Improved Control of Childhood Asthma with Low-Dose, Short-Term Vitamin D Supplementation: A Randomized, Double-Blind, Placebo-Controlled Trial

• Project/Area Number: 23591553
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: Jikei University School of Medicine
• Principal Investigator: URASHIMA Mitsuyoshi 東京慈恵会医科大学, 医学部, 教授 (80203602)
• Co-Investigator(Kenkyū-buntansha): TACHIMOTO Hiroshi 東京慈恵会医科大学, 医学科, 講師 (40256409)
• Project Period (FY): 2011-04-28 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ビタミンＤ / 小児 / アレルギー / プラセボ / 喘息 / ＧＩＮＡ / ＩｇＥ / ビタミンD / ランダム化臨床試験 / 小児喘息

Outline of Final Research Achievements

Objective: We aimed to clarify whether low-dose, short-term vitamin D supplementation, in addition to standard treatments, improves control of childhood asthma.　Methods: We conducted a randomized, double-blind, placebo-controlled trial comparing vitamin D3 supplements (800 IU/day) with placebo for 2 months in schoolchildren with asthma. The primary outcome was changes of asthma control levels defined by the Global Initiative for Asthma (GINA) at 2 months and 6 months. Results: Japanese schoolchildren with asthma (n=89) were randomly assigned to receive vitamin D (n=54) or placebo (n=35). At 2 months, GINA were significantly more improved in the vitamin D group compared with the placebo group (P=0.015). Conclusion: Low-dose, short-term vitamin D supplementation in addition to standard treatment may improve levels of asthma control in schoolchildren.

Research Products

• [Journal Article] High UBCH10 protein expression as a marker of poor prognosis in esophageal squamous cell carcinoma. (2014)
  • Author(s): Matsumoto A, Ishibashi Y, Urashima M, Omura N, Nakada K, Nishikawa K, Shida A, Takada K, Kashiwagi H, Yanaga K.
  • Journal Title: Anticancer Res Volume: ３４ Pages: 955-61
  • Peer Reviewed
• [Journal Article] Increased food allergy and vitamin D: randomized, double-blind, placebo-controlled trial. (2014)
  • Author(s): Norizoe C, Akiyama N, Segawa T, Tachimoto H, Mezawa H, Ida H, Urashima M.
  • Journal Title: Pediatr Int. Volume: ５６ Pages: 6-12
  • Peer Reviewed
• [Journal Article] Distinct effects of alcohol consumption and smoking on genetic alterations in head and neck carcinoma. (2013)
  • Author(s): Urashima M, Hama T, Suda T, Suzuki Y, Ikegami M, Sakanashi C, Akutsu T, Amagaya S, Horiuchi K, Imai Y, Mezawa H, Noya M, Nakashima A, Mafune A, Kato T, Kojima H.
  • Journal Title: PLoS One. Volume: ８
  • Peer Reviewed
• [Journal Article] Clinicopathological investigation of lymph node metastasis predictors in superficial esophageal squamous cell carcinoma with a focus on evaluation of lympho-vascular invasion. (2013)
  • Author(s): Mitobe J, Ikegami M, Urashima M, Takahashi H, Goda K, Tajiri H.
  • Journal Title: Scand J Gastroenterol. Volume: 48 Pages: 1173-82
  • Peer Reviewed
• [Journal Article] Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. (2013)
  • Author(s): Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Noya M, Takahashi D, Urashima M.
  • Journal Title: Am J Clin Nutr. Volume: 97 Pages: 1004-13
  • Peer Reviewed
• [Journal Article] Randomized, double-blind, placebo-controlled trial of vitamin D supplement in Parkinson's disease. (2012)
  • Author(s): Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Noya M, Takahashi D, Urashima M.
  • Journal Title: Am J Clin Nutr Volume: 00
  • Peer Reviewed
• [Journal Article] A cross-sectional study of the association between circulating 25-hydroxyvitamin D levels and predicted operative mortality of patients with cardiovascular disease. (2012)
  • Author(s): Tsutsumi Y, Sanui M, Shimojima A, Ishioka H, Urashima M.
  • Journal Title: J Nutr Sci Vitaminol Volume: 58 Pages: 327-32
  • NAID: 130003368124
  • Peer Reviewed
• [Journal Article] Interactions between serum vitamin D levels and vitamin D receptor gene FokI polymorphisms for renal function in patients with type 2 diabetes. (2012)
  • Author(s): Yokoyama K, Nakashima A, Urashima M, Suga H, Mimura T, Kimura Y, Kanazawa Y, Yokota T, Sakamoto M, Ishizawa S, Nishimura R, Kurata H, Tanno Y, Tojo K, et al
  • Journal Title: PLoS One. Volume: 7 Issue: 12 Pages: e51171-e51171
  • DOI: 10.1371/journal.pone.0051171
  • Peer Reviewed
• [Journal Article] Copy number amplification of the PIK3CA gene is associated with poor prognosis in non-lymph node metastatic head and neck squamous cell carcinoma. (2012)
  • Author(s): Suda T, Hama T, Kondo S, Yuza Y, Yoshikawa M, Urashima M, Kato T, Moriyama H.
  • Journal Title: BMC Cancer Volume: 12 Issue: 1 Pages: 416-416
  • DOI: 10.1186/1471-2407-12-416
  • Peer Reviewed
• [Journal Article] Cinacalcet for hemodialyzed patients with or without a high PTH level to control serum calcium and phosphorus: ECO (evaluation of cinacalcet HCl outcome) study. (2012)
  • Author(s): Yokoyama K, Ohkido I, Ishida M, Hashimoto H, Urae J, Sekino H, Kimura Y, Shimada H, Urashima M, Hosoya T.
  • Journal Title: Clin Nephrol. Volume: 78 Pages: 87-92
  • Peer Reviewed
• [Journal Article] Decrease of serum sphingosine-1-phosphate levels in hemodialysis patients with secondary hyperparathyroidism treated with cinacalcet. (2012)
  • Author(s): Yokoyama K, Ohkido I, Iwamoto T, Ishida M, Urashima M, Hosoya T.
  • Journal Title: Clin Nephrol Volume: 78 Pages: 85-6
  • Peer Reviewed
• [Journal Article] 25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease. (2012)
  • Author(s): Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Kawasaki K, Noya M, Takahashi D, Urashima M.
  • Journal Title: Mov Disord Volume: 27
• [Journal Article] Prognostic significance of vitamin d receptor polymorphisms in head and neck squamous cell carcinoma. (2011)
  • Author(s): Hama T, Norizoe C, Suga H, Mimura T, Kato T, Moriyama H, Urashima M.
  • Journal Title: PLoS One Volume: 6
  • Peer Reviewed