Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Research Abstract |
We investigated the metabolome analysis in leukemic stem/progenitor cells. We found that hexokinase (HK), Phosphofructokinase 1 and 2 (PFK1 and 2) and Pyruvate Kinase (PK) were activated in leukemic stem/progenitor cells. We identified the inhibitors (3-BP, 3PO and Alkinnin) of these kinases as target molecules in leukemic stem/progenitor cells. We showed that these inhibitors inhibited the proliferation of leukemic stem/progenitor cells. We will perform the development of cancer stem cell-specific drugs for leukemia therapy.
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