| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
Body weight and white adipose tissues weight were significantly less in AgRP neuron-specific knockout of glucocorticoid receptor mice compared to wild-type mice when they were subjected to a high fat diet. The expression levels of UCP1 mRNA in the brown adipose tissues were significantly higher in the knockout mice than in wild-type mice. On the other hand, thapsigargin, an ER stressor, increased phosphorylation of p65 and attenuated expression of AgRP and NPY mRNA stimulated by dexamethasone in hypothalamic cultures of wild-type mice. Furthermore, it is demonstrated that inhibitor of p65 cancelled the effects of thapsigargin on the AgRP and NPY mRNA expression stimulated by dexamethasone.
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