1133

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic peroxisome proliferator-activated receptor-γfat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vagal signals2012

    • Author(s)
      Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H
    • Journal Title

      Eur Heart J

      Volume: 33 Issue: 10 Pages: 1279

    • DOI

      10.1093/eurheartj/ehr265

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals.2012

    • Author(s)
      Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J et al,
    • Journal Title

      Cell Metab

      Volume: 16 Pages: 825-832

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of slowly progressive type 1 diabetes with insulin independence maintained for 10 years with alpha-glucosidase inhibitor monotherapy.2012

    • Author(s)
      Munakata Y, Yamada T, Takahashi K, Tsukita S, Sawada S, Imai J et al.
    • Journal Title

      Intern Med

      Volume: 51 Pages: 3391-3394

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] NF-kappaB 経路と老化についての論文2012

    • Author(s)
      Hasegawa Y, Saito T, Ogihara T, Imai J et al.
    • Journal Title

      Circulation

      Volume: 125 Pages: 1122-1133

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] CHOPの動脈硬化における役割についての論文2012

    • Author(s)
      Gao J, Ishigaki Y, Yamada T, Imai J et al.
    • Journal Title

      Circulation

      Volume: 124 Pages: 830-839

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses2011

    • Author(s)
      Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H
    • Journal Title

      Circulation

      Volume: 124 Pages: 830-839

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-6 enhances glucose-stimulated insulin secretion from pancreatic β-cells: Potential involvement of the PLC-IP<sub>3</sub>-dependent pathway2011

    • Author(s)
      Suzuki T, Imai J, Yamada T, IshigakiY, Kaneko K, Uno K, Hasegawa Y, Ishihara H, Oka Y, Katagiri H
    • Journal Title

      Diabetes

      Volume: 60 Issue: 2 Pages: 537

    • DOI

      10.2337/db10-0796

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 神経シグナルを介した膵β細胞制御機構2013

    • Author(s)
      今井淳太
    • Organizer
      第56回日本糖尿病学会総会
    • Place of Presentation
      熊本(シンポジウム講演)
    • Year and Date
      2013-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of pancreatic beta-cells by inter-organ networks2013

    • Author(s)
      Imai J
    • Organizer
      Beta Cell Workshop 2013
    • Place of Presentation
      京都(シンポジウム講演)
    • Year and Date
      2013-04-24
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of pancreatic beta-cells by inter-organ networks2013

    • Author(s)
      Junta Imai
    • Organizer
      Beta Cell Workshop 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Regulation of pancreatic beta-cells by Inter-organ Networks2012

    • Author(s)
      Imai J
    • Organizer
      第4回アジア糖尿病学会・第9回国際糖尿病連合西太平洋総会
    • Place of Presentation
      京都(シンポジウム講演)
    • Year and Date
      2012-11-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 臓器間ネットワークによる膵β細胞制御機構2012

    • Author(s)
      今井淳太
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋(シンポジウム講演)
    • Year and Date
      2012-04-19
    • Related Report
      2013 Final Research Report
  • [Presentation] 臓器間ネットワークによる膵β細胞制御機構,2012

    • Author(s)
      今井 淳太
    • Organizer
      第85回日本内分泌学会学術総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Regulation of pancreatic beta-cells by Inter-organ Networks2012

    • Author(s)
      Junta Imai
    • Organizer
      第4回アジア糖尿病学会・第9回国際糖尿病連合西太平洋総会
    • Place of Presentation
      京都
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Regulation of insulin secretion by Inter-organ Networks2011

    • Author(s)
      Imai J
    • Organizer
      International Beta-cell work shop
    • Place of Presentation
      デンマークヘルシンガー(シンポジウム講演)
    • Year and Date
      2011-10-25
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of pancreatic beta-cells by neuronal signal2011

    • Author(s)
      Imai J
    • Organizer
      Strategic Japanese-Danish Cooperative Program on Molecular Diabetology
    • Place of Presentation
      デンマークコペンハーゲン(シンポジウム講演)
    • Year and Date
      2011-10-21
    • Related Report
      2013 Final Research Report
  • [Presentation] Regulation of Insulin Secretion by Inter-Organ Communications2011

    • Author(s)
      Imai J
    • Organizer
      第54回日本糖尿病学会
    • Place of Presentation
      札幌(シンポジウム講演)
    • Year and Date
      2011-05-20
    • Related Report
      2013 Final Research Report
  • [Presentation] 臓器間連関と膵β細胞について2011

    • Author(s)
      Junta Imai
    • Organizer
      第54回日本糖尿病学会年次学術集会(招待講演)
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] 臓器間連関と膵β細胞について2011

    • Author(s)
      Junta Imai
    • Organizer
      Strategic Japanese-Danish Cooperative Program(招待講演)
    • Place of Presentation
      デンマーク、コペンハーゲン
    • Related Report
      2011 Research-status Report
  • [Presentation] 臓器間連関と膵β細胞について2011

    • Author(s)
      Junta Imai
    • Organizer
      Workshop Programming Beta Cell Development(招待講演)
    • Place of Presentation
      デンマーク、ヘルシンガー
    • Related Report
      2011 Research-status Report
  • [Book] 再生医療叢書52012

    • Author(s)
      今井淳太
    • Publisher
      朝倉書店
    • Related Report
      2012 Research-status Report
  • [Book] Helicobacter pylori感染とB型インスリン抵抗症2011

    • Author(s)
      今井淳太、山田哲也、岡芳知、片桐秀樹
    • Total Pages
      5
    • Publisher
      科学評論社
    • Related Report
      2011 Research-status Report
  • [Book] ヘリコバクター・ピロリ除菌により治癒したB型インスリン抵抗症2011

    • Author(s)
      今井淳太、山田哲也、岡芳知、片桐秀樹
    • Total Pages
      3
    • Publisher
      中山書店
    • Related Report
      2011 Research-status Report
  • [Patent(Industrial Property Rights)] 膵β細胞増殖促進剤、血中インスリン濃度上昇剤、血糖値低下剤・糖尿病治療・予防薬2013

    • Inventor(s)
      片桐 秀樹、岡 芳知、今井 淳太
    • Industrial Property Rights Holder
      片桐 秀樹、岡 芳知、今井 淳太
    • Industrial Property Rights Type
      特許
    • Acquisition Date
      2013-09-06
    • Related Report
      2013 Final Research Report
    • Overseas

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Published: 2011-08-05   Modified: 2019-07-29  

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