Strategy for the development of novel treatment for alopecia areata via chemokine and chemokine receptors

• Project/Area Number: 23591642
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dermatology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: ITO TAISUKE 浜松医科大学, 医学部附属病院, 講師 (90293638)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 皮膚炎症・再生学 / 円形脱毛症 / 細胞走化性 / 抗ヒスタミン薬 / CXCL10

Research Abstract

Prominent accumulation of lymphocytes is seen in the lesion of alopecia areata. These infiltrated cells are composed by Th1 and Tc1 cells. Th1 and Tc1 chemokine, such as CXCL10, is prominently expressed in hair bulbs of alopecia areata, and Th1 and Tc1 cells accumulate toward CXCL10 positive hair bulbs. The accumulation of CD8+ T cells is found not only acute phase of alopecia areata but also chronic phase of alopecia areata lesions. Inhibition of chemotaxis against CXCL10 can be new candidate of the treatment of alopecia areata. The Japanese guideline of alopecia areata suggests anti histaminic drugs. In this study, we reported that anti-histaminic drugs possess anti-chemotactic effects.

Research Products

• [Journal Article] Recent advances in the pathogenesis of autoimmune hair loss disease alopecia areata (2013)
  • Author(s): Ito T
  • Journal Title: Clin Dev Immunol Volume: 2013 Pages: 348546-348546
  • DOI: 10.1155/2013/348546
  • Peer Reviewed
• [Journal Article] Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology (2013)
  • Author(s): Ito T, Bertolini M, Funakoshi A, Ito N, Takayama T, Biro T, Paus R, Tokura Y
  • Journal Title: J Dermatol Sci Volume: 72 Issue: 3 Pages: 327-330
  • DOI: 10.1016/j.jdermsci.2013.07.014
  • Peer Reviewed
• [Journal Article] Alopecia areata possibly induced by autoimmune reaction in a patient with human T-cell lymphotropic virus-1-associated myelopathy (2013)
  • Author(s): Ito T, Shimada S, Mori T, Tokura Y
  • Journal Title: J Dermatol Volume: 40 Issue: 5 Pages: 399-401
  • DOI: 10.1111/1346-8138.12128
  • Peer Reviewed
• [Journal Article] Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CXCL10 by reducing CXCR3 expression, F-actin polymerization and calcium influx in patients with alopecia areata. (2013)
  • Author(s): Ito T, Fujiyama T, Hashizume H, Tokura Y
  • Journal Title: Journal of Dermatological Science Volume: 72 Issue: 1 Pages: 68-71
  • DOI: 10.1016/j.jdermsci.2013.04.029
  • Peer Reviewed
• [Journal Article] CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase. (2013)
  • Author(s): Ito T, Hashizume H, Shimauchi T, Funakoshi A, Ito N, Fukamizu H, Takigawa M, Tokura Y
  • Journal Title: Journal of Dermatological Science Volume: 69 Issue: 2 Pages: 140-147
  • DOI: 10.1016/j.jdermsci.2012.12.003
  • Peer Reviewed
• [Journal Article] CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase. (2013)
  • Author(s): Ito T, Hashizume H, Shimauchi T, Funakoshi A, Ito N, Fukamizu H, Takigawa M, Tokura Y.
  • Journal Title: Journal of Dermatological Science Volume: 69 Pages: 140-147
  • Peer Reviewed
• [Journal Article] Antihistaminic drug olopatadine downmodulates T cell chemotaxis toward CXCL10 by reducing CXCR3 expression, F-actin polymerization and calcium influx in patients with alopecia areata (2013)
  • Author(s): Ito T, Fujiyama T, Hashizume H, Tokura Y
  • Journal Title: Journal of Dermatological Science Volume: 未定
  • Peer Reviewed
• [Journal Article] Alopecia areata triggered or exacerbated by swine flu virus infection (2012)
  • Author(s): Ito T, Tokura Y
  • Journal Title: J Dermatol Volume: (in press) Issue: 10 Pages: 863-864
  • DOI: 10.1111/j.1346-8138.2011.01437.x
  • Peer Reviewed
• [Journal Article] Advances in the management of alopecia areata (2012)
  • Author(s): Ito T
  • Journal Title: J Dermatol Volume: 39 Issue: 1 Pages: 11-17
  • DOI: 10.1111/j.1346-8138.2011.01476.x
  • NAID: 10031184819
  • Peer Reviewed
• [Journal Article] Alopecia areata triggered or exacerbated by swine flu virus infection (2012)
  • Author(s): Ito T, Tokura Y
  • Journal Title: Journal of Dermatology Volume: 39 Pages: 863-864
  • Peer Reviewed
• [Presentation] Recent advances in the pathogenesis of alopecia areata (2013)
  • Organizer: Korean Hair Research Society
  • Place of Presentation: ソウル、韓国
  • Year and Date: 2013-05-25
  • Invited
• [Presentation] A case of trichorhinophalangeal syndrome (2012)
  • Author(s): Taisuke Ito, Tomomi Yokomatsu, Yutaka Shimomura, Yoshiki Tokura
  • Organizer: The 10th Meeting of the German-Japanese Society of Dermatology
  • Place of Presentation: The Pacific Harbor and Hotel Clement
  • Year and Date: 2012-12-07
• [Presentation] 脱毛症基礎と臨床 (2012)
  • Organizer: 静岡県保険医協会西部支部研究会
  • Place of Presentation: アクトシティ浜松研修交流センター6階62研修交流室 (upto date)
  • Year and Date: 2012-09-11
• [Presentation] AGA/円形脱毛症ガイドライン2010の見方 (2012)
  • Organizer: AGA Expert Meeting in 東海
  • Place of Presentation: キャッスルプラザホテル4階山吹(名古屋市)
  • Year and Date: 2012-09-01
• [Presentation] 2円形脱毛症の新規治療法 (2012)
  • Organizer: 第42回日本皮膚アレルギー・接触皮膚炎学会総会学術大会
  • Place of Presentation: 軽井沢プリンスホテルウエスト (シンポジウム)
  • Year and Date: 2012-07-15
• [Presentation] リンパ球走化性に対する抗アレルギー薬の影響 (2012)
  • Organizer: 第11回皮膚科EBMフォーラム
  • Place of Presentation: ルネッサンス札幌ホテルB1Fボールルーム
  • Year and Date: 2012-07-07
• [Presentation] 18円形脱毛症診療ガイドラインの見方と今後の発展 (2012)
  • Organizer: 第111回日本皮膚科学会総会
  • Place of Presentation: 京都市 (教育講演)
  • Year and Date: 2012-06-02
• [Presentation] CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase (2012)
  • Author(s): Taisuke Ito, Hideo Hashizume, Natsuho Ito, Atsuko Funakoshi, Takatoshi Shimauchi, Satoshi Hirakawa, and Yoshiki Tokura
  • Organizer: European Society for Dermatological Science
  • Place of Presentation: Venetia, Itary
• [Presentation] CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase. (2012)
  • Author(s): Ito T
  • Organizer: European Society for Dermatological Science
  • Place of Presentation: イタリア、ベネチア
• [Presentation] 円形脱毛症のTリンパ球細胞走化性に対するオロパタジン塩酸塩の影響 (2011)
  • Author(s): 伊藤泰介、平川聡史、戸倉新樹
  • Organizer: 毛髪科学研究会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-26
• [Presentation] Trichoimmunology (2011)
  • Author(s): 伊藤泰介
  • Organizer: 第5回宮城皮膚疾患懇話会
  • Place of Presentation: 仙台市
  • Year and Date: 2011-06-30
  • Invited
• [Presentation] 円形脱毛症の病態 (2011)
  • Author(s): 伊藤泰介
  • Organizer: 第74回日本皮膚科学会東京支部学術大会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-11
  • Invited
• [Presentation] Analysis of antigen-specific CTL to melanin-associated protein in the patients with recalcitrant alopecia areata (2011)
  • Author(s): Ito T, Hashizume H, Takigawa M, Tokura Y
  • Organizer: The 75th Annual meeting of Society for Investigative Dermatology
  • Place of Presentation: Phenix, Arizona USA (Poster presentation)
• [Presentation] Semaphorin 3A modified murine hair cycle via mast cell infiltration/activation (2011)
  • Author(s): Ito T, Sakabe J, Hirakawa S, Tokura Y
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: (Oral presentation)
• [Presentation] 円形脱毛症診療ガイドライン2010の見方 (2011)
  • Author(s): 伊藤泰介
  • Organizer: AGA EXPERT MEETING 2011
  • Place of Presentation: 東京
  • Invited
• [Presentation] Analysis of antigen-specific CTL to melanin-associated protein in the patients with recalcitrant alopecia areata. (2011)
  • Author(s): Ito T, Hashizume H, Takigawa M, Tokura Y.
  • Organizer: The 75th Annual meeting of Society for Investigative Dermatology
  • Place of Presentation: Phenix, Arizona USA
• [Presentation] Semaphorin 3A modified murine hair cycle via mast cell infiltration/activation. (2011)
  • Author(s): Ito T, Sakabe J, Hirakawa S, Tokura Y.
  • Organizer: The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 京都市
• [Presentation] Recent advances in the pathogenesis of alopecia areata
  • Author(s): Ito T
  • Organizer: 10th Meeting of Korean Hair Research Society
  • Place of Presentation: Seul, Korea
  • Invited
• [Presentation] 円形脱毛症 病態の理解と治療選択
  • Author(s): 伊藤泰介
  • Organizer: 第18回日本臨床毛髪学会
  • Place of Presentation: 東京パレスサイドビル
  • Invited
• [Presentation] CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase
  • Author(s): Ito T
  • Organizer: The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
  • Place of Presentation: 沖縄
• [Book] 今日の治療指針2013年版 (2013)
  • Author(s): 伊藤泰介
  • Total Pages: 1955
  • Publisher: 医学書院
• [Book] 円形脱毛症で白毛が残るわけ, WHAT'S NEW in 皮膚科学 (2012)
  • Author(s): 伊藤泰介 (宮地良樹編)
  • Total Pages: 100
  • Publisher: メディカルレビュー社(東京)
• [Book] 円形脱毛症と思うが?, Common diseaseから入る皮膚疾患 (2012)
  • Author(s): 伊藤泰介 (土田哲也編)
  • Total Pages: 8
  • Publisher: 文光堂(東京)
• [Book] 脱毛症研究の新知見円形脱毛症, Derma update-最新知見と臨床の実際 (2012)
  • Author(s): 伊藤泰介 (大山学編)
• [Book] 皮膚科臨床アセット脱毛症治療の新戦略6, 13円形脱毛症の病態 (2011)
  • Author(s): 伊藤泰介 (坪井良治編集)
• [Book] 毛の構造と機能毛に関する基本用語を解説してください。皮膚臨床臨時増刊号53 (2011)
  • Author(s): 伊藤泰介
• [Book] 毛の異常連珠毛など毛の形態異常について臨床症状と原因を教えてください。皮膚臨床臨時増刊号53 (2011)
  • Author(s): 伊藤泰介
• [Book] 脱毛症円形脱毛症において甲状腺の検査は必要ですか?円形脱毛症の病態について現在の考え方を教えてください。皮膚臨床臨時増刊号53 (2011)
  • Author(s): 伊藤泰介