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Modulation in the expressin of hypothalamic protein tyrosine phosphatase 1B

Research Project

Project/Area Number 23591302
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionNagoya University

Principal Investigator

BANNO Ryoichi  名古屋大学, 医学部附属病院, 助教 (80597865)

Co-Investigator(Kenkyū-buntansha) OISO Yutaka  名古屋大学, 大学院医学系研究科, 教授 (40203707)
ARIMA Hiroshi  名古屋大学, 大学院医学系研究科, 准教授 (50422770)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肥満 / 視床下部炎症 / PTP1B / エネルギーバランス
Research Abstract

Hypothalamus is well known to play an important role in the regulation of energy balance. High-fat diet (HFD) increases hypothalamic Protein tyrosine phosphatase 1B (PTP1B) expression levels, and hypothalamic PTP1B deficient models protect against diet induced obesity. While PTP1B has therefore been implicated as a key regulator of energy homeostasis, the factors regulating PTP1B expression in the hypothalamus, particularly under obese conditions, remain to be fully elucidated. Since several lines of evidence have suggested that HFD induces hypothalamic inflammation accompanied by increasing levels of inflammatory cytokines such as TNF-alpha and IL6, in addition to ER stress, we examined whether these factors could regulate PTP1B expression and activity by using hypothalamic organotypic cultures. Our data show that TNF-alpha significantly increases PTP1B expression and activity in the hypothalamus, and that these effects are mediated via TNF-alpha induced NF-kappa-B activation.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (11 results)

All 2014 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] TNFαincreases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures2012

    • Author(s)
      Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y
    • Journal Title

      Regul Pept

      Volume: 174(1-3) Pages: 58-64

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TNFα increases hypothalamic PTP1B activity via the NFκB pathway in rat hypothalamic organotypic cultures2012

    • Author(s)
      Ito Y, Banno R, Hagimoto S, Ozawa Y, Arima H, Oiso Y
    • Journal Title

      Regulatory Peptide

      Volume: 174 Issue: 1-3 Pages: 58-64

    • DOI

      10.1016/j.regpep.2011.11.010

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] TNFα刺激による視床下部TNFαの発現はPTP1B欠損下で減弱する2014

    • Author(s)
      恒川 卓、坂野僚一、尾上剛史、柴田みゆき、足立浩一、伊藤禎浩、後藤資実、有馬 寛、大磯ユタカ
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪 堂島リバーフォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] TNFαincreases hypothalamic PTP1B expression via the NFκB pathway in rat hypothalamic organotypic cultures2011

    • Author(s)
      Yoshihiro Ito, Ryoichi Banno, Shigeru Hagimoto, Yoshiharu Ozawa, Hiroshi Arima and Yutaka Oiso
    • Organizer
      The Endocrine Society 93rd Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFαはNFkBを介してPTP1Bの発現を増強する2011

    • Author(s)
      伊藤禎浩、坂野僚一、萩本繁、小澤由治、有馬寛、大磯ユタカ
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌プリンスホテル国際館パミール、札幌市
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFαはNFkBを介してPTP1Bの発現を増強する2011

    • Author(s)
      伊藤禎浩、坂野僚一、萩本繁、小澤由治、有馬寛、大磯ユタカ
    • Organizer
      第54回日本糖尿病学会年次学術集会
    • Place of Presentation
      札幌
    • Related Report
      2011 Research-status Report
  • [Presentation] Tumor Necrosis Factor-α increases Protein Tyrosine Phosphatase 1B expression via NF-kappa-B signaling2011

    • Author(s)
      Yoshihiro Ito, Ryouichi Banno, Shigeru Hagimoto, Yoshiharu Ozawa, Hiroshi Arima and Yutaka Oiso
    • Organizer
      The Endocrine Society’s 93th Annual Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Research-status Report
  • [Presentation] TNFαによる視床下部PTP1Bの発現および活性調節2010

    • Author(s)
      伊藤禎浩、坂野僚一、萩本繁、萩原大輔、小澤由治、森下啓明、有馬寛、大磯ユタカ
    • Organizer
      第37回日本神経内分泌学会学術集会
    • Place of Presentation
      京都大学医学部創立百周年記念施設芝蘭会館、京都府京都市
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFαは視床下部においてレプチンシグナルを阻害するPTP1Bの活性を増強する2010

    • Author(s)
      伊藤禎浩、坂野僚一、萩本繁、小澤由治、有馬寛、大磯ユタカ
    • Organizer
      第31回日本肥満学会
    • Place of Presentation
      前橋テルサ、前橋市
    • Related Report
      2013 Final Research Report
  • [Presentation] Tumor Necrosis Factor-αincreases Protein Tyrosine Phosphatase 1B activity in rat hypothalamic organotypic cultures2010

    • Author(s)
      Yoshihiro Ito, Ryoichi Banno, Yoshiharu Ozawa, Hiroshi Arima and Yutaka Oiso
    • Organizer
      The Endocrine Society 92nd Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] TNFαは視床下部においてレプチンシグナルを阻害するPTP1Bの活性を増強する2010

    • Author(s)
      伊藤禎浩、坂野僚一、萩本繁、小澤由治、有馬寛、大磯ユタカ
    • Organizer
      第53回日本糖尿病学会年次学術集会
    • Place of Presentation
      岡山市デジタルミュージアム、岡山市
    • Related Report
      2013 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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