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Investigation for the nuculear receptor functions to cure clonic inflammatory syndrome

Research Project

Project/Area Number 23591347
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionGunma University

Principal Investigator

SATO Takashi  群馬大学, 生体調節研究所, 准教授 (70344934)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords慢性炎症 / アンドロゲン / 核内受容体 / KOマウス / ノックアウトマウス / ステロイドホルモン / 小胞体ストレス
Research Abstract

In the present study, we investigated the mechanisms of hormonal action to regulate inflammation in metabolic organs which cause metabolic diseases. The research, we investigated the effect of the hormone on cell inflamed at the same time to analyzed the abnormality in mice lacking the receptor proteins essential for action of the hormone. As a result of research, it has been found possibility that androgen action repress inflammation via complex cellular process. And we are going to study the relationship between the onset of metabolic diseases and hormone secretion decline of older men.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2014 2013 2012 2011 Other

All Journal Article (14 results) (of which Peer Reviewed: 8 results,  Open Access: 2 results) Presentation (12 results) Remarks (1 results)

  • [Journal Article] Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis2014

    • Author(s)
      Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A
    • Journal Title

      J Cell Sci

      Volume: 127 Pages: 422-431

    • Related Report
      2013 Final Research Report
  • [Journal Article] Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice.2014

    • Author(s)
      Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T.
    • Journal Title

      Diabetologia

      Volume: 57 Issue: 4 Pages: 819-831

    • DOI

      10.1007/s00125-013-3140-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development.2014

    • Author(s)
      Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T.
    • Journal Title

      J Neurosci.

      Volume: 34 Issue: 4 Pages: 1370-1379

    • DOI

      10.1523/jneurosci.2440-13.2014

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypothalamic Sirt1 prevents age asso- -ciated weight gain by improving leptin sensitivity in mice2013

    • Author(s)
      Sasaki T, Kikuchi O, Shimpuku M, Susanti V-Y, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee Y-S, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M and Kitamura T
    • Journal Title

      Diabetologia

      Volume: 57 Pages: 819-831

    • Related Report
      2013 Final Research Report
  • [Journal Article] Dysregulation of ovarian follicular development in female rat : LH decreases FSH sensitivity during preantral-early antral transition2013

    • Author(s)
      Orisaka M, Hattori K, Fukuda S, Mizutani T, Miyamoto K, Sato T, Tsang BK, Kotsuji F, Yoshida Y
    • Journal Title

      Endocrinology

      Volume: 154 Pages: 2870-2880

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi2013

    • Author(s)
      D'Angelo G, Uemura T, Chuang CC, Polishchuk E, Santoro M, Ohvo-Rekilä H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T,Capuani F,Johannes L, Mattjus P, Monti M, Pucci P, Williams RL, Burke JE, Platt FM, Harada A, De Matteis MA
    • Journal Title

      Nature

      Volume: 501 Pages: 116-120

    • Related Report
      2013 Final Research Report
  • [Journal Article] Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi.2013

    • Author(s)
      D'Angelo G, Uemura T, Chuang CC, Polishchuk E, Santoro M, Ohvo-Rekila H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T, Capuani F, Johannes L, Mattjus P, Monti M, Pucci P, Williams RL, Burke JE, Platt FM, Harada A, De Matteis MA.
    • Journal Title

      Nature

      Volume: 501 Issue: 7465 Pages: 116-120

    • DOI

      10.1038/nature12423

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of ovarian follicular development in female rat: LH decreases FSH sensitivity during preantral-early antral transition.2013

    • Author(s)
      Orisaka M, Hattori K, Fukuda S, Mizutani T, Miyamoto K, Sato T, Tsang BK, Kotsuji F, Yoshida Y.
    • Journal Title

      Endocrinology

      Volume: 154 Issue: 8 Pages: 2870-2880

    • DOI

      10.1210/en.2012-2173

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rab8a and Rab8b are essential for multiple apical transport pathways but insufficient for ciliogenesis.2013

    • Author(s)
      Sato T, Iwano T, Kunii M, Matsuda S, Mizoguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A.
    • Journal Title

      J Cell Sci.

      Volume: 15;127(Pt 2) Pages: 422-31

    • DOI

      10.1242/jcs.136903

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamin D receptor in osteoblasts is a negative regulator of bone mass control2013

    • Author(s)
      Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Naka michi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y.
    • Journal Title

      Endocrinology.

      Volume: 154 Issue: 3 Pages: 1008-20

    • DOI

      10.1210/en.2012-1542

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector2012

    • Author(s)
      Hashimoto Y. Muramatsu K. Sato T. Harada A
    • Journal Title

      FASEB J

      Volume: 26 Pages: 4662-4674

    • Related Report
      2013 Final Research Report
  • [Journal Article] Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector.2012

    • Author(s)
      Hashimoto Y
    • Journal Title

      FASEB Journal

      Volume: 26 Issue: 11 Pages: 4662-4674

    • DOI

      10.1096/fj.12-207530

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] The role of VAMP7/TI-VAMP in cell poiarity and lysosomal exocytosis in vivo2011

    • Author(s)
      Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A
    • Journal Title

      Traffic

      Volume: 12 Pages: 1383-93

    • Related Report
      2013 Final Research Report
  • [Journal Article] The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo.2011

    • Author(s)
      Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Sato K, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A.
    • Journal Title

      Traffic

      Volume: 12 Issue: 10 Pages: 1383-1393

    • DOI

      10.1111/j.1600-0854.2011.01247.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 男性ホルモンは小胞体ストレス制御により肥満を抑制する2012

    • Author(s)
      佐藤 隆史
    • Organizer
      日本農芸化学会2012年度大会
    • Place of Presentation
      京都女子大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 男性ホルモンによる代謝機能制御機構の解析2011

    • Author(s)
      佐藤隆史
    • Organizer
      第84回日本内分泌学会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2011-04-22
    • Related Report
      2013 Final Research Report
  • [Presentation] 男性ホルモンによる代謝機能制御機構の解析2011

    • Author(s)
      佐藤隆史
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学(震災で非開催)
    • Year and Date
      2011-03-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 男性ホルモンによる代謝制御機構の解析2011

    • Author(s)
      佐藤 隆史
    • Organizer
      第84回 日本内分泌学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] 雄性個体の代謝機能制御におけるアンドロゲン作用機序2011

    • Author(s)
      佐藤 隆史
    • Organizer
      テストステロン研究会
    • Place of Presentation
      福岡大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 小胞体ストレス制御を介した新規アンドロゲン作用メカニズムの解析2011

    • Author(s)
      佐藤 隆史
    • Organizer
      第34回 日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Research-status Report
  • [Presentation] 男性ホルモンによる代謝機能制御機構の解析

    • Author(s)
      佐藤隆史
    • Organizer
      北関東医学会
    • Place of Presentation
      群馬大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 雄性個体の代謝機能制御におけるアンドロゲン作用機序

    • Author(s)
      佐藤隆史
    • Organizer
      テストステロン研究会
    • Place of Presentation
      福岡大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 小胞体ストレス制御を介した新規アンドロゲン作用メカニズムの解析

    • Author(s)
      佐藤隆史
    • Organizer
      第34回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 男性ホルモンは小胞体ストレス制御により肥満を抑制する

    • Author(s)
      佐藤隆史
    • Organizer
      日本農芸化学会
    • Place of Presentation
      京都女子大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 男性ホルモンは小胞体ストレス制御により肥満を抑制する

    • Author(s)
      佐藤隆史
    • Organizer
      第85回日本内分泌学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] アンドロゲン受容体欠損マウスの肥満は視床下部の小胞体ストレス制御破綻に起因する

    • Author(s)
      佐藤隆史
    • Organizer
      日本内分泌学会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2012 Research-status Report
  • [Remarks] 群馬大学 生体調節研究所 生体情報部門 核内情報制御分野

    • URL

      http://kakunai.dept.showa.gunma-u.ac.jp/kitagawa/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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