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Identification of cellular genes associated with pathogenesis of chronic active Epstein-Barr virus infection

Research Project

Project/Area Number 23591573
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionKochi University

Principal Investigator

FUJIEDA MIKIYA  高知大学, 教育研究部医療学系, 教授 (60209020)

Co-Investigator(Kenkyū-buntansha) DAIBATA Masanori  高知大学, 教育研究部医療学系, 教授 (50263976)
MURAKAMI Masanao  高知大学, 教育研究部医療学系, 助教 (80571017)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsウイルス / 感染症 / EBウイルス / 微生物
Research Abstract

The pathogenesis of chronic active Epstein-Barr virus infection (CAEBV) remains unclear. Previous studies have determined a number of candidate cellular genes associated with CAEBV. However, few data are available on the gene expression levels in freshly isolated cells from patients with CAEBV. In the present study, peripheral blood samples were obtained from patients with CAEBV. We investigated the host cellular gene expression profiles in CAEBV using a PCR array analysis that focused on T-cell and B-cell activation. We identified that four genes (IL-10, IL-2, IFNGR1, and INHBA) were upregulated in the CAEBV patients based on the PCR array analysis and the subsequent quantitative real-time PCR assay, where these four genes exhibited tenfold differences compared with the control subjects. These genes may be associated with inflammatory responses and with cell proliferation, and they may contribute to the development and progression of CAEBV.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (87 results)

All 2014 2013 2012 2011 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (50 results) (of which Invited: 6 results) Book (8 results) Remarks (3 results)

  • [Journal Article] PCR array analysis of gene expressi on profiles in chronic active Epste in-Barr virus infection2014

    • Author(s)
      Murakami M, Hashida Y, Imajoh M, Ma eda A, Kamioka M, Senda Y, Sato T, Fujieda M, Wakiguchi H, Daibata M
    • Journal Title

      Microbes a nd Infection

      Volume: (掲載決定) Issue: 7 Pages: 581-586

    • DOI

      10.1016/j.micinf.2014.04.004

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of eval uation of the right coronary artery by two-dimensional echocardiograph y in patients after Kawasaki diseas e : a right parasternal approach2014

    • Author(s)
      Tamaki W, Tsuda E, Igarashi T, Tana ka N, Fujieda M.
    • Journal Title

      He art Vessels

      Volume: (掲載決定) Issue: 2 Pages: 178-185

    • DOI

      10.1007/s00380-014-0476-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of evaluation of the right coronary artery by two-dimensional echocardiography in patients after Kawasaki disease: a right parasternal approach.2014

    • Author(s)
      Tamaki W, Tsuda E, Igarashi T, Tanaka N, Fujieda M.
    • Journal Title

      Heart Vessels

      Volume: Epub ahead of print

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-infect ion interface in children after tra nsplantation : posttranspalnt lympho proliferative disorder and Epstein- Barr virus infection2013

    • Author(s)
      Fujieda M, Hattori M.
    • Journal Title

      Curr Opin Org an Transplant

      Volume: 18 Issue: 5 Pages: 549-554

    • DOI

      10.1097/mot.0b013e3283651b0d

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury2013

    • Author(s)
      Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Terada Y
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 305(4) Issue: 4 Pages: 495-509

    • DOI

      10.1152/ajprenal.00642.2012

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Validation of a new biomarker in patients with Kawasaki disease identified by proteomics.2013

    • Author(s)
      Karasawa E, Fujieda M, Ohta K, Yudoh K.
    • Journal Title

      J Data Mining Genomics Proteomics

      Volume: 4 Issue: 01 Pages: 124-124

    • DOI

      10.4172/2153-0602.1000124

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cancer-infection interface in children after transplantation: posttranspalnt lymphoproliferative disorder and Epstein-Barr virus infection.2013

    • Author(s)
      Fujieda M, Hattori M.
    • Journal Title

      Curr Opin Organ Transplant

      Volume: 18 Pages: 549-554

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of Epstein-Barr virus (EBV) BZLF1 gene promoter variants and comparison of cellular gene expression profiles in Japanese patients with infectious mononucleosis, chronic active EBV infection, and EBV-associated hemophagocytic lymphohistioc2012

    • Author(s)
      Imajoh M, Hashida Y, Murakami M, Maeda A, Sato T, Fujieda M, Wakiguchi H, Daibata M.
    • Journal Title

      Journal of Medical Virology

      Volume: 84 Issue: 6 Pages: 940-946

    • DOI

      10.1002/jmv.23299

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] A novel anti-peroxiredoxin autoantibodyinpatients with Kawasaki disease.2012

    • Author(s)
      Fujieda M, Karasawa R, Takasugi H,Yamamoto M, Kataoka K, Yudoh K, KatoT, Ozaki S, Wakiguchi H.
    • Journal Title

      Microbiology andImmunology.

      Volume: 56 Issue: 1 Pages: 56-61

    • DOI

      10.1111/j.1348-0421.2011.00393.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of single-dose oral mizoribine pulse therapy twic e per week for frequently relapsing steroid-dependent nephritic syndro me2012

    • Author(s)
      Fujieda M, Ishihara N, Morita T, Ha yashi A, Okada S, Ohta T, Sakano T, Wakiguchi H.
    • Journal Title

      Clin Nephrol

      Volume: 78 Pages: 40-46

    • DOI

      10.5414/cn106635

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteris tics of obstructive uropathy associ ated with rotavirus gastroenteritis in Japan2012

    • Author(s)
      Ashida A, Fujieda M, Ohta K, Nakaku ra H, Matsumura H, Morita T, Igaras hi T, Tamai H.
    • Journal Title

      Clin Nephrol

      Volume: 77 Issue: 01 Pages: 49-54

    • DOI

      10.5414/cn107098

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical characteristics of obstructive uropathy associated with rotavirus gastroenteritis in Japan.2012

    • Author(s)
      Ashida A, et al.
    • Journal Title

      Clin Nephrol

      Volume: 77 Pages: 49-54

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of single-dose oral mizoribine pulse therapy twice per week for frequently relapsing steroid-dependent nephritic syndrome.2012

    • Author(s)
      Fujieda M, et al.
    • Journal Title

      Clin Nephrol

      Volume: 78 Pages: 40-46

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] ロタウイルス腸炎罹患後の急性腎不全2012

    • Author(s)
      藤枝幹也, 他
    • Journal Title

      小児内科

      Volume: 44 Pages: 190-193

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Characterization of Epstein-Barr Virus (EBV) BZLF1 Gene Promoter Variants and Comparison of Cellular Gene Expression Profiles in Japanese Patients with Infectious Mononucleosis, Chronic Active EBV Infection, and EBV-Associated Hemophagocytic Lymphohistiocytosis.2012

    • Author(s)
      Imajoh M, Hashida Y, Murakami M, Maeda A, Sato T, Fujieda M, Wakiguchi H, Daibata M.
    • Journal Title

      J Med Virol.

      Volume: 未定

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acidosis with hyperuricemia and renal tubular dam age in viral gastroenteritis2011

    • Author(s)
      Morita T, Fujieda M
    • Journal Title

      Pedia tric Nephrol

      Volume: 26 Issue: 12 Pages: 2259-2260

    • DOI

      10.1007/s00467-011-2003-x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yachie Molecular and immunohistochemica l detection of rotavirus in urinary sediment cells of children with ro tavirus gastroenteritis2011

    • Author(s)
      Yokoyama T, Sugimoto N, Taniguchi K, Komoto S, Yuno T, Ohta K, Hashimot o H, Seno A, Ashida A, Fujieda M, N ishio S, Ueno K, Shimizu M
    • Journal Title

      Clin Micro biol Infect

      Volume: 17 Issue: 8 Pages: 1190-1193

    • DOI

      10.1111/j.1469-0691.2011.03522.x

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] E pstein-Barr virus load for early de tection of lymphoproliferative diso rder in pediatric renal transplant recipients2011

    • Author(s)
      Ishihara M, Tanaka E, Sato T, Chika moto H, Hisano M, Akioka Y, Dohno S, Maeda A, Wakiguchi H, Fujieda M
    • Journal Title

      Clin Nephrol

      Volume: 76 Issue: 07 Pages: 40-48

    • DOI

      10.5414/cn106572

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced manner reinforcing resistance to endothelium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Kakinuma Y, et al
    • Journal Title

      Nephrol Dial Transplant

      Volume: 26 Issue: 12 Pages: 4023-4031

    • DOI

      10.1093/ndt/gfr176

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asymptomatic high Epstein-Barr viral load carriage in pediatric renal transplant recipients.2011

    • Author(s)
      Tanaka E, Sato T, Ishihara M, Tsutsumi Y, Hisano M, Chikamoto H, Akioka Y, Dohno S, Maeda A, Hattori M, Wakiguchi H, Fujieda M.
    • Journal Title

      Pediatr Transplantation

      Volume: 15 Issue: 3 Pages: 306-313

    • DOI

      10.1111/j.1399-3046.2010.01465.x

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of Limited Sampling Designs to Estimate Maximal Concentration and Area under the Curve of Mizoribine in Pediatric Patients with Renal Disease2011

    • Author(s)
      Ishida K, Kaneda H, Uemura O, Ushij ima K, Ohta K, Goto Y, Satomura K, Shimizu M, Fujieda M, Morooka M, Ya mada T, Yamada M, Wada N, Takaai M, Hashimoto Y.
    • Journal Title

      Drug Metabolism and Pharmacokinetics

      Volume: 26 Issue: 1 Pages: 71-78

    • DOI

      10.2133/dmpk.DMPK-10-RG-077

    • NAID

      130004463163

    • ISSN
      1347-4367, 1880-0920
    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effect of pravastatin on cisplatin-induced nephrotoxicity in rats.2011

    • Author(s)
      Fujieda M, Morita T, Naruse K, Hayashi Y, Ishihara M, Yokoyama T, Toma T, Ohta K, Wakiguchi H.
    • Journal Title

      Human & Experimental Toxicology.

      Volume: 30 Issue: 7 Pages: 603-615

    • DOI

      10.1177/0960327110376551

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of pseudohomozygous type II hyperlipoproteinemia in early infancy2011

    • Author(s)
      Tamaki W, Fujieda M, Maeda M, Hosokawa T, Morita H, Asami T, Wakiguchi H.
    • Journal Title

      Pediatrics International.

      Volume: 53 Issue: 1 Pages: 110-113

    • DOI

      10.1111/j.1442-200x.2010.03237.x

    • NAID

      10029557390

    • Related Report
      2013 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of pravastatin on cisplatin-induced nephrotoxicity in rats.2011

    • Author(s)
      Fujieda M, Morita T, Naruse K, Hayashi Y, Ishihara M, Yokoyama T, Toma T, Ohta K, Wakiguchi H.
    • Journal Title

      Hum Exp Toxicol.

      Volume: 30 Pages: 603-615

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of persistent cerebellar ataxia complicated by conversion disorder--confirmed by positive cerebrospinal fluid glutamate receptor delta2 and epsilon2 antibodies.2011

    • Author(s)
      Usui D, Mitsuda N, Hosokawa T, Fujieda M, Takahashi Y, Wakiguchi H.
    • Journal Title

      脳と発達

      Volume: 43 Pages: 41-45

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epstein-Barr virus load for early detection of lymphoproliferative disorder in pediatric renal transplant recipients.2011

    • Author(s)
      Ishihara M, Tanaka E, Sato T, Chikamoto H, Hisano M, Akioka Y, Dohno S, Maeda A, Hattori M, Wakiguchi H, Fujieda M.
    • Journal Title

      Clin Nephrol.

      Volume: 76 Pages: 40-48

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] BKウイルスによる生体腎移植後のウイルス腎症の一例2013

    • Author(s)
      石原正行,藤枝幹也, 他
    • Organizer
      第45回日本小児感染症学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2013-10-27
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗ドナー抗体陽性の二次性生体腎移植後にBKウイルス腎症を発症した一小児例2013

    • Author(s)
      石原正行,藤枝幹也, 他
    • Organizer
      第35回日本小児腎不全学会学術集会
    • Place of Presentation
      ホテル華の湯(郡山市)
    • Year and Date
      2013-10-24
    • Related Report
      2013 Final Research Report
  • [Presentation] The usef ulness of monitoring of Epstein-Bar r viral load after renal transplant ation in pediatric recepients with EBV seronegative2013

    • Author(s)
      Ishihara M, Fujieda M, 他
    • Organizer
      The 16 th Congres s of the International Pediatric Ne phrology Association
    • Place of Presentation
      Shanghai International Conventi on Center, Shanghai, China
    • Year and Date
      2013-09-01
    • Related Report
      2013 Final Research Report
  • [Presentation] A 14-yea r-old girl with fibronectin glomeru lopathy : a rare cause of lobular glo merulopathy2013

    • Author(s)
      Ishihara M, Fujieda M, 他
    • Organizer
      The 11 th Korea-Japan Pediatric Nephrology Seminar
    • Place of Presentation
      Seoul National University Children's Hospital, Seoul, Korea
    • Year and Date
      2013-04-06
    • Related Report
      2013 Final Research Report
  • [Presentation] 腸管出血性大腸菌O-157による溶血性尿毒症症候群の経過中に急性膵炎を合併した1例2012

    • Author(s)
      佐藤哲也,藤枝幹也, 他
    • Organizer
      第44回日本小児感染症学会総会・学術集会
    • Place of Presentation
      北九州国際会議場(福岡市)
    • Year and Date
      2012-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 1か月女児の腸管出血性大腸菌(O-157)感染症2012

    • Author(s)
      森下祐介,藤枝幹也, 他
    • Organizer
      第44回日本小児感染症学会総会・学術集会
    • Place of Presentation
      北九州国際会議場(福岡市)
    • Year and Date
      2012-11-25
    • Related Report
      2013 Final Research Report
  • [Presentation] ロタウイルス胃腸炎に関連した両側尿路結石による腎後性腎不全2012

    • Author(s)
      藤枝幹也
    • Organizer
      第44回日本小児感染症学会総会・学術集会
    • Place of Presentation
      北九州国際会議場(福岡市)
    • Year and Date
      2012-11-24
    • Related Report
      2013 Final Research Report
  • [Presentation] トシリズマブ投与で軽快した赤芽球癆合併多関節型若年性特発性関節炎(JIA)の1例2012

    • Author(s)
      佐藤哲也,藤枝幹也, 他
    • Organizer
      第22回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      ウィルあいち(名古屋市)
    • Year and Date
      2012-10-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 腎移植術前検査でクオンティフェロン陽性なため抗結核薬内服を行った男児例2012

    • Author(s)
      石原正行,藤枝幹也, 他
    • Organizer
      第34回日本小児腎不全学会学術集会
    • Place of Presentation
      ホテルニューアワジ(洲本市)
    • Year and Date
      2012-09-14
    • Related Report
      2013 Final Research Report
  • [Presentation] 生後1か月で両側腎石灰化のみられた遠位尿細管性アシドーシスの男児例2012

    • Author(s)
      石原正行,藤枝幹也, 他
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2012-06-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 開窓Fontan術後進行する腎不全のため10歳台で腹膜透析を導入したAlport症候群疑いの女児例2012

    • Author(s)
      森田拓,藤枝幹也, 他
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Year and Date
      2012-06-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 感染性硬膜下血腫の1例2011

    • Author(s)
      佐藤哲也,藤枝幹也, 他
    • Organizer
      第43回日本小児感染症学会総会・学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Year and Date
      2011-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] 抗LPL抗体による高脂血症を伴ったSLEの10歳女児例2011

    • Author(s)
      荒木まり子,藤枝幹也, 他
    • Organizer
      第21回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2011-10-16
    • Related Report
      2013 Final Research Report
  • [Presentation] AMPKを介して虚血再潅流AKIモデルの腎尿細管でのPGC-1α活性は増加し,ミトコンドリア関連酵素を亢進する2011

    • Author(s)
      石原正行,藤枝幹也, 他
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-06-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Conditiona l VHL gene deletion activates a loc al NO-VEGF axis in a balanced fashi on to reinforceresistance to endoth elium-targeted glomerulonephropathy2011

    • Author(s)
      Morita T, Fujieda M, 他
    • Organizer
      The 11th Asian Congress of Pediatr ic Nephrology
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Sestrin 2 induce renal tubular cells to aut ophagy in vitro acute kidney injury model2011

    • Author(s)
      Ishihara M, Fujieda M, 他
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Gain of function mutation of the calcium se nsing receptor in a mother and her son with hypocalcemia2011

    • Author(s)
      Ishihara M, Fujieda M, 他
    • Organizer
      The 11th Asi an Congress of Pediatric Nephrology
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2011-06-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Sestrin 2 induce renal tubular cells to autophagy in vitro acute kidney injury model.2011

    • Author(s)
      Ishihara M, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Kagawa T, Horin T, Fujieda M, Wakiguchi H, Terada Y.
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Gain of function mutation of the calcium sensing receptor in a mother and her son with hypocalcemia.2011

    • Author(s)
      Ishihara M, Miura N, Morita T, Takasugi H, Matsushita K, Arai J, Endo I, Tajima T, Fujieda M, Wakiguchi H.
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Conditional VHL gene deletion activates a local NO-VEGF axis in a balanced fashion to reinforce resistance to endothelium-targeted glomerulonephropathy.2011

    • Author(s)
      Morita T, Kakinuma Y, Kurabayahi A, Fujieda M, Sato T, Shuin T, Furihata M, Wakiguchi H.
    • Organizer
      The 11th Asian Congress of Pediatric Nephrology
    • Place of Presentation
      福岡国際会議(福岡市)
    • Related Report
      2011 Research-status Report
  • [Presentation] AMPKを介して虚血再潅流AKIモデルの腎尿細管でのPGC-1α活性は増加し,ミトコンドリア関連酵素を亢進する2011

    • Author(s)
      石原正行,島村芳子,上田訓子,緒方巧二,井上紘輔,谷口義典,香川 亨,藤枝幹也,脇口 宏,寺田典生
    • Organizer
      第54回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 石原正行,藤枝幹也,岡田晋一,大田敏之,坂野 堯.小児頻回再発型ネフローゼ症候群に対するミゾリビンパルス療法の有効性と適応2011

    • Author(s)
      石原正行,藤枝幹也,岡田晋一,大田敏之,坂野 堯.
    • Organizer
      第41回日本腎臓学会西部学術大会
    • Place of Presentation
      徳島県郷土文化会館(徳島市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 抗LPL抗体による高脂血症を伴ったSLEの10歳女児例.2011

    • Author(s)
      荒木まり子,石原正行,高杉尚志,藤枝幹也,脇口 宏,高木敦子,池田康行.
    • Organizer
      第21回日本小児リウマチ学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 腎血管性高血圧を認めた神経線維腫症1型の乳児例2011

    • Author(s)
      満田直美,田村玲子,石原正行,山本雅樹,佐藤哲也,高杉尚志,細川卓利,久川浩章,藤枝幹也,脇口 宏,浜田文彦
    • Organizer
      第28回中国四国小児腎臓病学会
    • Place of Presentation
      松山市総合コミュニティセンター(松山市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 感染性硬膜下血腫の1例2011

    • Author(s)
      佐藤哲也,前田明彦,石原正行,高杉尚志,久川浩章,藤枝幹也,脇口 宏
    • Organizer
      第43回日本小児感染症学会総会・学術集会
    • Place of Presentation
      岡山コンベンションセンター(岡山市)
    • Related Report
      2011 Research-status Report
  • [Presentation] 遷延する血便と成長障害を認め,内視鏡所見から大腸リンパ濾胞増殖症と診断した1例2011

    • Author(s)
      大石 拓,田村玲子,満田直美,佐藤哲也,荒木まり子,久川浩章,藤枝幹也,新井淳一,脇口 宏
    • Organizer
      第63回中国四国小児科学会
    • Place of Presentation
      松江テレサ(松江市)
    • Related Report
      2011 Research-status Report
  • [Presentation] A 14-year-old girl with fibronectin glomerulopathy: a rare cause of lobular glomerulopathy.

    • Author(s)
      Ishihara M, Sato T, Maeda M, Matsumoto M, Naruse K, Shono A, Ohtsubo H, Kaito H, Nozu K, Iijima K, Fujieda M
    • Organizer
      The 11 th Korea-Japan Pediatric Nephrology Seminar
    • Place of Presentation
      Seoul National University Children's Hospital, Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] The usefulness of monitoring of Epstein-Barr viral load after renal transplantation in pediatric recepients with EBV seronegative.

    • Author(s)
      Ishihara M, Tanaka E, Sato T, Chikamaot H, Hisano M, Akioka Y, Dohno S, Maeda A, Hattori M, Fujieda M.
    • Organizer
      The 16 th Congress of the International Pediatric Nephrology Association.
    • Place of Presentation
      Shanghai International Convention Center, Shanghai, China
    • Related Report
      2013 Annual Research Report
  • [Presentation] 癒着性イレウスを反復し,外科的治療後に急性腎不全を呈したLowe症候群の1例.

    • Author(s)
      石原正行, 富田 理, 中島絢子, 小野美樹, 高杉尚志, 前田明彦, 北川博之, 香川 亨, 染谷朋之介, 藤枝幹也.
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 小児ステロイド依存性・頻回再発型ネフローゼ症候群の治療.

    • Author(s)
      藤枝幹也
    • Organizer
      第48回日本小児腎臓病学会学術集会
    • Place of Presentation
      あわぎんホール(徳島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 抗ドナー抗体陽性の二次性生体腎移植後にBKウイルス腎症を発症した一小児例.

    • Author(s)
      石原正行, 浅野達雄, 吉田雅樹, 石塚喜世伸, 菅原典子, 近本裕子, 秋岡祐子, 田邊一成, 藤枝幹也, 服部元史.
    • Organizer
      第35回日本小児腎不全学会学術集会
    • Place of Presentation
      ホテル華の湯(福島県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] BKウイルスによる生体腎移植後のウイルス腎症の一例.

    • Author(s)
      石原正行, 浅野達雄, 吉田雅樹, 石塚喜世伸, 菅原典子, 近本裕子, 秋岡祐子, 田邊一成, 藤枝幹也, 服部元史.
    • Organizer
      第45回日本小児感染症学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Epstein-Barrウイルス(EBV)から学ぶ

    • Author(s)
      藤枝幹也
    • Organizer
      第186回倉敷小児科医会専門医会
    • Place of Presentation
      倉敷国際ホテル(倉敷市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] Epstein-Barrウイルス(EBV)から学ぶ

    • Author(s)
      藤枝幹也
    • Organizer
      第65回佐賀小児科地方会
    • Place of Presentation
      佐賀大学医学部(佐賀市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] EBウイルス感染症の診断と制御-伝染性単核症と移植後リンパ増殖症を中心に-

    • Author(s)
      藤枝幹也
    • Organizer
      第3回広島小児腎と免疫研究会
    • Place of Presentation
      オリエンタルホテル広島(広島市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 児リウマチ、血管炎の診療-自験例を中心に-

    • Author(s)
      藤枝幹也
    • Organizer
      第91回日本小児科学会香川地方会
    • Place of Presentation
      サンポートホテル高松(高松市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] EBウイルス感染症の予防と制御-小児腎移植におけるPTLDの予防を中心に-.

    • Author(s)
      藤枝幹也
    • Organizer
      第64回中国四国小児科学会
    • Place of Presentation
      阿波観光ホテル(徳島市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] ロタウイルス胃腸炎に関連した両側尿路結石による腎後性腎不全

    • Author(s)
      藤枝幹也, 他
    • Organizer
      第44回日本小児感染症学会
    • Place of Presentation
      北九州国際会議場(北九州市)
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] X-linked Myotubular myopathyの一例

    • Author(s)
      大石拓, 藤枝幹也, 他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡サンパレスホテル&ホール(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 川崎病における抗Peroxiredoxin2(Prx2)抗体の存在と意義

    • Author(s)
      藤枝幹也, 他
    • Organizer
      第115回日本小児科学会学術集会
    • Place of Presentation
      福岡サンパレスホテル&ホール(福岡市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 幼児期に言語発達遅滞を認めた小児の就学時の診断について

    • Author(s)
      満田直美, 藤枝幹也, 他
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] MRA、脳波所見が診断に有用であった家族性片麻痺性片頭痛の13歳男児例

    • Author(s)
      細川卓利 藤枝幹也, 他
    • Organizer
      第54回日本小児神経学会総会
    • Place of Presentation
      ロイトン札幌(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 後天的なVHL遺伝子の不活化によるNO-VEGF系活性化は、血管内皮細胞において糸球体腎症への抵抗を増強する

    • Author(s)
      森田拓 藤枝幹也, 他
    • Organizer
      第55回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 高知県の小児救急医療体制の現状

    • Author(s)
      吉川清志 藤枝幹也, 他
    • Organizer
      第23回日本小児科医会総会フォーラム
    • Place of Presentation
      ホテルさっぽろ芸文館(札幌市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 開窓Fontan術後進行する腎不全のため10歳台で腹膜透析を導入したAlport症候群疑いの女児例

    • Author(s)
      森田拓 藤枝幹也, 他
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] 生後1ヵ月で両側腎石灰化のみられた遠位尿細管性アシドーシスの男児例

    • Author(s)
      石原正行 藤枝幹也, 他
    • Organizer
      第47回日本小児腎臓病学会学術集会
    • Place of Presentation
      都市センターホテル(東京都)
    • Related Report
      2012 Research-status Report
  • [Presentation] ミトコンドリア呼吸鎖の酵素活性低下により診断されたミトコンドリア心筋症の姉妹例

    • Author(s)
      山本雅樹 藤枝幹也, 他
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      国立京都国際会館(京都市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 胆汁うっ滞が遷延し肝生検で肝内胆管減少症と診断された超低出生体重児の1例

    • Author(s)
      荒木まり子 藤枝幹也, 他
    • Organizer
      第39回日本小児栄養消化器肝臓学会
    • Place of Presentation
      新梅田シティ梅田スカイ(大阪市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 移植後髄外再発例に対するNelarabine単独投与の経験

    • Author(s)
      堂野純孝 藤枝幹也, 他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Research-status Report
  • [Presentation] 初発時に胸腺浸潤が認められ、治療終了後のFDG-PET/CTで再発が疑われたホジキンリンパ腫の1例

    • Author(s)
      久川浩章 藤枝幹也, 他
    • Organizer
      第54回日本小児血液・がん学会学術集会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2012 Research-status Report
  • [Book] 血管炎症候群,小児腎臓病学(日本小児腎臓病学会編)2012

    • Author(s)
      藤枝幹也
    • Publisher
      診断と治療社
    • Related Report
      2013 Final Research Report
  • [Book] 小児の慢性腎炎症候群,今日の治療指針2012

    • Author(s)
      藤枝幹也
    • Publisher
      医学書院
    • Related Report
      2013 Final Research Report
  • [Book] ロタウイルス胃腸炎と尿酸結石症.腎臓症候群(第2版)下-その他の腎臓疾患を含めて-.別冊腎臓症候群(下),新領域別症候群シリーズ2012

    • Author(s)
      藤枝幹也, 他
    • Publisher
      日本臨床社
    • Related Report
      2013 Final Research Report
  • [Book] 腎尿路結石症小児疾患の診断治療基準第4版小児内科増刊号2012

    • Author(s)
      藤枝幹也, 他
    • Publisher
      京医学社
    • Related Report
      2013 Final Research Report
  • [Book] 血管炎症候群 小児腎臓病学(日本小児腎臓病学会編)2012

    • Author(s)
      藤枝幹也
    • Total Pages
      5
    • Publisher
      診断と治療社
    • Related Report
      2012 Research-status Report
  • [Book] 小児の慢性腎炎症候群 今日の治療指針2012

    • Author(s)
      藤枝幹也
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2012 Research-status Report
  • [Book] ロタウイルス胃腸炎と尿酸結石症. 腎臓症候群(第2版)下-その他の腎臓疾患を含めて-.別冊腎臓症候群(下),新領域別症候群シリーズ2012

    • Author(s)
      藤枝幹也, 他
    • Total Pages
      4
    • Publisher
      日本臨床社
    • Related Report
      2012 Research-status Report
  • [Book] 腎尿路結石症 小児疾患の診断治療基準 第4版 小児内科増刊号2012

    • Author(s)
      藤枝幹也, 他
    • Total Pages
      2
    • Publisher
      京医学社
    • Related Report
      2012 Research-status Report
  • [Remarks] 高知大学医学部小児思春期医学講座

    • URL

      http://www.kochi-ms.ac.jp/~fm_pdatr/

    • Related Report
      2013 Final Research Report
  • [Remarks] 高知大学医学部 小児思春期医学

    • URL

      http://www.kochi-ms.ac.jp/~fm_pdatr/

    • Related Report
      2013 Annual Research Report
  • [Remarks] 高知大学医学部

    • URL

      http://www.kochi-ms.ac.jp/

    • Related Report
      2012 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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