HTLV-1-specific T cell suppression in infected individuals
Project/Area Number |
23591414
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
HASEGAWA Atsuhiko 東京医科歯科大学, 医歯(薬)学総合研究科, 助教 (90508334)
|
Project Period (FY) |
2011 – 2013
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | immunosuppression / CTL / ATL / HTLV-1 / 成人T細胞白血病 / HTLV-1特異的T細胞 / 免疫抑制 / Tax特異的T細胞 / Tax特異的T細胞応答 |
Research Abstract |
It is believed that a weak CD8+ T cell response specific for human T-cell leukemia virus type 1 (HTLV-1) may be one of risk factors for the development of adult T-cell leukemia (ATL). In this study, we showed that a low HTLV-1-specific CD8+ T cell response could be observed not only in most ATL patients but also in a small population of asymptomatic carriers. We also found that this low CD8+ T cell response might be attributed mainly to functional impairment of HTLV-1-specific CD8+ T cells themselves and in part to a reduced function of antigen-presenting cells and an immune suppression by regulatory T cells and infected cells.
|
Report
(4 results)
Research Products
(42 results)
-
-
-
-
-
-
-
-
[Presentation] Kinetics of Tax-specific CTL in ATL patients following hematopoietic stem cell transplantation from uninfected donors2013
Author(s)
Takamori A, Hasegawa A, Utsunomiya A, Choi I, Tanosaki R, Eto T, Kato K, Tamai Y, Sasada A, Suehiro Y, Uike N, Kannagi M
Organizer
第72回日本癌学会
Place of Presentation
横浜
Related Report
-
[Presentation] The phase-I study of a therapeutic vaccine to ATL patients with autologous dendritic cells pulsed with Tax peptides2013
Author(s)
Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Tanosaki R, Utsunomiya A, Matsuoka M, Teshima T, Akashi K, Okamura J, Kannagi M, Uike N
Organizer
第72回日本癌学会シンポジウム
Place of Presentation
横浜
Related Report
-
[Presentation] Identification of novel HTLV-1-specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantation2013
Author(s)
Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Suehiro Y, Maeda Y, Yamano Y, Uike N, Kannagi M
Organizer
第72回日本癌学会
Place of Presentation
横浜
Related Report
-
-
[Presentation] Augmentation of donor-derived Tax-specific CTL responses by a novel Tax epitope-specific CD4+ helper T-cells in ATL patients after allogeneic hematopoietic stem cell transplanation2013
Author(s)
Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M
Organizer
16th International Conference on Human Retrovirology HTLV and Related Viruses
Place of Presentation
Montréal, Canada
Related Report
-
[Presentation] The phase-I study of a therapeutic vaccine to ATL patients with autologous dendritic cells pulsed with peptides corresponding to Tax-specific CTL epitopes2013
Author(s)
Suehiro Y, Hasegawa A, Iino T, Sasada A, Watanabe N, Choi I, Fukuda T, Takaishi S, Tanosaki R, Utsunomiya A, Miura O, Matsuoka M, Teshima T, Akashi K, Okamura J, Kannagi M, Uike N
Organizer
16th International Conference on Human Retrovirology HTLV and Related Viruses
Place of Presentation
Montréal, Canada
Related Report
-
-
-
[Presentation] Identification of a novel HLA-DR1-restricted dominant epitope recognized by HTLV-1 Tax-specific CD4^+ T-cells augmenting HTLV-1-specific CTL expansion in ATL patients after allogeneic HSCT2013
Author(s)
Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M
Organizer
The 9^<th> AACR-Japanese cancer association joint conference
Place of Presentation
Maui, HI
Related Report
-
-
-
[Presentation] Augmentation of donor-derived Tax-specific CTL responses by a novel Tax epitope-specific CD4+ helper T-cells in ATL patients after allogeneic hematopoietic stem cell transplanation2013
Author(s)
Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M.
Organizer
The 16th International Conference on Human Retrovirology HTLV and Related Viruses
Place of Presentation
Montreal, Canada
Related Report
-
-
[Presentation] Identification of novel HTLV-1-specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantation2013
Author(s)
Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Suehiro Y, Maeda Y, Yamano Y, Uike N, Kannagi M.
Organizer
第72回日本癌学会学術集会
Place of Presentation
パシフィコ横浜、横浜
Related Report
-
-
[Presentation] Identification of a novel HLA-DR1-restricted dominant epitope recognized by HTLV-1 Tax-specific CD4+ T-cells augmenting HTLV-1-specific CTL expansion in ATL patients after allogeneic HSCT2013
Author(s)
1. Hasegawa A, Tamai Y, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Maeda Y, Yamano Y, Etoh T, Koh KR, Nakamae H, Suehiro Y, Kato K, Takemoto S, Okamura J, Uike N, Kannagi M.
Organizer
The 9th AACR-Japanese Cancer Association Joint Conference
Place of Presentation
Hyatt Regency Maui (Maui, HI)
Related Report
-
-
[Presentation] Functional impairment of CD8+ cytotoxic T lymphocytes selective for HTLV-1-specific responses in early stages of adult T-cell leukemia patients2012
Author(s)
Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Masuda M, Tamai Y, Sasada A, Choi I, Uike N, Okamura J, Watanabe T, Kannagi M
Organizer
第41回日本免疫学会総会・学術集会
Place of Presentation
神戸
Related Report
-
-
[Presentation] A novel HLA-DR-restricted epitope recognized by Tax-specific CD4+ T cells in ATL patients after allo-HSCT2012
Author(s)
Tamai Y, Hasegawa A, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Etoh T, Koh KR, Suehiro Y, Okamura J, Uike N, Kannagi M
Organizer
第71回日本癌学会学術総会
Place of Presentation
札幌
Related Report
-
-
-
[Presentation] A novel HLA-DR-restricted epitope recognized by Tax-specific CD4+ T cells in ATL patients after allo-HSCT2012
Author(s)
8. Tamai Y, Hasegawa A, Takamori A, Sasada A, Tanosaki R, Choi I, Utsunomiya A, Etoh T, Koh KR, Suehiro Y, Okamura J, Uike N, Kannagi M.
Organizer
第71回 日本癌学会学術総会
Place of Presentation
札幌教育文化会館(札幌)
Related Report
-
[Presentation] Functional impairment of Tax-specific but not CMV-specific CTLs in a minor population of asymptomatic carriers2011
Author(s)
Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
Organizer
第70回日本癌学会学術集会
Place of Presentation
名古屋
Related Report
-
-
[Presentation] Functional impairment of Tax-specific but not CMV-specific CD8+ T cells in a minor population of asymptomatic carriers2011
Author(s)
Hasegawa A, Takamori A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
Organizer
The XXV Symposium of the International Association for Comparative Research on Leukemia and Related Diseases
Place of Presentation
東京
Related Report
-
-
[Presentation] Functional impairment of Tax-specific but not CMV-specific CD8+ T cells in a minor population of asymptomatic carriers2011
Author(s)
Takamori A, Hasegawa A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
Organizer
XV International Congress of Virology
Place of Presentation
札幌
Related Report
-
-
-
[Presentation] Functional impairment of Tax-specific but not CMV-specific CTLs in a minor population of asymptomatic carriers2011
Author(s)
Hasegawa A, Takamori A, Utsunomiya A, Maeda Y, Yamano Y, Shimizu Y, Tamai Y, Sasada A, Zeng N, Choi I, Uike N, Okamura J, Watanabe T, Masuda T, Kannagi M
Organizer
The 15^<th> International Conference on Human Retrovirology : HTLV and Related Viruses
Place of Presentation
Leuven, Belgium
Related Report
-
-
-
-