| Project/Area Number |
23591453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
MAKINO Yuichi 旭川医科大学, 医学部, 准教授 (90345033)
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| Co-Investigator(Kenkyū-buntansha) |
HANEDA Masakazu 旭川医科大学, 医学部, 教授 (00124751)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 炎症 / 低酸素 / 単球 / マクロファージ / 単核球 / HIF-1 / 転写因子 / ChREBP |
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| Research Abstract |
This study was aimed to explore the role of hypoxia-inducible factors in regulation of immune response and to develop a novel therapeutic approach for inflammatory diseases by targeting the hypoxia-inducible factors. We demonstrated that IPAS, an endogenous dominant-negative regulator of HIF-1alpha, negatively regulates joint inflammation in mouse autoimmune-arthritis model via a mechanism other than suppression of inflammatory angiogenesis, indicating a possible multi-dimensional regulation of the hypoxia-mediated pathology by IPAS in inflammatory diseases. On the other hand, we found histamine 4 receptor as a hypoxia-inducible gene, suggesting a novel mechanism of hypoxia-mediated regulation of immune response.
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