| Project/Area Number |
23591394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | National Center of Neurology and Psychiatry (2012-2013)
Nagasaki University (2011) |
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Principal Investigator |
TSUKASAKI KUNIHIRO 独立行政法人国立がん研究センター, 東病院, 科長 (40274659)
|
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| Co-Investigator(Kenkyū-buntansha) |
IMAIZUMI Yoshitaka 長崎大学, 大学病院, 助教 (40404305)
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| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | HTLV-1 / キャリア / ATL / くすぶり型 / 多段階発がん / 併合解析 / 中間群 / 低悪性度 |
|---|
| Research Abstract |
To better understand indeterminate HTLV-1 carriers and indolent ATL, ATL-related biomarkers were examined in 57 indolent cases, including unusual carriers with a ATL-like cells. According to Southern blot hybridization analytic features, 28 pts with smoldering ATL could be divided into 3 groups consisting of 16 pts with a monoclonal band, 6 with oligoclonal bands and the remaining 6 with smears. Although no clinical differences were observed among the 3 subtypes, HTLV-1-infected CD4 T-cell counts increased in order of poly-, oligo- and monoclonal subtypes. This trend began in the carrier stage and also was observed in proviral load, CD25 and CCR4, indicating that a clone consisting of leukemic phenotypic cells was continuously growing. Then we evaluated clinical/molecular features in transformation of indolent ATL. Advanced PS, multi-organ involvement and high LDH/Ca values were frequent, and tumor suppressor genes and CD58 alterations were involved in the transformation.
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