| Project/Area Number |
23591333
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIYA Kyoji 東京大学, 医学部附属病院, 教授 (00272550)
WATANABE Tsuyoshi 福島県立医科大学, 医学部, 教授 (80158641)
SATOH Hiroaki 福島県立医科大学, 医学部, 准教授 (20323595)
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| Co-Investigator(Renkei-kenkyūsha) |
KURANO Makoto 東京大学, 医学部附属病院, 特任助教 (60621745)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 小胞体ストレス / コレステロール / 肝臓 / 糖代謝 |
|---|
| Research Abstract |
There are three pathways which increase hepatic cholesterol contents. In this study, these 3 pathways have been up-regulated by adenoviral gene transfer. All these pathways increased the hepatic cholesterol contents; however, none did induce the ER stress. On the other hand, all three pathways caused the amelioration of blood glucose level; however, the molecular mechanisms underlying the amelioration of blood glucose were different among the pathways. Both the pharmacological induction and inhibition of ER stress evoked the accumulation of hepatic triglycerides. These results suggest that the association between hepatic ER stress and glucose and lipid metabolism would not be straightforward.
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