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The effect of genetic and enviromental factor to the development of bronchial asthma

Research Project

Project/Area Number 23591534
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionGifu University

Principal Investigator

MATSUI Eiko  岐阜大学, 医学部附属病院, 講師 (90334929)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsアレルギー / 環境因子 / 遺伝子
Research Abstract

The purpose of this research is to examine the interaction of the genetic and environmental factors with allergy disease. Therefore, detaile questionnaire of the environment factors before birth and after birth was corrected.Moreover, a lymphocyte surface marker and gene polymorphism were examined using umbilical cord blood and the peripheral blood.
When the episode of wheezing and the family history of bronchial asthma was positive, the rate of bronchial asthma was high by the follow-up to 3 years old.
In gene polymorphism, when ADRB2 (R16G) was AA type, the rate of bronchial asthma was high.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2013 2012 2011

All Journal Article (8 results) (of which Peer Reviewed: 6 results) Presentation (8 results) (of which Invited: 1 results) Book (3 results)

  • [Journal Article] Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months2013

    • Author(s)
      Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, Arai T MD, Kondo M, Kawamoto M, Matsui E, Orii K, Kasahara K, Takemura M, Seishima M, Shiraki M, Iwasa S, Kondo N
    • Journal Title

      Allergy Asthma Proc

      Volume: 34 Pages: 362-369

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Analysis of the Functional Effects of an NLRP3 G809S Variant with the co-Existence of MEFV Haplotype Variants in Atypical Autoinflammatory Syndrome2013

    • Author(s)
      Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N.
    • Journal Title

      J Clin Immunol

      Volume: 33 Pages: 325-34

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total IgE at 6 months predicts remittance or persistence of atopic dermatitis at 14 months.2013

    • Author(s)
      Kawamoto N, Fukao T, Kaneko H, Hirayama K, Sakurai S, Arai T MD, Kondo M, Kawamoto M, Matsui E, Orii K, Kasahara K, Takemura M, Seishima M, Shiraki M, Iwasa S, Kondo N
    • Journal Title

      Allergy Asthma Proc

      Volume: 34 Issue: 4 Pages: 362-369

    • DOI

      10.2500/aap.2013.34.3678

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In Vitro Analysis of the Functional Effects of an NLRP3 G809S Variant with the co-Existence of MEFV Haplotype Variants in Atypical Autoinflammatory Syndrome2013

    • Author(s)
      Kubota K, Ohnishi H, Teramoto T, Matsui E, Murase K, Kanoh H, Kato Z, Kaneko H, Seishima M, Kondo N
    • Journal Title

      J Clin Immunol

      Volume: 33 Issue: 2 Pages: 325-34

    • DOI

      10.1007/s10875-012-9805-x

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Repeated-Dose Pharmacokinetics of Inhaled Ciclesonide (CIC-HFA) in Japanese Children with Bronchial Asthma : A Phase I Study2012

    • Author(s)
      Teramoto T, Matsui E, Fukao T, Sakai K, Yonezawa H, Kato Z, Ohnishi H, Kaneko H, Kondo N, Azuma J, Nishima S.
    • Journal Title

      Allergol Int

      Volume: 61 Pages: 619-624

    • NAID

      130004873052

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 喘息/COPD基礎研究最前線遺伝子検索による喘息、アレルギー疾患発症のテーラーメイド的予知および予防指導の試み2012

    • Author(s)
      松井永子、木全かおり、大西秀典、加藤善一郎、金子英雄、近藤直実
    • Journal Title

      International Review of Asthma and COPD

      Volume: 14 Pages: 23-28

    • Related Report
      2013 Final Research Report
  • [Journal Article] 喘息/COPDの基礎研究最前線 遺伝子検索による喘息、アレルギー疾患発症のテーラーメイド的予知および予防指導の試み2012

    • Author(s)
      松井永子,木全かおり,大西秀典,加藤善一郎,金子英雄,近藤直実
    • Journal Title

      International Review of Asthma & COPD

      Volume: 14 Pages: 23-28

    • NAID

      40019321539

    • Related Report
      2012 Research-status Report
  • [Journal Article] Repeated-Dose Pharmacokinetics of Inhaled Ciclesonide (CIC-HFA) in Japanese Children with Bronchial Asthma: A Phase I Study.2012

    • Author(s)
      Teramoto T, Matsui E, Fukao T, Sakai K, Yonezawa H, Kato Z, Ohnishi H, Kaneko H, Kondo N, Azuma J, Nishima S
    • Journal Title

      Allergol Int.

      Volume: 61 Pages: 619-624

    • NAID

      130004873052

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 発症予防の遺伝子ターゲット2013

    • Author(s)
      松井永子
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] アレルギー発症のテーラーメイド予知予防2013

    • Author(s)
      松井永子
    • Organizer
      第25回日本アレルギー学会春季臨床大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] アレルギー疾患のテーラーメイド医療をめざして2012

    • Author(s)
      松井永子
    • Organizer
      第49回日本小児アレルギー学会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 気管支喘息のテーラーメイド的予知および予防指導の試み2012

    • Author(s)
      松井永子, 木全かおり, 篠田紳司, 金子英雄, 加藤善一郎, 近藤直実
    • Organizer
      第24回日本アレルギー学会春季臨床大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Final Research Report
  • [Presentation] 気管支喘息のテーラーメイド的予知および予防指導の試み2012

    • Author(s)
      松井永子、木全かおり、篠田紳司、金子英雄、加藤善一郎、近藤直実
    • Organizer
      第24回日本アレルギー学会春季臨床大会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Research-status Report
  • [Presentation] アレルギー疾患のテーラーメイド医療をめざして2012

    • Author(s)
      松井永子
    • Organizer
      第49回日本小児アレルギー学会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 小児喘息の個別化予防指導および個別化治療を目指して2011

    • Author(s)
      松井永子
    • Organizer
      第48回日本小児アレルギー学会
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-28
    • Related Report
      2013 Final Research Report
  • [Presentation] 小児喘息の個別化予防指導および個別化治療を目指して2011

    • Author(s)
      松井永子
    • Organizer
      第48回日本小児アレルギー学会(招待講演)
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Book] 喘息アレルギーのテーラーメイド治療2013

    • Author(s)
      近藤直実, 松井永子
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 喘息アレルギーのテーラーメイド治療2013

    • Author(s)
      近藤直実 松井永子
    • Total Pages
      196
    • Publisher
      診断と治療者
    • Related Report
      2013 Annual Research Report
  • [Book] 喘息・アレルギーのテーラーメイド治療2013

    • Author(s)
      近藤直実、松井永子
    • Total Pages
      196
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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