Exhaustive analysis about the onset etiology of the pediatric inflammatory diseases by using the proteome method
| Project/Area Number |
23591545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pediatrics
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| Research Institution | Yokohama City University |
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Principal Investigator |
MORI MASAAKI 横浜市立大学, 大学病院, 准教授 (30254204)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サイトカイン / 小児炎症性疾患 / プロテーム解析 / ｻｲﾄｶｲﾝ / 小児炎症疾患 |
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| Research Abstract |
The purposes in this study were to analyze serum proteins for both acute and convalescent phases in the patients with hypercytokinemia using the proteome method which was comprehensive protein analytical method, In this study, the following findings should be elucidated.
(1) The mechanism of inflammation -Search of the cause of the cytokine storm-
Finally, we could identify original protein in this study in various inflammatory diseases, and we are planning to increase the number of the specimens and to perform the addition tests now.(2) A function of inflammatory cytokine and condition of a patient of " cytokine storm: We analyzed various proteins about expression, action mechanism of inflammatory cytokine, and accomplish to identify universal protein (under submission to English journal).(3) Cytokine storm to be seen in childhood: We could elucidate what caused "inflammation" of children at a low age and why could a cytokine storm raise. We got the interesting results in this study.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Long-term treatment of systemic juvenile idiopathic arthritis with tocilizumab: results of an open-label extension study in Japan.2013
Author(s)
Yokota S, Imagawa T, Mori M, Miyamae T, Takei S, Iwata N, Umebayashi H, Murata T, Miyoshi M, Tomiita M, Nishimoto N, Kishimoto T.
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Journal Title
Ann Rheum Dis.
Volume: 72
Issue: 4
Pages: 627-628
DOI
Related Report
Peer Reviewed
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[Journal Article] Analysis of gender differences in genetic risk: association of TNFAIP3 polymorphism with male childhood-onset systemic lupus erythematosus in the Japanese population.2013
Author(s)
Kadota K, Mori M, Yanagimachi M, Miyamae T, Hara T, Kanetaka T, Nozawa T, Kikuchi M, Hara R, Imagawa T, Kaneko T, Yokota S
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Respiratory severity and virus profiles in Japanese children with acute respiratory illness.2013
Author(s)
Miyaji Y, Kobayashi M, Sugai K, Tsukagoshi H, Niwa S, Fujitsuka-Nozawa A, Noda M, Kozawa K, Yamazaki F, Mori M, Yokota S, Kimura H
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Journal Title
Microbiol Immunol.
Volume: 57
Pages: 811-821
Related Report
Peer Reviewed
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