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JNK is Critical for Development of Candida albicans-induced Aneurysm in Mouse Model of Kawasaki Disease

Research Project

Project/Area Number 23591590
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Pediatrics
Research InstitutionFukuoka University

Principal Investigator

YOSHIKANE Yukako  福岡大学, 医学部, 講師 (00449927)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Kyoko (IMANAKA Kyoko)  三重大学, 医学系研究科, 准教授 (00242967)
YOSHIMURA Koichi  山口県立大学, 看護栄養学部, 教授 (00322248)
KOGA Mitsuhisa  福岡大学, 薬学部, 助教 (60570801)
CHO Tamaki  福岡歯科大学, 歯学部, 准教授 (90131870)
HASHIMOTO Junichi  福岡大学, 医学部, 助教 (90580291)
Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords川崎病 / 冠動脈瘤 / カンジダアルビカンス / JNK / テネイシンC / カンジダ / マウスモデル / JNK阻害薬 / 血管炎 / 国際情報交流
Research Abstract

We injected Candida albicans cell wall extract (CAWE) into 4-week-old C57BL/6 mice intraperitoneally, and found that CAWE caused the development of aneurysms at coronary artery, carotid artery, celiac artery, iliac artery and abdominal aorta. Histological examination of coronary artery and abdominal aorta in CAWE-treated mice showed marked inflammatory cell infiltration, destruction of elastic lamellae, loss of medial smooth muscle cells and intimal thickening, which are similar to histological features of vascular lesions of patients with KD. To find the role of JNK in aneurysm development, we evaluated the effects of JNK inhibitor, SP600125, on abdominal aortic aneurysms induced by CAWE. Ttreatment with SP600125 significantly decreased the incidence of aneurysm and also protected against vascular inflammation and tissue destruction histologically, compared with the placebo treatment. JNK potential represents novel therapeutic target for aneurysms in Kawasaki disease.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2014 2013 2012

All Presentation (15 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Presentation] 血管炎モデルマウスを用いた川崎病動脈瘤の病態診断と治療2014

    • Author(s)
      吉兼由佳子、山口耕一、吉田利通、今中恭子
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島
    • Related Report
      2013 Final Research Report
  • [Presentation] 川崎病冠動脈瘤形成予防薬開発;JNK阻害薬~汎血管炎モデルマウスを用いた検討~2014

    • Author(s)
      吉兼由佳子、橋本淳一、古賀允久、長環、吉村耕一、今中恭子、廣瀬伸一
    • Organizer
      第117回日本小児科学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Final Research Report
  • [Presentation] c-Jun N-terminal kinase is a novel therapeutic target for controlling the development of Kawasaki disease-related arterial aneurysm2013

    • Author(s)
      Yukako Yoshikane, Mitsuhisa Koga, Tamaki Cho, Kyoko Imanaka-Yoshida, Junichi Hashimoto, Hiroki Aoki, Koichi Yoshimura, Shinichi Hirose
    • Organizer
      American Heart Association Scientific Sessions
    • Related Report
      2013 Final Research Report
  • [Presentation] JNK抑制による川崎病冠動脈瘤予防薬の開発~汎血管炎モデルマウスを用いた検討~2013

    • Author(s)
      吉兼由佳子、古賀允久、長環、吉村耕一、今中恭子、橋本淳一、上田誠、山本由美子、青木浩樹、廣瀬伸一
    • Organizer
      第33回日本川崎病学会
    • Place of Presentation
      富山
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] Tissue remodeling in vascular wall in Kawasaki disease-related vasculitis model mice2013

    • Author(s)
      Yukako Yoshikane、Junichi Hashimoto、Kyoko Imanaka-Yoshida、Mitsuhisa Koga、Tamaki Cho、Koichi Yoshimura、Yumiko Yamamoto、Hiroki Aoki、Shinichi Hirose
    • Organizer
      7^<th> Takao Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Final Research Report
  • [Presentation] JNK阻害薬による動脈瘤形成の抑制川崎病類似汎血管炎モデルマウスを用いた検討2013

    • Author(s)
      吉兼由佳子、吉村耕一、今中恭子、長環、古賀允久、山本由美子、青木弘樹、橋本淳一、上田誠、廣瀬伸一
    • Organizer
      第49回小児循環器学会総会
    • Place of Presentation
      東京(日本小児循環器学会雑誌29巻Suppl. Page168)
    • Related Report
      2013 Final Research Report
  • [Presentation] 川崎病類似汎血管炎モデルマウス病理組織の経時的変化化~テネイシンとの関連~2013

    • Author(s)
      吉兼由佳子、橋本淳一、上田誠、長環、古賀允久、吉村耕一、山本由美子、今中恭子、廣瀬伸一
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島(日本小児科学会雑誌117巻2号Page333)
    • Related Report
      2013 Final Research Report
  • [Presentation] The role of tenascin C in an animal model of Kawasaki disease-related coronary artery aneurysm2013

    • Author(s)
      Yukako Yoshikane, Junichi Hashimoto、Kyoko Imanaka、Mitsuhisa Koga、Tamaki Cho、Koichi Yoshimura、Yumiko Yamamoto、Hiroki Aoki、Shinichi Hirose
    • Organizer
      The 19^<th> Asia-Pacific Conference of Cardiology (APCC 2013)
    • Place of Presentation
      Thai
    • Related Report
      2013 Final Research Report
  • [Presentation] 川崎病類似汎血管炎モデルマウス病理組織の経時的変化化~テネイシンとの関連~2013

    • Author(s)
      吉兼 由佳子
    • Organizer
      第116回日本小児科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2013 Annual Research Report
  • [Presentation] JNK阻害薬による動脈瘤形成の抑制 川崎病類似汎血管炎モデルマウスを用いた検討2013

    • Author(s)
      吉兼 由佳子
    • Organizer
      第49回小児循環器学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tissue remodeling in vascular wall in Kawasaki disease-related vasculitis model mice.2013

    • Author(s)
      Yukako Yoshikane
    • Organizer
      7th Takao Symposium
    • Place of Presentation
      Tokyo
    • Related Report
      2013 Annual Research Report
  • [Presentation] -Jun N-terminal kinase is a novel therapeutic target for controlling the development of Kawasaki disease-related arterial aneurysm2013

    • Author(s)
      Yukako Yoshikane
    • Organizer
      American Heart Association Scientific Sessions
    • Place of Presentation
      Dallas, America
    • Related Report
      2013 Annual Research Report
  • [Presentation] The role of tenascin C in an animal model of Kawasaki disease-related coronary artery aneurysm.2013

    • Author(s)
      Yukako Yoshikane, Junichi Hashimoto、Kyoko Imanaka、Mitsuhisa Koga、Tamaki Cho、Koichi Yoshimura、Yumiko Yamamoto、Hiroki Aoki、Shinichi Hirose
    • Organizer
      19th Asia-Pacific Conference on Communications
    • Place of Presentation
      タイ
    • Related Report
      2012 Research-status Report
  • [Presentation] 動脈炎におけるテネイシンCの役割~川崎病類似汎血管炎マウスモデルから~2012

    • Author(s)
      吉兼由佳子、橋本淳一、今中恭子、古賀允久、長環、吉村耕一、山本由美子、青木浩樹、廣瀬伸一
    • Organizer
      第11回心臓血管発生研究会
    • Place of Presentation
      福島
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Presentation] 川崎病類似汎血管炎マウスモデルの経時的病理組織変化~テネイシンCの発現~2012

    • Author(s)
      吉兼由佳子、今中恭子
    • Organizer
      第32回日本川崎病学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Final Research Report 2012 Research-status Report
  • [Patent(Industrial Property Rights)] 炎症性動脈瘤の診断方法2014

    • Inventor(s)
      吉田(今中)恭子、三谷義英、吉田 利通、清藤努、松下竹次、大熊喜彰、吉兼由 佳子、須田憲治、市田蕗子
    • Industrial Property Rights Holder
      吉田(今中)恭子
    • Industrial Property Rights Type
      特許
    • Patent Publication Number
      2014-025863
    • Filing Date
      2014-02-06
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 炎症性動脈瘤の診断方法2012

    • Inventor(s)
      吉田恭子
    • Industrial Property Rights Holder
      吉田恭子
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-168018
    • Filing Date
      2012
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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