Meta-analysis to follow-up genome-wide association study in scizophrenia

• Project/Area Number: 23591683
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Nihon University
• Principal Investigator: TAKAHASHI Sakae 日本大学, 医学部, 准教授 (70297802)
• Co-Investigator(Kenkyū-buntansha): UCHIYAMA Makoto 日本大学, 医学部, 教授 (20221111) ; AKIYAMA Mayumi 日本大学, 医学部, 助教 (50386017) ; YOKOSE Hiromi 日本大学, 医学部, 助手 (40465274)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 統合失調症 / ゲノムワイド相関研究 / 原因遺伝子 / 精神医学 / 遺伝学 / 分子遺伝学

Research Abstract

We have finished genotyping 12 Single Nucleotide Polymorphisms (SNPs)in 536 schizophrenic families (1633 members including 699 schizophrenics). These SNPs were important in previous genome-wide association study (GWAS). As a result, two genes were significantly associated with schizophrenia. We are submitting the results to a major English journal.

Research Products

• [Journal Article] Abdominal paresthesia resembling restless legs syndrome successfully treated with iron supplement : A case report (2014)
  • Author(s): Suzuki M, Yamada K, Kanamori T, Konno C, Konno M, Takahashi S, Aramaki O, Takayama T, Uchiyama M
  • Journal Title: J Neurol Sci Volume: 336 Pages: 291-292
  • Peer Reviewed
• [Journal Article] Heterogeneity of Schizopherenia : Genetic and Symptomatic Factors (2013)
  • Author(s): Takahashi S
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 162 B Pages: 648-652
  • Peer Reviewed
• [Journal Article] A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden (2013)
  • Author(s): Takahashi S, Suzuki M, Uchiyama M
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 25
  • Peer Reviewed
• [Journal Article] One-year follow-up study of psychotic patients treated with blonanserin : A case series (2013)
  • Author(s): Takahashi S, Suzuki M, Uchiyama M
  • Journal Title: ASIA-PACIFIC PSYCHIATRY Volume: 5 Pages: 164-167
  • Peer Reviewed
• [Journal Article] The association between sleep problems and perceived health status : A Japanese nationwide general population survey (2013)
  • Author(s): Furihata R, Uchiyama M, Takahashi S, Suzuki M, Konno C, Osaki K, Konno M, Kaneita Y, Ohida T, Akahoshi T, Hashimoto Shu, Akashiba T
  • Journal Title: Sleep Medicine Volume: 13 Pages: 831-837
  • Peer Reviewed
• [Journal Article] Heterogeneity of Schizopherenia: Genetic and Symptomatic Factors. (2013)
  • Author(s): Takahashi S
  • Journal Title: Am J Med Genet B Neuropsychiatr Genet Volume: 162 Pages: 648-652
  • Peer Reviewed
• [Journal Article] A case of schizophrenia with meige syndrome induced by perospirone successfully treated with biperiden. (2013)
  • Author(s): Takahashi S, Suzuki M, Uchiyama M
  • Journal Title: J Neuropsychiatry Clin Neurosci Volume: 25 Pages: 28-28
  • Peer Reviewed
• [Journal Article] One-year follow-up study of psychotic patients treated with blonanserin: A case series. (2013)
  • Author(s): Takahashi S, Suzuki M, Uchiyama M
  • Journal Title: ASIA-PACIFIC PSYCHIATRY Volume: 5 Pages: 164-167
  • Peer Reviewed
• [Journal Article] The association between sleep problems and perceived health status: A Japanese nationwide general population survey (2013)
  • Author(s): Furihata R, Takahashi S, et al.
  • Journal Title: Sleep Medicine Volume: 13 Pages: 831-837
  • Peer Reviewed
• [Journal Article] Relationships between exploratory eye movement dysfunction and clinical symptoms in schizophrenia (2012)
  • Author(s): Suzuki M, Takahashi S, Matsushima E, Tsunoda M, Kurachi M, Okada T, Hayashi T, Ishii Y, Morita K, Maeda H, Katayama S, Otsuka T, Hirayasu Y, Sekine M, Okubo Y, Motoshita M, Ohta K, Uchiyama M, Kojima T
  • Journal Title: Psychiatry and Clinical Neurosciences Volume: 66 Pages: 187-194
  • Peer Reviewed
• [Journal Article] 「近年における精神医学の進歩―生物学的な側面から」統合失調症 (2012)
  • Author(s): 高橋栄
  • Journal Title: 日大医学雑誌 Volume: 71 Pages: 369-374
  • Peer Reviewed
• [Presentation] Case history and genome-wide scans for copy number variants (CNVs) in a family with 22q11.2 deletion syndrome (22q11.2DS) (2013)
  • Author(s): Nakamura S, Takahashi S, Suzuki T, Oosaki K, Soutome Y, Nagai K, Sagawa T, Uchiyama M
  • Organizer: 11th World Congress of Biological Psychiatry
  • Place of Presentation: Kyoto, Japan
• [Presentation] 22番染色体欠失症候群(22q11.2DS)家系の長期経過観察と全ゲノムcopy number variants(CNVs)解析 (2012)
  • Author(s): 中村桜子, 高橋栄, 鈴木貴浩, 大嵜公一, 早乙女優太, 佐川倫啓, 鈴木正泰, 内山真
  • Organizer: 第34回日本生物学的精神医学会
  • Place of Presentation: 神戸
• [Book] メンタル医療―原因解明と診断, 治療の最前線―. 精神疾患における診断機器応用の可能性 (2013)
  • Author(s): 高橋栄 (糸川昌成監修)
  • Publisher: シーエムシー出版,東京
• [Book] 精神疾患診断のための脳形態・機能検査法.探索眼球運動による統合失調症の診断 (2012)
  • Author(s): 高橋栄, 鈴木正泰, 内山真, 小島卓也 (三國雅彦・福田正人・功刀浩編著)
  • Publisher: 新興医学出版社, 東京
• [Remarks] 8. 小島卓也, 松島英介, 高橋栄, 安藤克巳 : 脳科学辞典(加藤忠志 編集). 探索眼球運動, Web, 2013
  • URL: http://bsd.neuroinf.jp