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Clinical application and the identification of novel autoantibodies in hypopituitarism

Research Project

Project/Area Number 23591354
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Endocrinology
Research InstitutionKobe University

Principal Investigator

IGUCHI GENZO  神戸大学, 医学部附属病院, 助教 (60346260)

Co-Investigator(Kenkyū-buntansha) TAKAHASHI Yutaka  神戸大学, 医学(系)研究科(研究院), 講師 (70301281)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords下垂体機能低下症 / 抗Pit-1抗体 / 抗Pit-1抗体症候群
Research Abstract

Anti-pituitary-specific transcriptional factor 1 (PIT-1) antibody syndrome is characterized by acquired growth hormone (GH), prolactin (PRL), and thyroid-stimulating hormone (TSH) deficiencies associated with circulating anti-PIT-1 antibodies. To elucidate the involvement of antibody- or cell-mediated immunity in anti-PIT-1 antibody syndrome. Enzyme-linked immunospot (ELISpot) assay revealed the presence of cytotoxic T lymphocytes (CTLs) that specifically reacted to the recombinant PIT-1 protein in the patient's peripheral lymphocytes. This result suggest that the anti-PIT-1 antibody is not a cause but a marker of anti-PIT-1 antibody syndrome, in which CTLs play a pivotal role in the pathogenesis.The prevalence and clinical characteristics of IgG4-related hypophysitis have been clarified.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (52 results)

All 2014 2013 2012 2011

All Journal Article (15 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (33 results) (of which Invited: 17 results) Book (4 results)

  • [Journal Article] Involvement of PIT-1-reactive cytotoxic T lymphocytes in anti-PIT-1 antibody syndrome2014

    • Author(s)
      Bando H, Iguchi G, Fukuoka H, Yamamoto M, Takeno RH, Okimura Y, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Tojo K, and Takahashi Y
    • Journal Title

      J Clin Endocrinol Metab

      Volume: (2014/6/5 accepted)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A missense single-nucleotide polymorphism in the sialic acid acetylesterase (<i>SIAE</i>) gene is associated with anti&ndash;PIT-1 antibody syndrome2014

    • Author(s)
      Yamamoto M, Iguchi G, Bando H, Fukuoka H, Suda K, Takahashi M, Nishizawa H, Matsumoto R, Tojo K, Mokubo A, Ogata T, Takahashi Y
    • Journal Title

      Endocrine Journal

      Volume: 61 Issue: 6 Pages: 641-644

    • DOI

      10.1507/endocrj.EJ13-0539

    • NAID

      130004770453

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SIRT1 regulates adaptive response of the growth hormone--insulin-like growth factor-I axis under fasting conditions in liver.2013

    • Author(s)
      Yamamoto M, Iguchi G, Fukuoka H, Suda K, Bando H, Takahashi M, Nishizawa H, Seino S, Takahashi Y.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 110 Issue: 37 Pages: 14948-14953

    • DOI

      10.1073/pnas.1220606110

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The prevalence of IgG4-related hypophysitis in 170 consecutive patients with hypopituitarism and/or central diabetes insipidus and review of the literature.2013

    • Author(s)
      Bando H, Iguchi G, Fukuoka H, Taniguchi M, Yamamoto M, Matsumoto R, Suda K, Nishizawa H, Takahashi M, Kohmura E, Takahashi Y.
    • Journal Title

      Eur J Endocrinol.

      Volume: 170 Issue: 2 Pages: 161-172

    • DOI

      10.1530/eje-13-0642

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A PROP1-binding factor, AES cloned by yeast two-hybrid assay represses PROP1-induced Pit-1 gene expression.2013

    • Author(s)
      Sugiyama Y, Ikeshita N, Shibahara H, Yamamoto D, Kawagishi M, Iguchi G, Iida K, Takahashi Y, Kaji H, Chihara K, Okimura Y.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 376 Issue: 1-2 Pages: 93-98

    • DOI

      10.1016/j.mce.2013.05.022

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗PIT-1抗体症候群の病態と自己免疫性下垂体疾患における位置付け2013

    • Author(s)
      井口元三,坂東弘教,山本雅昭,高橋裕
    • Journal Title

      ホルモンと臨床

      Volume: 60巻 Pages: 33-39

    • Related Report
      2013 Final Research Report
  • [Journal Article] 抗PIT-1抗体症候群の病態と自己免疫性下垂体疾患における位置付け2013

    • Author(s)
      井口元三,坂東弘教,山本雅昭,高橋 裕
    • Journal Title

      ホルモンと臨床

      Volume: 60 Pages: 33-39

    • Related Report
      2013 Annual Research Report
  • [Journal Article] 小児発症下垂体機能低下症における抗PIT-1抗体症候群の検索2012

    • Author(s)
      井口元三
    • Journal Title

      成長科学協会研究年報

      Volume: 35巻 Pages: 93-95

    • Related Report
      2013 Final Research Report
  • [Journal Article] 【知っておきたい内科症候群】内分泌《複数の臓器に影響を及ぼす症候群》抗PIT-1抗体症候群2012

    • Author(s)
      高橋裕,井口元三
    • Journal Title

      内科

      Volume: 109巻 Pages: 1333-1334

    • Related Report
      2013 Final Research Report
  • [Journal Article] 下垂体機能低下症を呈する新たな疾患概念「抗PIT-1抗体症候群」2012

    • Author(s)
      高橋裕,山本雅昭,井口元三
    • Journal Title

      BIO Clinica

      Volume: 27巻 Pages: 1185-1188

    • Related Report
      2013 Final Research Report
  • [Journal Article] 下垂体機能低下症を呈する新たな疾患概念「抗PIT-1抗体症候群」2012

    • Author(s)
      高橋 裕, 山本 雅昭, 井口 元三
    • Journal Title

      BIO Clinica

      Volume: 27 Pages: 1185-1188

    • Related Report
      2012 Research-status Report
  • [Journal Article] 【知っておきたい内科症候群】 内分泌《複数の臓器に影響を及ぼす症候群》 抗PIT-1抗体症候群2012

    • Author(s)
      高橋 裕, 井口 元三
    • Journal Title

      内科

      Volume: 109 Pages: 1333-1334

    • Related Report
      2012 Research-status Report
  • [Journal Article] 小児発症下垂体機能低下症における抗PIT-1抗体症候群の検索2012

    • Author(s)
      井口 元三
    • Journal Title

      成長科学協会研究年報

      Volume: 35 Pages: 93-95

    • Related Report
      2012 Research-status Report
  • [Journal Article] 抗PIT-1抗体による下垂体前葉ホルモン複合分泌不全症2011

    • Author(s)
      井口元三、山本雅昭、高橋裕
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 33巻 Pages: 240-246

    • NAID

      40019036626

    • Related Report
      2013 Final Research Report
  • [Journal Article] 抗PIT-1抗体による下垂体前葉ホルモン複合分泌不全症2011

    • Author(s)
      井口元三, 山本雅昭, 高橋裕
    • Journal Title

      内分泌・糖尿病・代謝内科

      Volume: 33 Pages: 240-246

    • NAID

      40019036626

    • Related Report
      2011 Research-status Report
  • [Presentation] 頭部外傷後に発症し失神発作をきたしたACTH単独欠損症の一例2014

    • Author(s)
      西澤衡,井口元三,坂東弘教,隅田健太郎,山本雅昭,高橋路子,福岡秀規,廣田勇士,坂口一彦,小川渉,高橋裕
    • Organizer
      第23回臨床内分泌代謝UPDATE
    • Place of Presentation
      名古屋
    • Year and Date
      2014-01-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 下垂体機能低下症、中枢性尿崩症におけるIgG4関連下垂体炎の頻度2014

    • Author(s)
      坂東弘教,井口元三,福岡秀規,隅田健太郎,西澤衡,高橋路子,谷口理章,甲村英二,高橋裕
    • Organizer
      第23回臨床内分泌代謝UPDATE
    • Place of Presentation
      名古屋
    • Year and Date
      2014-01-24
    • Related Report
      2013 Final Research Report
  • [Presentation] 頭部外傷後に発症し失神発作をきたしたACTH単独欠損症の一例2014

    • Author(s)
      西澤 衡,井口 元三,坂東 弘教,隅田 健太郎,山本 雅昭,高橋路子,福岡 秀規,廣田勇士,坂口一彦,小川渉,高橋裕
    • Organizer
      第23回 臨床内分泌代謝UPDATE
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下垂体機能低下症、中枢性尿崩症におけるIgG4関連下垂体炎の頻度2014

    • Author(s)
      坂東弘教,井口元三,福岡秀規,隅田健太郎,西澤衡,高橋路子,谷口理章,甲村英二,高橋裕
    • Organizer
      第23回 臨床内分泌代謝UPDATE
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下垂体機能低下症を呈する新しい疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第33回千駄木内分泌懇話会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-31
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態NAFLD/NASH2013

    • Author(s)
      高橋裕
    • Organizer
      Endocrinology Forum in Supporo
    • Place of Presentation
      札幌
    • Year and Date
      2013-09-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 下垂体機能低下症を呈する新たな疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第46回間脳下垂体疾患研究会
    • Place of Presentation
      京都
    • Year and Date
      2013-08-31
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 下垂体機能低下症を呈する新たな疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      AGHD Advisory Board Meeting
    • Place of Presentation
      大阪
    • Year and Date
      2013-07-09
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第4回西神戸内分泌糖尿病オープンカンファレンス
    • Place of Presentation
      神戸
    • Year and Date
      2013-06-29
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第34回東京成長ホルモン、成長因子セミナー
    • Place of Presentation
      東京
    • Year and Date
      2013-06-28
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第1回成人GH分泌不全症セミナー
    • Place of Presentation
      鹿児島
    • Year and Date
      2013-06-04
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第77回宮城内分泌研究会
    • Place of Presentation
      仙台
    • Year and Date
      2013-05-29
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] IgG4陽性細胞が認められた肉芽腫性下垂体炎の1例2013

    • Author(s)
      坂東弘教,井口元三,福岡秀規,隅田健太郎,山本雅昭,西澤衡,高橋路子,谷口理章,甲村英二,清野進,高橋裕
    • Organizer
      第86回日本内分泌学会学術総会
    • Place of Presentation
      仙台
    • Year and Date
      2013-04-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋裕
    • Organizer
      第1回脳と生活習慣病セミナー
    • Place of Presentation
      出雲
    • Year and Date
      2013-04-18
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Novel mechanism leading to hypopituitarism、The 9th Joint Meeting of Pediatric Endocrinology2013

    • Author(s)
      Takahashi Y
    • Organizer
      ESPE, PES, APEG,ASPAE, JSPE, SLEP
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Final Research Report
  • [Presentation] The pathophysiological analysis of novel"anti-PIT-1 antibody syndrome"2013

    • Author(s)
      Genzo Iguchi, Hironori Bando, Masaaki Yamamoto, Ryoko Takeno, Kentaro Suda, Michiko Takahashi, Hitoshi Nishizawa, Hidenori Fukuoka and Yutaka Takahashi
    • Organizer
      Endo 2013 The 95th Annual Meeting & Expo
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第1回 脳と生活習慣病セミナー
    • Place of Presentation
      出雲
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第1回 成人GH分泌不全症セミナー
    • Place of Presentation
      鹿児島
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 下垂体機能低下症を呈する新しい疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第33回 千駄木内分泌懇話会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第34回 東京成長ホルモン、成長因子セミナー
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 下垂体機能低下症を呈する新たな疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第46回 間脳下垂体疾患研究会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第4回 西神戸内分泌糖尿病オープンカンファレンス
    • Place of Presentation
      神戸
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 成人GH分泌不全症の新たな病態と疾患概念2013

    • Author(s)
      高橋 裕
    • Organizer
      第77回 宮城内分泌研究会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] IgG4陽性細胞が認められた肉芽腫性下垂体炎の1例2013

    • Author(s)
      坂東弘教,井口元三,福岡秀規,隅田健太郎,山本雅昭,西澤衡,高橋路子,谷口理章,甲村英二,清野進,高橋裕
    • Organizer
      第86回 日本内分泌学会学術総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 成人GH分泌不全症の新たな病態 NAFLD/NASH2013

    • Author(s)
      高橋 裕
    • Organizer
      Endocrinology Forum in Supporo
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Novel mechanism leading to hypopituitarism2013

    • Author(s)
      Takahashi Y
    • Organizer
      The 9th Joint Meeting of Pediatric Endocrinology, ESPE, PES, APEG, ASPAE, JSPE, SLEP
    • Place of Presentation
      Milan, Italy
    • Related Report
      2013 Annual Research Report
  • [Presentation] The pathophysiological analysis of novel “anti-PIT-1 antibody syndrome”2013

    • Author(s)
      Genzo Iguchi, Hironori Bando, Masaaki Yamamoto, Ryoko Takeno, Kentaro Suda, Michiko Takahashi, Hitoshi Nishizawa, Hidenori Fukuoka and Yutaka Takahashi
    • Organizer
      Endo 2013 The 95th Annual Meeting & Expo
    • Place of Presentation
      San Francisco,USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 下垂体特異的転写因子に対する自己抗体の意義の解析2012

    • Author(s)
      山本雅昭,井口元三,高橋路子,西沢衡,隅田健太郎,高木優樹,長谷川奉延,清野進,高橋裕
    • Organizer
      第21回臨床内分泌代謝Update
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2012-01-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 下垂体と自己免疫抗PIT-1抗体症候群その後の展開2012

    • Author(s)
      高橋裕,坂東弘教,山本雅昭,井口元三
    • Organizer
      第39回日本神経内分泌学会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4関連下垂体炎5例の臨床的検討2012

    • Author(s)
      坂東弘教,井口元三,福岡秀規,隅田健太郎,山本雅昭,西澤衡,高橋路子,清野進,高橋裕
    • Organizer
      第22回臨床内分泌Update
    • Place of Presentation
      大宮ソニックシティ(優秀ポスター賞受賞)
    • Related Report
      2013 Final Research Report
  • [Presentation] IgG4関連下垂体炎5例の臨床的検討(優秀ポスター賞受賞)2012

    • Author(s)
      坂東 弘教, 井口 元三, 福岡 秀規, 隅田 健太郎, 山本 雅昭, 西澤 衡, 高橋 路子, 清野 進, 高橋 裕
    • Organizer
      第22回臨床内分泌Update
    • Place of Presentation
      大宮ソニックシティ
    • Related Report
      2012 Research-status Report
  • [Presentation] 下垂体と自己免疫 抗PIT-1抗体症候群 その後の展開2012

    • Author(s)
      高橋 裕, 坂東 弘教, 山本 雅昭, 井口 元三
    • Organizer
      第39回日本神経内分泌学会
    • Place of Presentation
      北九州国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] 下垂体特異的転写因子に対する自己抗体の意義の解析2012

    • Author(s)
      山本雅昭, 井口元三, 高橋路子, 西沢衡, 隅田健太郎, 高木優樹, 長谷川奉延, 清野進, 高橋裕
    • Organizer
      第21回臨床内分泌代謝Update
    • Place of Presentation
      アクトシティ浜松
    • Related Report
      2011 Research-status Report
  • [Book] 内科外来基本処方Navi2014

    • Author(s)
      井口元三、高橋裕
    • Publisher
      中外医学社(印刷中)
    • Related Report
      2013 Final Research Report
  • [Book] 内科外来基本処方Navi2014

    • Author(s)
      井口元三、高橋 裕
    • Publisher
      中外医学社
    • Related Report
      2013 Annual Research Report
  • [Book] 下垂体疾患診療マニュアル2012

    • Author(s)
      編集:平田結喜緒、山田正三、成瀬光栄
    • Total Pages
      274
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 下垂体疾患診療マニュアル2012

    • Author(s)
      編集:平田結喜緒、山田正三、成瀬光栄
    • Total Pages
      274
    • Publisher
      診断と治療社
    • Related Report
      2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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