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Leukemogenic property of acute promyelocytic leukemia gene, BCOR-RARA

Research Project

Project/Area Number 23591410
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Hematology
Research InstitutionFujita Health University

Principal Investigator

YAMAMOTO Yukiya  藤田保健衛生大学, 医学部, 講師 (90410703)

Project Period (FY) 2011-04-28 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords急性骨髄性白血病 / 急性前骨髄性白血病 / BCOR / RARA / 遺伝子異常 / 急性前骨髄性白血 / 急性骨髄性白血 / 転写因子 / 急性前骨髄球性白血病 / 急性骨髄球性白血病 / がん抑制因子
Outline of Final Research Achievements

32D cell lines with BCOR-RARA exhibited differentiation block under G-CSF condition, however ATRA administration induced myeloid differentiation. Whole exome sequences with t(X;17)(p11;q12) APL samples revealed no additional gene mutations except BCOR-RARA. Deep sequence by next generation sequence of BCOR region detected 5 different BCOR mutations from 4 samples. Taken together, BCOR has important roles as a tumor suppressor.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (12 results)

All 2015 2014 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] The fate of patients with acute myeloid leukemia not undergoing induction chemotherapy.2015

    • Author(s)
      Masamitsu Yanada, Akinao Okamoto, Yoko Inaguma, Masutaka Tokuda, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Shuichi Mizuta, Yoshiki Akatsuka, Masataka Okamoto, Nobuhiko Emi.
    • Journal Title

      International journal of hematology.

      Volume: Published online Issue: 1 Pages: 35-40

    • DOI

      10.1007/s12185-015-1786-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A varicella outbreak in B-cell lymphoma patients receiving rituximab-containing chemotherapy2014

    • Author(s)
      Akinao Okamoto, Akihiro Abe, Masataka Okamoto, Tsukane Kobayashi, Yoko Inaguma, Masutaka Tokuda, Masamitsu Yanada, Satoko Morishima, Tadaharu Kanie, Yukiya Yamamoto, Motohiro Tsuzuki, Shuichi Mizuta, Yoshiki Akatsuka, Hiroshi Yatsuya, Tetsushi Yoshikawa, Nobuhiko Emi.
    • Journal Title

      J Infect Chemother.

      Volume: 20 Pages: 774-7

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction and molecular characterization of a T-cell receptor-like antibody and CAR-T cells specific for minor histocompatibility antigen HA-1H.2014

    • Author(s)
      Inaguma Y, Akahori Y, Murayama Y, Shiraishi K, Tsuzuki-Iba S, Endoh A, Tsujikawa J, Demachi-Okamura A, Hiramatsu K, Saji H, Yamamoto Y, Yamamoto N, Nishimura Y, Takahashi T, Kuzushima K, Emi N, Akatsuka Y
    • Journal Title

      Gene Therapy

      Volume: 21 Pages: 575-84

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clarifying the Impact of Polycomb Complex Component Disruption in Human Cancers.2014

    • Author(s)
      Yamamoto Y, Abe A, Emi N
    • Journal Title

      Molecular Cancer Research

      Volume: 12 Issue: 4 Pages: 479-84

    • DOI

      10.1158/1541-7786.mcr-13-0596

    • Related Report
      2014 Annual Research Report 2013 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Functionally Deregulated AML1/RUNX1 Cooperates with BCR-ABL to Induce a Blastic Phase-Like Phenotype of Chronic Myelogenous Leukemia in Mice.2013

    • Author(s)
      Kiyoko Yamamoto, Shinobu Tsuzuki, Yosuke Minami, Yukiya Yamamoto, Akihiro Abe, Koichi Ohshima, Masao Seto, Tomoki Naoe.
    • Journal Title

      PLOS ONE

      Volume: 8 Issue: 9 Pages: e74864-e74864

    • DOI

      10.1371/journal.pone.0074864

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel RUNX1-C11orf41 fusion gene in a case of acute myeloid leukemia with t(11;21)(p14;q22).2012

    • Author(s)
      Abe A, Katsumi A, Kobayashi M, Okamoto A, Tokuda M, Kanie T, Yamamoto Y, Naoe T, Emi N.
    • Journal Title

      Cancer Genetics

      Volume: 205(11) Issue: 11 Pages: 608-11

    • DOI

      10.1016/j.cancergen.2012.10.001

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] t(X;17)(p11;q21) BCOR/RARA2012

    • Author(s)
      Yukiya Yamamoto
    • Journal Title

      Atlas Genet Cytogenet Oncol Haematol

      Volume: January 2012

    • URL

      http://AtlasGeneticsOncology.org/Anomalies/t0X17p11q21ID1594.html

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation of human mAbs that directly modulate FMS-related tyrosine kinase 3 signaling2012

    • Author(s)
      Yukiya Yamamoto
    • Journal Title

      Cancer Science

      Volume: 103(2) Pages: 350-9

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] Clarifying the Impact of Polycomb Complex Component Disruption in Human Cancers2014

    • Author(s)
      Yamamoto Y, Abe A, Emi N
    • Organizer
      American Association of Cancer Research Annual Meeting 2014
    • Place of Presentation
      San Diego Convention Center; San Diego, CA, USA
    • Year and Date
      2014-04-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] Isolation of human monoclonal antibodies with antagonistic activity for FLT3 targeting therapy2011

    • Author(s)
      Yukiya Yamamoto
    • Organizer
      第73回日本血液学会学術集会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2011 Research-status Report
  • [Presentation] BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia2011

    • Author(s)
      山本幸也
    • Organizer
      第8回基礎血液懇話会(招待講演)
    • Place of Presentation
      名古屋大学医学部
    • Related Report
      2011 Research-status Report
  • [Presentation] t(X;17)(p11;q12)急性前骨髄性白血病における融合遺伝子 BCOR-RARAのクローニングと機能解析2011

    • Author(s)
      山本幸也
    • Organizer
      第7回麒麟塾(招待講演)
    • Place of Presentation
      コクヨホール 東京都港区港南
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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