Regulatory roles of heme oxygenase-1 in autoinflammation and autoimmunity as a model of Behcet's disease

• Project/Area Number: 23591443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Yokohama City University
• Principal Investigator: TAKENO Mitsuhiro 横浜市立大学, 医学部, 准教授 (50236494)
• Co-Investigator(Kenkyū-buntansha): YOSHIMI Ryusuke 横浜市立大学, 医学部, 助教 (70585265)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ベーチェット病 / ヘムオキシゲナーゼ-1 / IL-10 / 自己免疫 / 自己炎症 / HLA-クラスI / ERAP-1 / TLR4 / HLA-クラス I / HO-1 / 腫瘍壊死因子

Research Abstract

In this study, we try to verify the hypothesis that impaired protective function by IL-10/HO-1 trigger autoimmune and autoinflammatory responses, leading to Behcet disease (BD). Further analyses after GWAS have identified CCR1, STAT4, KLRC4, ERAP1, TLR4, NOD2, and MEFV as susceptible genes, all of which are involved in the acquired and innate immunity systems. Of them, genetic contribution of TLR4 is concordant with our previous finding that overexpression of TLR4 is associated with defective expression of HO-1 in BD patients, suggesting validity of the hypothesis in part. Moreover, recent studies have shown that HO-1 is preferentially expressed on non-classical M2 macrophages, suggesting M1 deviation of M1/M2 balance is responsible for development of BD. The issue will be studied in the next grant (No. 26461469).

Research Products

• [Journal Article] Analysis of various factors on the relapse of acute neurological attacks in Behçet's disease (2014)
  • Author(s): Hirohata S, Takeno M, et al
  • Journal Title: Mod Rheumatol Volume: (in press)
  • URL: http://informahealthcare.com/mor
  • Peer Reviewed
• [Journal Article] Single center study on ethnic and clinical features of Behcet's disease in Moscow, Russia (2014)
  • Author(s): Lennikov A, Takeno M, et al
  • Journal Title: Clin Rheumatol Volume: (in press)
  • URL: http://link.springer.com/journal/10067
  • Peer Reviewed
• [Journal Article] ベーチェット病と妊娠 (2014)
  • Author(s): 岳野光洋
  • Journal Title: リウマチ科 Volume: (印刷中)
  • URL: http://www.kahyo.com/category/A1-R
• [Journal Article] ベーチェット病 (2014)
  • Author(s): 岳野光洋
  • Journal Title: 膠原病ハイグレード Volume: (印刷中)(電子ジャーナルなし)
• [Journal Article] Gastrointestinal manifestations of Behçet's disease in Japan : a study of 43 patients (2014)
  • Author(s): Ideguchi H, Takeno M, et al
  • Journal Title: Rheumatol Int Volume: 34 Issue: 6 Pages: 851-6
  • DOI: 10.1007/s00296-013-2838-5
  • Peer Reviewed
• [Journal Article] The 2nd edition of consensus statements for the diagnosis and management of intestinal Behcet's disease: indication of anti-TNFα monoclonal antibodies. (2014)
  • Author(s): Hisamatsu T, Ueno F, Matsumoto T, Kobayashi K, Koganei K, Kunisaki R, Hirai F,Nagahori M, Matsushita M, Kobayashi K, Kishimoto M, Takeno M, Tanaka M, Inoue N, Hibi T.
  • Journal Title: J Gastroenterol Volume: 49(1) Issue: 1 Pages: 156-62
  • DOI: 10.1007/s00535-013-0872-4
  • Peer Reviewed
• [Journal Article] Lymphopenia Helps Early Diagnosis of Systemic Lupus Erythematosus for Patients With Psychosis as an Initial Symptom. (2014)
  • Author(s): Chiba Y, Katsuse O, Fujishiro H, Kamada A, Saito T, Ikura T, Takahashi Y,Kunii M, Takeno M, Hirayasu Y.
  • Journal Title: Psychosomatics. Volume: Epub ahead of print Issue: 1 Pages: 85-88
  • DOI: 10.1016/j.psym.2013.07.001
  • Peer Reviewed
• [Journal Article] Gastrointestinal manifestations of Behcet's disease in Japan: a study of 43 patients. (2014)
  • Author(s): Ideguchi H, Suda A, Takeno M, Miyagi R, Ueda A, Ohno S, Ishigatsubo Y.
  • Journal Title: Rheumatol Int. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Ultrasonography predicts achievement of Boolean remission after DAS28-based clinical remission ofrheumatoid arthritis. (2014)
  • Author(s): Yoshimi R, Hama M, Minegishi K, Kishimoto D, Watanabe T, Kamiyama R, Kirino Y,Asami Y, Ihata A, Tsunoda S, Ueda A, Takeno M, Ishigatsubo Y.
  • Journal Title: Mod Rheumatol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Single center study onethnic and clinical features of Behcet's disease in Moscow, Russia. (2014)
  • Author(s): Lennikov A, Alekberova Z, Goloeva R, Kitaichi N, Denisov L, Namba K, Takeno M,Ishigatsubo Y, Mizuki N, Nasonov E, Ishida S, Ohno S.
  • Journal Title: Clin Rheumatol Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] Analysis of various factors on the relapse of acute neurological attacks in Behcet's disease. (2014)
  • Author(s): Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y.
  • Journal Title: Mod Rheumatol. Volume: Epub ahead of print
  • Peer Reviewed
• [Journal Article] 回帰性リウマチ (2014)
  • Author(s): 岳野 光洋
  • Journal Title: 日本臨床 最新関節リウマチ Volume: 76 (Suppl 3) Pages: 380-4
• [Journal Article] ベーチェット病と妊娠 (2014)
  • Author(s): 岳野 光洋
  • Journal Title: リウマチ科 Volume: 48(3)
• [Journal Article] Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behçet disease. (2013)
  • Author(s): Kirino Y, Zhou Q, Ishigatsubo Y, Mizuki N, Tugal-Tutkun I, Seyahi E, Özyazgan Y, Ugurlu S, Erer B, Abaci N, Ustek D, Meguro A, Ueda A, Takeno M, Inoko H, Ombrello MJ, Satorius CL, Maskeri B, Mullikin JC, Sun HW, et al
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110(20) Issue: 20 Pages: 8134-8139
  • DOI: 10.1073/pnas.1306352110
  • Peer Reviewed
• [Journal Article] Ultrasonography is a potent tool for the prediction of progressive joint destruction during clinical remission of rheumatoid arthritis. (2013)
  • Author(s): Yoshimi R, Hama M, Takase K, Ihata A, Kishimoto D, Terauchi K, Watanabe R, Uehara T, Samukawa S, Ueda A, Takeno M, Ishigatsubo Y.
  • Journal Title: Mod Rheumatol. Volume: 23(3) Issue: 3 Pages: 456-65
  • DOI: 10.1007/s10165-012-0690-1
  • NAID: 10031175904
  • Peer Reviewed
• [Journal Article] Preferences of Japanese rheumatoid arthritis patients in (2013)
  • Author(s): Aoki A, Suda A, Nagaoka S, Takeno M, Ishigatsubo Y, Ashizawa T, Ohde S, Takahashi O, Ohbu S.
  • Journal Title: Mod Rheumatol Volume: 23(5) Issue: 5 Pages: 891-6
  • DOI: 10.1007/s10165-012-0761-3
  • Peer Reviewed
• [Journal Article] Anti-glutamate receptor ɛ2 antibodies in psychiatric patients with anti-thyroid autoantibodies--a prevalence study in Japan. (2013)
  • Author(s): Chiba Y
  • Journal Title: Neurosci Lett Volume: 534 Pages: 217-222
  • DOI: 10.1016/j.neulet.2012.10.060
  • Peer Reviewed
• [Journal Article] Targeted resequencing implicates the familial Mediterranean fever gene MEFV and the toll-like receptor 4 gene TLR4 in Behcet disease. (2013)
  • Author(s): Kirino Y, Takeno M, et al
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Genome-wide association analysis identifies new susceptibility loci for Behcet's disease and epistasis between HLA-B*51 and ERAP1 (2012)
  • Author(s): Mizuki N, Meguro A
  • Journal Title: Nat Genet Volume: 45 Issue: 2 Pages: 202-7
  • DOI: 10.1038/ng.2520
  • Peer Reviewed
• [Journal Article] Bach1 regulates osteoclastogenesis via both heme oxygenase-1 dependent and independent pathways (2012)
  • Author(s): Maasa Hama, Yohei Kirino, Mitsuhiro Takeno, Kaoru Takase, Takuya Miyazaki, Ryusuke Yoshimi, Atsuhisa Ueda, Ari Itoh-Nakadai, Akihiko Muto, Kazuhiko Igarashi, Yoshiaki Ishigatsubo
  • Journal Title: American Rheumatism Association Volume: (In press) Issue: 5 Pages: 1518-28
  • DOI: 10.1002/art.33497
  • Peer Reviewed
• [Journal Article] ベーチェット病の免疫異常と治療の進歩(総説) (2012)
  • Author(s): 岳野光洋、水木信久、石ヶ坪良明
  • Journal Title: 日本脊椎関節炎学会誌 Volume: 4(電子ジャーナルなし) Pages: 13-8
• [Journal Article] 【RA診療におけるエビデンス-ガイドライン、推奨、提言など】EULARベーチェット病診療recommendation(解説/特集) (2012)
  • Author(s): 岳野光洋、石ヶ坪良明
  • Journal Title: リウマチ科 Volume: 48 Pages: 75-9
  • URL: http://www.kahyo.com/item/R201207-481
• [Journal Article] Clinical characteristics of neuro-Behcet's disease in Japan : a multicenter retrospective analysis (2012)
  • Author(s): Hirohata S, Takeno M, et al
  • Journal Title: Mod Rheumatol Volume: 22 Issue: 3 Pages: 405-13
  • DOI: 10.1007/s10165-011-0533-5
  • NAID: 10030782249
  • Peer Reviewed
• [Journal Article] 【RA診療におけるエビデンス-ガイドライン、推奨、提言など】EULARベーチェット病診療recommendation(解説/特集) (2012)
  • Author(s): 岳野光洋、石ヶ坪良明.
  • Journal Title: リウマチ科 Volume: 48(1) Pages: 75-79
• [Journal Article] ベーチェット病の免疫異常と治療の進歩(総説) (2012)
  • Author(s): 岳野光洋、水木信久、石ヶ坪良明.
  • Journal Title: 日本脊椎関節炎学会誌 Volume: 4(1):
• [Journal Article] Characteristics of vascular involvement in Behçet's disease in Japan : a retrospective cohort study (2011)
  • Author(s): Ideguchi H, Takeno M, et al
  • Journal Title: Clin Exp Rheumatol Volume: 29
  • URL: http://www.clinexprheumatol.org/pubmed/find-pii.asp?pii=21968236
  • Peer Reviewed
• [Journal Article] Clinical Course before and after Cataract and Glaucoma Surgery under Systemic Infliximab Therapy in Patients with Behcet's Disease (2011)
  • Author(s): Mizuki N
  • Journal Title: Case Rep Ophthalmol Volume: 2 Issue: 2 Pages: 189-92
  • DOI: 10.1159/000329190
  • Peer Reviewed
• [Journal Article] Behçet's disease and colon cancer (2011)
  • Author(s): Inamori M, Takeno M
  • Journal Title: Intern Med Volume: 50 Pages: 537-8
  • NAID: 130000649881
  • URL: https://www.jstage.jst.go.jp/article/internalmedicine/50/6/50_6_537/_pdf
• [Journal Article] Behcet病の病態と単球・好中球 (2011)
  • Author(s): 岳野光洋, 他
  • Journal Title: 炎症と免疫 Volume: 19 Pages: 487-90
  • URL: http://www.sentan.com/cgi-bin/db_n.cgi?mode=view_backno&no=809
• [Journal Article] 【膠原病の実地診療プライマリケアと難治性病態の克服】治療/実地医家のための最新の治療新しいべーチェト病の治療のガイドラインとその使い方 (2011)
  • Author(s): 岳野光洋, 石ヶ坪良明
  • Journal Title: Medical Practice Volume: 28 Pages: 1281-5
  • URL: http://www.fujisan.co.jp/product/1281681118/
• [Journal Article] Behcet’s disease and colon cancer. (2011)
  • Author(s): Inamori M, and Takeno M.
  • Journal Title: Internal Med Volume: 50(6) Pages: 537-8
  • Peer Reviewed
• [Journal Article] Successful switching to adalimumab in an infliximab-allergic patient with severe Behçet disease-related uveitis (2011)
  • Author(s): .Takase K, Ohno S, Ideguchi H, Uchio E, Takeno M, Ishigatsubo Y.
  • Journal Title: Rheumatol Int Volume: 31(2): Pages: 243-5
  • Peer Reviewed
• [Journal Article] Behçet disease: evolution of clinical manifestations (2011)
  • Author(s): Ideguchi H, Suda A, Takeno M, Ueda A, Ohno S, Ishigatsubo Y.
  • Journal Title: Medicine (Baltimore) Volume: 90(2) Pages: 125-32
  • Peer Reviewed
• [Journal Article] Clinical Course before and after Cataract and Glaucoma Surgery under Systemic Infliximab Therapy in Patients with Behçet's Disease. (2011)
  • Author(s): Nishida T, Shibuya E, Asukata Y, Nakamura S, Ishihara M, Hayashi K, Takeno M, Ishigatsubo Y, Mizuki N.
  • Journal Title: Case Report Ophthalmol Volume: 2(2) Pages: 189-92
  • Peer Reviewed
• [Journal Article] Clinical characteristics of neuro-Behcet's disease in Japan: a multicenter retrospective analysis (2011)
  • Author(s): Hirohata S, Kikuchi H, Sawada T, Nagafuchi H, Kuwana M, Takeno M, Ishigatsubo Y.
  • Journal Title: Mod Rheumatol Volume: 21
  • NAID: 10030782249
  • Peer Reviewed
• [Journal Article] Characteristics of vascular involvement in Behçet's disease in Japan: a retrospective cohort (2011)
  • Author(s): Ideguchi H, Suda A, Takeno M, Ueda A, Ohno S, Ishigatsubo Y.
  • Journal Title: Clin Exp Rheumatol. Volume: 29(4 Suppl 67):
  • Peer Reviewed
• [Journal Article] TNF阻害薬 （ベーチェット病および血管炎症候群） (2011)
  • Author(s): 岳野光洋、石ヶ坪良明.
  • Journal Title: リウマチ科 Volume: 45(1) Pages: 41-47
• [Journal Article] 腸管ベーチェット病に対するサイトカイン療法の基礎研究 (2011)
  • Author(s): 岳野光洋、石ヶ坪良明.
  • Journal Title: 胃と腸 Volume: 46(7): Pages: 1073-1080
• [Journal Article] 【膠原病の実地診療プライマリケアと難治性病態の克服】 治療/実地医家のための最新の治療 新しいべーチェト病の治療のガイドラインとその使い方 (2011)
  • Author(s): 岳野光洋、石ヶ坪良明
  • Journal Title: Medical Practice Volume: 28(7) Pages: 1281-1285
• [Presentation] Immunogenicity of infliximab modulates efficacy and safety in Behcet's disease patients with uveitis. American College of Rheumatology (2013)
  • Author(s): Takeno M, et al
  • Organizer: 78^<th> Annual Scientific Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 2013-10-29
• [Presentation] Clinical features of Japanese patients with vasculo- Behçet's disease : A multicentric study by Behçet's Disease Research Committee, MHLW (2013)
  • Author(s): Takeno M, et al
  • Organizer: 14^<th> Annual European Congress of Rheumatology, 2013 A scientific meeting
  • Place of Presentation: Madrid (Spain)
  • Year and Date: 2013-06-15
• [Presentation] 血管型ベーチェット病診療ガイドライン作成に向けて (2013)
  • Author(s): 岳野光洋,他
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 国立国際会館(京都)
  • Year and Date: 2013-04-19
• [Presentation] ベーチェット病ぶどう膜炎に対するインフリキシマブ治療効果減弱時の薬理動態とその対策 (2013)
  • Author(s): 岳野光洋,吉見竜介,他
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 国立国際会館(京都)
  • Year and Date: 2013-04-19
• [Presentation] The E3 ubiquitin ligase TRIM21 forms a complex with p62 and TRAF6 and promotes degradation of TRAF6. (2013)
  • Author(s): Yoshimi R, Watanabe R, Tsukahara T, Hama M, Ihata A, Ueda A, Takeno M, Morse III HC, Ozato K, Ishigatsubo Y
  • Organizer: The American Association of Immunologists 100th Annual Meeting,
  • Place of Presentation: Honolulu, USA
• [Presentation] The E3 ubiquitin ligase TRIM21 promotes degradation of TRAF6 via TRIM21-p62-TRAF6 complex formation. (2013)
  • Author(s): Yoshimi R, Tsukahara T, Watanabe R, Hama M, Ihata A, Ueda A, Takeno M, Morse III HC, Ozato K, Ishigatsubo Y
  • Organizer: The Joint International Meeting of The 78th Meeting of The Japanese Society of Interferon and Cytokine Research and The 21st International Symposium on Molecular Cell Biology of Macrophages
  • Place of Presentation: 都市センター、東京
• [Presentation] Ultrasonography is useful for Boolean remission after achieving DAS28-based clinical remission of rheumatoid arthritis. (2013)
  • Author(s): Yoshimi R, Hama M, Takase K, Sugiyama Y, Kishimoto D, Watanabe R, Uehara T, Asami Y, Ihata A, Ueda A, Takeno M, Ishigatsubo Y
  • Organizer: 14th Annual European Congress of Rheumatology, 2013 A scientific meeting
  • Place of Presentation: Madrid, Spain
• [Presentation] Total power Doppler score-8 is a useful diagnostic marker of musculoskeletal ultrasonography for screening and activity measurement of rheumatoid arthritis. (2013)
  • Author(s): Yoshimi R, Ihata A, Kishimoto D, Watanabe R, Uehara T, Takase K, Hama M, Asami Y, Ueda A, Takeno M, Ishigatsubo Y
  • Organizer: 14th Annual European Congress of Rheumatology, 2013 A scientific meeting
  • Place of Presentation: Madrid, Spain
• [Presentation] Relative FDG acucumulation of the aortic wall lesions to aortic blood pool in 18-FDG-PET/CT is auseful parameter for assessing the disease activity of Takayasu arteritis. (2013)
  • Author(s): Ihata A, Shizukuishi K, Kishimoto D, Watanabe T, Watanabe R, Hama M, Yoshimi R, Ueda A, Takeno M, Ishigatsubo Y
  • Organizer: 14th Annual European Congress of Rheumatology, 2013 A scientific meeting
  • Place of Presentation: Madrid, Spain
• [Presentation] Clinical features of Japanese patients with vasculo- Behcet’s disease: A multicentric study by Behçet’s Disease Research Committee, MHLW. (2013)
  • Author(s): Takeno M, Ideguchi H, Suda A, Watanabe R, Kikuchi H, H. Nagafuchi H, Kuwana M, Saito K, Hirohata S, Ishigatsubo Y
  • Organizer: 14th Annual European Congress of Rheumatology, 2013 A scientific meeting
  • Place of Presentation: Madrid, Spain
• [Presentation] Autoantigen TRIM21/Ro52 negatively regulates TRAF6 expression via TRIM21-p62-TRAF6 trimer formation. (2013)
  • Author(s): Yoshimi R, Kamiyama R, Tsukahara T, Minegishi K, Hama M, Kirino Y, Asami Y, Ueda A, Takeno M, Morse III HC, Ozato K, Ishigatsubo Y
  • Organizer: 12th International Symposium on Sjogren’s Syndrome:
  • Place of Presentation: 京都ホテル大谷、京都
• [Presentation] The analysis of prognostic factors in patients with inflammatory myopathies and amyopathic dermatomiositis complicated with interstitial lung disease. (2013)
  • Author(s): Hama M, Sugiyama Y, Kirino Y, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Yoshimi R, Asami Y, Ueda A, Takeno M, Aoki I, Ishigatsubo Y
  • Organizer: American College of Rheumatology, 78th Annual Scientific Meeting,
  • Place of Presentation: San Diego, USA
• [Presentation] Ultrasonography is helpful for optimizing the diagnosis of early rheumatoid arthritis. (2013)
  • Author(s): Hama M, Tsolmon D, Minegishi K, Yoshimi R, Kirino Y, Ueda A, Takeno M, Aoki I, Ishigatsubo Y
  • Organizer: American College of Rheumatology, 78th Annual Scientific Meeting,
  • Place of Presentation: San Diego, USA
• [Presentation] Immunogenicity of infliximab modulates efficacy and safety in Behcet’s disease patients with uveitis. (2013)
  • Author(s): Takeno M, Terauchi K, Kirino H, Yoshimi R, Ueda A, Mizuki N, Shibuya E, Ishigatsubo Y
  • Organizer: American College of Rheumatology, 78th Annual Scientific Meeting,
  • Place of Presentation: San Diego, USA
• [Presentation] Comparison of selected joint evaluation with comprehensive assessment in musculoskeletal ultrasonography for detection of synovitis in rheumatoid arthritis. (2013)
  • Author(s): Yoshimi R, Ihata A, Kunishita Y, Kishimoto D, Kamiyama R, Minegishi K, Hama M, Kirino Y, Asami Y, Ueda A, Takeno M, Aoki I, Ishigatsubo Y
  • Organizer: American College of Rheumatology, 78th Annual Scientific Meeting,
  • Place of Presentation: San Diego, USA
• [Presentation] ベーチェット病ぶどう膜炎に対するインフリキシマブ治療効果減弱時の薬理動態とその対策 (2013)
  • Author(s): 岳野光洋, 寺内佳余, 渡邉玲光, 上原武晃, 吉見竜介, 上田敦久, 澁谷悦子, 水木信久, 石ヶ坪良明
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] 血管型ベーチェット病診療ガイドライン作成に向けて (2013)
  • Author(s): 岳野光洋, 出口治子, 須田昭子, 渡邊玲光, 桑名正隆, 沢田哲治, 菊地弘敏, 永渕裕子, 廣畑俊成, 齋藤和義, 石ヶ坪良明
  • Organizer: 第57回日本リウマチ学会総会
  • Place of Presentation: 国立京都国際会館、京都
• [Presentation] ベーチェット病ぶどう膜炎に対する抗TNF抗体の効果減弱とその対策 (2012)
  • Author(s): 岳野光洋,吉見竜介,他
  • Organizer: 第27回日本臨床リウマチ学会
  • Place of Presentation: 神戸ポートピア(兵庫)
  • Year and Date: 2012-11-23
• [Presentation] Assessment of the disease (Epidemiology) (2012)
  • Author(s): Takeno M
  • Organizer: 15th International Conference on Behçet's Disease
  • Place of Presentation: 横浜パシフィコ(神奈川)(Overview)
  • Year and Date: 2012-07-14
• [Presentation] 治療からみたベーチェット病の免疫異常 (2012)
  • Author(s): 岳野光洋
  • Organizer: 第5回自己炎症研究会
  • Place of Presentation: 福岡朝日ビル(福岡)
  • Year and Date: 2012-07-06
• [Presentation] ベーチェット病に対する抗TNF抗体治療の有効性と問題点 (2012)
  • Author(s): 岳野光洋,吉見竜介,他
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡(福岡)
  • Year and Date: 2012-07-05
• [Presentation] 腸管ベーチェット病ガイドラインの改定案 (2012)
  • Author(s): 岳野光洋,他
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪(東京)
  • Year and Date: 2012-04-27
• [Presentation] Targeted Deep Re-Sequencing Implicates Rare and Low Frequency Coding Variants in IL23R, MEFV, TLR4, and NOD2 in Behcet's Disease (2012)
  • Author(s): Kirino Y, Takeno M et al.
  • Organizer: American College of Rheumatology, Annual Scientific Meeting,
  • Place of Presentation: Washington DC (USA)
• [Presentation] Genome-Wide Analysis Reveals a Recessive Association of ERAP1 Variants with Behcet's Disease and Epistasis Between ERAP1 and HLA-B*51 (2012)
  • Author(s): Remmers EF, Kirino Y, Takeno M, et al.
  • Organizer: American College of Rheumatology, Annual Scientific Meeting,
  • Place of Presentation: Washington DC (USA)
• [Presentation] ベーチェット病の臨床と治療の進歩 (2011)
  • Author(s): 岳野光洋
  • Organizer: 平成23年度石川地区リウマチ教育研修会.
  • Place of Presentation: ホテル金沢(石川)
  • Year and Date: 2011-11-13
• [Presentation] Behçet's Disease Reserch Commitee of Japan. Consensus Statements for Management for Intestinal Behçet's Disease in Japan (2011)
  • Author(s): Takeno M, et al
  • Organizer: American College of Rheumatology 76th Annual Scientific Meeting
  • Place of Presentation: Chicago (USA)
  • Year and Date: 2011-11-08
• [Presentation] ベーチェット病の免疫異常と治療の進歩 (2011)
  • Author(s): 岳野光洋,他
  • Organizer: 第21回日本脊椎関節炎学会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2011-09-17
• [Presentation] Bach1による抗炎症蛋白ヘムオキシゲナーゼ-1の発現制御-炎症性疾患への治療応用- (2011)
  • Author(s): 岳野光洋,他
  • Organizer: 第55回日本リウマチ学会総会
  • Place of Presentation: 神戸ポートピア(兵庫)
  • Year and Date: 2011-07-19
• [Presentation] ヒト単球におけるBach1によるheme oxygenase-1の発現調節 (2011)
  • Author(s): 岳野光洋, 他
  • Organizer: 第32回日本炎症・再生医学会・学術集会
  • Place of Presentation: 国立国際会館(京都)
  • Year and Date: 2011-06-03
• [Presentation] ヒト単球におけるBach1によるheme oxygenase-1の発現調節． , (2011)
  • Author(s): 岳野光洋, 宮崎拓也, 桐野洋平, 渡邉玲光, 寒川整, 高瀬薫, 浜真麻, 石ヶ坪良明:
  • Organizer: 第32回日本炎症・再生医学会・学術集会,
  • Place of Presentation: 国立京都国際会館（京都府）
• [Presentation] Bach1による抗炎症蛋白ヘムオキシゲナーゼ-1の発現制御-炎症性疾患への治療応用-. (2011)
  • Author(s): 岳野光洋, 宮崎拓也, 桐野洋平, 渡邉玲光, 寒川整, 浜真麻, 石ヶ坪良明
  • Organizer: 第55回日本リウマチ学会総会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
• [Presentation] ベーチェット病の免疫異常と治療の進歩 (2011)
  • Author(s): 岳野光洋, 水木信久, 石ヶ坪良明
  • Organizer: 第21回日本脊椎関節炎学会(招待講演)
  • Place of Presentation: 岡山コンベンションセンター（岡山県）
• [Presentation] ベーチェット病の免疫異常. (2011)
  • Author(s): 岳野光洋
  • Organizer: 第4回基礎と臨床を結ぶ分子病態研究会(招待講演)
  • Place of Presentation: 学士会館（東京都）
• [Presentation] ベーチェット病の臨床と治療の進歩 (2011)
  • Author(s): 岳野光洋
  • Organizer: 日本リウマチ学会.石川地区リウマチ教育研修会,(招待講演)
  • Place of Presentation: ホテル金沢（石川県）
• [Presentation] インフリキシマブ治療中に神経ベーチェット病を発症した一例
  • Author(s): 神山玲光, 國下洋輔, 岸本大河, 峰岸 薫, 浜 真麻, 吉見竜介, 桐野洋平, 浅見由希子, 上田敦久, 岳野光洋, 石ヶ坪良明
  • Organizer: 第24回日本リウマチ学会関東支部学術集会
  • Place of Presentation: 都市センター、東京
• [Presentation] Clinical features of Vasculo- Behçet's disease in Japan.
  • Author(s): Ideguchi H, Suda A, Watanabe R, Kuwana M, Kikuchi H, Nagafuchi H, Saito K, Hirohata S, Takeno M, Ishigatsubo Y.
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
• [Presentation] Targeted deep re-sequencing implicates rare and low frequency coding variants in IL23R, MEFV, TLR4, and NOD2 in Behçet's disease.
  • Author(s): Kirino Y, Takeno M et al.
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
• [Presentation] New Genetic Susceptibility Loci and Gene-Gene Interactions in Behçet's Disease.
  • Author(s): Remmers EF, Kirino Y, Takeno M, et al.
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
• [Presentation] Assessment of the disease (Epidemiology). Overview.
  • Author(s): Takeno M
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
  • Invited
• [Presentation] Infliximab therapy for uveitis in Behçet's disease.
  • Author(s): Terauchi K, Takeno M, Shibuya E, Mizuki N, Ishigatsubo Y.
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
• [Presentation] The efficacy of Infliximab therapy for intestinal Behcet’s disease -The retrospective study in Japan-
  • Author(s): Watanabe R, Takeno M, Nagahori M, Kurosawa M, Uehara R, Nagai M, Ishigatsubo Y
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
• [Presentation] Favorable responses to Infliximab after endovascular intervention in a Behcet’s disease patient with inflammatory aneurysm in subclavian artery.
  • Author(s): Watanabe R, Takeno M, Ueda A, Ihata A, Yoshimi R, Obata M, Ishigatsubo. Y.
  • Organizer: 15th International Conference on Beh&ccedil;et’s Disease
  • Place of Presentation: 横浜ﾊﾟｼﾌｨｺ（神奈川県）
• [Presentation] 新規ベーチェット病感受性遺伝子座としてのCCR1とSTAT4のImputationによる同定
  • Author(s): 桐野洋平, 岳野光洋 他:
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] 腸管ベーチェット病ガイドラインの改定案,
  • Author(s): 岳野光洋, 菊地弘敏, 齋藤和義, 石ヶ坪良明
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] ベーチェット病の眼病変に対するインフリキシマブ投与の有効性と安全性
  • Author(s): 寺内佳余, 岳野光洋, 上原武晃, 上田敦久, 石ヶ坪良明
  • Organizer: 第56回日本リウマチ学会総会・学術集会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都）
• [Presentation] ベーチェット病に対する抗TNF抗体治療の有効性と問題点
  • Author(s): 岳野光洋, 寺内佳余, 上原武晃, 吉見竜介, 澁谷悦子, 水木信久, 石ヶ坪良明
  • Organizer: 第33回日本炎症・再生医学会
  • Place of Presentation: ホテル日航福岡（福岡県）
• [Presentation] 治療からみたベーチェット病の免疫異常
  • Author(s): 岳野光洋
  • Organizer: 第5回自己炎症研究会
  • Place of Presentation: 福岡朝日ビル（福岡県）
  • Invited
• [Presentation] ベーチェット病ぶどう膜炎に対する抗TNF抗体の効果減弱とその対策
  • Author(s): 岳野光洋, 寺内佳余, 渡邊玲光, 上原武晃, 吉見竜介, 澁谷悦子, 水木信久, 石ヶ坪良明
  • Organizer: 第27回日本臨床リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル（兵庫県）
• [Book] Vascular involvement of Behçet's disease. Behçet's disease : from bench to bed (2014)
  • Author(s): Takeno M, et al(Ishigatsubo Y ed.)
  • Publisher: Springer, Tokyo(in press)
• [Book] やさしい臨床医学テキスト. (2014)
  • Author(s): 平井みどり、星恵子、石井亜紀子、古庄健太郎、鶴嶋英夫、大越教夫、冨所康志、辻浩史、石川欽也、河野豊、門前達哉、小國英一、藤井聡、大手信之、後藤信哉、山下純世、福田秀克、山下直美、岳野光洋ほか （大野 勲、柴崎敏昭、平井みどり、星 恵子、三木知博、山下直美編集）
  • Total Pages: 506
  • Publisher: 薬事日報社
• [Book] Behcet's Disease - From Genetics to Therapies (2014)
  • Author(s): Mitsuhiro Takeno (Ishigatsubo Y ed)
  • Publisher: Springer
• [Book] 膠原病ハイグレード (2014)
  • Author(s): 岳野光洋
  • Publisher: 文光堂
• [Book] 今日の治療と看護（改訂第三版） (2013)
  • Author(s): 五十嵐隆、大田健、太田康男、神田善伸、川合眞一、神庭重信、北川浩明、木下芳一、小池和彦、島田洋一、洲崎春海、千葉厚郎、坪田一男、寺内康夫、永井良三、南学正臣、福井次矢、水谷太郎、宮地良樹、岳野光洋 ほか（永井良三、大田健 総編集）
  • Total Pages: 1493
  • Publisher: 南江堂
• [Book] year note 2014 (2013)
  • Author(s): 朝倉均、岡住慎一、押谷伸英、冨木裕一、檜山英三、荒瀬康司、入沢篤志、水口徹、米田正人、関寿人、糸井隆夫、山上裕機、 三角和雄、大手信之、池田宇一、秦光賢、高橋尚彦、渡辺重行、尾辻豊、岳野光洋ほか （岡庭豊、荒瀬康司、三角和雄編）
  • Total Pages: 1665
  • Publisher: メディク・メディア
• [Book] 医師国家試験のためのレビューブック内科・外科 (2013)
  • Author(s): 伊豆津宏二、糸井隆夫、岩崎泰正、大泉弘幸、岡田忠雄、春日井邦夫、川並透、今田恒夫、齋藤伸二郎、鈴木昭広、高橋尚彦、岳野光洋、永井敦、宮良高雄、吉田和彦、横林賢一（岡庭豊編）
  • Total Pages: 776
  • Publisher: メディク・メディア
• [Book] イヤーノート Topics 2014-2015 (2013)
  • Author(s): 清村志乃、木下芳一、岡住慎一、春日井邦夫、平石秀俊、西田俊朗、後藤昌弘、檜山英三、金子宏、田中信治、田中篤、橋本悦子、荒井邦明、金子周一、平野聡、清水京子、清野精彦、高橋尚彦、池田隆徳、岳野光洋ほか
  • Total Pages: 334
  • Publisher: メディク・メディア