Role of hypoxia-inducible transcription factors in regulation of immune response and its therapeutic application
| Project/Area Number |
23591453
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
MAKINO Yuichi 旭川医科大学, 医学部, 准教授 (90345033)
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| Co-Investigator(Kenkyū-buntansha) |
HANEDA Masakazu 旭川医科大学, 医学部, 教授 (00124751)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 炎症 / 低酸素 / 単球 / マクロファージ / 単核球 / HIF-1 / 転写因子 / ChREBP |
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| Research Abstract |
This study was aimed to explore the role of hypoxia-inducible factors in regulation of immune response and to develop a novel therapeutic approach for inflammatory diseases by targeting the hypoxia-inducible factors. We demonstrated that IPAS, an endogenous dominant-negative regulator of HIF-1alpha, negatively regulates joint inflammation in mouse autoimmune-arthritis model via a mechanism other than suppression of inflammatory angiogenesis, indicating a possible multi-dimensional regulation of the hypoxia-mediated pathology by IPAS in inflammatory diseases. On the other hand, we found histamine 4 receptor as a hypoxia-inducible gene, suggesting a novel mechanism of hypoxia-mediated regulation of immune response.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis2013
Author(s)
Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, Aso K, Kanamori H, Ohashi T, Sato K, Nakao H, Haneda M, Yoneda M
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Journal Title
J Gastroenterol
Volume: 48
Pages: 491-503
NAID
Related Report
Peer Reviewed
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[Journal Article] The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms2013
Author(s)
Khalesi E, Nakamura H, Lee KL, Putra AC, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K
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Journal Title
Biochem Biophys Res Commun
Volume: 441
Pages: 499-506
Related Report
Peer Reviewed
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[Journal Article] The Krüppel-like zinc finger transcription factor, GLI-similar 1, is regulated by hypoxia-inducible factors via non-canonical mechanisms.2013
Author(s)
Khalesi E, Nakamura H, Leong Lee K, Chandra Putra A, Fukazawa T, Kawahara Y, Makino Y, Poellinger L, Yuge L, Tanimoto K.
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Journal Title
Biochem Biophys Res Commun
Volume: 441
Issue: 2
Pages: 499-506
DOI
Related Report
Peer Reviewed
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[Presentation] High glucose induces platelet derived growth factor C (PDGF-C) expression in glomerular mesangial cells via a glucose responsive transcription factor, carbohydrate response element binding protein (ChREBP)2012
Author(s)
Hiroya Kitsunai, Yuichi Makino, Hidemitsu Sakagami, Katsutoshi Mizumoto, Tsuyoshi Yanagimachi, Yasutaka Takeda, Yukihiro Fujita, Atsuko Abiko, Yumi Takiyama, and Masakazu Haneda
Organizer
72^<th > Scientific Sessions, American Diabetes Association
Place of Presentation
Philadelphia, USA
Related Report
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[Presentation] HIF-1αis a determinant of insulin-dependent glucose uptake by Skeletal Muscle Cells2012
Author(s)
Yuichi Makino, Hidemitsu Sakagami, Shuhei Tomita, Katsutoshi Mizumoto, Kensaku Okamoto, Hiroya Kitsunai, Yukihiro Fujita, Yumi Takiyama, and Masakazu Haneda
Organizer
Keystone Symposia, Advances in Hypoxic Signaling : From Bench to Bedside
Place of Presentation
Banff, Canada
Related Report
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