Development of novel diagnostic and therapeutic biomarkers for hypereosinophilic syndrome
Project/Area Number |
23591389
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Kobe University |
Principal Investigator |
SADA AKIKO 神戸大学, 医学(系)研究科(研究院), 研究員 (90467655)
|
Co-Investigator(Kenkyū-buntansha) |
MATSUI Toshimitsu 神戸大学, 医学研究科, 准教授 (10219371)
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Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 好酸球増多症候群 / チロシンキナーゼ / リン酸化プロテオミクス |
Research Abstract |
Hypereosinophilic syndrome (HES) is a heterogeneous disorders characterized by prolonged eosinophilia with causes unknown. We clarified the clinical differential diagnosis of the patients who participated in this study, and tested for the existence of FIP1L1-PDGFRA chimeric mRNA by RT-PCR. Moreover, we also performed phosphoproteomic studies by mass spectrometry (nanoLC-MS/MS) using the phsphopeptides extracted from peripheral blood of various patients and found the different profiles with which correlate the underlying condition of eosinophilia. This information of phosphopeptides could be useful in the differential diagnosis of HES.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Hes1 upregulation contributes to the development of FIP1L1-PDGRA-positive leukemia in blast crisis2014
Author(s)
Uchida T, Kitaura J, Nakahara F, Togami K, Inoue D, Maehara A, Nishimura K, Kawabata KC, Doki N, Kakihana K, Yoshioka K, Izawa K, Oki T, Sada A, Harada Y, Ohashi K, Katayama Y, Matsui T, Harada H, Kitamura T
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Journal Title
Experimental hematology
Volume: 42
Related Report
Peer Reviewed
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[Journal Article] Posttranscriptional modulation of cytokine production in T cells for the regulation of excessive inflammation by TFL2014
Author(s)
Minagawa K, Wakahashi K, Kawano H, Nishikawa S, Fukui C, Kawano Y, Asada N, Sato M, Sada A, Katayama Y, Matsui T
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Journal Title
J Immunol
Volume: 192(4)
Pages: 1512-24
Related Report
Peer Reviewed
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[Journal Article] Recurrence of abdominal large-vessel vasculitis and development of severe Sweet syndrome after a single cycle of 5-azacytidine in a patient with myelodysplastic syndrome2014
Author(s)
Kawano H, Suzuki T, Ishii S, Wakahashi K, Kawano Y, Sada A, Minagawa K, Ueno D, Yamasaki T, Itoh T, Yokozaki H, Katayama Y
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Journal Title
Eur J Haematol
Volume: 92(4)
Pages: 362-4
Related Report
Peer Reviewed
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[Journal Article] Unusual hepatic involvement with significant fibrosis in adult T cell leukemia2014
Author(s)
Kawano H, Wakahashi K, Ebara S, Ishii S, Suzuki T, Kawano Y, Sada A, Minagawa K, Matsui T, Kawakami F, Hayashi Y, Itoh T, Katayama Y
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Journal Title
Ann Hematol
Volume: 93(5)
Pages: 897-8
Related Report
Peer Reviewed
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[Journal Article] Eosinophilia and bone lesion as clinical manifestations of aggressive systemic mastocytosis2013
Author(s)
Sakane-Ishikawa E, Kodaka T, Tsunemine H, Itoh K, Akasaka H, Kusama T, Imaizumi K, Taketomi M, Sada A, Katayama Y, Itoh T, Takahashi T
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Journal Title
J Clin Exp Hematop
Volume: 53(3)
Pages: 207-13
NAID
Related Report
Peer Reviewed
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[Journal Article] Matrix-embedded osteocytes regulate mobilization of hematopoietic stem/progenitor cells2013
Author(s)
Asada N, Katayama Y, Sato M, Minagawa K, Wakahashi K, Kawano H, Kawano Y, Sada A, Ikeda K, Matsui T, Tanimoto M
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Journal Title
Cell Stem Cell
Volume: 12(6)
Pages: 737-47
NAID
Related Report
Peer Reviewed
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[Journal Article] Severe inhibitor-negative acquired factor XIII/13 deficiency with aggressive subdural haemorrhage2013
Author(s)
Kawano H, Yamamoto D, Uchihashi Y, Wakahashi K, Kawano Y, Sada A, Minagawa K, Katayama Y, Kohmura E, Souri M, Ichinose A
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Journal Title
Blood Coagul Fibrinolysis
Volume: 24(6)
Pages: 638-41
Related Report
Peer Reviewed
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[Journal Article] Pharmacokinetics-based optimal dose prediction of donor source-dependent response to mycophenolate mofetil in unrelated hematopoietic cell transplantation2011
Author(s)
Wakahashi K, Yamamori M, Minagawa K, Ishii S, Nishikawa S, Shimoyama M, Kawano H, Kawano Y, Kawamori Y, Sada A, Matsui T, Katayama Y
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Journal Title
Int J Hematol
Volume: 94(2)
Pages: 193-202
NAID
Related Report
Peer Reviewed
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