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Elucidation of the pathogenic mechanism of hyperuricemia in obesity and metabolic syndrome

Research Project

Project/Area Number 23591340
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionTeikyo University

Principal Investigator

HOSOYAMADA Makoto  帝京大学, 薬学部, 教授 (00291659)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Makiko  東京薬科大学, 薬学部, 助教 (80447557)
ICHIDA Kimiyoshi  東京薬科大学, 薬学部, 教授 (80183169)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords高尿酸血症
Research Abstract

It was studied using a high-fat diet-treated mice and obesity model of ob/ob mice to elucidate mechanism for the development of hyperuricemia in obesity and metabolic syndrome. Among the expression of urate transporters URAT1, GLUT9, ABCG2 in the kidney of these mice, urate reabsorptive transporter URAT1 was significantly increased in the amount of protein expression while the amount of mRNA expression was invariant.
In order to see the changes in plasma uric acid by high-fat diet administration, we conducted the establishment of the method of breeding maintenance of uricase knockout mice which is lost uricase activity like humans, and we also established a strain of uricase-URAT1 double knockout mice.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (11 results) (of which Peer Reviewed: 6 results) Presentation (18 results)

  • [Journal Article] False in vitro and in vivo elevations of uric acid levels in mouse blood.2014

    • Author(s)
      Watanabe T, Tomioka NH, Watanabe S, Tsuchiya M, Hosoyamada M
    • Journal Title

      Nucleosides, Nucleotides and Nucleic Acids

      Volume: 0

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ependymal cells of the mouse brain express urate transporter 1 (URAT1)2013

    • Author(s)
      Tomioka NH, Nakamura M, Doshi M, Deguchi Y, Ichida K, Morisaki T, Hosoyamada M
    • Journal Title

      Fluids Barriers CNS

      Volume: 10(1) Pages: 31-31

    • Related Report
      2013 Final Research Report
  • [Journal Article] Common dys-functional variants in ABCG2 are a major cause of early-onset gout2013

    • Author(s)
      Matsuo H, Ichida K, Takada T, Nakayama A, Nakashima H, Nakamura T, Kawamura Y, Takada Y, Yamamoto K, Inoue H, Oikawa Y, Naito M, Hishida A, Wakai K, Okada C, Shimizu S, Sakiyama M, Chiba T, Ogata H, Niwa K, Hosoyamada M, Mori A, Hamajima N, Suzuki H, Kanai Y, Sakurai Y, Hosoya T, Shimizu T, Shinomiya N
    • Journal Title

      Sci Rep

      Volume: 3 Pages: 2014-2014

    • Related Report
      2013 Final Research Report
  • [Journal Article] Macrophage migration inhibitory factor is a possible candidate for the induction of microalbuminuria in diabetic db/db mice2013

    • Author(s)
      Watanabe T, Tomioka NH, Doshi M, Watanabe S, Tsuchiya M, Hosoyamada M
    • Journal Title

      Biol Pharm Bull

      Volume: 36(5) Pages: 741-747

    • NAID

      130003361408

    • Related Report
      2013 Final Research Report
  • [Journal Article] Ependymal cells of the mouse brain express urate transporter 1 (URAT1)2013

    • Author(s)
      Tomioka NH, Nakamura M, Doshi M, et al
    • Journal Title

      Fluids Barriers CNS

      Volume: 10 Issue: 1 Pages: 31-31

    • DOI

      10.1186/2045-8118-10-31

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Common dysfunctional variants in ABCG2 are a major cause of early-onset gout2013

    • Author(s)
      Matsuo, H. Ichida, K. Takada, T. et al.
    • Journal Title

      Scientific reports

      Volume: 3 Issue: 1 Pages: 2014-2014

    • DOI

      10.1038/srep02014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophage migration inhibitory factor is a possible candidate for the induction of microalbuminuria in diabetic db/db mice.2013

    • Author(s)
      Watanabe T, Tomioka NH, Doshi M, Watanabe S, Tsuchiya M, Hosoyamada M.
    • Journal Title

      Biol Pharm Bull.

      Volume: 36(5) Pages: 741-747

    • NAID

      130003361408

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia2012

    • Author(s)
      Ichida K, Matsuo H, Takada T, Nakayama A, Murakami K, Shimizu T, Yamanashi Y, Kasuga H, Nakashima H, Nakamura T, Takada Y, Kawamura Y, Inoue H, Okada C, Utsumi Y, Ikebuchi Y, Ito K, Nakamura M, Shinohara Y, Hosoyamada M, Sakurai Y, Shinomiya N, Hosoya T, Suzuki H
    • Journal Title

      Nat Commun

      Volume: 3 Pages: 764-770

    • Related Report
      2013 Final Research Report
  • [Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia2012

    • Author(s)
      Kimiyoshi Ichida, Hirotaka Matsuo, Tappei Takada, et al (Hiroshi Suzuki)
    • Journal Title

      Nature Communication

      Volume: 3 Issue: 1 Pages: 1-7

    • DOI

      10.1038/ncomms1756

    • URL

      https://localhost/en/publications/719645f5-4ec4-4f6b-a2a8-f58d7f666857

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice2011

    • Author(s)
      Doshi M, Takiue Y, Saito H, Hosoyamada M
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids

      Volume: 30(12) Pages: 1290-4

    • Related Report
      2013 Final Research Report
  • [Journal Article] The increased protein level of URAT1 was observed in obesity/metabolic syndrome model mice.2011

    • Author(s)
      Doshi M, Takiue Y, Saito H, Hosoyamada M.
    • Journal Title

      Nucleosides Nucleotides Nucleic Acids.

      Volume: 30(12): Pages: 1290-4

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] マウスにおける採血前および採血後偽高尿酸血症2014

    • Author(s)
      渡部多真紀,富岡直子,渡辺茂和,土屋雅勇,細山田真
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Urate transporter 1 (URAT1)は脳室上衣細胞に発現する2014

    • Author(s)
      富岡直子、中村真希子、出口芳春、市田公美、森崎隆幸、細山田真
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス脳内URAT1は脳室上衣細胞脳室側膜に局在する2014

    • Author(s)
      富岡直子、中村真希子、市田公美、森崎隆幸、内田俊也、細山田真
    • Organizer
      第47回日本痛風核酸代謝学会
    • Place of Presentation
      神戸
    • Year and Date
      2014-02-21
    • Related Report
      2013 Final Research Report
  • [Presentation] マウスの採血前および採血後偽高尿酸血症2013

    • Author(s)
      渡部多真紀,富岡(原)直子,道志勝,渡辺茂和,細山田真,土屋雅勇
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-26
    • Related Report
      2013 Final Research Report
  • [Presentation] FALSE INCREASE OF URIC ACID LEVEL OF MOUSE BLOOD IN VITRO2013

    • Author(s)
      Hosoyamada-M, Watanabe-T, Tomioka-NH, Doshi-M, Watanabe-S, Tsuchiya-M
    • Organizer
      15th International Symposium on Purine and Pyrimidine Metabolism in Man
    • Place of Presentation
      Madrid, Spain
    • Year and Date
      2013-06-10
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 家族性若年性高尿酸血症性腎症1型モデルマウス腎臓では5'-レダクターゼ2発現が増加する2013

    • Author(s)
      細山田真、富岡直子、道志勝
    • Organizer
      第56回日本腎臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-11
    • Related Report
      2013 Final Research Report
  • [Presentation] ヘパリン加マウス血液のα受容体刺激による尿酸生成2013

    • Author(s)
      細山田真、渡部多真紀、富岡直子、道志勝、土屋雅勇
    • Organizer
      第86回日本薬理学会
    • Place of Presentation
      福岡
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス血清尿酸値のインビトロ上昇2013

    • Author(s)
      渡部多真紀、富岡直子、中村真希子、道志勝、金子希代子、内田俊也、藤森新、市田公美、土屋雅勇、細山田真
    • Organizer
      第46回日本痛風・核酸代謝学会総会
    • Place of Presentation
      東京
    • Year and Date
      2013-02-14
    • Related Report
      2013 Final Research Report
  • [Presentation] マウス血清尿酸値のインビトロ上昇2013

    • Author(s)
      渡部 多真紀、富岡 直子、中村 真希子、道志 勝、金子 希代子、内田 俊也、藤森 新、市田 公美、土屋 雅勇、細山田 真
    • Organizer
      第46回 日本痛風・核酸代謝学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] ヘパリン加マウス血液のα受容体刺激による尿酸生成2013

    • Author(s)
      細山田 真、渡部 多真紀、富岡 直子、道志 勝、土屋 雅勇
    • Organizer
      第86回 日本薬理学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Research-status Report
  • [Presentation] Fluoresceinを用いた尿酸トランスポーター機能評価法の開発2012

    • Author(s)
      中村真希子、荒川伸介、松尾広大、細山田真、安西尚彦、市田公美
    • Organizer
      第45回日本痛風・核酸代謝学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2012-02-17
    • Related Report
      2013 Final Research Report 2011 Research-status Report
  • [Presentation] ウリカーゼノックアウトマウスにおけるアロプリノール投与の影響2012

    • Author(s)
      細山田真、金子希代子、内田俊也、藤森新
    • Organizer
      第45回日本痛風・核酸代謝学会総会
    • Place of Presentation
      奈良
    • Year and Date
      2012-02-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 家族性若年性高尿酸血症性腎症1型モデルマウス腎臓では5’-レダクターゼ2発現が増加する

    • Author(s)
      細山田 真、富岡 直子、道志 勝
    • Organizer
      第56回日本腎臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウスの採血前および採血後偽高尿酸血症

    • Author(s)
      渡部多真紀,富岡(原)直子,道志 勝,渡辺茂和,細山田真,土屋雅勇
    • Organizer
      第57回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス脳内URAT1は脳室上衣細胞脳室側膜に局在する

    • Author(s)
      富岡 直子、中村 真希子、市田 公美、森崎 隆幸、内田 俊也、細山田 真
    • Organizer
      第47回日本痛風核酸代謝学会
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
  • [Presentation] Urate transporter 1 (URAT1) は脳室上衣細胞に発現する

    • Author(s)
      富岡 直子、中村 真希子、出口 芳春、市田 公美、森崎 隆幸、細山田 真
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウスにおける採血前および採血後偽高尿酸血症

    • Author(s)
      渡部 多真紀,富岡 直子,渡辺 茂和,土屋 雅勇,細山田 真
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Related Report
      2013 Annual Research Report
  • [Presentation] ウリカーゼノックアウトマウスにおけるアロプリノール投与の影響

    • Author(s)
      細山田 真、金子 希代子、内田 俊也、藤森 新
    • Organizer
      第45回日本痛風・核酸代謝学会総会
    • Place of Presentation
      奈良
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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