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Exhaustive analysis about the onset etiology of the pediatric inflammatory diseases by using the proteome method

Research Project

Project/Area Number 23591545
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionYokohama City University

Principal Investigator

MORI MASAAKI  横浜市立大学, 大学病院, 准教授 (30254204)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsサイトカイン / 小児炎症性疾患 / プロテーム解析 / サイトカイン / 小児炎症疾患
Research Abstract

The purposes in this study were to analyze serum proteins for both acute and convalescent phases in the patients with hypercytokinemia using the proteome method which was comprehensive protein analytical method, In this study, the following findings should be elucidated.
(1) The mechanism of inflammation -Search of the cause of the cytokine storm-
Finally, we could identify original protein in this study in various inflammatory diseases, and we are planning to increase the number of the specimens and to perform the addition tests now.(2) A function of inflammatory cytokine and condition of a patient of " cytokine storm: We analyzed various proteins about expression, action mechanism of inflammatory cytokine, and accomplish to identify universal protein (under submission to English journal).(3) Cytokine storm to be seen in childhood: We could elucidate what caused "inflammation" of children at a low age and why could a cytokine storm raise. We got the interesting results in this study.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (28 results)

All 2013 2012 2011

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (15 results) (of which Invited: 15 results)

  • [Journal Article] Human parechovirus-3 infection in nine neonates and infants presenting symptoms of hemophagocytic lymphohistiocytosis.2013

    • Author(s)
      Yuzurihara S, Ao K, Hara T, Tanaka F, Mori M, Kikuchi N, Kai S, Yokota S
    • Journal Title

      J Infect Chemother

      Volume: 19 Issue: 1 Pages: 144-148

    • DOI

      10.1007/s10156-012-0420-9

    • NAID

      10031155831

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term treatment of systemic juvenile idiopathic arthritis with tocilizumab: results of an open-label extension study in Japan.2013

    • Author(s)
      Yokota S, Imagawa T, Mori M, Miyamae T, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, Tomiita M, Nishimoto N, Kishimoto T.
    • Journal Title

      Ann Rheum Dis.

      Volume: 72 Issue: 4 Pages: 627-628

    • DOI

      10.1136/annrheumdis-2012-202310

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical analysis of fifty children with juvenile dermatomyositis.2013

    • Author(s)
      Kishi T, Miyamae T, Hara R, Nakajima S, Imagawa T, Mori M, Yokota S.
    • Journal Title

      Mod Rheumatol.

      Volume: 23 Issue: 2 Pages: 311-317

    • DOI

      10.1007/s10165-012-0647-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nationwide survey of treatment for pediatric patients with invasive fungal infections in Japan.2013

    • Author(s)
      Mori M.
    • Journal Title

      J Infect Chemother

      Volume: 19 Issue: 5 Pages: 946-950

    • DOI

      10.1007/s10156-013-0624-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population.2013

    • Author(s)
      Kadota K, Mori M, Yanagimachi M, Miyamae T, Hara T, Kanetaka T, Nozawa T, Kikuchi M, Hara R, Imagawa T, Kaneko T, Yokota S
    • Journal Title

      Pros One

      Volume: 11

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Respiratory severity and virus profiles in Japanese children with acute respiratory illness.2013

    • Author(s)
      Miyaji Y, Kobayashi M, Sugai K, Tsukagoshi H, Niwa S, Fujitsuka-Nozawa A, Noda M, Kozawa K, Yamazaki F, Mori M, Yokota S, Kimura H
    • Journal Title

      Microbiol Immunol.

      Volume: 57 Pages: 811-821

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis of cases of severe respiratory failure in children with influenza (H1N1) 2009 infection in Japan2012

    • Author(s)
      Uchimura T, Mori M, Nariai A, et al
    • Journal Title

      J Infect Chemother

      Volume: 18 Issue: 1 Pages: 59-65

    • DOI

      10.1007/s10156-011-0284-4

    • NAID

      10030226403

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and limitation of infliximab treatment for children with Kawasaki disease intractable to intravenous immunoglobulin therapy : report of an open-label case series2012

    • Author(s)
      Mori M, Imagawa T, Hara R, et al
    • Journal Title

      J Rheumatol

      Volume: 39 Issue: 4 Pages: 864-867

    • DOI

      10.3899/jrheum.110877

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] An approach to the patients with cryopyrin-associated periodic syndrome (CAPS) : a new biologic response modifier, canakinumab2012

    • Author(s)
      Yokota S, Kikuchi M, Mori M, et al
    • Journal Title

      Nihon Rinsho Meneki Gakkai Kaishi

      Volume: 35 Pages: 23-9

    • NAID

      10030465541

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] National survey of childhood febrile illness cases with fever of unknown origin in Japan2011

    • Author(s)
      Kasai K, Mori M, Hara R, et al
    • Journal Title

      Pediatr Int

      Volume: 53 Issue: 4 Pages: 401-25

    • DOI

      10.1111/j.1442-200x.2010.03296.x

    • NAID

      10029558664

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of IRF5 Polymorphisms with Susceptibility to Macrophage Activation Syndrome in Patients with Juvenile Idiopathic Arthritis2011

    • Author(s)
      Yanagimachi M, Naruto T, Mori M, et al
    • Journal Title

      J Rheumatol

      Volume: 38 Issue: 4 Pages: 769-74

    • DOI

      10.3899/jrheum.100655

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A molecular epidemiological study of respiratory viruses detected in Japanese children with acute wheezing illness2011

    • Author(s)
      Fujitsuka A, Tsukagoshi H, Mori M, et al
    • Journal Title

      BMC Infect Dis

      Volume: 11 Issue: 1 Pages: 168-168

    • DOI

      10.1186/1471-2334-11-168

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association of IRF5 polymorphisms with susceptibility to hemophagocytic lymphohistiocytosis in children2011

    • Author(s)
      Yanagimachi M, Goto H, Mori M, et al
    • Journal Title

      J Clin Immunol

      Volume: 31 Issue: 6 Pages: 946-51

    • DOI

      10.1007/s10875-011-9583-x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 小児のアフェレシス療法:最近の動向.難治性川崎病に対するアフェレシス療法2013

    • Author(s)
      森雅亮
    • Organizer
      第34回日本アフェレーシス学会学術大会
    • Place of Presentation
      軽井沢
    • Year and Date
      2013-11-02
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] IVIG不応性川崎病に対する血漿交換療法の安全性と有用性~本邦多施設共同データからの解析結果~2013

    • Author(s)
      森 雅亮
    • Organizer
      第22回 日本アフェレーシス学会関東甲信越地方会.
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神奈川県におけるRSウイルスに対する取り組み~有効なパリビズマブ投与を行うための方策~2013

    • Author(s)
      森 雅亮
    • Organizer
      第87回 日本感染症学会学術講演会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] リウマチ性疾患に対する免疫療法の実際と小児神経筋疾患への発展的アプローチ2013

    • Author(s)
      森 雅亮
    • Organizer
      第59回 日本小児神経学会関東地方会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 神奈川県内における、ベッドサイドで測定可能な検査値を用いた客観的な診断および冠動脈病変発症に関する多施設共同研究2013

    • Author(s)
      森 雅亮
    • Organizer
      第33回日本川崎病学会・学術集会.
    • Place of Presentation
      富山
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ガイドラインセッションII 「領域別」:小児領域.2013

    • Author(s)
      森 雅亮
    • Organizer
      第57回 日本医真菌学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 7価肺炎球菌ワクチン導入の効果と残された課題、そして13価への期待2013

    • Author(s)
      森 雅亮
    • Organizer
      第72回日本公衆衛生学会総会
    • Place of Presentation
      津
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] RSウイルス感染予防を必要とする小児の現状と今後の展望2013

    • Author(s)
      森 雅亮
    • Organizer
      第45回日本小児感染症学会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小児のアフェレシス療法:最近の動向. 難治性川崎病に対するアフェレシス療法2013

    • Author(s)
      森 雅亮
    • Organizer
      第34回日本アフェレーシス学会学術大会
    • Place of Presentation
      軽井沢.
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Plasma exchange therapy for cases refractory to IVIG treatment–from analysis in the multi-institutions in Japan -2012

    • Author(s)
      Mori M.
    • Organizer
      Intern 12th Kawasaki Disease Symposium
    • Place of Presentation
      Kyoto
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 一般診療における小児リウマチ性疾患の診かた・考え方2012

    • Author(s)
      森雅亮
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 既存治療で効果不十分な多関節に活動性を有する若年性特発性関節炎(JIA)患者にエタネルセプトを長期投与したときの安全性および有効性2012

    • Author(s)
      森雅亮
    • Organizer
      第56回日本リウマチ学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 生物学的製剤の新たな展開2011

    • Author(s)
      森雅亮
    • Organizer
      第20回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      那覇
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 大量ガンマグロブリン不応川崎病症例に対する、インフリキシマブ・血漿交換療法による「段階的治療法」の有用性2011

    • Author(s)
      森雅亮
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] RSウイルス感染予防を必要とする小児に関する全国調査の解析及び今後の対策2011

    • Author(s)
      森雅亮
    • Organizer
      第114回日本小児科学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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