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Elucidation of Kawasaki disease onset mechanism

Research Project

Project/Area Number 23591587
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionNippon Medical School

Principal Investigator

RYUJI Fukazawa  日本医科大学, 医学部, 准教授 (80277566)

Co-Investigator(Kenkyū-buntansha) OGAWA Shunichi  日本医科大学, 医学部, 教授 (50194436)
Co-Investigator(Renkei-kenkyūsha) OHNO Naohito  東京薬科大学, 薬学部, 教授 (80152213)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords川崎病 / 川崎病モデルマウス / 遺伝子プロファイリング / サイトカインプロファイリング / Tumor Necrosis Factor / Innate Immunity / 川崎病モデル / サイトカインプロファイル / CAWS / 血管炎 / 免疫異常 / CAWS
Research Abstract

To elucidate the mechanism of Kawasaki disease (KD) onset, we analyzed mouse KD model.
Intra-peritoneal injection of Candida Albicans Water Soluble Fraction (CAWS) induced severe arteritis resembling KD in mice. Arteritis was markedly reduced by Tumor Necrosis alpha (TNFa) receptor blocker, and serum TNFa level positively correlated with artelitis severity. In addition, Gene expression profiling revealed TNFa receptor blocker attenuated genes, associated with innate immunity. Serum cytokines expression profiling of KD patients was quite similar to that of CAWS arteritis.
All of these findings suggested that Kawasaki disease arteritis and CAWS arteritis have similar biological features. And innate immunity and TNF pathway are associated with KD onset.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 1 results) Presentation (11 results) (of which Invited: 2 results) Book (3 results)

  • [Journal Article] Etanercept Suppresses Arteritis in a Murine Model of Kawasaki Disease: A Comparative Study Involving Different Biological Agents2013

    • Author(s)
      Ohashi R, Fukazawa R, Watanabe M, Tajima H, Ngai-Miura N, Ohno N, Tsuchiya S, Fukuda Y, Ogawa S, Itoh Y
    • Journal Title

      International Journal of Vascular Medicine

      Volume: 2013 Pages: 1-10

    • DOI

      10.1155/2013/543141

    • Related Report
      2013 Final Research Report 2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of immunoglobulin plus prednisolone for prevention of coronary artery abnormalities in severe kawasaki disease (RAISE study): A randomised, open-label, blinded-endpoints trial2012

    • Author(s)
      Kobayashi T, Saji T, Otani T, Takeuchi K, Nakamura T, Arakawa H, Kato T, Hara T, Hamaoka K, Ogawa S, Miura M, Nomura Y, Fuse S, Ichida F, Seki M, Fukazawa R, Ogawa C, Furuno K, Tokunaga H, Takatsuki S, Hara S, Morikawa A, investigators Rsg
    • Journal Title

      Lancet

      Volume: 379 Pages: 1613-1620

    • Related Report
      2013 Final Research Report
  • [Journal Article] A genome-wide association study identifies three new risk loci for kawasaki disease2012

    • Author(s)
      Onouchi Y, Ozaki K, Burns JC, Shimizu C, Terai M, Hamada H, Honda T, Suzuki H, Suenaga T, Takeuchi T, Yoshikawa N, Suzuki Y, Yasukawa K, Ebata R, Higashi K, Saji T, Kemmotsu Y, Takatsuki S, Ouchi K, Kishi F, Yoshikawa T, Nagai T, Hamamoto K, Sato Y, Honda A, Kobayashi H, Sato J, Shibuta S, Miyawaki M, Oishi K, Yamaga H, Aoyagi N, Iwahashi S, Miyashita R, Murata Y, Sasago K, Takahashi A, Kamatani N, Kubo M, Tsunoda T, Hata A, Nakamura Y, Tanaka T, Japan Kawasaki Disease Genome C (Abe J, Kobayashi T, Arakawa H, Ichida F, Nomura Y, Miura M, Ikeda K, Hara T, Fukazawa R, Ogawa S, Hamaoka K), Consortium USKDG
    • Journal Title

      Nat Genet

      Volume: 44 Pages: 517-521

    • Related Report
      2013 Final Research Report
  • [Presentation] Steroid Significantly Reduces Immunoglobulin Therapy Resistance in High Risk Kawasaki Disease Patients with Elevated BNP: A Sub-analysis of RAISE Study2014

    • Author(s)
      Fukazawa R
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Who is at High Risk after Kawasaki Disease?2014

    • Author(s)
      Fukazawa R
    • Organizer
      he 5th Congress of Asia Pacific Cardiac Society
    • Place of Presentation
      New Delhi, India
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] What is new in Kawasaki disease : Any breakthrough in aetiology?2013

    • Author(s)
      Fukazawa R
    • Organizer
      NHAM (National Heart Association of Malaysia) annual scientific meeting 2013
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Related Report
      2013 Final Research Report
  • [Presentation] Nationwide Survey of Patients with Giant Aneurysm Caused by Kawasaki Disease in Recent 10 Years : Analysis of Myocardial Infarction and Cardiac Death2013

    • Author(s)
      Fukazawa R, Ogawa S, et al
    • Organizer
      American Heart Association Scientific Session
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Comparison of 4 Different Biological Agents for Suppression of Arteritis in a Kawasaki Disease Mouse Model2013

    • Author(s)
      Ohashi R, Fukazawa R, Ohno N, Ogawa S
    • Organizer
      The 77th Annual Scientific Meeting of the Japan Circulation Society
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 1999~2010年川崎病巨大冠動脈瘤全国調査における冠動脈閉鎖に関わる因子の解析2013

    • Author(s)
      深澤隆治
    • Organizer
      第33回日本川崎病学会・学術集会
    • Place of Presentation
      富山
    • Related Report
      2013 Annual Research Report
  • [Presentation] 1999~2010年川崎病全国調査に基づく巨大冠動脈瘤の全国実態調査2013

    • Author(s)
      深澤隆治
    • Organizer
      第49回日本小児循環器学会総会・学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] What is new in KD: Any Break through in Aetiology2013

    • Author(s)
      Fukazawa R
    • Organizer
      National Heart Association of Masaysia Pediatric Cardiology Satellite Symposium 2013
    • Place of Presentation
      クアラルンプール
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 川崎病モデルマウスにおける血管炎の発症機序の解明2012

    • Author(s)
      深澤隆治、渡邉誠、小川俊一
    • Organizer
      第60回日本心臓病学会
    • Place of Presentation
      金沢
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 川崎病モデルマウス遺伝子解析による川崎病発症機構の解明2012

    • Author(s)
      深澤隆治、大野尚仁、三浦典子、渡邉誠、阿部正徳、林美雪、池上英、橋本康司、小川俊一
    • Organizer
      第48回日本小児循環器学会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] Understanding the etiology of Kawasaki Disease - from the genetic standpoint-2012

    • Author(s)
      Ryuji Fukazawa
    • Organizer
      The 10th Ineternational Kawasaki Disease Symposium(招待講演)
    • Place of Presentation
      京都
    • Related Report
      2011 Research-status Report
  • [Book] 今日の小児資料指針 第16版2014

    • Author(s)
      深澤隆治(分担) 編集:水口雅、市橋光、崎山弘
    • Total Pages
      530
    • Publisher
      医学書院
    • Related Report
      2013 Annual Research Report
  • [Book] 小児期心疾患における薬物療法ガイドライン2013

    • Author(s)
      深澤隆治(分担) 班長:佐地勉
    • Total Pages
      27
    • Publisher
      日本循環器学会
    • Related Report
      2013 Annual Research Report
  • [Book] 川崎病心臓血管後遺症の診断と治療に関するガイドライン (2013年改訂版)2013

    • Author(s)
      深澤隆治(分担) 班長:小川俊一
    • Total Pages
      58
    • Publisher
      日本循環器学会
    • Related Report
      2013 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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