Analysis of HLA-DP-specific immune responses to develop a novel immunotherapy

• Project/Area Number: 23591415
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Hematology
• Research Institution: Nagoya University
• Principal Investigator: MURATA Makoto 名古屋大学, 医学部附属病院, 講師 (40378063)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 造血幹細胞移植 / HLA / Tリンパ球 / 抗体 / GVHD / GVL効果

Research Abstract

The 20-99% of leukemia cells was positive for HLA-DP expression. Twenty-four cytotoxic T cell (CTL) lines were isolated from blood obtained from seven patients who had received HLA-mismatched hematopoietic stem cell transplantation. All CTLs recognized HLA-class I or DR molecules but not DP molecule. Anti-HLA antibodies were detected in blood obtained from eight patients who had received multi-transfusion. All antibodies recognized HLA class I but not class II molecules. In vitro assay using patient serum containing anti-HLA antibody demonstrated that the hematopoietic stem cells were lysed by anti-HLA antibody through ADCC activity. Stimulation of T cells by .221 cells transfected with each HLA-DP cDNA construct is ongoing.

Research Products

• [Journal Article] Allogeneic transplantation for primary myelofibrosis with bone marrow, peripheral blood, or umbilical cord blood: An analysis of the JSHCT. (2014)
  • Author(s): Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Mori T, Kobayashi H, Nakaseko C, Yamagata N, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T.
  • Journal Title: Bone Marrow Transplantation Volume: 49 Issue: 3 Pages: 355-360
  • DOI: 10.1038/bmt.2013.180
  • Peer Reviewed
• [Journal Article] Leukemic evolution of donor-derived cells harboring IDH2 and DNMT3A mutations after allogeneic stem cell transplantation. (2014)
  • Author(s): Yasuda T, Ueno T, Fukumura K, Yamato A, Ando M, Yamaguchi H, Soda M, Kawazu M, Sai E, Yamashita Y, Murata M, Kiyoi H, Naoe T, Mano H.
  • Journal Title: Leukemia Volume: 28 Issue: 2 Pages: 426-428
  • DOI: 10.1038/leu.2013.278
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors and organ involvement of chronic graft-versus-host disease in Japan. (2014)
  • Author(s): Kanda J, Nakasone H, Atsuta Y, Toubai T, Yokoyama H, Fukuda T, Taniguchi S, Ohashi K, Ogawa H, Eto T, Miyamura K, Morishima Y, Nagamura-Inoue T, Sakamaki H, Murata M.
  • Journal Title: Bone Marrow Transplantation Volume: 49 Issue: 2 Pages: 228-235
  • DOI: 10.1038/bmt.2013.151
  • Peer Reviewed
• [Journal Article] Successful unrelated cord blood transplantation for adult acquired aplastic anemia using reduced intensity conditioning without ATG. (2014)
  • Author(s): Terakura S, Nishida T, Inamoto Y, Ohashi H, Naoe T, Murata M.
  • Journal Title: Immunology Letters Volume: - Issue: 1 Pages: 99-101
  • DOI: 10.1016/j.imlet.2014.01.013
  • Peer Reviewed
• [Journal Article] Clinical factors predicting the response of acute graft-versus-host disease to corticosteroid therapy: an analysis from the GVHD working group of the Japan Society for Hematopoietic Cell Transplantation. (2013)
  • Author(s): Murata M, Nakasone H, Kanda J, Nakane T, Furukawa T, Fukuda T, Mori T, Taniguchi S, Eto T, Ohashi K, Hino M, Inoue M, Ogawa H, Atsuta Y, Nagamura-Inoue T, Yabe H, Morishima Y, Sakamaki H, Suzuki R.
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 19 Issue: 8 Pages: 1183-1189
  • DOI: 10.1016/j.bbmt.2013.05.003
  • Peer Reviewed
• [Journal Article] Identification of a novel HLA-A^*24:02-restricted adenovirus serotype 11-specific CD8+ T-cell epitope for adoptive immunotherapy (2013)
  • Author(s): Imahashi N, Nishida T, Ito Y, Kawada J, Nakazawa Y, Toji S, Suzuki S, Terakura S, Kato T, Murata M, Naoe T.
  • Journal Title: Molecular Immunolgy Volume: 56 Issue: 4 Pages: 399-405
  • DOI: 10.1016/j.molimm.2013.05.232
  • Peer Reviewed
• [Journal Article] Impact of hepatitis C virus infection on clinical outcome in recipients after allogeneic hematopoietic cell transplantation. (2013)
  • Author(s): Nakasone H, Kurosawa S, Yakushijin K, Taniguchi S, Murata M, Ikegame K, Kobayashi T, Eto T, Miyamura K, Sakamaki H, Morishima Y, Nagamura T, Suzuki R, Fukuda T.
  • Journal Title: American Journal of Hematology Volume: 88 Issue: 6 Pages: 477-484
  • DOI: 10.1002/ajh.23436
  • Peer Reviewed
• [Journal Article] A case-control study of bronchiolitis obliterans syndrome following allogeneic hematopoietic stem cell transplantation. (2013)
  • Author(s): Nakasone H, Kanda J, Yano S, Atsuta Y, Ago H, Fukuda T, Kakihana K, Adachi T, Yujiri T, Taniguchi S, Taguchi J, Morishima Y, Nagamura T, Sakamaki H, Mori T, Murata M.
  • Journal Title: Transplant International Volume: 26 Issue: 6 Pages: 631-639
  • DOI: 10.1111/tri.12093
  • Peer Reviewed
• [Journal Article] Unrelated allogeneic bone marrow-derived mesenchymal stem cells for steroid-refractory acute graft-versus-host disease: a phase I/II study. (2013)
  • Author(s): Muroi K, Miyamura K, Ohashi K, Murata M, Eto T, Kobayashi N, Taniguchi S, Imamura M, Ando K, Kato S, Mori T, Teshima T, Mori M, Ozawa K.
  • Journal Title: Int J Hematol. Volume: 98 Issue: 2 Pages: 206-213
  • DOI: 10.1007/s12185-013-1399-4
  • NAID: 10031194736
  • Peer Reviewed
• [Journal Article] Efficacy and Long-Term Outcome of Treatment for Pure Red Cell Aplasia following Allogeneic Stem Cell Transplantation from Major ABO-Incompatible Donors. (2013)
  • Author(s): Hirokawa M, Fukuda T, Ohhashi K, Hidaka M, Ichinohe T, Iwato K, Kanamori H, Murata M, Sakura T, Imamura M, Adachi S, Suzuki R, Morishima Y, Sakamaki H.
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 19 Issue: 7 Pages: 1026-1032
  • DOI: 10.1016/j.bbmt.2013.04.004
  • Peer Reviewed
• [Journal Article] Escape of leukemia blasts from HLA-specific CTL pressure in a recipient of HLA one locus-mismatched bone marrow transplantation. (2012)
  • Author(s): Kato T, Terakura S, Murata M, Sugimoto K, Murase M, Iriyama C, Tomita A, Abe A, Suzuki M, Nishida T, Naoe T.
  • Journal Title: Cellular Immunology Volume: 276 Issue: 1-2 Pages: 75-82
  • DOI: 10.1016/j.cellimm.2012.03.011
  • Peer Reviewed
• [Journal Article] Phase II study of dose-modified busulfan by real-time targeting in allogeneic hematopoietic stem cell transplantation for myeloid malignancy. (2012)
  • Author(s): Kuwatsuka Y, Kohno A, Terakura S, Saito S, Shimada K, Yasuda T, Inamoto Y, Miyamura K, Sawa M, Murata M, et al.
  • Journal Title: Cancer Science Volume: 103 Issue: 9 Pages: 1688-1694
  • DOI: 10.1111/j.1349-7006.2012.02342.x
  • Peer Reviewed
• [Journal Article] Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation : macrophage-targeted steroid therapy (2012)
  • Author(s): 西脇聡史
  • Journal Title: International Journal of Hematology Volume: (Epub ahead of print) Issue: 4 Pages: 428-33
  • DOI: 10.1007/s12185-012-1023-z
  • NAID: 10030632677
  • Peer Reviewed
• [Journal Article] Efficacy and safety of human adipose tissue-derived mesenchymal stem cells for supporting hematopoiesis. (2012)
  • Author(s): Nishiwaki S
  • Journal Title: Int J Hematol. Volume: 96(3) Issue: 3 Pages: 295-300
  • DOI: 10.1007/s12185-012-1140-8
  • Peer Reviewed
• [Journal Article] A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hemato poietic malignancies (2011)
  • Author(s): Terakura S, et al
  • Journal Title: Annals of Oncology Volume: 22(8) Issue: 8 Pages: 1865-1871
  • DOI: 10.1093/annonc/mdq673
  • Peer Reviewed
• [Journal Article] Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure : results of a nationwide survey of 80 adult patients (2011)
  • Author(s): Waki F, Masuoka K, Fukuda T, Kanda Y, Nakamae M, Yakushijin K, Togami K, Nishiwaki K, Ueda Y, Kawano F, Kasai M, Nagafuji K, Hagihara M, Hatanaka K, Taniwaki M, Maeda Y, Shirafuji N, Mori T, Utsunomiya A, Eto T, Nakagawa H, Murata M, Uchida T, Iida H, Yakushiji K, Yamashita T, Wake A, Takahashi S, Takaue Y, Taniguchi S
  • Journal Title: Biol Blood Marrow Transplant Volume: 17 Issue: 6 Pages: 841-51
  • DOI: 10.1016/j.bbmt.2010.09.005
  • Peer Reviewed
• [Journal Article] Cytotoxic T-lymphocyte antigen 4 haplotype correlates with relapse and survival after allogeneic hematopoietic SCT. (2011)
  • Author(s): Murase M, Nishida T, Onizuka M, Inamoto Y, Sugimoto K, Imahashi N, Murata M, Miyamura K, Kodera Y, Inoko H, Naoe T.
  • Journal Title: Bone Marrow Transplantation Volume: 46(11) Pages: 1444-1449
  • Peer Reviewed
• [Journal Article] A prospective dose-finding trial using a modified continual reassessment method for optimization of fludarabine plus melphalan conditioning for marrow transplantation from unrelated donors in patients with hematopoietic malignancies. (2011)
  • Author(s): Terakura S, Atsuta Y, Sawa M, Ohashi H, Kato T, Nishiwaki S, Imahashi N, Yasuda T, Murata M, Miyamura K, Suzuki R, Naoe T, Ito T, Morishita Y.
  • Journal Title: Annals of Oncology Volume: 22(8) Pages: 1865-1875
  • Peer Reviewed
• [Journal Article] Feasibility of reduced-intensity cord blood transplantation as salvage therapy for graft failure: results of a nationwide survey of 80 adult patients. (2011)
  • Author(s): Waki F, Masuoka K, Murata M, et al.
  • Journal Title: Biology of Blood and Marrow Transplantation Volume: 17(6) Pages: 841-851
  • Peer Reviewed
• [Journal Article] Virus-associated hemophagocytic syndrome caused by pandemic swine-origin influenza A (H1N1) in a patient after unrelated bone marrow transplantation. (2011)
  • Author(s): Katsumi A, Nishida T, Murata M, Terakura S, Shimada K, Saito S, Kobayashi M, Kodaira A, Shibata S, Oda I, Yagi T, Kiyoi H, Matsushita T, Kojima T, Naoe T.
  • Journal Title: Journal of Clinical and Experimental Hematopathology Volume: 51(1) Pages: 63-65
  • NAID: 10028239126
  • Peer Reviewed
• [Journal Article] Dexamethasone palmitate successfully attenuates hemophagocytic syndrome after allogeneic stem cell transplantation: macrophage-targeted steroid therapy. (2011)
  • Author(s): Nishiwaki S, Nakayama T, Murata M, et al.
  • Journal Title: International Journal of Hematology Volume: -
  • NAID: 10030632677
  • Peer Reviewed
• [Presentation] 原発性骨髄線維症に対する幹細胞別の移植成績:JSHCTからの報告 (2014)
  • Author(s): 村田誠、西田徹也、谷口修一、大橋一輝、小川啓恭、福田隆浩、森毅彦、小林光、中世古知昭、山形昇、森島泰雄、長村登紀子、坂巻壽、熱田由子、鈴木律朗、直江知樹
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 原発性骨髄線維症に対する幹細胞別の移植成績：JSHCTからの報告. (2014)
  • Author(s): 村田 誠、西田徹也、谷口修一、大橋一輝、小川啓恭、福田隆浩、森 毅彦、小林 光、中世古知昭、山形 昇、森島泰雄、長村登紀子、坂巻 壽、熱田由子、鈴木律朗、直江知樹.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 非血縁者間骨髄移植後難治性CMV感染に対してCMV抗原特異的CTLが著効した2症例. (2014)
  • Author(s): 西田徹也、村田 誠、寺倉精太郎、勝見 章、直江知樹.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 臍帯血移植片拒絶症例におけるドナーHLA特異的抗体とドナーHLA特異的細胞傷害性T細胞の協働作用. (2014)
  • Author(s): 葉名尻 良、村田 誠、杉本恭子、村瀬未帆、大橋春彦、後藤辰徳、渡邊慶介、今橋伸彦、寺倉精太郎、西田徹也、直江知樹.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 小児造血幹細胞移植症例におけるシクロスポリン持続点滴法と分割静注法の有効性と安全性の比較検討：GVHD予防法とGVHD Working Groupによる後方視的検討. (2014)
  • Author(s): 梅田雄嗣、足立壮一、田中司朗、小川 淳、畠山直樹、坂田尚己、工藤寿子、五十嵐俊次、大島久美、百名伸之、澤田明久、加藤剛二、井上雅美、熱田由子、高見昭良、村田 誠.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] ステロイド抵抗性の急性GVHDに対するヒト間葉系幹細胞投与の有効性. (2014)
  • Author(s): 渡壁恭子、宮村耕一、岡田昌也、山下卓也、村田 誠、石川隆之、鵜池直邦、日高道弘、小林良二、今村雅寛、田中淳司、大橋一輝、谷口修一、池田宇次、衛藤徹也、森 政樹、室井一男、小澤敬也.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 非血縁者間造血幹細胞移植におけるHLA-DPB1適合度の移植免疫反応への影響. (2014)
  • Author(s): 森島泰雄、柏瀬貢一、松尾恵太郎、東 史啓、鬼塚真二、森島聡子、屋部登志雄、村田 誠、土岐典子、衛藤徹也、森 毅彦、宮村耕一、佐尾 浩、佐治博夫、加藤俊一、河 敬世、小寺良尚、笹月健彦.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 新規CD20キメラ抗原レセプター遺伝子導入T細胞の樹立とCD20低発現標的に対する効果の検討. (2014)
  • Author(s): 渡邊慶介、寺倉精太郎、後藤辰徳、葉名尻 良、今橋伸彦、西田徹也、村田 誠、直江知樹.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 同種臍帯血移植を行い良好な生着・生存を得た成人再生不良性貧血の3例. (2014)
  • Author(s): 寺倉精太郎、後藤辰徳、葉名尻 良、渡邊慶介、今橋伸彦、西田徹也、村田 誠、直江知樹.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] Fludarabine + Cyclophosphamideを用いた減量強度前処置による多発性骨髄腫に対する同種造血幹細胞移植の検討. (2014)
  • Author(s): 後藤辰徳、斉藤繁紀、寺倉精太郎、西田徹也、冨田章裕、村田 誠、直江知樹.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] 同種造血幹細胞移植後に食欲不振が持続した患者へチームとしての取り組み. (2014)
  • Author(s): 高木麻里、川口 綾、齊藤真衣子、間島野花、吉村香那、中村みゆき、西田徹也、村田 誠、木村宏之、宮内倫也.
  • Organizer: 第36回日本造血細胞移植学会総会
  • Place of Presentation: 沖縄コンベンションセンター、宜野湾市
• [Presentation] Transplantation for primary myelofibrosis using bone marrow, peripheral blood and umbilical cord blood : a retrospective analysis of the Japan Society for Hematopoietic Cell Transplantation (2013)
  • Author(s): Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T
  • Organizer: The 39th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: in London
• [Presentation] 慢性GVHDのマネジメント (2013)
  • Author(s): 村田誠
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: 石川県立音楽堂、金沢市, (教育講演)
• [Presentation] Cord blood allograft rejection mediated by coordinated donor-specific cellular and humoral immune process. (2013)
  • Author(s): Hanajiri R, Murata M, Sugimoto K, Murase M, Ohashi H, Goto T, Watanabe K, Imahashi N, Terakura S, Nishida T, Naoe T.
  • Organizer: The 55th Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans, USA
• [Presentation] Anti-CD20 chimeric antigen receptor transduced T cells can recognize very low antigen expression: determination of the lower threshold required to activate the CAR-T cells. (2013)
  • Author(s): Watanabe K, Terakura S, Goto T, Hanajiri R, Imahashi N, Shimada K, Nishida T, Tomita A, Murata M, Naoe T.
  • Organizer: The 55th Annual Meeting of the American Society of Hematology
  • Place of Presentation: New Orleans, USA
• [Presentation] The effect of sex mismatch on outcome in allogeneic hematopoietic stem cell transplantation. (2013)
  • Author(s): Oshima K, Imahashi N, Taniguchi S, Ohashi K, Fukuda T, Miyamura K, Mori T, Eto T, Morishima Y, Nagamura T, Sakamaki H, Atsuta Y, Murata M.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館、札幌市
• [Presentation] Identification of a novel HLA-A*24:02-restricted adenovirus serotype 11-specific CD8+ T-cell epitope. (2013)
  • Author(s): Imahashi N, Nishida T, Ito Y, Kawada J, Nakazawa Y, Toji S, Suzuki S, Terakura S, Kato T, Murata M, Naoe T.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館、札幌市
• [Presentation] Cord blood allograft rejection mediated by coordination of cellular and humoral immunity. (2013)
  • Author(s): Hanajiri R, Murata M, Sugimoto K, Murase M, Ohashi H, Goto T, Watanabe K, Imahashi N, Terakura S, Nishida T, Naoe T.
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: ロイトン札幌、さっぽろ芸文館、札幌市教育文化会館、札幌市
• [Presentation] Transplantation for primary myelofibrosis using bone marrow, peripheral blood and umbilical cord blood: a retrospective analysis of the Japan Society for Hematopoietic Cell Transplantation. (2013)
  • Author(s): Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T.
  • Organizer: The 39th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: London, UK
• [Presentation] Identification of an HLA-A*24:02-restricted adenovirus serotype 11 epitope recognized by cytotoxic T-cells. (2013)
  • Author(s): Imahashi N, Nishida T, Terakura S, Ito Y, Kawada J, Nakazawa Y, Kato T, Murata M, Naoe T.
  • Organizer: The 39th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: London, UK
• [Presentation] 慢性GVHDのマネジメント (2013)
  • Author(s): 村田 誠
  • Organizer: 第35回日本造血細胞移植学会総会
  • Place of Presentation: 金沢
• [Presentation] Clinical factors predicting the response of acute graft-versus- host disease to corticosteroid therapy (2012)
  • Author(s): Murata M, Nakasone H, Kanda J, Nakane T, Furukawa T, Fukuda T, Taniguchi S, Mori T, Eto T, Morishima Y, Nagamura-Inoue T, Yabe H, Atsuta Y, Sakamaki H, Suzuki R
  • Organizer: The 54th Annual Meeting of the American Society of Hematology
  • Place of Presentation: in Atlanta, USA
• [Presentation] Outcome of transplantation for primary myelofibrosis : A retrospective study of the JSHCT (2012)
  • Author(s): Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都国際会議場、京都市
• [Presentation] 日本の急性GVHD治療の現状 (2012)
  • Author(s): 村田誠
  • Organizer: 第74回日本血液学会学術集会, (シンポジウム)
  • Place of Presentation: 京都国際会議場、京都市
• [Presentation] Leukaemia escape from HLA-specific T-lymphocyte pressure in a recipient of HLA one locus-mismatched BMT (2012)
  • Author(s): Murata M, Kato T, Terakura S, Sugimoto K, Nishida T, Naoe T
  • Organizer: The 38th Annual Meeting of the European Group for Blood and Marrow Transplantation, (Best Science Poster Award)
  • Place of Presentation: in Geneva, Switzerland
• [Presentation] Grade II以上の急性GVHDに対する治療成績:TRUMPデータを用いた解析 (2012)
  • Author(s): 村田誠、仲宗根秀樹、諫田淳也、中根孝彦、古川達雄、福田隆浩、谷口修一、森毅彦、衛藤徹也、森島泰雄、長村登紀子、矢部普正、熱田由子、鈴木律朗、坂巻壽
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: グランキューブ大阪、大阪市
• [Presentation] Leukaemia escape from HLA-specific T-lymphocyte pressure in a recipient of HLA one locus-mismatched BMT. (2012)
  • Author(s): Murata M, Kato T, Terakura S, Sugimoto K, Nishida T, Naoe T.
  • Organizer: The 38th Annual Meeting of the European Group for Blood and Marrow Transplantation.
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Current status of acute graft-versus-host disease prophylaxis in Japan: Retrospective comparison of cyclosporine plus methotrexate versus tacrolimus plus methotrexate by donor source. (2012)
  • Author(s): Sakai R, Taguri M, Oshima K, Mori T, Ago H, Adachi S, Morita S, Taniguchi S, Fukuda T, Ohashi K, Eto T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Murata M.
  • Organizer: The 38th Annual Meeting of the European Group for Blood and Marrow Transplantation.
  • Place of Presentation: Geneva, Switzerland
• [Presentation] Clinical factors predicting the response of acute graft-versus-host disease to corticosteroid therapy. (2012)
  • Author(s): Murata M, Nakasone H, Kanda J, Nakane T, Furukawa T, Fukuda T, Taniguchi S, Mori T, Eto T, Morishima Y, Nagamura-Inoue T, Yabe H, Atsuta Y, Sakamaki H, Suzuki R.
  • Organizer: The 54rd Annual Meeting of the American Society of Hematology.
  • Place of Presentation: Atlanta, USA
• [Presentation] Older age increases non-relapse mortality in patients with grade II-IV acute GVHD after allogeneic hematopoietic cell transplantation: A retrospective analysis of the Japanese TRUMP database. (2012)
  • Author(s): Nakane T, Fukuda T, Kanda J, Taniguchi S, Eto T, Ohashi K, Morishima Y, Nagamura T, Sakamaki H, Atsuta Y, Murata M.
  • Organizer: The 54rd Annual Meeting of the American Society of Hematology.
  • Place of Presentation: Atlanta, USA
• [Presentation] The impact of ATG/ALG in preconditioning on the allogeneic stem cell transplantation for patients with acute leukemia. (2012)
  • Author(s): Kato K, Atsuta Y, Ohashi K, Fukuda T, Taniguchi S, Kanamori H, Sakamaki H, Yabe H, Murata M.
  • Organizer: The 54rd Annual Meeting of the American Society of Hematology.
  • Place of Presentation: Atlanta, USA
• [Presentation] 日本の急性GVHD治療の現状 (2012)
  • Author(s): 村田 誠
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Outcome of transplantation for primary myelofibrosis: A retrospective study of the JSHCT. (2012)
  • Author(s): Murata M, Nishida T, Taniguchi S, Ohashi K, Ogawa H, Fukuda T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Suzuki R, Naoe T.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Current status of GVHD prophylaxis in Japan: Retrospective analysis by GVHD WG of the JSHCT. (2012)
  • Author(s): Sakai R, Taguri M, Ohshima K, Mori T, Ago H, Adachi S, Morita S, Taniguchi S, Fukuda T, Ohashi K, Etou T, Morishima Y, Nagamura-Inoue T, Sakamaki H, Atsuta Y, Murata M.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] The impact of ATG/ALG on the allogeneic stem cell transplantation for patients with acute leukemia. (2012)
  • Author(s): Kato K, Atsuta Y, Ohashi K, Fukuda T, Taniguchi S, Kanamori H, Kawa K, Sakamaki H, Yabe H, Murata M.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Analysis of influence of GVHD prophylaxis and GVHD on TMA with centralized data of JSHCT by GVHD-WG. (2012)
  • Author(s): Ago H, Inamoto Y, Murata M, Taniguchi S, Fukuda T, Ohashi K, Ogawa Y, Morishima Y, Nagamura T, Sakamaki H, Yabe H, Atsuta Y.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Older age is an influencing factor in increased NRM after aGVHD: A retrospective analysis from TRUMP. (2012)
  • Author(s): Nakane T, Fukuda T, Kanda J, Taniguchi S, Eto T, Ohashi K, Morishima Y, Nagamura T, Sakamai H, Atsuta Y, Murata M.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] The effectiveness of macrophage-targeted therapy by dexamethasone palmitate for refractory GVHD. (2012)
  • Author(s): Nishiwaki S, Nakayama T, Murata M, Nishida T, Terakura S, Saito S, Kato T, Mizuno H, Imahashi N, Seto A, Ozawa Y, Miyamura K, Ito M, Toyokuni S, Nagao K, Naoe T.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Correlation of IL-6 with exhausted CMV-specific T cells after allogeneic stem cell transplantation. (2012)
  • Author(s): Nishida T, Kato T, Ito Y, Murata M, Naoe T.
  • Organizer: 第74回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] The effect of sex mismatch on outcome in allogeneic hematopoietic stem cell transplantation. (2012)
  • Author(s): Oshima K, Taniguchi S, Fukuda T, Kakihana K, Eto T, Ikegame K, Morishima Y, Nagamura T, Sakamaki H, Atsuta Y, Murata M.
  • Organizer: 2012 BMT Tandem Meetings
  • Place of Presentation: Manchester Grand Hyatt San Diego (San Diego, USA)
• [Presentation] ステロイド治療抵抗性急性GVHDに対してヒト間葉系幹細胞が著効した2例 (2012)
  • Author(s): 西田徹也、村田 誠、入山智沙子、後藤絵美、勝見 章、冨田彰裕、直江知樹
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] パルミチン酸デキサメタゾンは、マクロファージの増加した難治性GVHDを改善する：マクロファージを標的とした試み (2012)
  • Author(s): 西脇聡史、中山享之、村田 誠、西田徹也、齊藤繁樹、瀬戸愛花、小澤幸泰、宮村耕一、伊藤雅文、豊國伸哉、永尾圭介、直江知樹
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] HLA不一致骨髄移植後患者におけるHLA特異的CTLからの白血病エスケープ (2012)
  • Author(s): 加藤智則、村田 誠、寺倉精太郎、杉本恭子、西田徹也、直江知樹
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] TRUMPデータに基づく同種造血幹細胞移植後の閉塞性細気管支炎の症例対照研究 (2012)
  • Author(s): 仲宗根秀樹、諫田淳也、吾郷浩厚、福田隆浩、中根孝彦、小林 武、谷口修一、森島泰雄、長村登紀子、坂巻 壽、熱田由子、村田 誠
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] Grade II以上の急性GVHDに対する治療成績：TRUMPデータを用いた解析 (2012)
  • Author(s): 村田 誠、仲宗根秀樹、諫田淳也、中根孝彦、古川達雄、福田隆浩、谷口修一、森 毅彦、衛藤徹也、森島泰雄、長村登紀子、矢部普正、熱田由子、鈴木律朗、坂巻 壽
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] 同種造血幹細胞移植後合併症と長期予後に与えるHCV陽性の影響 (2012)
  • Author(s): 仲宗根秀樹、薬師神公和、黒澤彩子、小川啓恭、大橋一輝、衛藤徹也、坂巻 壽、森島泰雄、長村登紀子、鈴木律朗、村田 誠、谷口修一、福田隆浩
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] 同種造血幹細胞移植患者に対する精神科リエゾン活動の導入 (2012)
  • Author(s): 功刀愛子、川口 綾、鈴木絢子、高木麻里、有友裕子、仙波晴美、小林律子、宮内倫也、杉山由佳、佐藤直弘、西田徹也、木村宏之、村田 誠
  • Organizer: 第34回日本造血細胞移植学会総会
  • Place of Presentation: 大阪国際会議場（大阪市）
• [Presentation] Correlation of Serum IL-6 Level with Exhaustion of Cytomegalovirus-specific T Cells After Hematopoietic Stem Cell Transplantation. (2011)
  • Author(s): Kato T, Nishida T, Murase M, Ito Y, Murata M, Naoe T.
  • Organizer: The 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Leukemia Escape From HLA-Specific T Lymphocyte Pressure in a Recipient of HLA One Locus-Mismatched Bone Marrow Transplantation. (2011)
  • Author(s): Kato T, Murata M, Terakura S, Sugimoto K, Murase M, Nishida T, Naoe T.
  • Organizer: The 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] Mesenchymal Stem Cells As a Treatment for Steroid-Resistant Acute Graft Versus Host Disease (aGVHD); A Multicenter Phase I/II Study. (2011)
  • Author(s): Ozawa Y, Goto T, Ohashi K, Murata M, Eto T, Kobayashi N, Taniguchi S, Imamura M, Ando K, Kato K, Mori T, Teshima T, Mori M, Muroi K, Miyamura K, Ozawa K.
  • Organizer: The 53rd Annual Meeting of the American Society of Hematology
  • Place of Presentation: San Diego Convention Center (San Diego, USA)
• [Presentation] HLA不一致骨髄移植後患者におけるHLA特異的CTLからの白血病エスケープ (2011)
  • Author(s): 加藤智則、村田 誠、寺倉精太郎、杉本恭子、西田徹也、直江知樹
  • Organizer: 第3回造血器腫瘍免疫療法研究会学術集会
  • Place of Presentation: ホテル白菊（別府市）
• [Presentation] 同種造血幹細胞移植後難治性CMV感染患者におけるCMV抗原特異的T細胞機能低下のメカニズム (2011)
  • Author(s): 加藤智則、西田徹也、村田 誠、直江知樹
  • Organizer: 第3回造血器腫瘍免疫療法研究会学術集会
  • Place of Presentation: ホテル白菊（別府市）
• [Presentation] Exhaustion of cytomegalovirus specific T cells after allogeneic stem cell transplantation. (2011)
  • Author(s): Kato T, Nishida T, Ito Y, Takahashi Y, Murata M, Kojima S, Naoe T.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] 移植患者生涯手帳作成の試み (2011)
  • Author(s): 宮村耕一、後藤辰徳、小野寺晃一、横畠絵美、小山大輔、渡邊慶介、瀬戸愛花、小澤幸泰、松本公一、加藤剛二、熱田由子、河野彰夫、村田 誠
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Presentation] Efficacy and Safety of human adipose tissue-derived MSCs for supporting hematopoiesis. (2011)
  • Author(s): Nakayama T, Nishiwaki S, Saito S, Ozaki T, Takahashi Y, Maruyama S, Nishida T, Murata M, Kojima S, Naoe T.
  • Organizer: 第73回日本血液学会学術集会
  • Place of Presentation: 名古屋国際会議場（名古屋市）
• [Book] 急性GVHDの一次治療.みんなに役立つGVHDの基礎と臨床編集 (2013)
  • Author(s): 村田誠, (豊嶋崇徳)
  • Publisher: 医薬ジャーナル社, (東京)
• [Book] みんなに役立つGVHDの基礎と臨床 (2013)
  • Author(s): 村田 誠、他40名.
  • Total Pages: 424
  • Publisher: 医薬ジャーナル社
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/naika/outline/ketsueki-syuyou.html
• [Remarks] 名古屋大学大学院医学系研究科 病態内科学講座 血液・腫瘍内科学
  • URL: http://www.med.nagoya-u.ac.jp/naika/outline/ketsueki-syuyou.html
• [Remarks] 名古屋大学大学院医学系研究科 病態内科学講座 血液・腫瘍内科学
  • URL: http://www.med.nagoya-u.ac.jp/medical/6391/6393/ketsuekishuyounaikagaku.html
• [Remarks]
  • URL: http://www.med.nagoya-u.ac.jp/medical/1639/1674/ketsuekishuyounaikagaku.html