| Project/Area Number |
23591500
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Ehime University |
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Principal Investigator |
SUZUKI Yuka 愛媛大学, 医学(系)研究科(研究院), 寄附講座准教授 (00304634)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Mitsumasa 愛媛大学, 医学部附属病院, 准教授 (80274330)
TANAKA Junya 愛媛大学, 大学院医学系研究科, 教授 (70217040)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ケトン体エステル / 脱随疾患 / ケトン食療法 / EAEマウスモデル / ケトン体 / EAEモデル |
|---|
| Research Abstract |
We have analyzed ketone-bodies effect on experimental autoimmune encephalomyelitis (EAE) mouse model. To design most physiological and stable administration method, we experimented several methods. We synthesized the ketone ester, R, S-1, 3-butanediol acetoacetate diester (BD-AcAc2). BD-AcAc2 was administered orally and blood Acetone and beta-hydroxybutylate level were increased. Extreme acidosis caused high mortality rate and we were unable to get stable results.
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