The preferential anticancer effect on pediatric malignancies by mesencymal stem cells
| Project/Area Number |
23591541
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Osaka University (2012-2014)
Okayama University (2011) |
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Principal Investigator |
MIYAMURA Takako 大阪大学, 医学(系)研究科(研究院), 特任助教(常勤) (20379796)
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| Co-Investigator(Kenkyū-buntansha) |
HASHII Yoshiko 大阪大学, 大学院医学系研究科, 講師 (60343258)
NANBA Noriyuki 大阪大学, 大学院医学系研究科, 講師 (10379076)
YAMASHITA Nobuko 岡山大学, 医歯(薬)学総合研究科, 助教 (40379798)
WASHIO Kana 岡山大学, 大学病院, 助教 (10379802)
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 間葉系幹細胞 / 小児 / 悪性腫瘍 / 急性白血病 / TRAIL / 移植・再生医療 / 細胞・組織 / 癌 |
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| Outline of Final Research Achievements |
Mesenchymal stem cells (MSC) have the capacity to differentiate into several tissues. Furthermore, it has reported that MSC could target the injured part including cancer. We investigated the enhancement of anti-tumor effects of anticancer drugs for Ewing Sarcoma (EWS) by administration of MSC. We use the EWS cell line by coculture of MSC and anticancer drugs, and evaluate the enhancement of anti-tumor effects by apoptosis assay. It had the tendency to enhance the anti-tumor effects although there was no significant difference. The antitumor effects tended to enhance depending on the concentration of MSC. We should investigate the more detailed analysis of the mechanism of MSC and antitumor effects.
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Report
(5 results)
Research Products
(30 results)
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[Journal Article] Early use of allogeneic hematopoietic stem cell transplantation for infants with MLL gene-rearrangement-positive acute lymphoblastic leukemia.2015
Author(s)
Koh K, Tomizawa D, Moriya Saito A, Watanabe T, Miyamura T, Hirayama M, Takahashi Y, Ogawa A, Kato K, Sugita K, Sato T, Deguchi T, Hayashi Y, Takita J, Takeshita Y, Tsurusawa M, Horibe K, Mizutani S, Ishii E.
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Journal Title
Leukemia
Volume: 29(2)
Issue: 2
Pages: 290-6
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ABL kinase mutation and relapse in 4 pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia cases2014
Author(s)
Aoe M, Shimada A, Muraoka M, Washio K, Nakamura Y, Takahashi T, Imada M, Watanabe T, Okada K, Nishiuchi R, Ishida T, Miyamura T, Chayama K, Shibakura M, Oda M, Morishima T.
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Journal Title
Int J Hematol
Volume: 99
Issue: 5
Pages: 609-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Outcome of children with relapsed acute myeloid leukemia following initial therapy under the AML99 protocol2014
Author(s)
Nakayama H, Tabuchi K, Tawa A, Tsukimoto I, Tsuchida M, Morimoto A, Yabe H, Horibe K, Hanada R, Imaizumi M, Hayashi Y, Hamamoto K, Kobayashi R, Kudo K, Shimada A, Miyamura T, Moritake H, Tomizawa D, Taga T, Adachi S.
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Journal Title
Int J Hematol
Volume: 100(2)
Issue: 2
Pages: 171-9
DOI
Related Report
Peer Reviewed / Open Access
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