| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
Prominent accumulation of lymphocytes is seen in the lesion of alopecia areata. These infiltrated cells are composed by Th1 and Tc1 cells. Th1 and Tc1 chemokine, such as CXCL10, is prominently expressed in hair bulbs of alopecia areata, and Th1 and Tc1 cells accumulate toward CXCL10 positive hair bulbs. The accumulation of CD8+ T cells is found not only acute phase of alopecia areata but also chronic phase of alopecia areata lesions. Inhibition of chemotaxis against CXCL10 can be new candidate of the treatment of alopecia areata. The Japanese guideline of alopecia areata suggests anti histaminic drugs. In this study, we reported that anti-histaminic drugs possess anti-chemotactic effects.
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