Clinical application and the identification of novel autoantibodies in hypopituitarism
| Project/Area Number |
23591354
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Kobe University |
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Principal Investigator |
IGUCHI GENZO 神戸大学, 医学部附属病院, 助教 (60346260)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Yutaka 神戸大学, 医学(系)研究科(研究院), 講師 (70301281)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 下垂体機能低下症 / 抗Pit-1抗体 / 抗Pit-1抗体症候群 |
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| Research Abstract |
Anti-pituitary-specific transcriptional factor 1 (PIT-1) antibody syndrome is characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with circulating anti-PIT-1 antibodies. To elucidate the involvement of antibody- or cell-mediated immunity in anti-PIT-1 antibody syndrome. Enzyme-linked immunospot (ELISpot) assay revealed the presence of cytotoxic T lymphocytes (CTLs) that specifically reacted to the recombinant PIT-1 protein in the patient's peripheral lymphocytes. This result suggest that the anti-PIT-1 antibody is not a cause but a marker of anti-PIT-1 antibody syndrome, in which CTLs play a pivotal role in the pathogenesis.The prevalence and clinical characteristics of IgG4-related hypophysitis have been clarified.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome2014
Author(s)
Bando H, Iguchi G, Fukuoka H, Yamamoto M, Takeno RH, Okimura Y, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Tojo K, and Takahashi Y
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Journal Title
J Clin Endocrinol Metab
Volume: (2014/6/5 accepted)
Related Report
Peer Reviewed
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[Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetylesterase (<i>SIAE</i>) gene is associated with anti–PIT-1 antibody syndrome2014
Author(s)
Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
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Journal Title
Endocrine Journal
Volume: 61
Issue: 6
Pages: 641-644
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed / Open Access
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[Journal Article] The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature.2013
Author(s)
Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y.
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Journal Title
Eur J Endocrinol.
Volume: 170
Issue: 2
Pages: 161-172
DOI
Related Report
Peer Reviewed
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[Journal Article] A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.2013
Author(s)
Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y.
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Journal Title
Mol Cell Endocrinol.
Volume: 376
Issue: 1-2
Pages: 93-98
DOI
Related Report
Peer Reviewed
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[Presentation] 頭部外傷後に発症し失神発作をきたしたACTH単独欠損症の一例2014
Author(s)
西澤衡,井口元三,坂東弘教,隅田健太郎,山本雅昭,高橋路子,福岡秀規,廣田勇士,坂口一彦,小川渉,高橋裕
Organizer
第23回臨床内分泌代謝UPDATE
Place of Presentation
名古屋
Year and Date
2014-01-24
Related Report
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[Presentation] 頭部外傷後に発症し失神発作をきたしたACTH単独欠損症の一例2014
Author(s)
西澤 衡,井口 元三,坂東 弘教,隅田 健太郎,山本 雅昭,高橋路子,福岡 秀規,廣田勇士,坂口一彦,小川渉,高橋裕
Organizer
第23回 臨床内分泌代謝UPDATE
Place of Presentation
名古屋
Related Report
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[Presentation] IgG4陽性細胞が認められた肉芽腫性下垂体炎の1例2013
Author(s)
坂東弘教,井口元三,福岡秀規,隅田健太郎,山本雅昭,西澤衡,高橋路子,谷口理章,甲村英二,清野進,高橋裕
Organizer
第86回日本内分泌学会学術総会
Place of Presentation
仙台
Year and Date
2013-04-27
Related Report
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[Presentation] IgG4陽性細胞が認められた肉芽腫性下垂体炎の1例2013
Author(s)
坂東弘教,井口元三,福岡秀規,隅田健太郎,山本雅昭,西澤衡,高橋路子,谷口理章,甲村英二,清野進,高橋裕
Organizer
第86回 日本内分泌学会学術総会
Place of Presentation
仙台
Related Report
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