Leukemogenic property of acute promyelocytic leukemia gene, BCOR-RARA

• Project/Area Number: 23591410
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Fujita Health University
• Principal Investigator: YAMAMOTO Yukiya 藤田保健衛生大学, 医学部, 講師 (90410703)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 急性骨髄性白血病 / 急性前骨髄性白血病 / BCOR / RARA / 遺伝子異常 / 急性前骨髄性白血 / 急性骨髄性白血 / 転写因子 / 急性前骨髄球性白血病 / 急性骨髄球性白血病 / がん抑制因子

Outline of Final Research Achievements

32D cell lines with BCOR-RARA exhibited differentiation block under G-CSF condition, however ATRA administration induced myeloid differentiation. Whole exome sequences with t(X;17)(p11;q12) APL samples revealed no additional gene mutations except BCOR-RARA. Deep sequence by next generation sequence of BCOR region detected 5 different BCOR mutations from 4 samples. Taken together, BCOR has important roles as a tumor suppressor.

Research Products

• [Journal Article] The fate of patients with acute myeloid leukemia not undergoing induction chemotherapy. (2015)
  • Author(s): Masamitsu Yanada, Akinao Okamoto, Yoko Inaguma, Masutaka Tokuda, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Shuichi Mizuta, Yoshiki Akatsuka, Masataka Okamoto, Nobuhiko Emi.
  • Journal Title: International journal of hematology. Volume: Published online Issue: 1 Pages: 35-40
  • DOI: 10.1007/s12185-015-1786-0
  • Peer Reviewed
• [Journal Article] A varicella outbreak in B-cell lymphoma patients receiving rituximab-containing chemotherapy (2014)
  • Author(s): Akinao Okamoto, Akihiro Abe, Masataka Okamoto, Tsukane Kobayashi, Yoko Inaguma, Masutaka Tokuda, Masamitsu Yanada, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Motohiro Tsuzuki, Shuichi Mizuta, Yoshiki Akatsuka, Hiroshi Yatsuya, Tetsushi Yoshikawa, Nobuhiko Emi.
  • Journal Title: J Infect Chemother. Volume: 20 Pages: 774-7
  • Peer Reviewed
• [Journal Article] Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H. (2014)
  • Author(s): Inaguma Y, Akahori Y, Murayama Y, Shiraishi K, Tsuzuki-Iba S, Endoh A, Tsujikawa J, Demachi-Okamura A, Hiramatsu K, Saji H, Yamamoto Y, Yamamoto N, Nishimura Y, Takahashi T, Kuzushima K, Emi N, Akatsuka Y
  • Journal Title: Gene Therapy Volume: 21 Pages: 575-84
  • Peer Reviewed
• [Journal Article] Clarifying the Impact of Polycomb Complex Component Disruption in Human Cancers. (2014)
  • Author(s): Yamamoto Y, Abe A, Emi N
  • Journal Title: Molecular Cancer Research Volume: 12 Issue: 4 Pages: 479-84
  • DOI: 10.1158/1541-7786.mcr-13-0596
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Functionally Deregulated AML1/RUNX1 Cooperates with BCR-ABL to Induce a Blastic Phase-Like Phenotype of Chronic Myelogenous Leukemia in Mice. (2013)
  • Author(s): Kiyoko Yamamoto, Shinobu Tsuzuki, Yosuke Minami, Yukiya Yamamoto, Akihiro Abe, Koichi Ohshima, Masao Seto, Tomoki Naoe.
  • Journal Title: PLOS ONE Volume: 8 Issue: 9 Pages: e74864-e74864
  • DOI: 10.1371/journal.pone.0074864
  • Peer Reviewed
• [Journal Article] A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with t(11;21)(p14;q22). (2012)
  • Author(s): Abe A, Katsumi A, Kobayashi M, Okamoto A, Tokuda M, Kanie T, Yamamoto Y, Naoe T, Emi N.
  • Journal Title: Cancer Genetics Volume: 205(11) Issue: 11 Pages: 608-11
  • DOI: 10.1016/j.cancergen.2012.10.001
  • Peer Reviewed
• [Journal Article] t(X;17)(p11;q21) BCOR/RARA (2012)
  • Author(s): Yukiya Yamamoto
  • Journal Title: Atlas Genet Cytogenet Oncol Haematol Volume: January 2012
  • URL: http://AtlasGeneticsOncology.org/Anomalies/t0X17p11q21ID1594.html
  • Peer Reviewed
• [Journal Article] Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling (2012)
  • Author(s): Yukiya Yamamoto
  • Journal Title: Cancer Science Volume: 103(2) Pages: 350-9
  • Peer Reviewed
• [Presentation] Clarifying the Impact of Polycomb Complex Component Disruption in Human Cancers (2014)
  • Author(s): Yamamoto Y, Abe A, Emi N
  • Organizer: American Association of Cancer Research Annual Meeting 2014
  • Place of Presentation: San Diego Convention Center; San Diego, CA, USA
  • Year and Date: 2014-04-06
• [Presentation] Isolation of human monoclonal antibodies with antagonistic activity for FLT3 targeting therapy (2011)
  • Author(s): Yukiya Yamamoto
  • Organizer: 第７３回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia (2011)
  • Author(s): 山本幸也
  • Organizer: 第８回基礎血液懇話会(招待講演)
  • Place of Presentation: 名古屋大学医学部
• [Presentation] t(X;17)(p11;q12)急性前骨髄性白血病における融合遺伝子 BCOR-RARAのクローニングと機能解析 (2011)
  • Author(s): 山本幸也
  • Organizer: 第7回麒麟塾(招待講演)
  • Place of Presentation: コクヨホール 東京都港区港南