Investigation for the nuculear receptor functions to cure clonic inflammatory syndrome

• Project/Area Number: 23591347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Endocrinology
• Research Institution: Gunma University
• Principal Investigator: SATO Takashi 群馬大学, 生体調節研究所, 准教授 (70344934)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 慢性炎症 / アンドロゲン / 核内受容体 / KOマウス / ノックアウトマウス / ステロイドホルモン / 小胞体ストレス

Research Abstract

In the present study, we investigated the mechanisms of hormonal action to regulate inflammation in metabolic organs which cause metabolic diseases. The research, we investigated the effect of the hormone on cell inflamed at the same time to analyzed the abnormality in mice lacking the receptor proteins essential for action of the hormone. As a result of research, it has been found possibility that androgen action repress inflammation via complex cellular process. And we are going to study the relationship between the onset of metabolic diseases and hormone secretion decline of older men.

Research Products

• [Journal Article] Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis (2014)
  • Author(s): Sato T, Iwano T, Kunii M, Matsuda S, Mizuguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A
  • Journal Title: J Cell Sci Volume: 127 Pages: 422-431
• [Journal Article] Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. (2014)
  • Author(s): Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T.
  • Journal Title: Diabetologia Volume: 57 Issue: 4 Pages: 819-831
  • DOI: 10.1007/s00125-013-3140-5
  • Peer Reviewed / Open Access
• [Journal Article] CLAC-P/collagen type XXV is required for the intramuscular innervation of motoneurons during neuromuscular development. (2014)
  • Author(s): Tanaka T, Wakabayashi T, Oizumi H, Nishio S, Sato T, Harada A, Fujii D, Matsuo Y, Hashimoto T, Iwatsubo T.
  • Journal Title: J Neurosci. Volume: 34 Issue: 4 Pages: 1370-1379
  • DOI: 10.1523/jneurosci.2440-13.2014
  • Peer Reviewed
• [Journal Article] Hypothalamic Sirt1 prevents age asso- -ciated weight gain by improving leptin sensitivity in mice (2013)
  • Author(s): Sasaki T, Kikuchi O, Shimpuku M, Susanti V-Y, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee Y-S, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M and Kitamura T
  • Journal Title: Diabetologia Volume: 57 Pages: 819-831
• [Journal Article] Dysregulation of ovarian follicular development in female rat : LH decreases FSH sensitivity during preantral-early antral transition (2013)
  • Author(s): Orisaka M, Hattori K, Fukuda S, Mizutani T, Miyamoto K, Sato T, Tsang BK, Kotsuji F, Yoshida Y
  • Journal Title: Endocrinology Volume: 154 Pages: 2870-2880
• [Journal Article] Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi (2013)
  • Author(s): D'Angelo G, Uemura T, Chuang CC, Polishchuk E, Santoro M, Ohvo-Rekilä H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T,Capuani F,Johannes L, Mattjus P, Monti M, Pucci P, Williams RL, Burke JE, Platt FM, Harada A, De Matteis MA
  • Journal Title: Nature Volume: 501 Pages: 116-120
• [Journal Article] Vesicular and non-vesicular transport feed distinct glycosylation pathways in the Golgi. (2013)
  • Author(s): D'Angelo G, Uemura T, Chuang CC, Polishchuk E, Santoro M, Ohvo-Rekila H, Sato T, Di Tullio G, Varriale A, D'Auria S, Daniele T, Capuani F, Johannes L, Mattjus P, Monti M, Pucci P, Williams RL, Burke JE, Platt FM, Harada A, De Matteis MA.
  • Journal Title: Nature Volume: 501 Issue: 7465 Pages: 116-120
  • DOI: 10.1038/nature12423
  • Peer Reviewed
• [Journal Article] Dysregulation of ovarian follicular development in female rat: LH decreases FSH sensitivity during preantral-early antral transition. (2013)
  • Author(s): Orisaka M, Hattori K, Fukuda S, Mizutani T, Miyamoto K, Sato T, Tsang BK, Kotsuji F, Yoshida Y.
  • Journal Title: Endocrinology Volume: 154 Issue: 8 Pages: 2870-2880
  • DOI: 10.1210/en.2012-2173
  • Peer Reviewed
• [Journal Article] Rab8a and Rab8b are essential for multiple apical transport pathways but insufficient for ciliogenesis. (2013)
  • Author(s): Sato T, Iwano T, Kunii M, Matsuda S, Mizoguchi R, Jung Y, Hagiwara H, Yoshihara Y, Yuzaki M, Harada R, Harada A.
  • Journal Title: J Cell Sci. Volume: 15;127(Pt 2) Pages: 422-31
  • DOI: 10.1242/jcs.136903
  • Peer Reviewed / Open Access
• [Journal Article] Vitamin D receptor in osteoblasts is a negative regulator of bone mass control (2013)
  • Author(s): Yamamoto Y, Yoshizawa T, Fukuda T, Shirode-Fukuda Y, Yu T, Sekine K, Sato T, Kawano H, Aihara K, Naka michi Y, Watanabe T, Shindo M, Inoue K, Inoue E, Tsuji N, Hoshino M, Karsenty G, Metzger D, Chambon P, Kato S, Imai Y.
  • Journal Title: Endocrinology. Volume: 154 Issue: 3 Pages: 1008-20
  • DOI: 10.1210/en.2012-1542
  • Peer Reviewed
• [Journal Article] Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector (2012)
  • Author(s): Hashimoto Y. Muramatsu K. Sato T. Harada A
  • Journal Title: FASEB J Volume: 26 Pages: 4662-4674
• [Journal Article] Uncovering genes required for neuronal morphology by morphology-based gene trap screening with a revertible retrovirus vector. (2012)
  • Author(s): Hashimoto Y
  • Journal Title: FASEB Journal Volume: 26 Issue: 11 Pages: 4662-4674
  • DOI: 10.1096/fj.12-207530
  • Peer Reviewed
• [Journal Article] The role of VAMP7/TI-VAMP in cell poiarity and lysosomal exocytosis in vivo (2011)
  • Author(s): Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A
  • Journal Title: Traffic Volume: 12 Pages: 1383-93
• [Journal Article] The role of VAMP7/TI-VAMP in cell polarity and lysosomal exocytosis in vivo. (2011)
  • Author(s): Sato M, Yoshimura S, Hirai R, Goto A, Kunii M, Atik N, Sato T, Sato K, Harada R, Shimada J, Hatabu T, Yorifuji H, Harada A.
  • Journal Title: Traffic Volume: 12 Issue: 10 Pages: 1383-1393
  • DOI: 10.1111/j.1600-0854.2011.01247.x
  • Peer Reviewed
• [Presentation] 男性ホルモンは小胞体ストレス制御により肥満を抑制する (2012)
  • Author(s): 佐藤 隆史
  • Organizer: 日本農芸化学会2012年度大会
  • Place of Presentation: 京都女子大学
• [Presentation] 男性ホルモンによる代謝機能制御機構の解析 (2011)
  • Author(s): 佐藤隆史
  • Organizer: 第84回日本内分泌学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2011-04-22
• [Presentation] 男性ホルモンによる代謝機能制御機構の解析 (2011)
  • Author(s): 佐藤隆史
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学(震災で非開催)
  • Year and Date: 2011-03-27
• [Presentation] 男性ホルモンによる代謝制御機構の解析 (2011)
  • Author(s): 佐藤 隆史
  • Organizer: 第84回 日本内分泌学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] 雄性個体の代謝機能制御におけるアンドロゲン作用機序 (2011)
  • Author(s): 佐藤 隆史
  • Organizer: テストステロン研究会
  • Place of Presentation: 福岡大学
• [Presentation] 小胞体ストレス制御を介した新規アンドロゲン作用メカニズムの解析 (2011)
  • Author(s): 佐藤 隆史
  • Organizer: 第34回 日本分子生物学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 男性ホルモンによる代謝機能制御機構の解析
  • Author(s): 佐藤隆史
  • Organizer: 北関東医学会
  • Place of Presentation: 群馬大学
• [Presentation] 雄性個体の代謝機能制御におけるアンドロゲン作用機序
  • Author(s): 佐藤隆史
  • Organizer: テストステロン研究会
  • Place of Presentation: 福岡大学
• [Presentation] 小胞体ストレス制御を介した新規アンドロゲン作用メカニズムの解析
  • Author(s): 佐藤隆史
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] 男性ホルモンは小胞体ストレス制御により肥満を抑制する
  • Author(s): 佐藤隆史
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
• [Presentation] 男性ホルモンは小胞体ストレス制御により肥満を抑制する
  • Author(s): 佐藤隆史
  • Organizer: 第85回日本内分泌学会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] アンドロゲン受容体欠損マウスの肥満は視床下部の小胞体ストレス制御破綻に起因する
  • Author(s): 佐藤隆史
  • Organizer: 日本内分泌学会
  • Place of Presentation: 名古屋国際会議場
• [Remarks] 群馬大学 生体調節研究所 生体情報部門 核内情報制御分野
  • URL: http://kakunai.dept.showa.gunma-u.ac.jp/kitagawa/