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Development of a novel oral therapeutic HCV vaccine using bifidobacterium displaying antigen

Research Project

Project/Area Number 23591475
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Infectious disease medicine
Research InstitutionKobe University

Principal Investigator

SHIRAKAWA Toshiro  神戸大学, 保健学研究科, 准教授 (70335446)

Co-Investigator(Kenkyū-buntansha) HOTTA Haku  神戸大学, 医学研究科, 教授 (40116249)
片山 高嶺  石川県立大学, 公私立大学の部局等, 教授 (70346104)
Co-Investigator(Renkei-kenkyūsha) KATAYAMA Takane  石川県立大学, 生物資源環境学部, 教授 (70346104)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords慢性C型肝炎 / 経口ワクチン / ビフィズス菌 / C型肝炎 / 治療ワクチン / C型肝炎
Research Abstract

More than 170 million people worldwide are chronic HCV (Hepatitis C virus) carriers. A combination of pegylated interferon-alpha with ribavirin, the standard treatment for HCV infection, has been effective in fewer than 50 percent of patients infected with HCV genotype 1. A strong T cell response against the nonstructural protein 3 (NS3) is important for recovery from acute HCV infection, and an early multi-specific CD4 helper and CD8 cytotoxic T cell response is critical for HCV clearance. In the present study, we successfully constructed a genetically modified Bifidobacterium longum displaying recombinant HCV-NS3 peptides containing some CD4 and CD8 epitopes located in the HCV-NS3 region as an oral vaccine against chronic HCV infection. The oral administration of this vaccine could induce NS3-specific immune responses in mice through intestinal mucosal immunity.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (10 results)

All 2014 2013 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results) Book (1 results) Remarks (3 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Oral administration of genetically modified Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein could induce an HCV-NS3-specific systemic immune response in mice2014

    • Author(s)
      Takei S, Omoto C, Kitagawa K, Morishita N, Katayama T, Shigemura K, FujisawaM, Kawabata M, Hotta H, Shirakawa T.
    • Journal Title

      Vaccine

      Volume: 32 Issue: 25 Pages: 3066

    • DOI

      10.1016/j.vaccine.2014.03.022

    • URL

      https://pure.teikyo.jp/en/publications/7293ec10-1fb1-4b21-846e-106fd71efddf

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ORAL ADMINISTRATION OF GENETICALLY MODIFIED BIFIDOBACTERIUM DISPLAYING HCV-NS3 MULTI-EPITOPE FUSION PROTEIN CAN INDUCE THE HCV-NS3 SPECIFIC SYSTEMIC IMMUNE2013

    • Author(s)
      大本知佳、北川孝一、竹井咲希、森下直矢、片山高嶺、堀田博、川端眞人、白川利朗
    • Organizer
      第19回日本遺伝子治療学会学術総会
    • Place of Presentation
      岡山
    • Year and Date
      2013-07-04
    • Related Report
      2013 Final Research Report
  • [Presentation] ORAL ADMINISTRATION OF GENETICALLY MODIFIED BIFIDOBACTERIUM DISPLAYING HCV-NS3 MULTI-EPITOPE FUSION PROTEIN CAN INDUCE THE HCV-NS3 SPECIFIC SYSTEMIC IMMUNE RESPONSE IN MICE2013

    • Author(s)
      大本 知佳*、北川 孝一、竹井 咲希、森下 直矢、片山 高嶺、堀田 博、川端 眞人、白川 利朗
    • Organizer
      第19回日本遺伝子治療学会学術集会
    • Place of Presentation
      岡山
    • Related Report
      2013 Annual Research Report
  • [Book] 第6節経口ワクチン、ワクチン開発における最新動向2013

    • Author(s)
      白川利朗
    • Publisher
      株式会社情報機構
    • Related Report
      2013 Final Research Report
  • [Remarks] [医学研究科] 堀田博教授、白川利朗准教授らがC型肝炎の経口治療ワクチン候補を開発しました 2014年3月20日

    • URL

      http://www.kobe-u.ac.jp/NEWS/research/t2014_03_20_02.html

    • Related Report
      2013 Final Research Report
  • [Remarks] [科学技術振興機構(JST)] 2014年03月20日 善玉ビフィズス菌を利用したC型肝炎の経口治療ワクチン候補の開発に成功[成果]

    • URL

      http://www.jst.go.jp/pr/announce/20140320/index.html

    • Related Report
      2013 Final Research Report
  • [Remarks] [医学研究科] 堀田博教授、白川利朗准教授らがC型肝炎の経口治療ワクチン候補を開発しました

    • URL

      http://www.kobe-u.ac.jp/NEWS/research/t2014_03_20_02.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 免疫原性ポリペプチド表層発現ビフィズス菌2014

    • Inventor(s)
      白川利朗、堀田博、片山高嶺
    • Industrial Property Rights Holder
      神戸大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-14
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 免疫原性ポリペプチド表層発現ビフィズス菌2014

    • Inventor(s)
      白川利朗、堀田博、片山高嶺
    • Industrial Property Rights Holder
      白川利朗、堀田博、片山高嶺
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-14
    • Related Report
      2013 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 免疫原性ポリペプチド表層発現ビフィズス菌2013

    • Inventor(s)
      白川利朗、堀田博、片山高嶺
    • Industrial Property Rights Holder
      神戸大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-030477
    • Filing Date
      2013-02-19
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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