Development of inter-organ network-mediated beta-cell mass increasing strategies
Project/Area Number |
23591294
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
|
Research Institution | Tohoku University |
Principal Investigator |
IMAI Junta 東北大学, 大学病院, 講師 (80431500)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 糖尿病 / 膵β細胞 / インスリン / 臓器間ネットワーク / 自律神経 |
Research Abstract |
We tested the effects of previously reported pancreatic vagal nerve-derived peptides on proliferation of pancreatic islet cells using isolated pancreatic islets from rats and mice. We found vagal nerve derived factors to induce proliferation of pancreatic islet cells. We also examined gene expressions of pancreatic islets from hepatic ERK- activated mice by microarray analysis, and identified the transcription factor which plays an important role in inducing proliferation of pancreatic beta-cells. In addition, we found that the activity of the transcription factor is up-regulated in isolated pancreatic islets from rats and mice stimulated by aforementioned vagal nerve-derived peptides.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Cognitive dysfunction associated with anti-glutamic acid decarboxylase autoimmunity: a case-control study.2013
Author(s)
Takagi M, Ishigaki Y, Uno K, Sawada S, Imai J, Kaneko K, Hasegawa Y, Yamada T, Tokita A, Iseki K, Kanno S, Nishio Y, Katagiri H and Mori E
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Journal Title
BMC Neurol
Volume: 13
Issue: 1
Pages: 76-76
DOI
Related Report
Peer Reviewed
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[Journal Article] Chronic mild stress alters circadian expressions ofmolecular clock genes in the liver2012
Author(s)
Takahashi K, Yamada T, Tsukita S, Kaneko K, Shirai Y, Munakata Y, Ishigaki Y, Imai J, Uno K, Hasegawa Y, Sawada S, Oka Y, Katagiri H.
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Journal Title
Am J Physiol Endocrinol Metab
Volume: 304(3)
Issue: 3
Pages: E301-E309
DOI
Related Report
Peer Reviewed
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[Journal Article] Hepatic glucokinase modulates obesity predisposition by regulating BAT thermogenesis via neural signals2012
Author(s)
Tsukita S, Yamada T, Uno K, Takahashi K, Kaneko K, Ishigaki Y, Imai J, Hasegawa Y, Sawada S, Ishihara H, Oka Y, Katagiri H.
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Journal Title
Cell Metab
Volume: 16(6)
Issue: 6
Pages: 825-832
DOI
Related Report
Peer Reviewed
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[Journal Article] Importance of endothelial NF-κB signaling in vascular remodeling and aortic aneurysm formation2012
Author(s)
Saito T, Hasegawa Y, Ishigaki Y, Yamada T, Gao J, Imai J, Uno K, Kaneko K, Ogihara T, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H.
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Journal Title
Cardiovascular Research
Volume: 97(1)
Issue: 1
Pages: 106-114
DOI
Related Report
Peer Reviewed
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[Journal Article] Blockade of the nuclear factor-kappaB pathway in the endothelium prevents insulin resistance and prolongs life spans2012
Author(s)
Hasegawa Y, Saito T, Ogihara T, Ishigaki Y, Yamada T, Imai J, Uno K, Gao J, Kaneko K, Shimosawa T, Asano T, Fujita T, Oka Y, Katagiri H
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Journal Title
Circulation
Volume: 125
Pages: 1122-1133
Related Report
Peer Reviewed
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[Journal Article] Hepatic peroxisome proliferator-activated receptor-{gamma}-fat-specific protein 27 pathway contributes to obesity-related hypertension via afferent vasal signals2012
Author(s)
Uno K, Yamada T, Ishigaki Y, Imai J, Hasegawa Y, Gao J, Kaneko K, Matsusue K, Yamazaki T, Oka Y, Katagiri H
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Journal Title
Eur Heart J
Volume: (In Press)
Issue: 10
Pages: 1279-1289
DOI
Related Report
Peer Reviewed
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[Journal Article] Involvement of endoplasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses2011
Author(s)
Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J, Uno K, Hasegawa Y, Sawada S, Ishihara H, Oyadomari S, Mori M, Oka Y, Katagiri H
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Journal Title
Circulation
Volume: 124
Pages: 830-839
Related Report
Peer Reviewed
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